Q8BN21
PR
Gene name |
Vrk2 |
Protein name |
Serine/threonine-protein kinase VRK2 |
Names |
Vaccinia-related kinase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69922 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BN21
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BN21-F1 | Predicted | AlphaFoldDB |
34 variants for Q8BN21
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs241167803 | 36 | G>C | No | EVA | |
| rs3400763161 | 62 | L>M | No | EVA | |
| rs26856396 | 114 | R>K | No | EVA | |
| rs3389147845 | 141 | L>I | No | EVA | |
| rs3389121799 | 243 | W>L | No | EVA | |
| rs3401613070 | 261 | Q>RAKTK* | No | EVA | |
| rs3402230379 | 261 | Q>SAKTK* | No | EVA | |
| rs29480498 | 262 | T>S | No | EVA | |
| rs3389118817 | 275 | V>G | No | EVA | |
| rs3389134520 | 277 | K>R | No | EVA | |
| rs3389109505 | 293 | M>I | No | EVA | |
| rs3402048365 | 296 | H>Q | No | EVA | |
| rs3402111784 | 300 | Y>S | No | EVA | |
| rs13466583 | 319 | P>L | No | EVA | |
| rs217190675 | 321 | G>R | No | EVA | |
| rs13466580 | 333 | H>R | No | EVA | |
| rs230456445 | 335 | R>Q | No | EVA | |
| rs3389146513 | 335 | R>W | No | EVA | |
| rs3389139267 | 337 | P>L | No | EVA | |
| rs213627437 | 339 | Q>H | No | EVA | |
| rs3389144130 | 348 | T>A | No | EVA | |
| rs221899962 | 364 | H>Y | No | EVA | |
| rs3389145331 | 375 | Q>* | No | EVA | |
| rs3389151745 | 378 | S>N | No | EVA | |
| rs3389145317 | 388 | A>T | No | EVA | |
| rs3389145370 | 405 | F>L | No | EVA | |
| rs241987632 | 411 | L>R | No | EVA | |
| rs3389149233 | 432 | T>I | No | EVA | |
| rs3389146522 | 433 | R>S | No | EVA | |
| rs262733604 | 457 | T>K | No | EVA | |
| rs26870330 | 469 | I>V | No | EVA | |
| rs3389118780 | 470 | F>I | No | EVA | |
| rs3389155855 | 483 | Y>* | No | EVA | |
| rs235271299 | 491 | C>S | No | EVA |
No associated diseases with Q8BN21
7 regional properties for Q8BN21
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 264 - 299 | IPR002048 |
| domain | FAD-binding 8 | 625 - 739 | IPR013112 |
| domain | Ferric reductase, NAD binding domain | 746 - 927 | IPR013121 |
| domain | Ferric reductase transmembrane component-like domain | 427 - 583 | IPR013130 |
| domain | NADPH oxidase Respiratory burst | 168 - 267 | IPR013623 |
| domain | FAD-binding domain, ferredoxin reductase-type | 622 - 742 | IPR017927 |
| binding_site | EF-Hand 1, calcium-binding site | 277 - 289 | IPR018247 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrial membrane | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to oxidative stress | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of interleukin-1-mediated signaling pathway | Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway. |
| regulation of MAPK cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P29295 | HRR25 | Casein kinase I homolog HRR25 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35508 | CSNK1D | Casein kinase I isoform delta | Bos taurus (Bovine) | SS |
| Q5ZLL1 | CSNK1E | Casein kinase I isoform epsilon | Gallus gallus (Chicken) | SS |
| P48730 | CSNK1D | Casein kinase I isoform delta | Homo sapiens (Human) | SS |
| P49674 | CSNK1E | Casein kinase I isoform epsilon | Homo sapiens (Human) | EV |
| Q86Y07 | VRK2 | Serine/threonine-protein kinase VRK2 | Homo sapiens (Human) | PR |
| Q9DC28 | Csnk1d | Casein kinase I isoform delta | Mus musculus (Mouse) | PR |
| Q9JMK2 | Csnk1e | Casein kinase I isoform epsilon | Mus musculus (Mouse) | SS |
| Q06486 | Csnk1d | Casein kinase I isoform delta | Rattus norvegicus (Rat) | PR |
| P42169 | C03C10.2 | Putative casein kinase I C03C10.2 | Caenorhabditis elegans | PR |
| P34516 | K06H7.8 | Putative serine/threonine-protein kinase K06H7.1 | Caenorhabditis elegans | PR |
| Q6P647 | csnk1d | Casein kinase I isoform delta | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q7T2E3 | csnk1da | Casein kinase I isoform delta-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6P3K7 | csnk1db | Casein kinase I isoform delta-B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7ZUS1 | vrk1 | Serine/threonine-protein kinase VRK1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPRRKEKYK | LPVPLPEGKI | LDDMEGNRWA | LGKMIGSGGF | GLIYLAFPTN | KPNKDARHVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KLEYQENGPL | FSELKFYQRA | AKRECIQKWI | QQRKLDYLGI | PVFYGFGLTD | FKGRSYRFMV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MERLGIDLQK | LLDQNGGFKK | LTVLQLGIRM | LDVLEYIHEN | EYVHGDIKAA | NLLLDFTNPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVYLADYGLS | YRYCPNGNHK | QYQEDPRKGH | NGTIEFTSLD | AHKGVAPSRR | SDVEILGYCM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHWLFGKLPW | EAKLDDPVAV | QTAKTNLLDE | LPESVLKWAP | SGSSCSELVK | YLMYVHNLAY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDKPDYQKLK | KILNPDGVPL | GPLEFSTKVQ | SVHVRTPAQQ | KVDSPKATRK | PANEFPAKFP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKVHRETRAR | QREEQEDSQP | TMLQSRPAAP | ENSRTRKIHE | YSDIFSEMQS | LQQTPSYMSF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QGSYCKPYLD | CTRRDPIRKP | RSLPRYRHTP | TGNLGVTDLE | SSPRFWPAIF | QLTLSEETKA |
| 490 | 500 | ||||
| DVYYYGITIF | CLLIFVFLAL | YFL |