AiPD: Autoinhibited Protein Database

Gene name	Dyrk4
Protein name	Dual specificity tyrosine-phosphorylation-regulated kinase 4
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:101320
EC number	2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-236 (Predicted disordered autoinhibitory region) PR

1-236 (Predicted disordered autoinhibitory region)

cis-regPred

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BI55-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388863270	72	I>F	No	EVA
rs3388856627	111	Q>*	No	EVA
rs3388826843	121	L>V	No	EVA
rs1133908308	137	T>I	No	EVA
rs3388863798	193	E>*	No	EVA
rs3388853406	233	V>G	No	EVA
rs224602281	315	H>Q	No	EVA
rs3388865069	329	I>F	No	EVA
rs3388853408	381	Q>E	No	EVA
rs3388839743	381	Q>R	No	EVA
rs3388861095	391	I>N	No	EVA
rs3388865074	396	Y>*	No	EVA
rs3388865000	399	A>G	No	EVA
rs3388844998	408	I>V	No	EVA
rs3388861389	434	V>L	No	EVA
rs217012827	441	H>D	No	EVA
rs3388860070	453	F>S	No	EVA
rs3388861120	454	D>E	No	EVA
rs3388864662	466	R>*	No	EVA
rs3388844999	516	H>Q	No	EVA
rs3388853341	526	K>N	No	EVA
rs3388868445	549	Q>*	No	EVA
rs3388853339	583	S>N	No	EVA
rs1135293876	584	S>F	No	EVA
rs3388868468	587	H>N	No	EVA
rs3397385889	602	G>V	No	EVA
rs47087308	604	S>P	No	EVA
rs864280737	631	I>V	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	219 - 515	IPR000719
active_site	Serine/threonine-protein kinase, active site	341 - 353	IPR008271
binding_site	Protein kinase, ATP binding site	225 - 248	IPR017441

		Description
EC Number	2.7.12.1	Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity	Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

Name	Definition
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NE63	HIPK4	Homeodomain-interacting protein kinase 4	Homo sapiens (Human)	PR
Q9H422	HIPK3	Homeodomain-interacting protein kinase 3	Homo sapiens (Human)	SS
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (Human)	PR
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (Human)	PR
Q9H2X6	HIPK2	Homeodomain-interacting protein kinase 2	Homo sapiens (Human)	EV
Q9NR20	DYRK4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens (Human)	PR
Q61214	Dyrk1a	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Mus musculus (Mouse)	PR
Q3V016	Hipk4	Homeodomain-interacting protein kinase 4	Mus musculus (Mouse)	PR
Q9QZR5	Hipk2	Homeodomain-interacting protein kinase 2	Mus musculus (Mouse)	SS
Q4V793	Hipk4	Homeodomain-interacting protein kinase 4	Rattus norvegicus (Rat)	PR