Q8BM75
PR
Gene name |
Arid5b (Desrt, Mrf2) |
Protein name |
AT-rich interactive domain-containing protein 5B |
Names |
ARID domain-containing protein 5B, Developmentally and sexually retarded with transient immune abnormalities protein, Desrt, MRF1-like, Modulator recognition factor protein 2, MRF-2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:71371 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BM75
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BM75-F1 | Predicted | AlphaFoldDB |
62 variants for Q8BM75
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389114741 | 6 | L>F | No | EVA | |
| rs3401545166 | 46 | C>* | No | EVA | |
| rs3401545216 | 49 | K>R | No | EVA | |
| rs3401042075 | 66 | S>I | No | EVA | |
| rs3389071364 | 67 | R>Q | No | EVA | |
| rs3401042044 | 67 | R>V* | No | EVA | |
| rs3401336064 | 68 | Q>* | No | EVA | |
| rs3389109769 | 69 | L>P | No | EVA | |
| rs3389083105 | 94 | E>V | No | EVA | |
| rs29713139 | 113 | A>V | No | EVA | |
| rs3401273032 | 217 | S>C | No | EVA | |
| rs3401370444 | 218 | R>* | No | EVA | |
| rs3401169042 | 228 | T>A | No | EVA | |
| rs3401382503 | 231 | H>THSRFLSEWGDQRYPGSTGSGGFC* | No | EVA | |
| rs3401432894 | 232 | P>T | No | EVA | |
| rs3401273042 | 238 | E>A | No | EVA | |
| rs3389101820 | 239 | S>C | No | EVA | |
| rs3389092613 | 245 | A>V | No | EVA | |
| rs3389103585 | 262 | R>I | No | EVA | |
| rs3389113835 | 313 | S>F | No | EVA | |
| rs3389101848 | 331 | K>E | No | EVA | |
| rs3401542196 | 333 | M>L | No | EVA | |
| rs3389078229 | 355 | T>I | No | EVA | |
| rs3389097447 | 359 | A>T | No | EVA | |
| rs3389097519 | 455 | E>V | No | EVA | |
| rs29340774 | 474 | K>E | No | EVA | |
| rs29363880 | 480 | N>S | No | EVA | |
| rs3389107711 | 491 | P>T | No | EVA | |
| rs1135109495 | 526 | S>R | No | EVA | |
| rs3389114724 | 558 | G>W | No | EVA | |
| rs3389083045 | 615 | Q>* | No | EVA | |
| rs3389104764 | 618 | A>P | No | EVA | |
| rs1132462986 | 666 | M>V | No | EVA | |
| rs3389101691 | 706 | S>R | No | EVA | |
| rs3413066650 | 720 | K>R | No | EVA | |
| rs3389109767 | 729 | C>Y | No | EVA | |
| rs3389048144 | 790 | K>* | No | EVA | |
| rs3389104820 | 792 | Q>* | No | EVA | |
| rs1132633221 | 793 | L>H | No | EVA | |
| rs1132302232 | 797 | A>T | No | EVA | |
| rs1133822556 | 798 | D>Y | No | EVA | |
| rs29708124 | 869 | A>S | No | EVA | |
| rs29708124 | 869 | A>T | No | EVA | |
| rs50617431 | 872 | S>Y | No | EVA | |
| rs3389078290 | 873 | H>Q | No | EVA | |
| rs46314633 | 875 | H>N | No | EVA | |
| rs3389113891 | 876 | P>L | No | EVA | |
| rs1134357854 | 911 | P>S | No | EVA | |
| rs29380667 | 928 | T>A | No | EVA | |
| rs3389104583 | 929 | S>P | No | EVA | |
| rs46056561 | 937 | A>T | No | EVA | |
| rs47950696 | 995 | P>S | No | EVA | |
| rs3389114754 | 1014 | R>H | No | EVA | |
| rs3389048139 | 1017 | E>K | No | EVA | |
| rs3389101821 | 1038 | K>M | No | EVA | |
| rs29336984 | 1056 | G>S | No | EVA | |
| rs3401542199 | 1088 | N>S | No | EVA | |
| rs3401272106 | 1089 | S>* | No | EVA | |
| rs3389103501 | 1121 | F>L | No | EVA | |
| rs3389101811 | 1144 | L>M | No | EVA | |
| rs3400675609 | 1152 | S>T | No | EVA | |
| rs3389078201 | 1182 | V>E | No | EVA |
No associated diseases with Q8BM75
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| adipose tissue development | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
| adrenal gland development | The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. |
| cell development | The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. |
| cellular response to leukemia inhibitory factor | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. |
| face morphogenesis | The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. |
| fat cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. |
| fat pad development | The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. |
| female gonad development | The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. |
