AiPD: Autoinhibited Protein Database

Gene name	Lpp
Protein name	Lipoma-preferred partner homolog
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:210126
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

79-152 (Predicted disordered autoinhibitory region) PR

79-152 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8BFW7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389389445	8	P>Q	No	EVA
rs3389389444	22	R>L	No	EVA
rs3389402481	28	S>Y	No	EVA
rs3413096086	59	K>T	No	EVA
rs3389419285	61	P>A	No	EVA
rs3389400744	73	P>Q	No	EVA
rs3389402507	130	A>P	No	EVA
rs259714740	143	P>L	No	EVA
rs213721868	169	Q>H	No	EVA
rs3389400727	184	Q>R	No	EVA
rs3389377978	201	K>N	No	EVA
rs3389359515	204	P>L	No	EVA
rs219035428	254	N>T	No	EVA
rs3389406676	277	I>F	No	EVA
rs3389368942	305	G>A	No	EVA
rs3389406672	323	Q>K	No	EVA
rs3389325313	365	C>Y	No	EVA
rs32442220	373	G>S	No	EVA
rs251668839	384	I>V	No	EVA
rs3389400758	385	P>L	No	EVA
rs3389368984	387	S>T	No	EVA
rs3389419301	399	K>M	No	EVA
rs3389407694	423	N>I	No	EVA
rs3389416191	451	K>M	No	EVA
rs3389370471	478	S>R	No	EVA
rs3389389452	495	A>D	No	EVA
rs3389359430	506	C>S	No	EVA
rs3389406647	512	G>D	No	EVA
rs3389410090	546	P>S	No	EVA
rs3389410000	583	Q>*	No	EVA
rs3389402739	611	T>I	No	EVA

Type	Name	Position	InterPro Accession
domain	SH3 domain	125 - 184	IPR001452-1
domain	SH3 domain	187 - 252	IPR001452-2
domain	SH3 domain	382 - 443	IPR001452-3
domain	Zinc finger, RING-type	12 - 53	IPR001841
conserved_site	Zinc finger, RING-type, conserved site	28 - 37	IPR017907
domain	Zinc finger, C3HC4 RING-type	12 - 52	IPR018957
domain	E3 ubiquitin-protein ligase SH3RF2, RING finger, HC subclass	11 - 55	IPR028511
domain	E3 ubiquitin-protein ligase SH3RF2, first SH3 domain	128 - 181	IPR035792
domain	E3 ubiquitin-protein ligase SH3RF2, second SH3 domain	191 - 247	IPR035794
domain	SH3RF2, third SH3 domain	386 - 440	IPR035822

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm Cell junction	Found in the nucleus, in the cytoplasm and at cell adhesion sites
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
stress fiber	A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

Name	Definition
metal ion binding	Binding to a metal ion.

Name	Definition
cell-cell adhesion	The attachment of one cell to another cell via adhesion molecules.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q04584	ZYX	Zyxin	Gallus gallus (Chicken)	EV
Q15942	ZYX	Zyxin	Homo sapiens (Human)	EV
Q62523	Zyx	Zyxin	Mus musculus (Mouse)	SS
Q5XI07	Lpp	Lipoma-preferred partner homolog	Rattus norvegicus (Rat)	PR