Q86YW0
PR
Gene name |
PLCZ1 |
Protein name |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
Names |
Phosphoinositide phospholipase C-zeta-1, Phospholipase C-zeta-1, PLC-zeta-1, Testis-development protein NYD-SP27 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:89869 |
EC number |
3.1.4.11: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q86YW0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q86YW0-F1 | Predicted | AlphaFoldDB |
542 variants for Q86YW0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA6471454 rs535719220 RCV001256026 |
196 | C>* | Spermatogenic failure 17 [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD |
|
rs1956460756 RCV001256028 |
246 | L>F | Spermatogenic failure 17 [ClinVar] | Yes |
ClinVar dbSNP |
|
RCV001256027 rs1955655663 |
350 | S>P | Spermatogenic failure 17 [ClinVar] | Yes |
ClinVar dbSNP |
|
CA6471256 RCV001332757 COSM1220994 rs758890842 |
385 | R>Q | Spermatogenic failure 17 large_intestine breast [ClinVar, Cosmic] | Yes |
ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA6471146 rs757326350 RCV000258930 VAR_077876 |
489 | I>F | Spermatogenic failure 17 SPGF17; loss of function in egg activation [ClinVar, UniProt] | Yes |
ClinGen ClinVar UniProt ExAC dbSNP gnomAD |
|
rs745622886 CA6471654 |
3 | M>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471653 rs781129128 |
4 | R>I | No |
ClinGen ExAC gnomAD |
|
|
rs781129128 CA233396448 |
4 | R>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs747562068 CA6471630 |
4 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471629 rs778662066 |
6 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA384080279 rs1436760090 |
8 | S>L | No |
ClinGen gnomAD |
|
|
rs1351205340 CA384080277 |
9 | K>E | No |
ClinGen gnomAD |
|
|
rs768055363 CA6471626 |
10 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA384080264 rs1344363315 |
11 | Q>E | No |
ClinGen TOPMed |
|
|
rs757688976 CA6471625 COSM139949 |
12 | D>N | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA6471623 rs764482291 |
14 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs949353410 CA233395559 |
15 | R>K | No |
ClinGen TOPMed gnomAD |
|
|
CA384080220 rs1220012411 |
17 | G>R | No |
ClinGen gnomAD |
|
|
CA384080206 rs1191492332 |
19 | I>L | No |
ClinGen gnomAD |
|
|
rs1248665450 CA384080201 |
20 | N>H | No |
ClinGen gnomAD |
|
|
rs763112497 CA6471622 |
21 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs775392782 CA6471621 |
22 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1219478779 CA384080167 |
25 | Q>E | No |
ClinGen gnomAD |
|
|
rs1473811239 CA384080165 |
25 | Q>P | No |
ClinGen TOPMed |
|
|
rs1320608679 CA384080149 |
27 | L>* | No |
ClinGen gnomAD |
|
| TCGA novel | 30 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 30 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 31 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1278380911 CA384080114 |
32 | D>G | No |
ClinGen gnomAD |
|
| TCGA novel | 32 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs372753672 CA6471620 |
32 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471618 rs150538125 |
34 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs376713289 CA6471619 |
34 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1173770110 CA384080094 |
35 | C>* | No |
ClinGen TOPMed |
|
|
rs1398904269 CA384080083 |
36 | S>T | No |
ClinGen gnomAD |
|
|
CA6471614 rs141710608 |
38 | I>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471613 rs747701482 |
38 | I>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs931161965 CA233395527 |
39 | H>N | No |
ClinGen TOPMed |
|
| TCGA novel | 40 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384080031 rs1176604403 |
41 | K>E | No |
ClinGen gnomAD |
|
| TCGA novel | 44 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs202206940 CA6471577 |
46 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs202206940 CA233383123 |
46 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA384078299 rs1456541123 |
48 | D>E | No |
ClinGen gnomAD |
|
|
CA384078285 rs1248422210 |
49 | R>K | No |
ClinGen TOPMed |
|
|
rs760831734 CA6471576 |
49 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs750648027 CA6471575 |
51 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1426133467 CA384078236 |
52 | Q>H | No |
ClinGen gnomAD |
|
|
rs1406418781 CA384078214 |
54 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1478233489 CA384078169 |
56 | T>A | No |
ClinGen TOPMed |
|
|
CA6471573 rs371926945 |
57 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471574 rs138075971 |
57 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs199887344 CA6471572 |
60 | F>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 60 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384078098 rs1265530907 |
61 | R>G | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 61 | R>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471570 rs775070073 |
62 | A>E | No |
ClinGen ExAC gnomAD |
|
|
CA6471569 rs775070073 |
62 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs768662327 CA6471571 |
62 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA384078054 rs1378868746 |
64 | Y>* | No |
ClinGen gnomAD |
|
|
CA6471567 rs201108085 |
64 | Y>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs745955620 CA6471564 |
65 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471566 rs745955620 |
65 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779427460 CA6471563 COSM182322 |
65 | R>Q | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs755411887 CA6471562 |
66 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA384078031 rs1294261261 |
67 | I>V | No |
ClinGen gnomAD |
|
|
COSM1360546 rs753931496 CA6471561 |
68 | T>M | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1459480434 CA384078024 |
68 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1440802648 CA384078014 |
69 | H>R | No |
ClinGen gnomAD |
|
|
rs756184469 CA6471559 |
70 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA6471558 rs750654459 COSM1705243 |
