Q8AXB3
SS
Gene name |
kdrl (flk, flk-1, flk1, flka, kdr, kdra, vegfr2, vegfr4, vegr2, si:ch211-276g21.4) |
Protein name |
Vascular endothelial growth factor receptor kdr-like |
Names |
EC 2.7.10.1 , Fetal liver kinase 1 , FLK-1 , Kinase insert domain receptor-A , Kinase insert domain receptor-like , Protein-tyrosine kinase receptor flk-1 , Vascular endothelial growth factor receptor 4 , VEGFR-4 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:796537 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
809-1137 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Roskoski R Jr (2008) "VEGF receptor protein-tyrosine kinases: structure and regulation", Biochemical and biophysical research communications, 375, 287-91
- Wang X et al. (2020) "Molecular Bases of VEGFR-2-Mediated Physiological Function and Pathological Role", Frontiers in cell and developmental biology, 8, 599281
- Shewchuk LM et al. (2000) "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail", Structure (London, England : 1993), 8, 1105-13
- Stuttfeld E et al. (2009) "Structure and function of VEGF receptors", IUBMB life, 61, 915-22
Autoinhibited structure
Activated structure
1 structures for Q8AXB3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8AXB3-F1 | Predicted | AlphaFoldDB |
No variants for Q8AXB3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8AXB3 | |||||
No associated diseases with Q8AXB3
27 regional properties for Q8AXB3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 809 - 1139 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 810 - 1135 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 868 - 881 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 46 - 111 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 234 - 309 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 338 - 403 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 435 - 531 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 556 - 625 | IPR003598-5 |
| domain | Immunoglobulin subtype 2 | 655 - 719 | IPR003598-6 |
| domain | Immunoglobulin subtype | 40 - 121 | IPR003599-1 |
| domain | Immunoglobulin subtype | 228 - 320 | IPR003599-2 |
| domain | Immunoglobulin subtype | 332 - 416 | IPR003599-3 |
| domain | Immunoglobulin subtype | 429 - 542 | IPR003599-4 |
| domain | Immunoglobulin subtype | 550 - 638 | IPR003599-5 |
| domain | Immunoglobulin subtype | 649 - 730 | IPR003599-6 |
| domain | Immunoglobulin-like domain | 32 - 115 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 222 - 312 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 323 - 410 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 419 - 536 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 545 - 636 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 643 - 728 | IPR007110-6 |
| active_site | Tyrosine-protein kinase, active site | 999 - 1011 | IPR008266 |
| domain | Immunoglobulin I-set | 646 - 729 | IPR013098 |
| domain | Immunoglobulin-like beta-sandwich domain | 232 - 306 | IPR013151 |
| binding_site | Protein kinase, ATP binding site | 815 - 843 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 809 - 1135 | IPR020635 |
| domain | VEGFR-2, transmembrane domain | 735 - 768 | IPR041348 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| artery morphogenesis | The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. |
| blood vessel development | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| embryonic heart tube development | The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. |
| lymphangiogenesis | Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| sprouting angiogenesis | The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. |
| thyroid gland development | The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. |
77 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q9LDQ3 | CRK34 | Cysteine-rich receptor-like protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| E7F3X9 | ddr1 | receptor protein-tyrosine kinase | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| F1QVU0 | ltk | Tyrosine-protein kinase receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8X3 | fgfr3 | Fibroblast growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTPLKTSVKA | FFTLHVLFSC | ISHGLVEGSR | LPDPQLLPDG | DTHLQHVGGT | LTLICRGSTA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LHWRLASRNV | SSVRIESCEE | RLHKHCSKLV | IHNLRHNDTG | IYSCSHKKSS | DHEVSTYVFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDPHHPFVEA | YSLPHPLFAY | RNDPYFVVPC | RTTYPNQNVI | LETQMNPMAD | DVKRGVQWDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKGFTVPLKP | YDSYHLITCL | TRVDNAEFSS | VYLLKRLTME | IKNLAIEPER | PRVLVGDTLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNCSAETTYN | GRIHFEWEFH | KERINRTHHF | STTPVQLAQI | MVMSKALIVP | NVTMEDKGTY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TCTGSIEFKK | LQMSTKVIVY | EHPFLNVTHN | KRKFTSTVEG | RRVQFEPRVN | AVPAPDRVLW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YKDGVAISEN | STCYETAGYN | LTIKQVRQKD | AGIFTIALSN | QERGLYRNIS | YKLEVRVKPK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IFEEDVAPAG | PQTFRYDQRH | KLTCTAFGIP | MPNITWFWQP | CDPSANLTEC | KLYTDPLPIE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NVDDHFPQNP | IKDVNSKVGL | LKSKNRTIST | LVVKTANVSG | VYSCTARNEL | GNRTMRIPFY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VDDHPQPFEI | EPSTAVAGDD | ITLTCRGTRY | LYDRLTWYDP | LGHKVPKDET | TLRIEPYTIS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSIKLPNVSR | NHTLGYECQA | LKINTNKVVN | VTSALTIDER | QGPWLMQNLT | NQDVNSSSTL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TLACLAYGVP | APFITWYKDK | TPVTEGPGIT | LKDDGTLIIE | RVKKDDEGIY | ECRASNDGGE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AKTSAVITVV | GEDGKPNIEV | IILVSTGAAA | TFLWIMLILF | IRKLRKPSSA | DLKTGYLSII |
| 790 | 800 | 810 | 820 | 830 | 840 |
| MDPEQMPLDE | QCDRLPYDSN | KWEFPQDRLR | LGKTLGHGAF | GKVVEASAFG | IDKISTCKTV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AVKMLKVGAT | NNEWRALMSE | LKILIHIGHH | LNVVNLLGAC | TKRGGPLMII | VEFCKYGNLS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NYLRSKRGDF | VVYKSQDGKA | VRSSSGCDLS | ELIKRRLESV | ASTGSSASSG | FIEDKSYCDS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EEEEEEQEDL | YKKVLTLEDL | ICYSFQVAKG | MEFLASRKCI | HRDLAARNIL | LSENNVVKIC |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DFGLARDVYK | DPDYVRKGDA | RLPLKWMAPE | AIFDKIYTTQ | SDVWSFGVLM | WEIFSLGASP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| YPGLHIDEEF | CCRLKEGTRM | KAPEYSSSEI | YQTMLDCWHG | EPSQRPTFTE | LVERLGDLLQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| ASVQQEGKHY | IPINTALLTK | ADPSNQSPTE | ETSTRPVSLR | DSGTAWNIKI | RPESVKTFDE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| VILENGTNKI | HEGGQSDSGI | GLSSDDLKTL | KRLESLARPR | SFMSRAMKRK | SKESVLLEGE |
| 1270 | 1280 | 1290 | 1300 | ||
| MDKYPPLVPS | LSLEDSSLDS | EMECHSPPPD | YNYVVRYSTP | PV |