AiPD: Autoinhibited Protein Database

Q86Y07

Gene name	VRK2
Protein name	Serine/threonine-protein kinase VRK2
Names	Vaccinia-related kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7444
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

300-382 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

300-382 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

185-215 (Activation loop from InterPro)

Target domain	29-319 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for Q86Y07

Entry ID	Method	Resolution	Chain	Position	Source
2V62	X-ray	170 A	A/B	14-335	PDB
5UU1	X-ray	200 A	A	14-335	PDB
6NCG	X-ray	245 A	A/B	14-335	PDB
8Q1Z	X-ray	185 A	A	14-335	PDB
AF-Q86Y07-F1	Predicted				AlphaFoldDB

492 variants for Q86Y07

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs201610023 RCV000259387 RCV003168510 CA1670204	435	D>N	Fanconi anemia complementation group L Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001139581 rs951671744 CA48349939	440	D>H	Fanconi anemia complementation group L [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
RCV001139583 CA1670245 rs781556579	491	R>C	Fanconi anemia complementation group L Variant assessed as Somatic; 0.0 impact. [ClinVar, NCI-TCGA]	Yes	ClinGen ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA1670258 rs76348639 RCV001537367 RCV001139584	502	F>L	Fanconi anemia complementation group L [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1684780470 RCV001139585	504	A>T	Fanconi anemia complementation group L [ClinVar]	Yes	ClinVar dbSNP
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1193583209 CA347033518	2	P>S		No	ClinGen TOPMed gnomAD
rs149155455 CA1669636	5	R>K		No	ClinGen ESP ExAC gnomAD
CA1669637 rs149155455	5	R>T		No	ClinGen ESP ExAC gnomAD
CA347033566 rs1172365668	9	Y>H		No	ClinGen gnomAD
TCGA novel	9	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759887505 CA1669639	10	K>R		No	ClinGen ExAC gnomAD
CA1669641 rs763657380	12	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1228024879 CA347033587	12	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1317346828 CA347033603	14	P>L		No	ClinGen TOPMed
rs925391571 CA48729003	15	F>L		No	ClinGen gnomAD
CA347033608 rs1247914804	15	F>S		No	ClinGen TOPMed
TCGA novel	16	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370499341 CA1669646	20	V>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370499341 CA1669643	20	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1669644 rs370499341	20	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1669648 rs138787216	21	L>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	25	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347033686 rs1431343236	27	N>D		No	ClinGen TOPMed
rs374589546 CA1669651 COSM3962954	27	N>S	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1314044764 CA347033693	28	Q>*		No	ClinGen Ensembl
CA347033699 rs1311781124	28	Q>H		No	ClinGen gnomAD
CA347033703 rs1211129736	29	W>*		No	ClinGen gnomAD
rs749045675 CA1669652	30	V>L		No	ClinGen ExAC gnomAD
rs562481384 CA347033714	31	L>M		No	ClinGen gnomAD
rs768497359 CA1669653	31	L>Q		No	ClinGen ExAC gnomAD
CA347033717 rs768497359	31	L>R		No	ClinGen ExAC gnomAD
rs1320997368 CA347033721	32	G>D		No	ClinGen TOPMed
rs748359792 CA1669655	33	K>N		No	ClinGen ExAC gnomAD
TCGA novel	33	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1669656 rs144870539	35	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347033748 rs1365812094	36	G>D		No	ClinGen TOPMed
CA48729005 rs943968000	38	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA347033762 rs1036939858 CA48729006	39	G>R		No	ClinGen TOPMed gnomAD
rs747062607 CA1669658	40	F>C		No	ClinGen ExAC gnomAD
CA1669657 rs773457432	40	F>L		No	ClinGen ExAC TOPMed gnomAD
rs771355411 CA347033773 CA1669659	41	G>R		No	ClinGen ExAC gnomAD
CA1669662 rs765571345	43	I>M		No	ClinGen ExAC TOPMed gnomAD
rs759882735 CA1669661	43	I>V		No	ClinGen ExAC gnomAD
CA1669663 rs141719281	44	Y>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347033790 rs141719281	44	Y>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371129971 CA1669664	45	L>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs767112405 CA1669665	46	A>T		No	ClinGen ExAC gnomAD