72 | E>K | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA384077986 rs750654459 |
72 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs767754815 CA6471557 |
73 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA6471556 rs145549980 |
74 | I>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs568377547 CA6471552 |
78 | N>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA384077910 rs1277992971 |
78 | N>K | No |
ClinGen gnomAD |
|
|
rs1355685472 CA384077915 |
78 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1195569995 CA384077892 |
80 | Y>C | No |
ClinGen TOPMed |
|
|
rs1388689275 CA384077869 |
82 | E>G | No |
ClinGen gnomAD |
|
|
rs1302217967 CA384077876 |
82 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
TCGA novel rs1235990040 CA384077850 |
83 | N>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen TOPMed |
|
rs759053785 CA6471549 |
84 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1644903 CA233383046 rs983663409 |
84 | R>W | NS [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs188614103 CA233383039 COSM1360545 |
87 | L>I | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes NCI-TCGA gnomAD |
|
CA6471547 rs201528465 |
89 | A>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs748467168 CA6471546 |
89 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs774641368 CA6471545 |
90 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs372585048 CA6471544 |
92 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372585048 CA384077704 |
92 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471542 rs138801851 |
94 | Q>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA384077633 rs1199710651 |
97 | T>I | No |
ClinGen gnomAD |
|
|
CA233383006 rs539972609 |
99 | E>K | No |
ClinGen Ensembl |
|
|
rs756200378 CA6471540 |
100 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs745909177 CA6471539 |
101 | Y>H | No |
ClinGen ExAC |
|
|
CA384077567 rs1316231294 |
102 | A>V | No |
ClinGen gnomAD |
|
|
rs781298617 CA384077541 |
103 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781298617 CA6471538 |
103 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384077499 rs368394365 CA6471537 |
105 | M>I | No |
ClinGen ESP ExAC gnomAD |
|
|
rs964760864 CA233382996 |
105 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA384077491 rs1448322168 |
106 | S>N | No |
ClinGen TOPMed |
|
| TCGA novel | 108 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471536 rs751409870 |
109 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1565732727 CA384077432 |
110 | A>T | No |
ClinGen Ensembl |
|
|
CA6471534 rs149325247 |
111 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6471533 rs752719993 |
112 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs765243398 CA6471532 |
113 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA233382972 rs184534521 |
114 | I>V | No |
ClinGen 1000Genomes |
|
|
rs143224003 CA384077290 |
117 | Y>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA384077298 rs1592266527 |
117 | Y>S | No |
ClinGen Ensembl |
|
|
CA6471529 rs765962741 |
118 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA6471530 rs149142969 |
118 | E>K | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6471528 rs373834036 |
119 | P>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs79487790 CA6471526 |
120 | I>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1366151977 CA384077264 |
120 | I>N | No |
ClinGen gnomAD |
|
|
rs749634271 CA6471525 |
121 | E>D | No |
ClinGen ExAC |
|
|
rs1442862540 CA384077262 COSM3458904 |
121 | E>K | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA384077228 rs1258025233 |
122 | E>A | No |
ClinGen gnomAD |
|
|
CA384075962 rs1347741123 |
124 | R>K | No |
ClinGen gnomAD |
|
| TCGA novel | 125 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 125 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs375295991 CA384075864 |
127 | H>N | No |
ClinGen gnomAD |
|
|
CA384075837 rs1565728087 |
127 | H>Q | No |
ClinGen Ensembl |
|
|
CA233381461 rs375295991 |
127 | H>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 128 | Q>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs760148993 CA6471508 |
129 | M>I | No |
ClinGen ExAC gnomAD |
|
|
rs750129159 CA6471507 |
132 | E>Q | No |
ClinGen ExAC gnomAD |
|
| rs1456837081 | 132 | E>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767112029 CA6471506 |
135 | T>I | No |
ClinGen ExAC |
|
|
CA6471504 rs775760120 |
136 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA233381443 rs899962141 |
136 | R>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1008245844 CA233381435 |
138 | M>T | No |
ClinGen TOPMed |
|
|
CA6471503 rs377250749 |
138 | M>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 139 | D>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs903290971 CA233381431 |
140 | S>* | No |
ClinGen TOPMed |
|
|
rs61742629 CA6471501 |
141 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs202034240 CA6471500 |
141 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA233381422 rs202034240 |
141 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs61742629 CA384075369 |
141 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6471498 rs778161829 |
144 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384075204 rs1365103463 |
147 | K>N | No |
ClinGen gnomAD |
|
|
CA233381394 rs937264344 |
147 | K>T | No |
ClinGen TOPMed |
|
|
CA6471494 rs754728641 |
150 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA6471493 rs753856477 |
150 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1295735707 CA384075115 |
151 | R>G | No |
ClinGen gnomAD |
|
|
CA384075082 rs1351698623 |
152 | K>R | No |
ClinGen gnomAD |
|
|
CA6471491 rs779838173 |
155 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1256344296 COSM937733 CA384074999 |
156 | D>Y | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed |
|
CA233381384 rs370993260 |
158 | T>I | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA6471489 rs200664557 |
159 | H>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1313879966 CA384074883 |
