Q8BLF2

PR
Gene name
Cdkl3
Protein name
Cyclin-dependent kinase-like 3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:213084
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

302-537 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BLF2

Entry ID Method Resolution Chain Position Source
AF-Q8BLF2-F1 Predicted AlphaFoldDB

29 variants for Q8BLF2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389125691 108 Q>H No EVA
rs3389150632 163 T>A No EVA
rs3389161854 175 D>H No EVA
rs3389161854 175 D>N No EVA
rs212962434 198 H>N No EVA
rs238341948 200 F>Y No EVA
rs3389161905 223 H>N No EVA
rs3389118211 223 H>R No EVA
rs3389143172 226 N>T No EVA
rs3389166577 227 I>T No EVA
rs3389153518 230 K>N No EVA
rs3389155192 231 S>T No EVA
rs3389118245 232 P>H No EVA
rs3389149467 249 R>S No EVA
rs3389118216 313 I>K No EVA
rs3401852911 341 N>K No EVA
rs3402362535 341 N>Y No EVA
rs26947299 385 R>H No EVA
rs230214435 404 V>A No EVA
rs261868080 404 V>I No EVA
rs251503568 455 N>S No EVA
rs3389143166 471 T>I No EVA
rs3402313792 473 G>R No EVA
rs3402483214 475 T>S No EVA
rs3389155218 490 Q>K No EVA
rs3402205676 528 E>A No EVA
rs222223034 535 A>S No EVA
rs3389143236 554 K>N No EVA
rs3389153293 564 L>F No EVA

No associated diseases with Q8BLF2

3 regional properties for Q8BLF2

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 286 IPR000719
active_site Serine/threonine-protein kinase, active site 121 - 133 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

4 GO annotations of biological process

Name Definition
dendrite extension Long distance growth of a single dendrite involved in cellular development.
negative regulation of axon extension Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
protein phosphorylation The process of introducing a phosphate group on to a protein.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00532 CDKL1 Cyclin-dependent kinase-like 1 Homo sapiens (Human) PR
Q5MAI5 CDKL4 Cyclin-dependent kinase-like 4 Homo sapiens (Human) PR
Q92772 CDKL2 Cyclin-dependent kinase-like 2 Homo sapiens (Human) PR
Q3UMM4 Cdk10 Cyclin-dependent kinase 10 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
Q8R3L8 Cdk8 Cyclin-dependent kinase 8 Mus musculus (Mouse) PR
Q8BWD8 Cdk19 Cyclin-dependent kinase 19 Mus musculus (Mouse) PR
Q99J95 Cdk9 Cyclin-dependent kinase 9 Mus musculus (Mouse) PR
Q3TZA2 Cdkl4 Cyclin-dependent kinase-like 4 Mus musculus (Mouse) PR
Q8CEQ0 Cdkl1 Cyclin-dependent kinase-like 1 Mus musculus (Mouse) PR
Q9QUK0 Cdkl2 Cyclin-dependent kinase-like 2 Mus musculus (Mouse) PR
Q9JHU3 Cdk20 Cyclin-dependent kinase 20 Mus musculus (Mouse) PR
Q5XIT0 Cdkl2 Cyclin-dependent kinase-like 2 Rattus norvegicus (Rat) PR
Q66HE7 Cdkl1 Cyclin-dependent kinase-like 1 Rattus norvegicus (Rat) PR
Q9JM01 Cdkl3 Cyclin-dependent kinase-like 3 Rattus norvegicus (Rat) PR
Q6AXJ9 cdkl1 Cyclin-dependent kinase-like 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE IKFLKQFRHE
70 80 90 100 110 120
NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIEYLHNNN
130 140 150 160 170 180
IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDVYTDY VATRWYRAPE LVLKDTSYGK
190 200 210 220 230 240
PVDIWALGCM IIEMATGHPF LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP
250 260 270 280 290 300
QVQHPKTARK KYPKLNGLLA DIVHACLQID PAERTSSTDL LRHDYFTRDG FIEKFIPELR
310 320 330 340 350 360
AKLLQEAKVN SFIKPKENFK ENEPVRDEKK SVFTNTLLYG NPSLYGKEVD RDKRAKELKV
370 380 390 400 410 420
RVIKAKGGKG DVPDQKKPEY EGDHRQQGTA DDTQPSSLDK KPSVLELTNP LNPSENSDGV
430 440 450 460 470 480
KEDPHAGGCM IMPPINLTSS NLLAANLSSN LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR
490 500 510 520 530 540
QEDTGPTQVQ TEKGAFNERT GQNDQISSGN KRKLNFPKCD RKEFHFPELP FTVQAKEMKG
550 560 570 580 590
MEVKQIKVLK RESKKTDSSK IPTLLSMDPN QEKQEGGDGD CEGKNLKRNR FFFSR