rs555993721 CA1669691	47	F>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA346924196 TCGA novel rs1413004719	48	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA48344470 rs757136629	49	T>A		No	ClinGen Ensembl
rs34130684 VAR_041293 CA1669692	50	N>D		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA346924207 rs1360116175	50	N>T		No	ClinGen gnomAD
rs765218773 CA1669693	52	P>L		No	ClinGen ExAC gnomAD
CA48344472 rs371516428	54	K>E		No	ClinGen ESP
rs1406311135 CA346924240	55	D>N		No	ClinGen TOPMed
CA346924245 rs1276929798	55	D>V		No	ClinGen TOPMed gnomAD
rs778206641 CA1669696	56	A>E		No	ClinGen ExAC TOPMed gnomAD
rs778852734 CA1669694	56	A>P		No	ClinGen ExAC TOPMed gnomAD
CA1669695 rs778852734	56	A>S		No	ClinGen ExAC TOPMed gnomAD
CA48344494 rs200928672	58	H>R		No	ClinGen Ensembl
CA1669698 rs757329042	59	V>A		No	ClinGen ExAC gnomAD
CA346924268 rs757329042	59	V>G		No	ClinGen ExAC gnomAD
CA1669697 rs374084410	59	V>L		No	ClinGen ESP ExAC gnomAD
CA1669699 rs781297733	60	V>I		No	ClinGen ExAC gnomAD
TCGA novel	62	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535808651 CA1669700	62	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA48345366 rs982524033	63	E>D		No	ClinGen TOPMed gnomAD
CA346924768 rs1322434643	63	E>K		No	ClinGen TOPMed gnomAD
CA346924797 rs1442691336	65	Q>E		No	ClinGen gnomAD
CA346924813 rs1306724750	66	E>Q		No	ClinGen gnomAD
rs1268160332 CA346924841	68	G>R		No	ClinGen TOPMed
CA346924851 rs1203890028	69	P>A		No	ClinGen gnomAD
CA1669727 rs779367998	69	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1247407305 CA346924876	71	F>L		No	ClinGen TOPMed gnomAD
rs1226168919 CA346924920	74	L>H		No	ClinGen TOPMed
rs529796004 CA1669731	75	K>I		No	ClinGen ExAC gnomAD
rs529796004 CA1669732	75	K>T		No	ClinGen ExAC gnomAD
CA346924986 rs1237890313	79	R>K		No	ClinGen gnomAD
rs775616179 CA1669734	80	V>A		No	ClinGen ExAC gnomAD
CA346924995 rs1440759470	80	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1669735 rs775616179	80	V>G		No	ClinGen ExAC gnomAD
rs1197962100 CA346925004	81	A>T		No	ClinGen gnomAD
rs761453842 CA1669739	83	K>N		No	ClinGen ExAC gnomAD
CA1669740 rs767781504	84	D>E		No	ClinGen ExAC gnomAD
CA346925027 rs1394584415	84	D>N		No	ClinGen TOPMed gnomAD
rs780517094	84	D>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA346925041 rs1345410198	86	I>V		No	ClinGen TOPMed
rs1331503010 CA346925062	87	K>R		No	ClinGen TOPMed
rs1433688951 CA346925072	88	K>N		No	ClinGen gnomAD
rs981876712 CA48346669	88	K>Q		No	ClinGen Ensembl
rs1254573115 CA346925088	90	I>M		No	ClinGen gnomAD
rs1201527327 CA346925095	91	E>D		No	ClinGen gnomAD
rs1483162142 CA346925089 COSM3839742	91	E>K	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs140286253 CA1669766	92	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA1669767 COSM267751 rs765840317	92	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA346925100 rs765840317 COSM316485	92	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA1669768 rs753131070	93	K>N		No	ClinGen ExAC TOPMed gnomAD
rs758845875 CA1669769	94	Q>*		No	ClinGen ExAC gnomAD
CA346925113 rs1428668819	94	Q>H		No	ClinGen gnomAD
rs778249587 CA1669770	97	Y>D		No	ClinGen ExAC gnomAD
rs1465414516 CA346925139	98	L>*		No	ClinGen gnomAD
rs1375705165 CA346925136	98	L>I		No	ClinGen gnomAD
CA1669771 rs747335639	99	G>A		No	ClinGen ExAC TOPMed gnomAD
rs377003543 CA1669773	101	P>R		No	ClinGen ESP ExAC gnomAD
CA48346717 rs765005527	102	L>P		No	ClinGen Ensembl
CA346925165 rs1297612290	103	F>I		No	ClinGen TOPMed gnomAD
rs375372500 CA1669774	104	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1299550885 CA346925190	106	S>F		No	ClinGen gnomAD
CA48346756 rs79227349	107	G>C		No	ClinGen ExAC gnomAD
CA1669776 rs79227349	107	G>S		No	ClinGen ExAC gnomAD
rs748009265 CA1669777	108	L>V		No	ClinGen ExAC gnomAD
TCGA novel	110	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs147530902 CA1669779	113	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1485940448 CA346925231	113	G>R		No	ClinGen gnomAD