| fibroblast migration | Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. |
| kidney development | The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
| male gonad development | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. |
| multicellular organism growth | The increase in size or mass of an entire multicellular organism, as opposed to cell growth. |
| muscle organ morphogenesis | The process in which the anatomical structures of muscle are generated and organized. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nitrogen compound metabolic process | The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. |
| platelet-derived growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
| skeletal system morphogenesis | The process in which the anatomical structures of the skeleton are generated and organized. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q03124 | RSC9 | Chromatin structure-remodeling complex subunit RSC9 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q99856 | ARID3A | AT-rich interactive domain-containing protein 3A | Homo sapiens (Human) | SS |
| Q62431 | Arid3a | AT-rich interactive domain-containing protein 3A | Mus musculus (Mouse) | PR |
| O02326 | cfi-1 | AT-rich interactive domain-containing protein cfi-1 | Caenorhabditis elegans | PR |
| C0SUW7 | ARID6 | AT-rich interactive domain-containing protein 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WNR6 | ARID5 | AT-rich interactive domain-containing protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPNSLQWVG | SPCGLHGPYI | FYKAFQFHLE | GKPRILSLGD | FFFVRCTPKD | PICIAELQLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WEERTSRQLL | SSSKLYFLPE | DTPQGRNSDH | GEDEVIAVSE | KVIVKLEDLV | KWAHSDFSKW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RCGLRATPVK | TEAFGRNGQK | EALLRYRQST | LNSGLNFKDV | LKEKADLGED | EEETNVIVLS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YPQYCRYRSM | LKRIQDKPSS | ILTDQFALAL | GGIAVVSRNP | QILYCRDTFD | HPTLIENESV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CDEFAPNLKG | RPRKKKTCPQ | RRDSFSGSKD | PNNNCDGKVI | SKVKGEARSA | LTKPKNNHNN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CKKTSNEEKP | KLSIGEECRA | DEQAFLVALY | KYMKERKTPI | ERIPYLGFKQ | INLWTMFQAA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKLGGYETIT | ARRQWKHIYD | ELGGNPGSTS | AATCTRRHYE | RLILPYERFI | KGEEDKPLPP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IKPRKQENNT | QENENKTKVS | GNKRIKQEMA | KNKKEKENTP | KPQDTSEVSS | EQRKEEETLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HKSAPEPLPA | PEVKGKPEGH | KDLGARAPVS | RADPEKANET | DQGSNSEKEA | EEMGDKGLAP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LLPSPPLPPE | KDSAPTPGAG | KQPLASPSTQ | MDSKQEAKPC | CFTESPEKDL | QGAPFSSFSA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TKPPLTSQNE | AEEEQLPATA | NYIANCTVKV | DQLGSDDIHT | ALKQTPKVLV | VQSFDMFKDK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DLTGPMNENH | GLNYTPLLYS | RGNPGIMSPL | AKKKLLSQVS | GASLSSSYPY | GSPPPLISKK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KLIAREDLCS | GLSQGHHSQS | SDHTAVSRPS | VIQHVQSFKN | KASEDRKSIN | DIFKHDKLSR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SDAHRCGFSK | HQLGSLADSY | ILKQETQEGK | DKLLEKRAVS | HAHVPSFLAD | FYSSPHLHSL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YRHTEHHLHN | EQSSKYAARD | AYQESENGAF | LSHKHPEKIH | VNYLASLHLQ | DKKVAAAEAS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TDDQPTDLSL | PKNPHKLTSK | VLGLAHSTSG | SQEIKGASQF | QVVSNQSRDC | HPKACRVSPM |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TMSGPKKYPE | SLARSGKPHQ | VRLENFRKME | GMVHPILHRK | MSPQNIGAAR | PIKRSLEDLD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LVIAGKKARA | VSPLDPAKEA | SGKEKASEQE | SEGNKGAYGG | HSGAASEGHK | LPLSTPIFPG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LYSGSLCNSG | LNSRLPAGYS | HSLQYLKNQT | VLSPLMQPLA | FHSLVMQRGI | FTSPTNSQQL |
| 1150 | 1160 | 1170 | 1180 | ||
| YRHLAAATPV | GSSYGDLLHN | SIYPLAGINP | QAAFPSSQLS | SVHPSTKL |