159 | H>R | No |
ClinGen Ensembl |
|
|
CA6471488 rs200664557 |
159 | H>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6471487 COSM1705241 rs767157264 |
160 | P>L | skin [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA384074822 rs1472394132 |
161 | L>* | No |
ClinGen TOPMed |
|
|
CA6471486 rs761395578 |
163 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384074691 rs1414319019 |
166 | I>V | No |
ClinGen TOPMed |
|
|
CA233381366 rs907647673 |
168 | S>A | No |
ClinGen TOPMed |
|
|
CA6471485 rs751155763 |
169 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA6471483 rs572061421 |
170 | H>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs765699207 CA6471484 |
170 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1264488269 CA384074584 |
172 | T>I | No |
ClinGen gnomAD |
|
|
CA6471481 rs77907218 |
174 | L>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA233381345 rs866317202 |
176 | S>F | No |
ClinGen Ensembl |
|
|
CA233381342 rs1015780629 |
178 | Q>K | No |
ClinGen gnomAD |
|
|
CA384074498 rs1467841799 |
179 | L>* | No |
ClinGen TOPMed |
|
|
CA6471478 rs772266425 |
181 | G>E | No |
ClinGen ExAC gnomAD |
|
|
CA233381319 rs748449465 |
182 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA6471477 rs748449465 |
182 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA6471475 rs768546809 |
183 | S>C | No |
ClinGen ExAC gnomAD |
|
|
rs748990848 CA6471474 |
183 | S>T | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 184 | D>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs867642318 CA233381306 |
184 | D>N | No |
ClinGen Ensembl |
|
|
rs755975788 CA6471472 |
185 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6471473 rs755975788 |
185 | L>I | No |
ClinGen ExAC gnomAD |
|
|
CA384074389 rs1334498268 |
187 | G>E | No |
ClinGen gnomAD |
|
|
rs1334498268 CA384074386 |
187 | G>V | No |
ClinGen gnomAD |
|
|
CA6471458 rs774660155 |
190 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs1168670331 CA384074357 |
190 | S>T | No |
ClinGen gnomAD |
|
|
CA6471457 rs201726178 |
191 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 193 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs775085774 CA6471455 |
194 | K>T | No |
ClinGen ExAC TOPMed |
|
|
rs1329589888 CA384073342 |
195 | G>V | No |
ClinGen gnomAD |
|
|
rs745869429 CA6471453 |
197 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA6471452 rs781075636 COSM1220993 |
197 | R>H | large_intestine Variant assessed as Somatic; 4.62e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471451 rs756807372 |
199 | L>W | No |
ClinGen ExAC gnomAD |
|
|
CA6471450 rs746454182 |
201 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA233378166 rs544364887 |
205 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA6471447 rs752381629 |
206 | G>A | No |
ClinGen ExAC gnomAD |
|
|
COSM108213 CA233378162 rs143372033 |
206 | G>R | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
CA6471446 rs376004144 |
207 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1321087968 CA384073042 |
208 | Q>K | No |
ClinGen gnomAD |
|
|
CA384073028 rs1290476185 |
208 | Q>P | No |
ClinGen gnomAD |
|
|
CA384072968 rs1248020562 |
210 | E>D | No |
ClinGen gnomAD |
|
|
CA384072978 rs1592211125 |
210 | E>K | No |
ClinGen Ensembl |
|
| TCGA novel | 211 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471445 rs199690574 |
211 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs199690574 CA6471444 |
211 | P>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1592211030 CA384072932 |
212 | V>A | No |
ClinGen Ensembl |
|
|
rs1465924779 CA384072830 |
218 | T>I | No |
ClinGen TOPMed |
|
| TCGA novel | 219 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471443 rs768092099 |
220 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA384072756 rs1374316725 |
222 | K>N | No |
ClinGen gnomAD |
|
|
rs769718898 CA6471442 |
223 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs144902254 CA6471440 |
224 | L>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 226 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1164807164 CA384072687 |
230 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs1164807164 CA384072688 |
230 | Q>E | No |
ClinGen TOPMed gnomAD |
|
|
rs570671609 CA6471439 |
232 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6471436 rs200061726 |
233 | H>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6471437 rs200061726 |
233 | H>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA384072667 rs200061726 |
233 | H>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs775682338 CA6471438 |
233 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776570767 CA6471435 |
235 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471434 rs770815446 |
236 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471433 COSM1686171 rs746532758 |
237 | F>L | skin [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA384072633 rs777207511 |
238 | M>K | No |
ClinGen ExAC gnomAD |
|
|
CA6471432 rs777207511 |
238 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA384071936 rs1486739703 |
239 | T>I | No |
ClinGen gnomAD |
|
|
rs1253952763 CA384071934 |
240 | S>T | No |
ClinGen gnomAD |
|
|
rs770746933 CA233374430 |
242 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471418 rs776341320 |
242 | Y>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA6471416 rs760597828 |
243 | P>T | No |
ClinGen ExAC gnomAD |
|
|
rs1473420795 CA384071884 |
244 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA384071846 rs1165570426 |
247 | S>C | No |
ClinGen TOPMed |
|
|
rs1565695718 CA384071840 |
248 | L>S | No |
ClinGen Ensembl |
|
|
CA6471414 rs771533355 |
248 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs140991344 CA6471412 |
250 | N>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6471413 rs747615409 |
250 | N>Y | No |
ClinGen ExAC gnomAD |
|
|
CA233374413 rs147329540 |
254 | T>A | No |
ClinGen ESP |
|
|
CA384071769 rs1387605052 |
255 | A>T | No |
ClinGen gnomAD |
|
| TCGA novel | 258 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384071736 rs1321616568 |
