Q8BKX1

SS
Gene name
Baiap2
Protein name
BAR/IMD domain-containing adapter protein 2
Names
Brain-specific angiogenesis inhibitor 1-associated protein 2 , BAI-associated protein 2 , BAI1-associated protein 2 , Insulin receptor substrate protein of 53 kDa , IRSp53 , Insulin receptor substrate p53 , Insulin receptor tyrosine kinase 53 kDa substrate
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:108100
EC number
Protein Class

Descriptions

BAIAP2 (IRSp53) is a SH3-containing protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. The N-terminal autoinhibitory region interacts intramolecularly with the central region containing CRIB motif and Cdc42 binding domain. When GTP-loaded Cdc42 binds to the CRIB motif, it abrogates the autoinhibitory, intramolecular interaction and allows the SH3 domain to interact with BAIAP2 effector proteins such as Mena. When the N-terminal autoinhibitory fragment is co-expressed with BAIAP2, the fragment inhibits the function of BAIAP2.

Autoinhibitory domains (AIDs)

1-178 (N-terminal autoinhibitory region) SS

Target domain

180-318 (Central region)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BKX1

Entry ID Method Resolution Chain Position Source
AF-Q8BKX1-F1 Predicted AlphaFoldDB

21 variants for Q8BKX1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389236745 31 F>L No EVA
rs3389223317 68 G>D No EVA
rs3389221741 114 R>K No EVA
rs3389232992 115 Y>C No EVA
rs3389232975 184 K>R No EVA
rs3389232927 301 N>K No EVA
rs3389194749 318 K>Q No EVA
rs3402186050 320 A>G No EVA
rs3389236711 323 K>N No EVA
rs3389238587 340 N>H No EVA
rs3389223273 340 N>T No EVA
rs3389236698 360 K>M No EVA
rs3389236697 387 A>V No EVA
rs3389232929 390 D>G No EVA
rs3389236735 402 L>P No EVA
rs3389236710 404 T>M No EVA
rs3389236707 418 E>D No EVA
rs3389194709 430 F>I No EVA
rs3389238532 468 P>R No EVA
rs3389211802 469 P>R No EVA
rs3389224359 502 G>C No EVA

No associated diseases with Q8BKX1

3 regional properties for Q8BKX1

Type Name Position InterPro Accession
domain von Willebrand factor, type A 50 - 233 IPR002035-1
domain von Willebrand factor, type A 271 - 430 IPR002035-2
domain von Willebrand factor, VWA N-terminal domain 1 - 51 IPR032361

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • Cell projection, filopodium
  • Cell projection, ruffle
  • Cytoplasm, cytoskeleton
  • Detected throughout the cytoplasm in the absence of specific binding partners
  • Detected in filopodia and close to membrane ruffles
  • Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

24 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
dendritic spine cytoplasm The region of the neuronal cytoplasm located in dendritic spines.
excitatory synapse A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuron projection branch point The location where a secondary projection arises from a neuron projection.
neuron projection terminus The specialized, terminal region of a neuron projection such as an axon or a dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
postsynapse The part of a synapse that is part of the post-synaptic cell.
postsynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the postsynapse.
postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
presynapse The part of a synapse that is part of the presynaptic cell.
presynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the presynapse.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

6 GO annotations of molecular function

Name Definition
cytoskeletal anchor activity The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
identical protein binding Binding to an identical protein or proteins.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
proline-rich region binding Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.
scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
transcription coregulator binding Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.

18 GO annotations of biological process

Name Definition
actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
cellular response to L-glutamate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-glutamate(1-) stimulus.
dendrite development The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure.
modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of dendritic spine morphogenesis Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
positive regulation of excitatory postsynaptic potential Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
protein localization to synapse Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of modification of postsynaptic actin cytoskeleton Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton.
regulation of postsynapse organization Any process that modulates the physical form of a postsynapse.
regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
Rho protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5EAD0 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 Bos taurus (Bovine) PR
Q6UXY1 BAIAP2L2 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 Homo sapiens (Human) PR
Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 Homo sapiens (Human) PR
Q9UQB8 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 Homo sapiens (Human) EV
Q80Y61 Baiap2l2 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 Mus musculus (Mouse) PR
Q6GMN2 Baiap2 BAR/IMD domain-containing adapter protein 2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK GYFDALVKMG
70 80 90 100 110 120
ELASESQGSK ELGDVLFQMA EVHRQIQNQL EETLKSFHNE LLTQLEQKVE LDSRYLSAAL
130 140 150 160 170 180
KKYQTEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS
190 200 210 220 230 240
DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA
250 260 270 280 290 300
VQLMQQMANS NGSILPSALS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM
310 320 330 340 350 360
NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP KNSYATTENK
370 380 390 400 410 420
TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE
430 440 450 460 470 480
KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLALPPP DYGTSSRAFP
490 500 510 520 530
TQTAGTFKQR PYSVAVPAFS QGLDDYGARS VSRNPFANVH LKPTVTNDRS APLLS