Q8AXU9

PR
Gene name
SH3GL3
Protein name
Endophilin-A3
Names
Endophilin-3, SH3 domain-containing GRB2-like protein 3, SH3p13
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395201
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

219-303 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AXU9

Entry ID Method Resolution Chain Position Source
AF-Q8AXU9-F1 Predicted AlphaFoldDB

No variants for Q8AXU9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AXU9

No associated diseases with Q8AXU9

4 regional properties for Q8AXU9

Type Name Position InterPro Accession
domain SH3 domain 291 - 350 IPR001452
domain BAR domain 5 - 249 IPR004148
domain Endophilin-A3, BAR domain 25 - 247 IPR032469
domain Endophilin-A, SH3 domain 294 - 348 IPR035824

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Early endosome membrane ; Peripheral membrane protein
  • Associated with postsynaptic endosomes in hippocampal neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome membrane The lipid bilayer surrounding an early endosome.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
presynapse The part of a synapse that is part of the presynaptic cell.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

1 GO annotations of biological process

Name Definition
synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2KJA1 SH3GL1 Endophilin-A2 Bos taurus (Bovine) PR
Q8AXV1 SH3GL2 Endophilin-A1 Gallus gallus (Chicken) PR
Q99961 SH3GL1 Endophilin-A2 Homo sapiens (Human) PR
Q99962 SH3GL2 Endophilin-A1 Homo sapiens (Human) PR
Q99963 SH3GL3 Endophilin-A3 Homo sapiens (Human) PR
Q62419 Sh3gl1 Endophilin-A2 Mus musculus (Mouse) PR
Q62420 Sh3gl2 Endophilin-A1 Mus musculus (Mouse) PR
Q62421 Sh3gl3 Endophilin-A3 Mus musculus (Mouse) PR
O35179 Sh3gl2 Endophilin-A1 Rattus norvegicus (Rat) PR
O35180 Sh3gl3 Endophilin-A3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSVAGLKKQF HKASQLFSEK ISGAEGTKLD EEFQEMERKI DVTNKAVAEL LSKSTEYLQP
70 80 90 100 110 120
NPAYRAKLGM LNTMSKIRGQ VKTTGYPQTE GLLGDCMIRY GRELGDDSMF GLALLDAGES
130 140 150 160 170 180
MKQMAEVKDS LDINVKQNFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRLGKIPD
190 200 210 220 230 240
EEVKQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFVE AALDYHKQST EILEDLQSKL
250 260 270 280 290 300
QNRINVASSR PKREFKPKPV ITTTLETGDN QQHNGIAYSS SIKSSGSSMH VDQPCCQALY
310 320 330 340 350
DFEPENEGEL GFKEGDIITL TNQIDENWYE GMLNGESGFF PHNYVEVMVP LPQ