Q8BGM5
SS
Gene name |
Best2 (Vmd2l1) |
Protein name |
Bestrophin-2 |
Names |
Vitelliform macular dystrophy 2-like protein 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:212989 |
EC number |
|
Protein Class |
|
Descriptions
Best3, a member of the bestrophin Cl- channel family, is a candidate of cGMP-sensitive, Ca2+-activated Cl- channel in vascular smooth muscle cells. Best3 has an autoinhibitory domain (356-362) and deletion of the domain robustly activates Best3 channel. <br>Best3 also has a C-terminal membrane association domain (368-383) and basic residue domain (384-397). The basic residue domain (384–397) is also partially involved in the membrane association. Dissociation of Best3 from membrane activates Best3.
Autoinhibitory domains (AIDs)
Target domain |
1-412 (Bestrophin) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8BGM5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8BGM5-F1 | Predicted | AlphaFoldDB |
No variants for Q8BGM5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8BGM5 | |||||
No associated diseases with Q8BGM5
No regional properties for Q8BGM5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8BGM5 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| cilium | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| intracellularly ligand-gated monoatomic ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. |
| ligand-gated monoatomic anion channel activity | Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
| ligand-gated monoatomic cation channel activity | Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| bicarbonate transport | The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| membrane depolarization | The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N1M1 | BEST3 | Bestrophin-3 | Homo sapiens (Human) | SS |
| Q8NFU0 | BEST4 | Bestrophin-4 | Homo sapiens (Human) | SS |
| O76090 | BEST1 | Bestrophin-1 | Homo sapiens (Human) | SS |
| Q8NFU1 | BEST2 | Bestrophin-2a | Homo sapiens (Human) | SS |
| Q6H1V1 | Best3 | Bestrophin-3 | Mus musculus (Mouse) | EV |
| O88870 | Best1 | Bestrophin-1 | Mus musculus (Mouse) | SS |
| P34319 | best-5 | Bestrophin homolog 5 | Caenorhabditis elegans | PR |
| P34672 | best-24 | Bestrophin homolog 24 | Caenorhabditis elegans | PR |
| Q23369 | best-22 | Bestrophin homolog 22 | Caenorhabditis elegans | PR |
| O45435 | best-13 | Bestrophin homolog 13 | Caenorhabditis elegans | PR |
| Q19978 | best-14 | Bestrophin homolog 14 | Caenorhabditis elegans | PR |
| O18303 | best-25 | Bestrophin homolog 25 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVTYTARVA | NARFGGFSQL | LLLWRGSIYK | LLWRELLCFL | GLYMALSAAY | RFLLAEEQKR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YFEKLVIYCD | QYASLIPVSF | VLGFYVTLVV | HRWWNQYLCM | PLPDALMCIV | AGTVHGRDDR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GRLYRRTLMR | YAGLSAVLIL | RSVSTAVFKR | FPTIDHVVEA | GFMTREERKK | FENLNSSYNK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YWVPCVWFSS | LAAQARREGR | IRDNSALKLL | LEELNVFRSK | CGMLFHYDWI | SIPLVYTQVV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TIAVYSYFLA | CLIGRQFLDP | AQGYKDHTLD | LCVPIFTLLQ | FFFYAGWLKV | AEQLINPFGE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DDDDFETNFL | IDRNFQVSML | AVDEMYDDLA | MLEKDLYWDA | AEARAPYTAA | TAFLLQQPSF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QGSTFDIALA | KEDMQFQRLD | GVDGPLGEVH | GDFLQRLLPA | GAGSVGPLGR | RLSLLRRKNS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CVSEASTAAS | CGCAGAADGG | GVECGCGDPL | LDPSLREPEL | EPPACPEPPA | PIPGPTPEPF |
| 490 | 500 | ||||
| TTVSIPGPRA | PAPPWLPSPI | GEEEESPA |