259 | V>I | No |
ClinGen TOPMed |
|
|
rs1429553170 CA384071724 |
260 | M>I | No |
ClinGen gnomAD |
|
|
CA384071710 rs1178023070 |
262 | D>E | No |
ClinGen gnomAD |
|
|
rs1393886770 CA384071698 |
264 | L>* | No |
ClinGen TOPMed |
|
|
rs757632834 CA6471408 |
264 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1340485141 CA384071680 |
267 | T>A | No |
ClinGen TOPMed |
|
|
CA6471406 rs778318534 |
269 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA233374374 rs898419315 |
270 | E>D | No |
ClinGen Ensembl |
|
|
CA233374370 rs1030169111 |
271 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs373717680 CA6471403 |
272 | L>F | No |
ClinGen ESP ExAC gnomAD |
|
|
rs148612256 CA6471404 |
272 | L>S | No |
ClinGen ESP ExAC gnomAD |
|
| TCGA novel | 272 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384071642 rs1205752745 |
273 | L>F | No |
ClinGen gnomAD |
|
|
CA6471400 rs766128890 |
275 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs1277575553 CA384071631 |
275 | D>H | No |
ClinGen gnomAD |
|
|
CA233374351 rs879036629 |
275 | D>V | No |
ClinGen gnomAD |
|
|
rs997310439 CA384071626 |
276 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1311113029 CA384071624 |
276 | M>T | No |
ClinGen gnomAD |
|
|
CA233374348 rs997310439 |
276 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1228806714 CA384071617 |
277 | L>V | No |
ClinGen TOPMed |
|
|
rs1395780982 CA384071605 |
278 | D>E | No |
ClinGen gnomAD |
|
|
CA6471399 rs760497052 |
279 | D>H | No |
ClinGen ExAC gnomAD |
|
|
CA233374346 rs760497052 COSM1511514 |
279 | D>N | lung Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1565695193 CA384071589 |
281 | P>A | No |
ClinGen Ensembl |
|
|
CA233374343 rs1038287524 |
281 | P>L | No |
ClinGen Ensembl |
|
|
CA384071578 rs1006753677 |
282 | D>E | No |
ClinGen TOPMed |
|
|
rs1338323073 CA384071581 |
282 | D>G | No |
ClinGen gnomAD |
|
|
rs773048335 CA6471398 |
283 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773048335 CA233374338 |
283 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 285 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs761416193 CA6471396 |
286 | S>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384071559 rs1443142009 |
286 | S>L | No |
ClinGen TOPMed |
|
|
CA6471395 rs773945669 |
287 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA233374327 rs773945669 |
287 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384070759 rs1380833846 |
289 | A>V | No |
ClinGen TOPMed |
|
|
CA384070734 rs1389184857 |
292 | F>C | No |
ClinGen TOPMed |
|
|
rs1220949638 CA384070732 |
292 | F>L | No |
ClinGen Ensembl |
|
|
CA384070634 rs1443874418 |
299 | K>N | No |
ClinGen gnomAD |
|
|
rs1328849518 CA384070627 |
300 | K>T | No |
ClinGen gnomAD |
|
|
rs772413107 CA6471367 |
301 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs1405545213 CA384070605 |
302 | G>R | No |
ClinGen gnomAD |
|
|
rs748693932 CA6471366 |
304 | L>F | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 306 | E>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384070520 rs1418844199 |
309 | E>* | No |
ClinGen gnomAD |
|
|
CA233372460 rs989844257 |
309 | E>G | No |
ClinGen TOPMed |
|
|
rs1418844199 CA384070522 |
309 | E>K | No |
ClinGen gnomAD |
|
|
CA384070505 rs1471244614 |
311 | K>E | No |
ClinGen gnomAD |
|
|
CA384070502 rs1311440754 |
311 | K>R | No |
ClinGen TOPMed |
|
|
rs756305954 CA384070497 COSM430849 |
312 | G>A | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs780146013 CA6471363 |
312 | G>C | No |
ClinGen ExAC gnomAD |
|
|
rs756305954 CA384070496 |
312 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780146013 CA6471362 |
312 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs756305954 CA6471361 |
312 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs143949392 CA6471360 |
313 | S>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 314 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 315 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751593977 CA6471356 COSM1360542 |
316 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471355 rs200642156 |
316 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471357 rs751593977 |
316 | R>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs762172750 CA6471319 |
318 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs1025854076 CA233372232 |
319 | N>S | No |
ClinGen TOPMed |
|
|
rs763588296 CA6471316 |
320 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1308051972 CA384069877 |
323 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs769962068 CA6471314 |
324 | T>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471312 rs528644759 COSM1299198 |
326 | V>I | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
| rs777169092 | 326 | V>K | Variant assessed as Somatic; 9.242e-05 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 328 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 328 | K>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs771209382 CA6471310 |
330 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA384069799 rs771209382 |
330 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA233372214 rs559535019 |
331 | G>R | No |
ClinGen 1000Genomes gnomAD |
|
|
rs777770093 CA6471308 |
333 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA6471309 rs746812257 |
333 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA6471307 rs375022030 |
334 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471306 rs200084345 |
336 | K>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs574082799 CA6471305 |
336 | K>T | No |
ClinGen 1000Genomes ExAC |
|
|
rs200951053 CA6471304 |
338 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6471303 rs753277199 |
339 | K>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471274 rs777273699 |
340 | T>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 346 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs760787755 CA6471272 |
346 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201354911 COSM3811620 CA233371254 |