COSM1632066 rs1287047874 CA346925676	115	S>R	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1014294644 CA48348643	117	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	117	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346925757 rs1558619686	119	M>T		No	ClinGen Ensembl
CA1669803 rs202150387	119	M>V		No	ClinGen ExAC gnomAD
CA346925765 rs1274707992	120	V>I		No	ClinGen TOPMed gnomAD
rs1456262266 CA346925780	122	E>K		No	ClinGen gnomAD
CA1669804 rs368977421	123	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA48348692 rs931213441	126	I>T		No	ClinGen gnomAD
CA346925807 rs1233277614	126	I>V		No	ClinGen gnomAD
CA346925814 rs1196259656	127	D>H		No	ClinGen gnomAD
CA346925842 rs1240783927	129	Q>*		No	ClinGen gnomAD
CA1669806 rs775454184	129	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA1669808 rs764697966	130	K>N		No	ClinGen ExAC TOPMed gnomAD
CA1669807 rs763027520	130	K>T		No	ClinGen ExAC gnomAD
rs1439271270 CA346925876	131	I>M		No	ClinGen TOPMed
rs1278006498 CA346925886	132	S>L		No	ClinGen TOPMed
CA346925925 rs1163418826	135	N>K		No	ClinGen gnomAD
rs142982287 CA1669809	135	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142982287 CA1669810	135	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201232703 CA1669811	136	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750762302 CA1669812	137	T>N		No	ClinGen ExAC gnomAD
CA346925965 rs1446389808	139	K>E		No	ClinGen gnomAD
rs754614058 CA1669813	140	K>R		No	ClinGen ExAC gnomAD
rs141045353 CA1669814	142	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752154121 CA346926008	142	T>I		No	ClinGen ExAC TOPMed gnomAD
rs752154121 CA1669815	142	T>S		No	ClinGen ExAC TOPMed gnomAD
CA346926049 rs1312718976	146	L>V		No	ClinGen TOPMed
rs1273381699 CA346926062	147	G>R		No	ClinGen gnomAD
CA1669818 rs746927837	149	R>*		No	ClinGen ExAC TOPMed gnomAD
rs768716776 CA1669819	149	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1669820 rs780878605	150	M>I		No	ClinGen ExAC gnomAD
rs772465160 CA1669847	151	L>F		No	ClinGen ExAC gnomAD
TCGA novel	152	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1669848 rs773766763	152	D>N		No	ClinGen ExAC TOPMed gnomAD
rs143605636 CA1669850	155	E>G		No	ClinGen ESP ExAC gnomAD
CA346926366 rs1265195650	155	E>K		No	ClinGen TOPMed
CA1669851 rs535615162	157	I>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs35966666 CA1669853 VAR_041294	157	I>M		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
CA1669852 rs535615162	157	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA48350008 rs910273959	157	I>V		No	ClinGen gnomAD
rs1248039057 CA346926456	161	E>G		No	ClinGen Ensembl
CA1669855 rs756689245	164	H>R		No	ClinGen ExAC gnomAD
rs767418182 CA1669856	165	G>D		No	ClinGen ExAC gnomAD
TCGA novel	167	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_017095 rs1051061 CA1669857	167	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA1669858 rs755909448	169	A>T		No	ClinGen ExAC gnomAD
CA346926566 rs1573033842	170	A>G		No	ClinGen Ensembl
rs763240464 CA1669859	170	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1669860 rs749046235	171	N>H		No	ClinGen ExAC gnomAD
CA346926587 rs1437146452	172	L>V		No	ClinGen TOPMed
rs1380456141 CA346926623	175	G>D		No	ClinGen TOPMed gnomAD
TCGA novel	176	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1669862 rs755267609	179	P>S		No	ClinGen ExAC gnomAD
CA1669864 rs748308544	180	D>G		No	ClinGen ExAC gnomAD
CA346926670 rs1455902135	180	D>N		No	ClinGen gnomAD
rs1454786007 CA346926692	181	Q>H		No	ClinGen gnomAD
CA48379669 rs941482762	182	V>F		No	ClinGen TOPMed gnomAD
rs1294833091 CA346931242	182	V>G		No	ClinGen TOPMed
rs1251054642 CA346931296	184	L>V		No	ClinGen gnomAD
rs1558664957 CA346931320	185	A>G		No	ClinGen Ensembl
rs1254737152 CA346931426	188	G>A		No	ClinGen TOPMed gnomAD
rs541143340 CA1669886	189	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs746298070 CA1669887	190	S>A		No	ClinGen ExAC TOPMed gnomAD
CA346931483 rs1417953894	190	S>C		No	ClinGen gnomAD
rs1459697627 CA346931499	191	Y>N		No	ClinGen gnomAD
