Q8BHC1
Gene name |
Rab39b |
Protein name |
Ras-related protein Rab-39B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BHC1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BHC1-F1 | Predicted | AlphaFoldDB |
8 variants for Q8BHC1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3410714015 | 101 | H>Q | No | EVA | |
| rs3409442384 | 114 | Y>* | No | EVA | |
| rs3410336917 | 114 | Y>D | No | EVA | |
| rs3410336939 | 117 | V>E | No | EVA | |
| rs3409351529 | 117 | V>L | No | EVA | |
| rs3410826317 | 124 | K>N | No | EVA | |
| rs3410861907 | 124 | K>T | No | EVA | |
| rs3410970012 | 127 | L>P | No | EVA |
No associated diseases with Q8BHC1
1 regional properties for Q8BHC1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 8 - 165 | IPR005225 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
| myosin V binding | Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53994 | Rab2a | Ras-related protein Rab-2A | Mus musculus (Mouse) | PR |
| Q91ZR1 | Rab4b | Ras-related protein Rab-4B | Mus musculus (Mouse) | PR |
| P46638 | Rab11b | Ras-related protein Rab-11B | Mus musculus (Mouse) | PR |
| P62492 | Rab11a | Ras-related protein Rab-11A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEAIWLYQFR | LIVIGDSTVG | KSCLIRRFTE | GRFAQVSDPT | VGVDFFSRLV | EIEPGKRIKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QIWDTAGQER | FRSITRAYYR | NSVGGLLLFD | ITNRRSFQNV | HEWLEETKVH | VQPYQIVFVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VGHKCDLDTQ | RQVTRHEAEK | LAAAYGMKYI | ETSARDAINV | EKAFTDLTRD | IYELVKRGEI |
| 190 | 200 | 210 | |||
| TIQEGWEGVK | SGFVPNVVHS | SEEVIKSERR | CLC |