Q8BGI7

PR
Gene name
Lrrc39
Protein name
Leucine-rich repeat-containing protein 39
Names
Myosin-interacting M-band-associated stress-responsive protein, Myomasp
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:109245
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-197 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8BGI7

Entry ID Method Resolution Chain Position Source
AF-Q8BGI7-F1 Predicted AlphaFoldDB

20 variants for Q8BGI7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs48323015 5 A>V No EVA
rs3388657226 17 V>A No EVA
rs3393576499 38 K>T No EVA
rs3388648238 59 E>D No EVA
rs3388659761 60 D>N No EVA
rs3388661508 69 K>T No EVA
rs3388648182 83 N>Y No EVA
rs3388664164 97 K>N No EVA
rs3388661188 106 Q>* No EVA
rs3388642286 110 V>A No EVA
rs3388657336 125 I>F No EVA
rs3388648831 130 R>K No EVA
rs3388660529 147 E>V No EVA
rs47233413 193 H>L No EVA
rs3393463947 193 H>Q No EVA
rs3388654791 218 L>Q No EVA
rs259366678 222 R>Q No EVA
rs230139366 242 K>R No EVA
rs244500886 246 N>S No EVA
rs224755469 266 E>D No EVA

No associated diseases with Q8BGI7

9 regional properties for Q8BGI7

Type Name Position InterPro Accession
repeat Leucine-rich repeat 86 - 152 IPR001611-1
repeat Leucine-rich repeat 153 - 211 IPR001611-2
repeat Leucine-rich repeat 222 - 280 IPR001611-3
repeat Leucine-rich repeat, typical subtype 105 - 127 IPR003591-1
repeat Leucine-rich repeat, typical subtype 128 - 151 IPR003591-2
repeat Leucine-rich repeat, typical subtype 175 - 197 IPR003591-3
repeat Leucine-rich repeat, typical subtype 198 - 220 IPR003591-4
repeat Leucine-rich repeat, typical subtype 221 - 243 IPR003591-5
repeat Leucine-rich repeat, typical subtype 244 - 267 IPR003591-6

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, myofibril, sarcomere, M line
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
M band The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.

1 GO annotations of molecular function

Name Definition
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

1 GO annotations of biological process

Name Definition
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHH9 ECM2 Extracellular matrix protein 2 Bos taurus (Bovine) PR
P58874 OPTC Opticin Bos taurus (Bovine) PR
Q24K06 LRRC10 Leucine-rich repeat-containing protein 10 Bos taurus (Bovine) PR
Q9V780 Lap1 Protein lap1 Drosophila melanogaster (Fruit fly) PR
Q96NW7 LRRC7 Leucine-rich repeat-containing protein 7 Homo sapiens (Human) PR
Q8IWT6 LRRC8A Volume-regulated anion channel subunit LRRC8A Homo sapiens (Human) PR
Q9HCJ2 LRRC4C Leucine-rich repeat-containing protein 4C Homo sapiens (Human) PR
Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 Homo sapiens (Human) PR
Q96L50 LRR1 Leucine-rich repeat protein 1 Homo sapiens (Human) PR
Q86UN2 RTN4RL1 Reticulon-4 receptor-like 1 Homo sapiens (Human) PR
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q7L1W4 LRRC8D Volume-regulated anion channel subunit LRRC8D Homo sapiens (Human) PR
Q96FE5 LINGO1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Homo sapiens (Human) PR
Q8TDW0 LRRC8C Volume-regulated anion channel subunit LRRC8C Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
P59383 Lrrn4 Leucine-rich repeat neuronal protein 4 Mus musculus (Mouse) PR
Q9D1T0 Lingo1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Mus musculus (Mouse) PR
Q8K0S5 Rtn4rl1 Reticulon-4 receptor-like 1 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
Q5RKR3 Islr2 Immunoglobulin superfamily containing leucine-rich repeat protein 2 Mus musculus (Mouse) PR
Q8C031 Lrrc4c Leucine-rich repeat-containing protein 4C Mus musculus (Mouse) PR
Q80WG5 Lrrc8a Volume-regulated anion channel subunit LRRC8A Mus musculus (Mouse) PR
Q8R502 Lrrc8c Volume-regulated anion channel subunit LRRC8C Mus musculus (Mouse) PR
Q9D9Q0 Lrrc69 Leucine-rich repeat-containing protein 69 Mus musculus (Mouse) PR
A6H694 Lrrc63 Leucine-rich repeat-containing protein 63 Mus musculus (Mouse) PR
Q5DU41 Lrrc8b Volume-regulated anion channel subunit LRRC8B Mus musculus (Mouse) PR
P70587 Lrrc7 Leucine-rich repeat-containing protein 7 Rattus norvegicus (Rat) PR
Q4V8G0 Lrrc63 Leucine-rich repeat-containing protein 63 Rattus norvegicus (Rat) PR
Q80WD0 Rtn4rl1 Reticulon-4 receptor-like 1 Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q5G5E0 PIRL5 Plant intracellular Ras-group-related LRR protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
B0JZ65 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q68F79 lrrc8e Volume-regulated anion channel subunit LRRC8E Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B0R160 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTESAVCTGA VSAVKEVWEE RIKKHHEDVK REKEFQHKLV RIWEDRVSLT KLKEKVTRED
70 80 90 100 110 120
GRVILRIEKE EWKTLPSSLL KLNQLQEWQL HRTGLLKIPE FIGRFQHLIV LDLSRNTISE
130 140 150 160 170 180
IPRGIGLLTR LQELILSYNK IKTVPKELSN CTSLEKLELA VNRDISDLPP ELSKLLKLTH
190 200 210 220 230 240
LDLSMNQFTT IPHAVLDMPA LEWLDMGSNS LQQLPDSLDR MRSLHTLWLQ RNEITCLPET
250 260 270 280 290 300
IKNMKNLGTL VLSNNKLQDI PGCMEEMTNL RFVNFRDNPL RLEVTLPPSD NTDGEEEQEL
310 320 330
FGLQFMHAYI QESRRTEDQV NCLTQMPSSI HSDGESN