CA346931627 rs559471489	193	Y>*		No	ClinGen 1000Genomes gnomAD
rs1056212237 CA48379715	194	C>F		No	ClinGen TOPMed
rs1372281548 CA346931655	196	N>H		No	ClinGen gnomAD
CA1669888 rs147166402	196	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1669889 rs147166402	196	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs142690362 CA1669891	198	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1414130276 CA346931726	199	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA346931736 rs1313490183	200	K>Q		No	ClinGen gnomAD
TCGA novel	200	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1357463274 CA346931771	201	Q>H		No	ClinGen gnomAD
CA346931770 rs1181642305	201	Q>L		No	ClinGen Ensembl
rs1269722901 CA346931795	202	Y>*		No	ClinGen TOPMed
rs772794778 CA1669892	202	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	203	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	203	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1669893 rs760039901	204	E>A		No	ClinGen ExAC gnomAD
rs1015708609 CA48379742	205	N>D		No	ClinGen TOPMed gnomAD
rs766496255 CA1669894	208	K>E		No	ClinGen ExAC gnomAD
CA346931902 rs1347707584	209	G>R		No	ClinGen gnomAD
CA1669895 rs753816759	209	G>V		No	ClinGen ExAC gnomAD
CA1669896 rs139475807	210	H>R		No	ClinGen ESP ExAC gnomAD
CA1669897 VAR_051681 rs36081172	211	N>S		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
CA1669899 rs750647897	212	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1669898 rs750647897	212	G>E		No	ClinGen ExAC TOPMed gnomAD
rs144394613 CA1669900	214	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA1669901 rs751662781	215	E>G		No	ClinGen ExAC TOPMed gnomAD
CA48379779 rs1028587343	215	E>Q		No	ClinGen TOPMed
CA1669902 rs751662781	215	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1433966864 CA346932081	216	F>I		No	ClinGen gnomAD
CA1669904 rs17049354	216	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA346932107 rs1284767640	217	T>A		No	ClinGen TOPMed
TCGA novel	218	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	218	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346932240 rs1451772319	220	D>E		No	ClinGen gnomAD
rs770181704 CA1669905	220	D>Y		No	ClinGen ExAC gnomAD
CA48379799 rs764150715	222	H>Y		No	ClinGen gnomAD
rs1384138022 CA346932309	223	K>E		No	ClinGen gnomAD
rs1301627824 CA346932325	223	K>M		No	ClinGen gnomAD
TCGA novel	225	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346932385 rs1370796738	226	A>T		No	ClinGen TOPMed gnomAD
CA1669927 rs749731864	227	L>F		No	ClinGen ExAC TOPMed gnomAD
CA48316054 rs186975464	227	L>V		No	ClinGen 1000Genomes
CA346924123 rs1408801076	228	S>Y		No	ClinGen gnomAD
CA346924132 rs1573297181	229	R>S		No	ClinGen Ensembl
CA48316056 rs755287817	230	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA48316057 rs912137366	230	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA1669929 rs777534671	232	D>E		No	ClinGen ExAC TOPMed gnomAD
CA346924151 rs144319023	233	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs144319023 CA1669930	233	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1669931 rs201406382	234	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs145144904 CA48316059	235	I>F		No	ClinGen ESP ExAC TOPMed
CA1669933 rs145144904	235	I>V		No	ClinGen ESP ExAC TOPMed
CA48316060 rs1045089784	236	L>V		No	ClinGen Ensembl
rs775284608 CA1669935	237	G>S		No	ClinGen ExAC gnomAD
CA1669936 rs762863823	238	Y>C		No	ClinGen ExAC gnomAD
rs1229752299 CA346924330	240	M>V		No	ClinGen gnomAD
CA346924351 rs1290927589	241	L>P		No	ClinGen TOPMed gnomAD
CA346924348 rs1290927589	241	L>R		No	ClinGen TOPMed gnomAD
CA48316061 rs1034927922	242	R>P		No	ClinGen TOPMed gnomAD
CA346924357 rs1034927922	242	R>Q		No	ClinGen TOPMed gnomAD
CA1669937 rs779052033	242	R>W		No	ClinGen ExAC TOPMed gnomAD
CA1669938 rs774670488	243	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1340109216 CA346924364	243	W>R		No	ClinGen TOPMed
rs1213917726 CA346924409	246	G>R		No	ClinGen TOPMed
CA1669939 rs762051577	247	K>E		No	ClinGen ExAC TOPMed gnomAD
rs767674577 CA1669940	247	K>R		No	ClinGen ExAC gnomAD