348 | A>T | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
| TCGA novel | 348 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384069116 rs773598471 |
352 | L>H | No |
ClinGen ExAC gnomAD |
|
|
rs773598471 CA6471271 |
352 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1025265193 CA233371242 |
355 | Y>F | No |
ClinGen Ensembl |
|
|
CA384069076 rs1401778994 |
356 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs146251347 CA6471270 COSM1262433 |
356 | T>M | oesophagus Variant assessed as Somatic; 4.632e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471268 rs774069197 |
358 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA384069028 rs1199724639 |
358 | A>V | No |
ClinGen TOPMed |
|
|
CA384069006 rs1368459023 |
361 | F>C | No |
ClinGen gnomAD |
|
|
rs768491279 CA6471267 |
361 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749260837 CA6471266 |
362 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA384068937 rs1201508237 |
366 | H>Y | No |
ClinGen gnomAD |
|
|
rs779940838 CA6471265 |
367 | S>A | No |
ClinGen ExAC gnomAD |
|
|
rs1260852539 CA384068923 |
367 | S>L | No |
ClinGen gnomAD |
|
|
CA6471263 rs778265588 |
368 | R>S | No |
ClinGen ExAC gnomAD |
|
|
CA384068912 rs1486341069 |
369 | L>* | No |
ClinGen gnomAD |
|
| TCGA novel | 371 | Q>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1201959941 CA384068869 |
374 | N>K | No |
ClinGen gnomAD |
|
|
CA233371211 rs942447862 |
375 | E>* | No |
ClinGen Ensembl |
|
| TCGA novel | 377 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs756804721 CA6471260 |
378 | S>F | No |
ClinGen ExAC gnomAD |
|
|
CA384068839 rs751212547 |
379 | I>F | No |
ClinGen ExAC gnomAD |
|
|
rs201548309 CA6471258 |
379 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471259 rs751212547 |
379 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1295362346 CA384068831 |
380 | G>E | No |
ClinGen gnomAD |
|
|
CA233371187 rs867053530 |
381 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs1240081555 CA384068814 |
383 | Q>E | No |
ClinGen gnomAD |
|
|
rs1334320857 CA384068804 |
384 | A>D | No |
ClinGen gnomAD |
|
|
rs1334320857 CA384068803 |
384 | A>G | No |
ClinGen gnomAD |
|
|
CA384068802 rs1334320857 |
384 | A>V | No |
ClinGen gnomAD |
|
|
rs755363982 CA6471257 |
385 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs766953145 CA6471255 |
386 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 386 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471252 rs750410796 |
390 | L>S | No |
ClinGen ExAC gnomAD |
|
|
rs138740994 COSM1220991 CA6471249 |
391 | R>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA233371147 rs868146904 |
391 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA6471230 rs751748831 |
392 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA233830850 rs866027680 |
394 | E>K | No |
ClinGen Ensembl |
|
|
CA384290923 rs1359777791 |
398 | H>P | No |
ClinGen TOPMed gnomAD |
|
|
CA6471227 rs769302749 |
398 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1486297807 CA384290916 |
399 | T>N | No |
ClinGen TOPMed |
|
|
CA233830848 rs964372593 |
400 | R>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs199835667 CA6471226 |
400 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs759461298 CA6471224 CA6471225 |
401 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384290890 rs1475170703 |
403 | I>T | No |
ClinGen TOPMed |
|
|
CA384290876 rs1416442699 |
405 | R>S | No |
ClinGen TOPMed |
|
|
CA6471223 rs776602317 |
407 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA6471222 rs770397160 |
408 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA6471220 rs546469440 |
409 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs747788606 CA6471218 |
411 | T>K | No |
ClinGen ExAC gnomAD |
|
|
CA6471219 rs147366281 |
411 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 415 | S>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384290799 rs1468745851 CA384290798 |
417 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA6471217 rs530423672 |
422 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA384290749 rs1182616130 |
424 | W>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA384290739 rs1310560334 |
425 | N>S | No |
ClinGen TOPMed |
|
|
CA6471216 rs756514047 |
426 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA384290734 rs1484347751 |
426 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA6471215 rs374938372 |
427 | G>A | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6471214 rs374938372 |
427 | G>D | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1415352852 CA384290720 |
428 | C>F | No |
ClinGen TOPMed |
|
| TCGA novel | 430 | M>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs201166300 CA6471212 |
431 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6471188 rs765395210 |
432 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1470610454 CA384290684 |
432 | A>P | No |
ClinGen gnomAD |
|
|
rs754761342 CA6471187 |
434 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA384290645 rs367728469 |
437 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs367728469 CA384290646 |
437 | T>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6471186 rs367728469 |
437 | T>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs903069813 CA233830716 |
438 | P>L | No |
ClinGen gnomAD |
|
|
rs1190136164 CA384290636 |
439 | G>D | No |
ClinGen gnomAD |
|
|
CA233830715 rs769119861 |
442 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1423779663 CA384290621 |
442 | M>V | No |
ClinGen TOPMed |
|
|
CA233830714 COSM1705239 rs868835001 |
443 | D>N | skin [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs868835001 CA384290613 |
443 | D>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 446 | N>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6471183 rs773252235 |
447 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs760730677 CA6471184 |
447 | G>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 448 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767182202 CA6471182 |
