Q8AYG3

PR
Gene name
ttk (mps1, ncp)
Protein name
Dual specificity protein kinase Ttk
Names
Mitotic checkpoint serine/threonine-protein kinase Mps1, Monopolar spindle protein 1, Protein nightcap
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:317763
EC number
2.7.12.1: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

465-663 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

791-816 (Activation loop from InterPro)

Target domain

653-916 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q8AYG3

Entry ID Method Resolution Chain Position Source
AF-Q8AYG3-F1 Predicted AlphaFoldDB

No variants for Q8AYG3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AYG3

No associated diseases with Q8AYG3

4 regional properties for Q8AYG3

Type Name Position InterPro Accession
domain Protein kinase domain 653 - 916 IPR000719
active_site Serine/threonine-protein kinase, active site 771 - 783 IPR008271
binding_site Protein kinase, ATP binding site 659 - 681 IPR017441
domain Protein kinase Mps1 family, catalytic domain 651 - 916 IPR027084

Functions

Description
EC Number 2.7.12.1 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

13 GO annotations of biological process

Name Definition
anatomical structure homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
female meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.
fin regeneration The regrowth of fin tissue following its loss or destruction.
male meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male.
meiotic spindle assembly checkpoint signaling A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle.
mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
negative regulation of exit from mitosis Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore.
tissue regeneration The regrowth of lost or destroyed tissues.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P33981 TTK Dual specificity protein kinase TTK Homo sapiens (Human) EV
P35761 Ttk Dual specificity protein kinase TTK Mus musculus (Mouse) SS
Q84VX4 MPS1 Serine/threonine-protein kinase MPS1 Arabidopsis thaliana (Mouse-ear cress) SS
Q1ECX4 tlk2 Serine/threonine-protein kinase tousled-like 2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDEEESTERQ MQIAMLCQKL AMMKQLFNED DTDYINQAIS SNSPDTCRTF LSNLEKKGNP
70 80 90 100 110 120
QADPSLLSKL MDSYTRVFSS MPLGKYSQNE SYAKMLVRFA ELKAIQDVND AQTSFDIARS
130 140 150 160 170 180
HCKDFAFVHV AYAQFELLQG NMKKCTMILQ KAFEMNAKPR HVLEAAVRNL KTGKRQLLSH
190 200 210 220 230 240
EDKENLSVSA LDHTQGSRRS DGTCELKPSN TFLHSDQKFS PQEENGPVWR TGSQHRRTAM
250 260 270 280 290 300
AERVPMVPLS IPENETSDSD CAQKAEAPFT HSSGFSRQTS GSSVRSAFSL CSSKKGTPDG
310 320 330 340 350 360
DSYSLNIKPP VISPDYLRED IEEGHTITAL LNRAEKRETA RTEETTDINQ IISTNSTEGC
370 380 390 400 410 420
QAFLKNLEKR ADPHSDAAFL SKLLDCYSKV FARFPLAEHC KTESYARMLV RYAELKGIED
430 440 450 460 470 480
PEDAADDFSI ARSHCKAFAF VHIAHAQFEL SRGNSRKSVS ILQKALSSNA RPIELLQTAI
490 500 510 520 530 540
RNLKSGKTLL LPAEHQESSE AENVEAQNGM KREENPVKAP EDHQKPFSKE TSSEWKIPAL
550 560 570 580 590 600
ITKHTSPEDR KAPVEPVSSS SSHHAVRTPA PLRLNPSLSC QTPNYRQPNP NSFVTPVVKQ
610 620 630 640 650 660
RPVIVSVPAT AQKMCPTALP CTPQSGVSYI QPPTQTPSSA FSNESITIKG KQFFIFKMIG
670 680 690 700 710 720
RGGSSKVYQV FDHKKHVYAV KYVNLEEADA QAVESYKNEI EHLNHLQQYS DQIIKLYDYE
730 740 750 760 770 780
ITSSYIYMLM ECGHLDLNTW LRNRKTVKPL DRKAYWRNML EAVHTIHKHG IVHSDLKPAN
790 800 810 820 830 840
FLIVDGSLKL IDFGIANQIQ PDVTSIMKDS QVGTLNYMPP EAIKDTSSNG KPGSKISAKG
850 860 870 880 890 900
DVWSLGCILY CMTYGKTPFQ NITNQISKIH AIIDPSHEID FPDIPEKDLL DVLKKCLVRN
910 920 930 940 950 960
PRERISIAEL LDHPYLQLQP QPAPEPAETS SSDFKRILNE LVALQSPNSI ARAASNLAMM
970 980
CNSGRKLDVS ECVKSSSQTL WK