Q8BMD7
SS
Gene name |
Morc4 (Zcwcc2) |
Protein name |
MORC family CW-type zinc finger protein 4 |
Names |
Zinc finger CW-type coiled-coil domain protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75746 |
EC number |
|
Protein Class |
|
Descriptions
Microrchidia 3 is a human protein linked to autoimmune disorders, Down syndrome, and cancer. The extensive ATPase:CW interface stabilizes the protein fold and inhibits the catalytic activity of MORC3. The CW domain sterically impedes binding of the ATPase domain to DNA. MORC3 autoinhibition is released by disrupting the intramolecular ATPase:DW coupling through the competitive interaction of CW with histone H3 tail. Binding of CW to H3 leads to a marked rearrangement in the ATPase-CW cassette, which frees the DNA-binding site in active MORC3.
Autoinhibitory domains (AIDs)
Target domain |
38-307 (C-terminal ATPase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Zhang Y et al. (2019) "Mechanism for autoinhibition and activation of the MORC3 ATPase", Proceedings of the National Academy of Sciences of the United States of America, 116, 6111-6119
- Zhang Y et al. (2019) "MORC3 Is a Target of the Influenza A Viral Protein NS1", Structure (London, England : 1993), 27, 1029-1033.e3
- Zhang Y et al. (2019) "MORC3 Forms Nuclear Condensates through Phase Separation", iScience, 17, 182-189
Autoinhibited structure
Activated structure
1 structures for Q8BMD7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BMD7-F1 | Predicted | AlphaFoldDB |
70 variants for Q8BMD7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3555131550 | 10 | G>C | No | EVA | |
| rs3412296227 | 116 | R>C | No | EVA | |
| rs248730053 | 136 | A>V | No | EVA | |
| rs212669973 | 160 | Q>E | No | EVA | |
| rs3389576284 | 164 | V>L | No | EVA | |
| rs252247341 | 172 | S>G | No | EVA | |
| rs230682686 | 175 | N>S | No | EVA | |
| rs3389585315 | 177 | K>E | No | EVA | |
| rs3411960130 | 186 | P>GYSK* | No | EVA | |
| rs29256594 | 253 | E>A | No | EVA | |
| rs3389569364 | 268 | L>S | No | EVA | |
| rs3389577037 | 270 | A>G | No | EVA | |
| rs3411960142 | 271 | F>L | No | EVA | |
| rs3410801923 | 272 | C>Y | No | EVA | |
| rs3412192570 | 273 | S>I | No | EVA | |
| rs3389575092 | 288 | K>R | No | EVA | |
| rs3412375972 | 289 | K>M | No | EVA | |
| rs3389577023 | 295 | I>S | No | EVA | |
| rs3389533994 | 363 | G>V | No | EVA | |
| rs3409419442 | 380 | E>D | No | EVA | |
| rs3389575045 | 392 | L>H | No | EVA | |
| rs247728667 | 394 | R>K | No | EVA | |
| rs1131727898 | 403 | K>N | No | EVA | |
| rs3389483494 | 412 | L>F | No | EVA | |
| rs13484031 | 412 | L>S | No | EVA | |
| rs3389544287 | 413 | P>H | No | EVA | |
| rs254862842 | 434 | R>K | No | EVA | |
| rs3412168256 | 438 | M>I | No | EVA | |
| rs3412060005 | 438 | M>K | No | EVA | |
| rs3412099937 | 441 | P>A | No | EVA | |
| rs3412375876 | 441 | P>R | No | EVA | |
| rs3412898678 | 452 | Y>* | No | EVA | |
| rs3410801872 | 460 | R>A | No | EVA | |
| rs223541667 | 475 | H>N | No | EVA | |
| rs3389576308 | 477 | S>I | No | EVA | |
| rs229029843 | 486 | A>V | No | EVA | |
| rs3389576304 | 496 | D>N | No | EVA | |
| rs3389544282 | 544 | R>L | No | EVA | |
| rs243327241 | 549 | D>E | No | EVA | |
| rs3389585275 | 566 | E>D | No | EVA | |
| rs244229738 | 573 | K>R | No | EVA | |
| rs223575120 | 576 | T>N | No | EVA | |
| rs3389586718 | 585 | Y>C | No | EVA | |
| rs3389580469 | 589 | G>A | No | EVA | |
| rs1134649235 | 589 | G>S | No | EVA | |
| rs3411452438 | 591 | Y>N | No | EVA | |
| rs3389586688 | 604 | E>G | No | EVA | |
| rs3389572364 | 606 | S>N | No | EVA | |
| rs3389576973 | 607 | P>H | No | EVA | |
