Q8AWH2

PR
Gene name
sox17b.1 (TNeu127g05.1)
Protein name
Transcription factor Sox-17-beta.1
Names
SRY (sex determining region Y)-box 17-beta.1, tSox17beta
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:394440
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8AWH2

Entry ID Method Resolution Chain Position Source
AF-Q8AWH2-F1 Predicted AlphaFoldDB

No variants for Q8AWH2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8AWH2

No associated diseases with Q8AWH2

5 regional properties for Q8AWH2

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 651 - 892 IPR003439
domain AAA+ ATPase domain 678 - 869 IPR003593
domain ABC transporter type 1, transmembrane domain 315 - 621 IPR011527-1
domain ABC transporter type 1, transmembrane domain 962 - 1218 IPR011527-2
conserved_site ABC transporter-like, conserved site 792 - 806 IPR017871

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

9 GO annotations of biological process

Name Definition
anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O15370 SOX12 Transcription factor SOX-12 Homo sapiens (Human) SS
Q04890 Sox12 Transcription factor SOX-12 Mus musculus (Mouse) SS
Q05738 Sry Sex-determining region Y protein Mus musculus (Mouse) SS
Q8T3B9 sem-2 Transcription factor sem-2 Caenorhabditis elegans SS
Q6GLH8 sox17b.2 Transcription factor Sox-17-beta.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q66JF1 sox11 Transcription factor Sox-11 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MSSPDGGYAS DDQFHGNCSV PIMMGQYEWT DPLTMFQDAK TKKEAGSANS RGKAEARIRR
70 80 90 100 110 120
PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKSLT LASKRPFVEE AERLRVQHIQ
130 140 150 160 170 180
DYPDYKYRPR RKKQVKRMKR EEEGFLPSAD IPGPQVMGCN AMVGQNYKMQ YSGQNSQQSQ
190 200 210 220 230 240
ITPAGYFEDH NPVGYYYRGY NVPEYYMSQN SSVTCGPPAQ GEYQALSYNF NSSYIPYQQN
250 260 270 280 290 300
ASAPAMGKQM AVKENIIQES PEHGIMGCQV SPQMYNGQMY VPECAKTHPV AQTEQHSSLH
310 320 330 340 350 360
QSQQMVTQNY LPSQQDGHLE SDIDKTEFDQ YLMYEPKSDT ELIYTIDQDS GAYSTNLLPS
370
LISEANSVCY YDYCGV