Q8BLK9
Gene name |
Rps6kc1 |
Protein name |
Ribosomal protein S6 kinase delta-1 |
Names |
S6K-delta-1, 52 kDa ribosomal protein S6 kinase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320119 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
936-956 (Activation loop from InterPro)
Target domain |
789-1046 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q8BLK9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BLK9-F1 | Predicted | AlphaFoldDB |
No variants for Q8BLK9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8BLK9 | |||||
No associated diseases with Q8BLK9
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P18652 | RPS6KA | Ribosomal protein S6 kinase 2 alpha | Gallus gallus (Chicken) | SS |
| Q5F3L1 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Gallus gallus (Chicken) | SS |
| Q9UK32 | RPS6KA6 | Ribosomal protein S6 kinase alpha-6 | Homo sapiens (Human) | SS |
| O75676 | RPS6KA4 | Ribosomal protein S6 kinase alpha-4 | Homo sapiens (Human) | SS |
| P51812 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Homo sapiens (Human) | EV |
| Q15349 | RPS6KA2 | Ribosomal protein S6 kinase alpha-2 | Homo sapiens (Human) | SS |
| Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | Homo sapiens (Human) | EV |
| O75582 | RPS6KA5 | Ribosomal protein S6 kinase alpha-5 | Homo sapiens (Human) | SS |
| Q9Y5W7 | SNX14 | Sorting nexin-14 | Homo sapiens (Human) | PR |
| Q9Y5W8 | SNX13 | Sorting nexin-13 | Homo sapiens (Human) | PR |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q96S38 | RPS6KC1 | Ribosomal protein S6 kinase delta-1 | Homo sapiens (Human) | PR |
| Q9WUT3 | Rps6ka2 | Ribosomal protein S6 kinase alpha-2 | Mus musculus (Mouse) | SS |
| Q9Z2B9 | Rps6ka4 | Ribosomal protein S6 kinase alpha-4 | Mus musculus (Mouse) | SS |
| P18654 | Rps6ka3 | Ribosomal protein S6 kinase alpha-3 | Mus musculus (Mouse) | SS |
| Q8C050 | Rps6ka5 | Ribosomal protein S6 kinase alpha-5 | Mus musculus (Mouse) | PR |
| P18653 | Rps6ka1 | Ribosomal protein S6 kinase alpha-1 | Mus musculus (Mouse) | SS |
| Q6PHS6 | Snx13 | Sorting nexin-13 | Mus musculus (Mouse) | PR |
| Q3ZT31 | Snx25 | Sorting nexin-25 | Mus musculus (Mouse) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q8BHY8 | Snx14 | Sorting nexin-14 | Mus musculus (Mouse) | PR |
| Q63531 | Rps6ka1 | Ribosomal protein S6 kinase alpha-1 | Rattus norvegicus (Rat) | SS |
| Q18846 | rskn-2 | Putative ribosomal protein S6 kinase alpha-2 | Caenorhabditis elegans | PR |
| Q21734 | rskn-1 | Putative ribosomal protein S6 kinase alpha-1 | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSPWGHSAD | LARFYTVTEP | QRHPRGYTVY | KVTARVVSRR | NPEDVQEIIV | WRRYSDFKKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HRELWQIHRN | AFRHSELFPP | FAKGTVFGRF | DKTVIEERRQ | CAEDLLQFSA | NIPALYNSRQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQDFFKGGVI | SDGSELIGPA | EAYPDSPANA | FPECGTEGFS | SDSDLLSLTV | DADSLAEVDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GMASRQGSPS | RTFGLSLSTD | SSAVGAVASD | SEPSRVEDRE | SRSLFPSSLK | PRLGRRDYLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KAGELIKLAL | KKEEEDDYEA | ASDFYRKGVD | LLLEGVQGES | SPTRREAVKR | RTAEYLMRAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SICSLRAAPQ | LHTGPQPPGS | LSSRPPWSLR | SPAEELKAFR | VLGVIDKVLL | VMDTRTEQTF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ILKGLRKSSE | CSRNRKTIIP | RCVPNMVCLH | TYIISEESVF | LVLQRAEGGK | LWSYISKFLN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RSSQESLDIK | EGRPSMPPRV | CLQQPSASPQ | GGSSFESRGS | DTGSMLKALP | LKTSLTPSSQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DDSNQEDDGQ | PSSPKWLDSG | SSSEDECTAG | YLTLCNEYGQ | EKMDLVSLSE | ESVMQPEGDK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ADTQAVSSPA | SLATGSVSPS | THLRVFSGGE | DLEAVSSPPT | SESLSRSKNS | PMEFFRIDSK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DSTSELLGLD | FGEKLHSLKP | EPLKALFTLE | DGDSPSQSLD | PGESKRESEA | QDSVSRGSDD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SVPVISFKEA | AAEAISGAEE | GRPDLLVNLP | GELQPTKEAS | AMDPKFSQAS | AGRLDSKLLE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| APDVLCLRLS | SEQCHGLGPE | GPEELSDPTE | FCPGGVIPEH | DAQADPGVLF | EAAVDHRSSP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DQFLFSSLRS | ESDRLGQVEV | VVTAQALQES | LFHISSPCSG | ANKEHSAYAD | TATSEEVLLF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TEPTKEEANS | LFQRGSEAQE | RGVGAGEADK | EIHQIFEDLD | KRLAASSRFF | IPEGCIQRWA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AEMVVALDAL | HREGIVCRDL | NPNNILLNDG | GHIQLTYFSR | WSEVEDSCDS | DAVARMYCAP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EVGAVTEETE | ACDWWSLGAV | LFELLTGKTL | VECHPAGINT | HTTLNMPGCV | SEEARSLIQQ |
| 1030 | 1040 | 1050 | |||
| LLQFNPMERL | GAGVAGVEDI | KSHPFFTPVD | WAELTR |