| rs241290629 | 610 | C>S | No | EVA | |
| rs3389576331 | 714 | G>S | No | EVA | |
| rs3389586650 | 715 | K>Q | No | EVA | |
| rs3389570299 | 717 | K>N | No | EVA | |
| rs3389556152 | 724 | R>* | No | EVA | |
| rs3389590109 | 737 | A>T | No | EVA | |
| rs3389483431 | 739 | K>* | No | EVA | |
| rs256088086 | 745 | D>E | No | EVA | |
| rs3412060859 | 749 | R>W | No | EVA | |
| rs29255340 | 757 | P>Q | No | EVA | |
| rs3411959031 | 764 | K>M | No | EVA | |
| rs3389556147 | 783 | K>N | No | EVA | |
| rs3389483481 | 793 | H>R | No | EVA | |
| rs222901582 | 816 | I>L | No | EVA | |
| rs3389585253 | 828 | A>D | No | EVA | |
| rs3389590112 | 830 | F>I | No | EVA | |
| rs3389483468 | 881 | A>T | No | EVA | |
| rs3389556160 | 911 | E>D | No | EVA | |
| rs3389569346 | 919 | T>A | No | EVA | |
| rs3389556132 | 924 | N>I | No | EVA | |
| rs3389575052 | 928 | D>Y | No | EVA |
No associated diseases with Q8BMD7
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP hydrolysis activity | Catalysis of the reaction |
| methylated histone binding | Binding to a histone in which a residue has been modified by methylation. |
| zinc ion binding | Binding to a zinc ion (Zn). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q14149 | MORC3 | MORC family CW-type zinc finger protein 3 | Homo sapiens (Human) | EV |
| Q9Y6X9 | MORC2 | ATPase MORC2 | Homo sapiens (Human) | PR |
| Q8TE76 | MORC4 | MORC family CW-type zinc finger protein 4 | Homo sapiens (Human) | SS |
| Q69ZX6 | Morc2a | ATPase MORC2A | Mus musculus (Mouse) | PR |
| Q8C5W4 | Morc2b | ATPase MORC2B | Mus musculus (Mouse) | PR |
| F7BJB9 | Morc3 | MORC family CW-type zinc finger protein 3 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLYRGAPAG | PGTPGGGLAR | AGSVPQAFRI | RLSTMSPRYL | QSNSSSHTRP | FSAIAELLDN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVDPDVSART | VFIDVEEVKK | KPCLTFTDDG | CGMTPHKLHR | MLSFGFTDKV | IKKSQRPIGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGNGFKSGSM | RLGKDALVFT | KNGNTLAVGL | LSQTYLECIQ | AQAVIVPIVP | FSQQNKKMIV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TEDSLPSLEA | ILNYSIFNCE | KDLLSQFDAI | PGKKGTRVLI | WNIRRNKDGK | SELDFDTDQY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DILVSDFDAE | EKEIGGVTSE | LPETEYSLRA | FCSILYMKPR | MKIFLRQKKV | TTQMIAKSLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NVEYDIYKPT | STNKQVRITF | GFSCKYHNQF | GVMMYHNNRL | IKAFEKAGCQ | LKPTCGEGVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VIGVIECNFL | KPAYNKQDFE | YTKEYRLTIN | ALARKLNAYW | KEKISQENFE | PLPTSRRIPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QTWVQCDECL | KWRRLPGMVD | PSTLPARWFC | YYNPHPKFKR | CSVPEEQERI | DEDLHRSKAK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QQVEAAEKKQ | KPMESDKYQV | FSNPPKTPPL | QDMAELNDKT | IGYEQINSPS | LLPSVREESR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SPPRLKSLDS | SAFQISRKYK | LILGEEPVEK | RRKIQTEMPL | SPIDYSMSGF | YRRVEAATAY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PEGENSPDKC | SSERSTPPHL | IPEYPESNKH | TEENREAPAL | CPGSQDQDQG | FLLPEELEDQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MPKLVAEESN | RSSENIDKDM | NKGPFVAVVG | VAKGVADSGA | PIQLVPFNRE | EFVGKRKRAE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SWKRANPYSS | AAPAATAGKG | KDCQDSRSRN | MPKIKTPKES | EELKRTTEKL | ERVLAERNLF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QQKVEELEQE | KNHWHSEYKK | AQHELVTYST | QETEGIYWSK | KHMGYRQAEF | QILKAELERT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KEEKQELKEK | LKETESHLEV | LQKAQVSFRN | PEGDDLERAL | ARLTRLRVHV | SYLLTSVLPH |
| 910 | 920 | ||||
| LELREIGYDS | EQVDGILYTV | LEANHILD |