Q8BHY8
PR
Gene name |
Snx14 |
Protein name |
Sorting nexin-14 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:244962 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BHY8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BHY8-F1 | Predicted | AlphaFoldDB |
37 variants for Q8BHY8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs387282004 | 7 | G>R | No | EVA | |
| rs3389029698 | 9 | G>R | No | EVA | |
| rs48148251 | 26 | T>N | No | EVA | |
| rs3389056163 | 37 | G>R | No | EVA | |
| rs3389064285 | 37 | G>V | No | EVA | |
| rs3389061926 | 89 | V>A | No | EVA | |
| rs3389060292 | 128 | C>R | No | EVA | |
| rs3389038029 | 145 | L>I | No | EVA | |
| rs3389064227 | 289 | D>Y | No | EVA | |
| rs3389070854 | 463 | M>T | No | EVA | |
| rs3413147409 | 476 | L>M | No | EVA | |
| rs227713241 | 496 | L>V | No | EVA | |
| rs3389060286 | 498 | G>C | No | EVA | |
| rs265314524 | 505 | N>S | No | EVA | |
| rs237914016 | 562 | M>L | No | EVA | |
| rs3389060087 | 569 | E>* | No | EVA | |
| rs221685599 | 571 | V>A | No | EVA | |
| rs3400383965 | 598 | S>F | No | EVA | |
| rs3400468737 | 599 | E>Q | No | EVA | |
| rs3400470644 | 601 | K>R | No | EVA | |
| rs3389042088 | 628 | H>Q | No | EVA | |
| rs3389064232 | 660 | K>Q | No | EVA | |
| rs3400518586 | 664 | G>D | No | EVA | |
| rs3400607031 | 665 | P>L | No | EVA | |
| rs3400468725 | 665 | P>S | No | EVA | |
| rs3389070857 | 698 | A>P | No | EVA | |
| rs3389061909 | 749 | S>C | No | EVA | |
| rs3389056213 | 771 | N>H | No | EVA | |
| rs3389061902 | 799 | F>I | No | EVA | |
| rs3389029780 | 801 | E>G | No | EVA | |
| rs3389067057 | 832 | G>R | No | EVA | |
| rs3389009099 | 833 | T>A | No | EVA | |
| rs3400470699 | 848 | Y>* | No | EVA | |
| rs3389060226 | 869 | L>I | No | EVA | |
| rs3389058243 | 892 | Q>R | No | EVA | |
| rs3389029774 | 895 | E>D | No | EVA | |
| rs3389067020 | 947 | F>S | No | EVA |
No associated diseases with Q8BHY8
4 regional properties for Q8BHY8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 105 - 194 | IPR001179 |
| repeat | Tetratricopeptide repeat | 211 - 244 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 262 - 295 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 296 - 329 | IPR019734-3 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phosphatidylinositol-3,5-bisphosphate binding | Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96S38 | RPS6KC1 | Ribosomal protein S6 kinase delta-1 | Homo sapiens (Human) | PR |
| Q9Y5W8 | SNX13 | Sorting nexin-13 | Homo sapiens (Human) | PR |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q9Y5W7 | SNX14 | Sorting nexin-14 | Homo sapiens (Human) | PR |
| Q8BLK9 | Rps6kc1 | Ribosomal protein S6 kinase delta-1 | Mus musculus (Mouse) | PR |
| Q9ERE3 | Sgk3 | Serine/threonine-protein kinase Sgk3 | Mus musculus (Mouse) | PR |
| Q3ZT31 | Snx25 | Sorting nexin-25 | Mus musculus (Mouse) | PR |
| Q6PHS6 | Snx13 | Sorting nexin-13 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWLRRRGLGV | PSASASEGGT | SSPAWTEMGS | WVRTICGRLK | QRLRLDVGRE | ICRQYPLFCF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLLCLSVASL | LLNRYLHVLM | IFWSFVAGVV | TFYCSLGPDS | LLPNIFFTIK | YKPKQLGLQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFPQGHSCAV | CGKVKCKRHR | PSLLLENYQP | WLDLKVSSKV | DASLSEVLEL | VLENFVYPWY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDVTDDESFV | DELRITLRFF | ASVLVRRIHK | VDIPSIITKK | LLKAAMKHIE | VIVKARQKVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NTEYLQQAAL | EEYGPELHVA | LRSRRDELQY | LRKLTELLFP | YILPPKATDC | RSLTLLIREI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSGSVLLPSL | DFLADPDTVN | HLLIIFIDDS | PPEKATEPAS | PLVPFLQKFA | EPRNKKPSVL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLELKQIREQ | QDLLFRFMNF | LKQEGAVHVL | QFCLTVEEFN | DRILRPELSN | DEMLSLHEEL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QKIYKTYCLD | ESIDKIRFDP | FIVEEIQRIA | EGPYIDVVKL | QTMRCLFEAY | EHVLSLLENV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FTPMFCHSDE | YFRQLLRGAE | SPTRNSKFNR | STQKRGESFG | ISRIGSKIKG | VFKSTTMEGA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VLPNYGVAEG | EDDFIEEGIV | VMEDDSPVEA | VSTPNTPRNL | AAWKISIPYV | DFFEDPSSER |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KEKKERIPVF | CIDVERNDRR | AVGHEPEHWS | VYRRYLEFYV | LESKLTEFHG | TFPDAQLPSK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RIIGPKNYEF | LKSKREEFQE | YLQKLVQHPE | LSNSQLLADF | LSPNGGETQF | LDKILPDVNL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GKIIKSVPGK | LMKEKGQHLE | PFIMSFINSC | ESPKPKPSRP | ELTILSPTSE | NNKKLFNDLF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KNNANRAENT | ERKQNQNYFM | EVMTVDGVYD | YLMYVGRVVF | QVPDWLHHLL | MGTRILFKNT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LEMYTDYYLQ | CKLEQLFQEH | RLVSLITLLR | DAIFCENTEP | RSLQDKQKGA | KQTFEEMMNY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IPDLIVKCIG | EETKYESIRL | LFDGLQQPVL | NKQLTYVLLD | IVIQELFPEL | NKVQKEATSM |
| TSWM |