rs369326737 CA1669941	248	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs756184673 CA346924445	249	P>A		No	ClinGen ExAC TOPMed gnomAD
CA346924451 rs1417260150	249	P>R		No	ClinGen gnomAD
CA346924447 rs756184673	249	P>S		No	ClinGen ExAC TOPMed gnomAD
rs756184673 CA1669942	249	P>T		No	ClinGen ExAC TOPMed gnomAD
CA48316064 rs146023220	250	W>G		No	ClinGen ESP gnomAD
rs146023220 CA346924457	250	W>R		No	ClinGen ESP gnomAD
CA1669944 rs766972076	252	Q>H		No	ClinGen ExAC
CA346924521 rs1409793489	254	L>V		No	ClinGen gnomAD
CA346924560 rs1171709314	257	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA346924559 rs1171709314	257	P>R		No	ClinGen gnomAD
rs200483690 CA1669946	259	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1413506734 CA346924582	259	A>V		No	ClinGen gnomAD
CA48316066 rs75161943	260	V>G		No	ClinGen Ensembl
CA1669947 rs779177111	260	V>L		No	ClinGen ExAC gnomAD
rs146957547 CA1669949	262	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1479964419 CA346924625	263	A>T		No	ClinGen gnomAD
rs755741364 CA1669991	268	L>S		No	ClinGen ExAC gnomAD
TCGA novel	269	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346925280 rs1213411092	270	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1440785190 CA346925290	271	L>F		No	ClinGen TOPMed
rs376537647 CA48317389	272	P>S		No	ClinGen ESP TOPMed gnomAD
CA1669993 rs753290532	273	Q>*		No	ClinGen ExAC gnomAD
CA1669994 rs754501037	275	V>L		No	ClinGen ExAC gnomAD
CA346925312 rs754501037	275	V>M		No	ClinGen ExAC gnomAD
CA346925320 rs1469220987	276	L>R		No	ClinGen gnomAD
CA346925330 rs370715573	277	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1573317969 CA346925333	278	W>*		No	ClinGen Ensembl
rs748050076 CA1669996	278	W>R		No	ClinGen ExAC gnomAD
rs758297224 CA346925339	279	A>P		No	ClinGen ExAC gnomAD
CA1669997 rs758297224	279	A>T		No	ClinGen ExAC gnomAD
CA346925343 rs1324897637	279	A>V		No	ClinGen gnomAD
rs1211143100 CA346925351	281	S>P		No	ClinGen gnomAD
rs777568110 CA346925373	284	S>N		No	ClinGen ExAC gnomAD
rs777568110 CA1669998	284	S>T		No	ClinGen ExAC gnomAD
rs1388440005 CA346925379	285	C>S		No	ClinGen gnomAD
CA346926205 rs1158119781	286	C>Y		No	ClinGen TOPMed
rs1225641709 CA346926210	287	E>K		No	ClinGen gnomAD
rs374086826 CA1670026	288	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA346926227 rs1340596305	289	A>D		No	ClinGen gnomAD
rs771587514	292	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA346926253 rs1484426495	293	V>I		No	ClinGen gnomAD
TCGA novel	295	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA48321638 rs767894317	296	H>Q		No	ClinGen ExAC gnomAD
rs1256363642 CA346926277	296	H>R		No	ClinGen gnomAD
CA346926275 rs1458441605	296	H>Y		No	ClinGen gnomAD
CA346926284 rs1408594037	297	S>T		No	ClinGen TOPMed
CA1670032 rs759254799	300	Y>C		No	ClinGen ExAC gnomAD
CA346926371 rs1373679205	305	N>H		No	ClinGen gnomAD
rs978318198 CA48321724	306	Y>C		No	ClinGen TOPMed gnomAD
rs1434241216 CA346926387	306	Y>N		No	ClinGen gnomAD
rs1471705503 CA346926399	307	Q>E		No	ClinGen TOPMed
CA1670035 rs147504112	307	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs752212302 CA1670034	307	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs1424657213 CA346926415	308	A>P		No	ClinGen gnomAD
CA1670036 rs764079360	309	L>H		No	ClinGen ExAC gnomAD
CA1670037 rs372766947	310	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA346926469 rs1214438598	312	I>N		No	ClinGen TOPMed
TCGA novel	312	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	313	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1448124491 CA346926496	314	N>H		No	ClinGen TOPMed
rs757039760 CA1670038	314	N>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	314	N>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1670039 rs140015622	316	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA346926570 rs1256074513	319	P>S		No	ClinGen gnomAD
rs201301792 CA1670041	321	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs780354988 CA1670042	322	P>S		No	ClinGen ExAC gnomAD
CA346926618 rs1573358694	323	L>Q		No	ClinGen Ensembl
CA1670043 rs749443952	323	L>V		No	ClinGen ExAC gnomAD
