Descriptions

SUN proteins are the core components of LINC complexes that span across the nuclear envelope for nuclear positioning and migration. SUN proteins contain two coiled-coil domains (CC1 and CC2), exhibiting distinct oligomeric states. The structure of the CC2-SUN monomer reveals that CC2 unexpectedly folds as a three-helix bundle that interacts with the SUN domain and locks it in an inactive conformation. In contrast, the structure of the CC1 trimer shows that CC1 is an imperfect coiled coil for the trimerization and activation of the SUN domain. Modulations of CC1 and CC2 dictate different oligomeric states of CC1-CC2-SUN, which is essential for LINC complex formation.

Autoinhibitory domains (AIDs)

Target domain

524-699 (SUN domain)

Relief mechanism

Partner binding

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

3 structures for Q8BJS4

Entry ID Method Resolution Chain Position Source
5ED8 X-ray 250 A A 470-731 PDB
5ED9 X-ray 201 A A/B/C 410-481 PDB
AF-Q8BJS4-F1 Predicted AlphaFoldDB

35 variants for Q8BJS4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs227672005 15 D>E No EVA
rs257274701 25 A>G No EVA
rs3389367305 87 V>M No EVA
rs3406030374 92 S>R No EVA
rs3389368423 103 P>L No EVA
rs3389371174 105 W>S No EVA
rs246494111 130 A>E No EVA
rs221327616 161 S>N No EVA
rs232461033 165 R>G No EVA
rs213314661 172 R>W No EVA
rs3389363337 198 T>I No EVA
rs226490837 232 L>M No EVA
rs3389380541 283 H>D No EVA
rs583436050 286 A>T No EVA
rs259764185 290 V>I No EVA
rs3411306391 341 D>E No EVA
rs3406401012 347 E>Q No EVA
rs228449702 352 R>C No EVA
rs3389384102 428 L>Q No EVA
rs3389363351 440 A>T No EVA
rs3389377343 446 Q>R No EVA
rs3389384137 476 R>G No EVA
rs36373653 485 A>V No EVA
rs3389335500 513 M>K No EVA
rs3389335543 518 A>V No EVA
rs3389325636 542 V>M No EVA
rs3389377344 578 S>T No EVA
rs3406284841 597 Y>C No EVA
rs3389371180 597 Y>H No EVA
rs3406498978 599 S>T No EVA
rs3389343198 603 R>W No EVA
rs3389343236 623 G>S No EVA
rs3389371146 701 Y>* No EVA
rs3389325618 702 Q>K No EVA
rs3389352896 711 N>H No EVA

No associated diseases with Q8BJS4

5 regional properties for Q8BJS4

Type Name Position InterPro Accession
domain Protein kinase domain 249 - 500 IPR000719
active_site Serine/threonine-protein kinase, active site 364 - 376 IPR008271
binding_site Protein kinase, ATP binding site 255 - 278 IPR017441
domain p21 activated kinase binding domain 72 - 117 IPR033923
domain p21-activated kinase 2, catalytic domain 229 - 524 IPR035064

Functions

Description
EC Number
Subcellular Localization
  • Nucleus inner membrane ; Single-pass type II membrane protein
  • Nucleus envelope
  • Endosome membrane ; Single-pass type II membrane protein
  • Colocalizes with KASH5 at sites of telomere attachment in meiocytes
PANTHER Family PTHR12911 SAD1/UNC-84-LIKE PROTEIN-RELATED
PANTHER Subfamily PTHR12911:SF22 SUN DOMAIN-CONTAINING PROTEIN 2
PANTHER Protein Class cytoskeletal protein
non-motor microtubule binding protein
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
endosome membrane The lipid bilayer surrounding an endosome.
meiotic nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

4 GO annotations of molecular function

Name Definition
cytoskeleton-nuclear membrane anchor activity The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane.
identical protein binding Binding to an identical protein or proteins.
lamin binding Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.
protein-membrane adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle.

7 GO annotations of biological process

Name Definition
centrosome localization Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.
nuclear matrix anchoring at nuclear membrane The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.
nuclear migration along microfilament The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47069 MPS3 Spindle pole body assembly component MPS3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O94901 SUN1 SUN domain-containing protein 1 Homo sapiens (Human) SS
Q8TC36 SUN5 SUN domain-containing protein 5 Homo sapiens (Human) PR
Q9UH99 SUN2 SUN domain-containing protein 2 Homo sapiens (Human) SS
Q9DA32 Sun5 SUN domain-containing protein 5 Mus musculus (Mouse) PR
Q9D666 Sun1 SUN domain-containing protein 1 Mus musculus (Mouse) EV
10 20 30 40 50 60
MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN MKHLSPAPQL
70 80 90 100 110 120
GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH SEPYWSGDLR GRRRRGTGGS
130 140 150 160 170 180
ESSKANGLTA ESKASEDFFG SSSGYSSEDD LAGYTDSDQH SSGSRLRSAA SRAGSFVWTL
190 200 210 220 230 240
VTFPGRLFGL LYWWIGTTWY RLTTAASLLD VFVLTRSRHF SLNLKSFLWF LLLLLLLTGL
250 260 270 280 290 300
TYGAWHFYPL GLQTLQPAVV SWWAAKESRK QPEVWESRDA SQHFQAEQRV LSRVHSLERR
310 320 330 340 350 360
LEALAADFSS NWQKEAIRLE RLELRQGAAG HGGGSSLSHE DALSLLEGLV SRREATLKED
370 380 390 400 410 420
LRRDTVAHIQ EELATLRAEH HQDSEDLFKK IVQASQESEA RVQQLKTEWK SMTQEAFQES
430 440 450 460 470 480
SVKELGRLEA QLASLRQELA ALTLKQNSVA DEVGLLPQKI QAARADVESQ FPDWIRQFLL
490 500 510 520 530 540
GDRGARSGLL QRDEMHAQLQ ELENKILTKM AEMQGKSARE AAASLGQILQ KEGIVGVTEE
550 560 570 580 590 600
QVHRIVKQAL QRYSEDRIGM VDYALESGGA SVISTRCSET YETKTALLSL FGIPLWYHSQ
610 620 630 640 650 660
SPRVILQPDV HPGNCWAFQG PQGFAVVRLS ARIRPTAVTL EHVPKALSPN STISSAPKDF
670 680 690 700 710 720
AIFGFDEDLQ QEGTLLGTFA YDQDGEPIQT FYFQASKMAT YQVVELRILT NWGHPEYTCI
730
YRFRVHGEPA H