449 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA6471180 rs774174183 |
451 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA6471179 rs749562548 |
453 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA233830713 rs749562548 |
453 | G>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 454 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1360900704 CA384290538 |
454 | G>D | No |
ClinGen gnomAD |
|
|
rs777116401 CA6471177 |
455 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA384290527 rs1336040146 |
456 | G>A | No |
ClinGen TOPMed |
|
|
rs771198317 CA6471176 |
457 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 457 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA233830712 rs200740057 |
459 | L>F | No |
ClinGen Ensembl |
|
|
rs778233451 CA6471174 |
460 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA384290492 rs1183756784 |
461 | P>L | No |
ClinGen gnomAD |
|
|
rs1242127347 CA384290497 |
461 | P>T | No |
ClinGen gnomAD |
|
|
rs1055494413 CA233830711 |
462 | H>R | No |
ClinGen Ensembl |
|
|
rs955258605 CA233830710 |
463 | F>L | No |
ClinGen TOPMed |
|
| TCGA novel | 466 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384290462 rs1285002950 |
466 | E>Q | No |
ClinGen gnomAD |
|
|
rs1214259553 CA384290454 |
467 | S>G | No |
ClinGen gnomAD |
|
|
CA6471173 rs201761082 |
469 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1449191020 CA384290439 |
469 | S>P | No |
ClinGen TOPMed |
|
|
rs573941980 CA233830709 |
470 | Y>* | No |
ClinGen 1000Genomes |
|
|
rs563553688 CA6471171 |
471 | F>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6471167 rs755839748 |
474 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1032753329 CA233830708 |
474 | S>N | No |
ClinGen TOPMed |
|
|
rs1000392258 CA233830707 |
476 | I>V | No |
ClinGen TOPMed |
|
|
rs1198474672 CA384290370 |
479 | G>S | No |
ClinGen TOPMed |
|
|
rs1239113491 CA384290359 |
480 | M>I | No |
ClinGen TOPMed |
|
|
CA6471166 rs578005805 |
480 | M>R | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA384290356 rs1458820872 |
481 | P>T | No |
ClinGen TOPMed |
|
|
CA384290342 rs1229065080 |
483 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1296499986 CA384290335 |
484 | L>F | No |
ClinGen gnomAD |
|
|
rs761409846 CA6471164 |
487 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA6471163 rs751060116 |
487 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs757326350 CA6471145 |
489 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA233829940 rs998637111 |
490 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
CA6471143 rs375785880 |
491 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1270037124 CA384290266 |
493 | Q>H | No |
ClinGen gnomAD |
|
|
rs1565653072 CA384290269 |
493 | Q>R | No |
ClinGen Ensembl |
|
|
CA6471141 rs752418470 |
494 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471139 rs761033704 |
495 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs761033704 CA384290255 |
495 | P>R | No |
ClinGen ExAC gnomAD |
|
|
CA6471140 rs764757392 |
495 | P>S | No |
ClinGen ExAC |
|
|
rs773624229 CA6471138 |
496 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1388903092 CA384290252 |
496 | L>P | No |
ClinGen gnomAD |
|
|
CA233829939 rs773624229 |
496 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384290249 rs1360232726 |
497 | T>A | No |
ClinGen gnomAD |
|
|
CA6471137 rs375699309 |
498 | H>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs762346443 CA6471136 |
499 | S>* | No |
ClinGen ExAC gnomAD |
|
|
rs10505830 CA6471135 VAR_050542 |
500 | S>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1469286902 CA384290221 |
502 | N>D | No |
ClinGen gnomAD |
|
|
CA384290211 rs1378119644 |
503 | K>E | No |
ClinGen gnomAD |
|
|
rs1426519546 CA384290202 |
504 | G>D | No |
ClinGen gnomAD |
|
|
rs1418319077 CA384290203 |
504 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs749285005 CA6471133 |
505 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1186165869 CA384290188 |
506 | S>* | No |
ClinGen gnomAD |
|
|
CA6471131 rs746077652 |
510 | I>R | No |
ClinGen ExAC gnomAD |
|
|
rs746077652 CA6471130 |
510 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs372739448 CA6471132 |
510 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 511 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781203685 CA6471129 |
511 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1362849229 CA384290148 |
513 | F>L | No |
ClinGen gnomAD |
|
|
rs143705661 CA233829937 |
514 | G>D | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA233829936 rs143705661 |
514 | G>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs747019678 CA6471127 |
516 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs757089938 CA6471128 |
516 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA233829935 rs762517624 |
517 | N>D | No |
ClinGen gnomAD |
|
|
rs1295277613 CA384290122 |
517 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA384290118 rs1287617910 |
518 | D>H | No |
ClinGen TOPMed |
|
|
CA384290100 rs1159433807 |
520 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA6471126 rs777524015 |
521 | K>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774791716 CA233829933 |
524 | T>A | No |
ClinGen Ensembl |
|
|
CA6471123 rs764883389 COSM937727 |
525 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs764883389 CA6471124 |
525 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754691461 CA6471122 |
525 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754691461 CA384290065 |
525 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 526 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs753457750 CA6471121 |
526 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs556354031 CA6471120 |
527 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6471119 rs762115617 |
530 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA233829931 rs982833347 |
530 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs753282259 CA6471075 |
531 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289998 rs1190644019 |