rs1294356946 CA346926625	324	D>H		No	ClinGen gnomAD
CA48321799 rs867550402	326	S>F		No	ClinGen Ensembl
rs1553423606 CA346926696	327	T>R		No	ClinGen Ensembl
rs1288416103 CA346926702	328	K>E		No	ClinGen TOPMed
CA1670044 rs768835989	328	K>R		No	ClinGen ExAC TOPMed gnomAD
CA346926722 rs1247503593	330	Q>H		No	ClinGen gnomAD
rs200839928 CA48321814	330	Q>R		No	ClinGen 1000Genomes TOPMed gnomAD
rs779330212 CA1670045	331	S>G		No	ClinGen ExAC TOPMed gnomAD
CA346926736 rs1403477641	332	I>M		No	ClinGen TOPMed
TCGA novel	334	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372039455 CA1670048	335	H>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1670047 rs772409945	335	H>Y		No	ClinGen ExAC gnomAD
CA346926761 rs760966383	336	T>I		No	ClinGen ExAC TOPMed gnomAD
CA1670049 rs760966383	336	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1389810595 CA346926763	337	P>S		No	ClinGen gnomAD
CA1670052 rs552864455	338	N>D		No	ClinGen ExAC TOPMed gnomAD
CA346926785 rs1475470403	340	Q>E		No	ClinGen TOPMed
rs185638327 CA1670069	342	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs570821056 CA1670070	347	A>G		No	ClinGen 1000Genomes ExAC gnomAD
CA346927204 rs1271024887	347	A>P		No	ClinGen TOPMed gnomAD
rs1271024887 CA346927206	347	A>S		No	ClinGen TOPMed gnomAD
CA1670071 rs771265352	348	A>T		No	ClinGen ExAC gnomAD
CA346927234 rs1159706666	349	T>I		No	ClinGen TOPMed gnomAD
CA346927245 rs1479634236	350	K>M		No	ClinGen TOPMed gnomAD
CA346927236 rs1248335439	350	K>Q		No	ClinGen gnomAD
rs762621713 CA1670073	351	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs762621713 CA346927249	351	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs768142185 CA1670074	353	N>D		No	ClinGen ExAC TOPMed gnomAD
CA346927317 rs773924519	356	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs369691181 CA1670076	357	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs146351868 CA1670077	358	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1175815357 CA346927343	358	R>S		No	ClinGen TOPMed
CA1670078 rs146351868	358	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs760589119 CA1670086	361	E>G		No	ClinGen ExAC TOPMed gnomAD
COSM2153896 rs139700760 CA1670084	361	E>K	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
CA346927425 rs766309498	363	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1016401694 CA48328905	363	K>R		No	ClinGen TOPMed gnomAD
rs753639112 CA1670088	364	V>I		No	ClinGen ExAC gnomAD
rs768472226	364	V>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA1670090 rs765314013	369	S>G		No	ClinGen ExAC gnomAD
rs201050311 CA1670091	370	A>T		No	ClinGen ExAC TOPMed gnomAD
CA346927536 rs1305636315	372	S>T		No	ClinGen TOPMed gnomAD
CA1670092 rs377313037	372	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs747481486 CA1670094	373	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs757718898 CA1670095	376	W>C		No	ClinGen ExAC gnomAD
rs148716461 CA48328991	377	K>*		No	ClinGen ESP TOPMed gnomAD
CA346927584 rs148716461	377	K>E		No	ClinGen ESP TOPMed gnomAD
CA346927596 rs1573393096	378	V>G		No	ClinGen Ensembl
rs1466932109 CA346927591	378	V>M		No	ClinGen TOPMed
CA346927598 rs1240251657	379	Q>E		No	ClinGen TOPMed gnomAD
rs1157185593 CA346927601	379	Q>R		No	ClinGen TOPMed
rs1183898557 CA346927606	380	K>*		No	ClinGen gnomAD
CA346927607 rs1183898557	380	K>E		No	ClinGen gnomAD
CA1670097 rs746169386	381	E>G		No	ClinGen ExAC gnomAD
CA346927621 rs1429658189	382	E>*		No	ClinGen gnomAD
CA1670098 rs190406376	382	E>V		No	ClinGen 1000Genomes ExAC gnomAD
CA1670100 rs773870590	384	L>P		No	ClinGen ExAC
rs773870590 CA1670099	384	L>R		No	ClinGen ExAC
CA1670101 rs369008157	385	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1558700242 CA346927647	386	G>A		No	ClinGen Ensembl
CA346927653 rs1358146130	387	L>S		No	ClinGen gnomAD
CA1670104 rs146208280	388	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA346927658 rs146208280	388	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA1670105 rs776572424	390	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1214118101 CA346927701	394	Q>E		No	ClinGen TOPMed
