Q8BJS4
Gene name |
Sun2 (Unc84b) |
Protein name |
SUN domain-containing protein 2 |
Names |
Protein unc-84 homolog B , Sad1/unc-84 protein-like 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:223697 |
EC number |
|
Protein Class |
SAD1/UNC-84-LIKE PROTEIN-RELATED (PTHR12911) |

Descriptions
SUN proteins are the core components of LINC complexes that span across the nuclear envelope for nuclear positioning and migration. SUN proteins contain two coiled-coil domains (CC1 and CC2), exhibiting distinct oligomeric states. The structure of the CC2-SUN monomer reveals that CC2 unexpectedly folds as a three-helix bundle that interacts with the SUN domain and locks it in an inactive conformation. In contrast, the structure of the CC1 trimer shows that CC1 is an imperfect coiled coil for the trimerization and activation of the SUN domain. Modulations of CC1 and CC2 dictate different oligomeric states of CC1-CC2-SUN, which is essential for LINC complex formation.
Autoinhibitory domains (AIDs)
Target domain |
524-699 (SUN domain) |
Relief mechanism |
Partner binding |
Assay |
Deletion assay, Mutagenesis experiment, Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

3 structures for Q8BJS4
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
5ED8 | X-ray | 250 A | A | 470-731 | PDB |
5ED9 | X-ray | 201 A | A/B/C | 410-481 | PDB |
AF-Q8BJS4-F1 | Predicted | AlphaFoldDB |
35 variants for Q8BJS4
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
rs227672005 | 15 | D>E | No | EVA | |
rs257274701 | 25 | A>G | No | EVA | |
rs3389367305 | 87 | V>M | No | EVA | |
rs3406030374 | 92 | S>R | No | EVA | |
rs3389368423 | 103 | P>L | No | EVA | |
rs3389371174 | 105 | W>S | No | EVA | |
rs246494111 | 130 | A>E | No | EVA | |
rs221327616 | 161 | S>N | No | EVA | |
rs232461033 | 165 | R>G | No | EVA | |
rs213314661 | 172 | R>W | No | EVA | |
rs3389363337 | 198 | T>I | No | EVA | |
rs226490837 | 232 | L>M | No | EVA | |
rs3389380541 | 283 | H>D | No | EVA | |
rs583436050 | 286 | A>T | No | EVA | |
rs259764185 | 290 | V>I | No | EVA | |
rs3411306391 | 341 | D>E | No | EVA | |
rs3406401012 | 347 | E>Q | No | EVA | |
rs228449702 | 352 | R>C | No | EVA | |
rs3389384102 | 428 | L>Q | No | EVA | |
rs3389363351 | 440 | A>T | No | EVA | |
rs3389377343 | 446 | Q>R | No | EVA | |
rs3389384137 | 476 | R>G | No | EVA | |
rs36373653 | 485 | A>V | No | EVA | |
rs3389335500 | 513 | M>K | No | EVA | |
rs3389335543 | 518 | A>V | No | EVA | |
rs3389325636 | 542 | V>M | No | EVA | |
rs3389377344 | 578 | S>T | No | EVA | |
rs3406284841 | 597 | Y>C | No | EVA | |
rs3389371180 | 597 | Y>H | No | EVA | |
rs3406498978 | 599 | S>T | No | EVA | |
rs3389343198 | 603 | R>W | No | EVA | |
rs3389343236 | 623 | G>S | No | EVA | |
rs3389371146 | 701 | Y>* | No | EVA | |
rs3389325618 | 702 | Q>K | No | EVA | |
rs3389352896 | 711 | N>H | No | EVA |
No associated diseases with Q8BJS4
5 regional properties for Q8BJS4
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Protein kinase domain | 249 - 500 | IPR000719 |
active_site | Serine/threonine-protein kinase, active site | 364 - 376 | IPR008271 |
binding_site | Protein kinase, ATP binding site | 255 - 278 | IPR017441 |
domain | p21 activated kinase binding domain | 72 - 117 | IPR033923 |
domain | p21-activated kinase 2, catalytic domain | 229 - 524 | IPR035064 |
Functions
Description | ||
---|---|---|
EC Number | ||
Subcellular Localization |
|
|
PANTHER Family | PTHR12911 | SAD1/UNC-84-LIKE PROTEIN-RELATED |
PANTHER Subfamily | PTHR12911:SF22 | SUN DOMAIN-CONTAINING PROTEIN 2 |