534 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1168406425 CA384289975 |
537 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs551867055 CA233829510 |
543 | I>L | No |
ClinGen 1000Genomes |
|
|
CA233829509 rs921193342 |
544 | I>S | No |
ClinGen Ensembl |
|
|
rs765803035 CA6471074 |
545 | H>L | No |
ClinGen ExAC gnomAD |
|
|
CA384289916 rs1371898909 |
545 | H>Q | No |
ClinGen TOPMed |
|
|
rs1320728575 CA384289901 COSM1360540 |
548 | E>* | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA6471072 rs753912831 |
550 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753912831 CA384289887 |
550 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289884 rs1346886433 |
550 | A>V | No |
ClinGen gnomAD |
|
|
rs766470697 CA384289883 |
551 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs760846175 CA384289875 |
552 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289871 rs1268205021 |
552 | I>M | No |
ClinGen TOPMed |
|
|
rs760846175 CA6471070 |
552 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289868 rs1424048703 |
553 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA6471069 rs773460175 |
553 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764575794 CA6471068 |
557 | E>A | No |
ClinGen ExAC gnomAD |
|
|
rs764575794 CA233829508 |
557 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA6471067 rs761628985 COSM1732492 |
558 | G>S | Variant assessed as Somatic; 0.0 impact. bone [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA384289833 rs1334112989 |
559 | Q>E | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1334112989 CA384289834 |
559 | Q>K | No |
ClinGen TOPMed gnomAD |
|
|
rs980750992 CA233829507 |
560 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
CA6471066 rs774273679 |
560 | G>V | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 561 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768519319 CA6471064 |
562 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs749207835 CA384289808 |
563 | A>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749207835 CA6471063 |
563 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6471062 rs779603156 |
565 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1440335704 CA384289763 |
570 | Q>K | No |
ClinGen gnomAD |
|
|
CA233829506 rs1024791243 |
570 | Q>R | No |
ClinGen TOPMed |
|
|
CA384289737 rs1444032727 |
573 | L>F | No |
ClinGen gnomAD |
|
|
rs769319345 CA6471061 |
573 | L>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289734 rs1270699975 |
574 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs745559226 CA6471060 |
575 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs267603406 COSM1705236 CA233829505 |
578 | M>I | skin [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs758723831 CA6471058 |
578 | M>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758723831 CA384289710 |
578 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780852544 CA6471059 |
578 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA384289703 rs1200690947 |
579 | N>T | No |
ClinGen gnomAD |
|
|
rs753044914 CA6471057 |
580 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1377138386 CA384289694 |
580 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1449492009 CA384289689 |
581 | G>C | No |
ClinGen gnomAD |
|
|
rs371997935 COSM937724 CA6471026 |
583 | R>C | Variant assessed as Somatic; 0.0 impact. NS endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs758982697 CA6471025 |
583 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA6471024 rs776263166 COSM23086 |
584 | R>C | lung large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs770563339 COSM1360537 CA6471023 |
584 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs918476999 CA233829422 |
585 | I>T | No |
ClinGen TOPMed |
|
|
CA384289616 rs1319402442 |
591 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs772949794 CA384289617 |
591 | M>R | No |
ClinGen ExAC gnomAD |
|
|
CA6471020 rs772949794 |
591 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs1220668097 CA384289620 |
591 | M>V | No |
ClinGen gnomAD |
|
|
rs749597291 CA6471018 |
592 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA6471019 rs769172901 |
592 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA384289608 rs1438749227 |
593 | E>Q | No |
ClinGen gnomAD |
|
|
rs1301038364 CA384289596 |
594 | S>I | No |
ClinGen gnomAD |
|
|
rs1235794078 CA384289595 |
594 | S>R | No |
ClinGen gnomAD |
|
|
CA384289591 rs1465464584 |
595 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 596 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA384289578 rs780438880 |
597 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs780438880 CA6471017 |
597 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA6471016 rs756699022 |
600 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs746351999 CA6471015 |
601 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368073546 CA6471014 |
602 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA233829418 rs955097824 |
604 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
CA384289537 rs955097824 |
604 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA384289517 rs375530262 |
606 | Y>* | No |
ClinGen ESP ExAC gnomAD |
|
|
CA6471012 rs751805291 |
607 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA384289510 rs1257019153 |
608 | R>G | No |
ClinGen gnomAD |
|
|
CA384289507 rs1565641278 |
608 | R>T | No |
ClinGen Ensembl |
1 associated diseases with Q86YW0
[MIM: 617214]: Spermatogenic failure 17 (SPGF17)
An autosomal recessive infertility disorder due to failure of oocyte activation and fertilization by sperm that otherwise exhibits normal morphology. {ECO:0000269|PubMed:26721930}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- An autosomal recessive infertility disorder due to failure of oocyte activation and fertilization by sperm that otherwise exhibits normal morphology. {ECO:0000269|PubMed:26721930}. Note=The disease is caused by variants affecting the gene represented in this entry.