rs1359687489 CA346927706	394	Q>H		No	ClinGen gnomAD
CA346929112 rs1482062218	395	E>*		No	ClinGen gnomAD
rs374683786 CA1670176	397	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA346929190 rs1256553125	397	T>I		No	ClinGen gnomAD
CA48349698 rs1046921367	400	R>G		No	ClinGen gnomAD
TCGA novel	401	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402847552 CA346929341	403	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA346929365 rs760023098	404	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs760023098 CA1670178	404	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs1170502564 CA346929369	404	Q>P		No	ClinGen gnomAD
rs903823275 CA48349741	405	E>A		No	ClinGen TOPMed
rs575242941 CA1670179	405	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs935173321 CA48349748	407	Q>E		No	ClinGen Ensembl
CA346929437 rs1404775219	407	Q>L		No	ClinGen gnomAD
TCGA novel	408	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1670180 rs753065395	408	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1376865841 CA346929452	408	E>K		No	ClinGen TOPMed
rs756980264 CA1670182	409	P>A		No	ClinGen ExAC TOPMed gnomAD
CA48349776 rs756980264	409	P>S		No	ClinGen ExAC TOPMed gnomAD
CA346929506 rs1215440566	410	L>*		No	ClinGen gnomAD
CA346929489 rs377436957	410	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1054282181 CA48349795	411	N>D		No	ClinGen TOPMed
CA346929527 rs1297089311	411	N>K		No	ClinGen gnomAD
CA1670184 rs749963743	411	N>S		No	ClinGen ExAC gnomAD
CA346929534 rs1466775407	412	E>*		No	ClinGen TOPMed
CA1670188 rs779903784	415	S>C		No	ClinGen ExAC TOPMed gnomAD
CA346929599 rs779903784	415	S>G		No	ClinGen ExAC TOPMed gnomAD
CA532803149 rs1256169047	415	S>T		No	ClinGen gnomAD
rs749191700 CA1670190	416	F>C		No	ClinGen ExAC TOPMed gnomAD
CA1670181 rs764517006	417	P>L		No	ClinGen ExAC
rs754868989 CA1670192	418	Q>K		No	ClinGen ExAC TOPMed
rs778693777 CA48349832	418	Q>P		No	ClinGen ExAC gnomAD
rs778693777 CA1670193	418	Q>R		No	ClinGen ExAC gnomAD
CA1670194 rs535874314	420	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA1670199 rs747110288	425	F>C		No	ClinGen ExAC TOPMed gnomAD
rs771016640 CA1670200	426	P>Q		No	ClinGen ExAC gnomAD
CA346929853 rs1259142882	426	P>S		No	ClinGen TOPMed
rs1213911879 CA770590467	428	S>*		No	ClinGen TOPMed
rs1352314776 CA346929968	431	E>D		No	ClinGen TOPMed
rs776536382 CA1670201	431	E>K		No	ClinGen ExAC gnomAD
rs1437860171 CA346929973	432	P>T		No	ClinGen gnomAD
rs760145730 CA1670202	434	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA346930009 rs760145730	434	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs765778508 CA1670203	434	Q>H		No	ClinGen ExAC gnomAD
CA346930060 rs1301366425	437	T>A		No	ClinGen TOPMed gnomAD
rs1301366425 CA346930062	437	T>S		No	ClinGen TOPMed gnomAD
rs1325171728 CA346930073	438	S>G		No	ClinGen gnomAD
CA346930071 rs1325171728	438	S>R		No	ClinGen gnomAD
rs951141798 CA48349958	441	I>T		No	ClinGen gnomAD
TCGA novel	442	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1670209 rs138006413	443	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs138006413 CA1670208	443	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA346930126 rs1488136542	444	K>*		No	ClinGen gnomAD
rs765943099 CA1670211	447	S>A		No	ClinGen ExAC
CA1670213 rs558816519	450	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1670214 rs778820117	452	K>N		No	ClinGen ExAC gnomAD
rs866227401 CA48350003	453	Y>H		No	ClinGen gnomAD
rs747996761 CA1670215	454	T>P		No	ClinGen ExAC gnomAD
rs1015035479 CA48350043	456	T>I		No	ClinGen TOPMed gnomAD
rs758190931 CA1670217	457	V>L		No	ClinGen ExAC gnomAD
rs201239590 CA48350079	458	S>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA1670219 rs371409919	459	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA1670218 rs371409919	459	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA1670222 rs368279793	460	G>R		No	ClinGen ESP ExAC gnomAD
CA346930230 rs1225222385	461	I>V		No	ClinGen gnomAD
rs776125101 CA1670225	462	T>R		No	ClinGen ExAC