PANTHER Protein Class |
cytoskeletal protein
non-motor microtubule binding protein |
|
PANTHER Pathway Category | No pathway information available |
7 GO annotations of cellular component
Name | Definition |
---|---|
chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
endosome membrane | The lipid bilayer surrounding an endosome. |
meiotic nuclear membrane microtubule tethering complex | A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. |
nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
4 GO annotations of molecular function
Name | Definition |
---|---|
cytoskeleton-nuclear membrane anchor activity | The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. |
identical protein binding | Binding to an identical protein or proteins. |
lamin binding | Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. |
protein-membrane adaptor activity | The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. |
7 GO annotations of biological process
Name | Definition |
---|---|
centrosome localization | Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
nuclear envelope organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
nuclear matrix anchoring at nuclear membrane | The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. |
nuclear migration along microfilament | The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. |
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration | The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. |
positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
6 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
P47069 | MPS3 | Spindle pole body assembly component MPS3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
O94901 | SUN1 | SUN domain-containing protein 1 | Homo sapiens (Human) | SS |
Q8TC36 | SUN5 | SUN domain-containing protein 5 | Homo sapiens (Human) | PR |
Q9UH99 | SUN2 | SUN domain-containing protein 2 | Homo sapiens (Human) | SS |
Q9DA32 | Sun5 | SUN domain-containing protein 5 | Mus musculus (Mouse) | PR |
Q9D666 | Sun1 | SUN domain-containing protein 1 | Mus musculus (Mouse) | EV |
10 | 20 | 30 | 40 | 50 | 60 |
MSRRSQRLTR | YSQDDNDGGS | SSSGASSVAG | SQGTVFKDSP | LRTLKRKSSN | MKHLSPAPQL |
70 | 80 | 90 | 100 | 110 | 120 |
GPSSDSHTSY | YSESVVRESY | IGSPRAVSLA | RSALLDDHLH | SEPYWSGDLR | GRRRRGTGGS |
130 | 140 | 150 | 160 | 170 | 180 |
ESSKANGLTA | ESKASEDFFG | SSSGYSSEDD | LAGYTDSDQH | SSGSRLRSAA | SRAGSFVWTL |
190 | 200 | 210 | 220 | 230 | 240 |
VTFPGRLFGL | LYWWIGTTWY | RLTTAASLLD | VFVLTRSRHF | SLNLKSFLWF | LLLLLLLTGL |
250 | 260 | 270 | 280 | 290 | 300 |
TYGAWHFYPL | GLQTLQPAVV | SWWAAKESRK | QPEVWESRDA | SQHFQAEQRV | LSRVHSLERR |
310 | 320 | 330 | 340 | 350 | 360 |
LEALAADFSS | NWQKEAIRLE | RLELRQGAAG | HGGGSSLSHE | DALSLLEGLV | SRREATLKED |
370 | 380 | 390 | 400 | 410 | 420 |
LRRDTVAHIQ | EELATLRAEH | HQDSEDLFKK | IVQASQESEA | RVQQLKTEWK | SMTQEAFQES |
430 | 440 | 450 | 460 | 470 | 480 |
SVKELGRLEA | QLASLRQELA | ALTLKQNSVA | DEVGLLPQKI | QAARADVESQ | FPDWIRQFLL |
490 | 500 | 510 | 520 | 530 | 540 |
GDRGARSGLL | QRDEMHAQLQ | ELENKILTKM | AEMQGKSARE | AAASLGQILQ | KEGIVGVTEE |
550 | 560 | 570 | 580 | 590 | 600 |
QVHRIVKQAL | QRYSEDRIGM | VDYALESGGA | SVISTRCSET | YETKTALLSL | FGIPLWYHSQ |
610 | 620 | 630 | 640 | 650 | 660 |
SPRVILQPDV | HPGNCWAFQG | PQGFAVVRLS | ARIRPTAVTL | EHVPKALSPN | STISSAPKDF |
670 | 680 | 690 | 700 | 710 | 720 |
AIFGFDEDLQ | QEGTLLGTFA | YDQDGEPIQT | FYFQASKMAT | YQVVELRILT | NWGHPEYTCI |
730 | |||||
YRFRVHGEPA | H |