5 regional properties for Q86YW0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 465 - 589 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 155 - 300 | IPR000909 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 349 - 465 | IPR001711 |
| domain | EF-hand domain | 35 - 70 | IPR002048 |
| domain | Phosphoinositide-specific phospholipase C, EF-hand-like domain | 64 - 147 | IPR015359 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.11 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| pronucleus | The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. |
| sperm head | The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| phosphatidylinositol phospholipase C activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). |
| phosphatidylinositol-3-phosphate binding | Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| phosphatidylinositol-5-phosphate binding | Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| egg activation | The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. |
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| positive regulation of cytosolic calcium ion concentration involved in egg activation | The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg. |
31 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32383 | PLC1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P10895 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Bos taurus (Bovine) | SS |
| Q1RML2 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Bos taurus (Bovine) | PR |
| Q2VRL0 | PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Gallus gallus (Chicken) | PR |
| Q15111 | PLCL1 | Inactive phospholipase C-like protein 1 | Homo sapiens (Human) | PR |
| Q9UPR0 | PLCL2 | Inactive phospholipase C-like protein 2 | Homo sapiens (Human) | PR |
| Q8N3E9 | PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Homo sapiens (Human) | SS |
| Q9BRC7 | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 | Homo sapiens (Human) | SS |
| P16885 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | Homo sapiens (Human) | SS |
| P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Homo sapiens (Human) | EV |
| Q00722 | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | Homo sapiens (Human) | EV |
| Q01970 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | Homo sapiens (Human) | EV |
| Q9NQ66 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | Homo sapiens (Human) | EV |
| Q9P212 | PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Homo sapiens (Human) | SS |
| P51178 | PLCD1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Homo sapiens (Human) | EV |
| Q15147 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | Homo sapiens (Human) | PR |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Mus musculus (Mouse) | SS |
| Q8K394 | Plcl2 | Inactive phospholipase C-like protein 2 | Mus musculus (Mouse) | PR |
| Q8K2J0 | Plcd3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 | Mus musculus (Mouse) | PR |
| Q8K4S1 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Mus musculus (Mouse) | SS |
| Q7YRU3 | PLCZ | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 | Sus scrofa (Pig) | PR |
| P10688 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | Rattus norvegicus (Rat) | SS |
| Q99P84 | Plce1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 | Rattus norvegicus (Rat) | EV |
| Q8GV43 | PLC6 | Phosphoinositide phospholipase C 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C2 | PLC5 | Phosphoinositide phospholipase C 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NMA7 | PLC9 | Phosphoinositide phospholipase C 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9STZ3 | PLC8 | Phosphoinositide phospholipase C 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56W08 | PLC3 | Phosphoinositide phospholipase C 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39032 | PLC1 | Phosphoinositide phospholipase C 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q944C1 | PLC4 | Phosphoinositide phospholipase C 4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A5D6R3 | plcd3a | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMRWFLSKI | QDDFRGGKIN | LEKTQRLLEK | LDIRCSYIHV | KQIFKDNDRL | KQGRITIEEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAIYRIITHR | EEIIEIFNTY | SENRKILLAS | NLAQFLTQEQ | YAAEMSKAIA | FEIIQKYEPI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEVRKAHQMS | LEGFTRYMDS | RECLLFKNEC | RKVYQDMTHP | LNDYFISSSH | NTYLVSDQLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPSDLWGYVS | ALVKGCRCLE | IDCWDGAQNE | PVVYHGYTLT | SKLLFKTVIQ | AIHKYAFMTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DYPVVLSLEN | HCSTAQQEVM | ADNLQATFGE | SLLSDMLDDF | PDTLPSPEAL | KFKILVKNKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IGTLKETHER | KGSDKRGDNQ | DKETGVKKLP | GVMLFKKKKT | RKLKIALALS | DLVIYTKAEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FKSFQHSRLY | QQFNENNSIG | ETQARKLSKL | RVHEFIFHTR | KFITRIYPKA | TRADSSNFNP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QEFWNIGCQM | VALNFQTPGL | PMDLQNGKFL | DNGGSGYILK | PHFLRESKSY | FNPSNIKEGM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PITLTIRLIS | GIQLPLTHSS | SNKGDSLVII | EVFGVPNDQM | KQQTRVIKKN | AFSPRWNETF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TFIIHVPELA | LIRFVVEGQG | LIAGNEFLGQ | YTLPLLCMNK | GYRRIPLFSR | MGESLEPASL |
| FVYVWYVR |