rs149451697 CA1670228	463	D>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	463	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763456981 CA1670227	463	D>Y		No	ClinGen ExAC
rs562772305 CA1670230	464	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs760396835 CA346930257	465	E>G		No	ClinGen ExAC TOPMed gnomAD
CA1670231 rs760396835	465	E>V		No	ClinGen ExAC TOPMed gnomAD
rs765881788 CA1670232	468	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1265363822 CA346930277	468	T>S		No	ClinGen TOPMed
rs1337418647 CA346930297	471	W>C		No	ClinGen TOPMed
rs1234343264 CA346930292	471	W>R		No	ClinGen TOPMed
rs753412993 CA1670233	472	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1670234 rs148197441	473	T>A		No	ClinGen ESP ExAC
CA346930309 rs1276621824	473	T>I		No	ClinGen TOPMed
rs752602996 CA1670236	474	I>T		No	ClinGen ExAC gnomAD
CA346930323 rs976332865	476	Q>*		No	ClinGen TOPMed
CA48350273 rs976332865	476	Q>E		No	ClinGen TOPMed
rs1317563567 CA346930348	479	L>R		No	ClinGen TOPMed
rs1408807730 CA346930353	480	S>T		No	ClinGen TOPMed gnomAD
rs969803024 CA48350308	481	E>*		No	ClinGen Ensembl
rs1427209487 CA346930359	481	E>A		No	ClinGen TOPMed gnomAD
CA1670237 rs773974224	481	E>S		No	ClinGen ExAC gnomAD
CA346930366 rs1306907046	482	E>K		No	ClinGen gnomAD
rs923398613 CA48350310	483	T>A		No	ClinGen TOPMed gnomAD
TCGA novel	483	T>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1430934039 CA346930383	484	N>K		No	ClinGen TOPMed
CA48350321 rs199732201	485	A>V		No	ClinGen Ensembl
CA346930394 rs1558724441	486	D>G		No	ClinGen Ensembl
CA346930392 rs1265983706	486	D>Y		No	ClinGen TOPMed
rs1553432643 CA346930401	487	V>D		No	ClinGen Ensembl
rs1553432643 CA1670240	487	V>G		No	ClinGen Ensembl
CA1670242 rs777650949	488	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA346930422 rs1228793029	490	Y>C		No	ClinGen gnomAD
rs781556579 CA346930426	491	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM1021951 rs192754138 CA1670247	491	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes TOPMed gnomAD
CA1670248 rs192754138	491	R>L		No	ClinGen 1000Genomes TOPMed gnomAD
CA346930427 rs192754138	491	R>P		No	ClinGen 1000Genomes TOPMed gnomAD
rs781556579 CA1670246	491	R>S		No	ClinGen ExAC TOPMed gnomAD
CA346930437 rs1275459390	493	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA1670251 rs146396399	496	V>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA346930456 rs1439763818	496	V>L		No	ClinGen gnomAD
CA1670255 rs560604367	499	M>I		No	ClinGen 1000Genomes ExAC gnomAD
CA1670256 rs768994925	500	L>S		No	ClinGen ExAC TOPMed gnomAD
CA1670257 rs774791078	501	V>I		No	ClinGen ExAC gnomAD
CA346930572 rs1272106077	508	L>P		No	ClinGen TOPMed gnomAD
CA346930588 rs1338457697	509	L>W		No	ClinGen gnomAD

No associated diseases with Q86Y07

4 regional properties for Q86Y07

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	45 - 301	IPR000719
domain	AGC-kinase, C-terminal	302 - 354	IPR000961
active_site	Serine/threonine-protein kinase, active site	164 - 176	IPR008271
binding_site	Protein kinase, ATP binding site	51 - 74	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	[Isoform 1]: Cytoplasm Endoplasmic reticulum membrane ; Single-pass type IV membrane protein Mitochondrion membrane ; Single-pass type IV membrane protein Nucleus envelope ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

5 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein domain specific binding	Binding to a specific domain of a protein.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

7 GO annotations of biological process

Name	Definition
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
peptidyl-serine phosphorylation	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of interleukin-1-mediated signaling pathway	Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway.
regulation of MAPK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

16 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P29295	HRR25	Casein kinase I homolog HRR25	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P35508	CSNK1D	Casein kinase I isoform delta	Bos taurus (Bovine)	SS
Q5ZLL1	CSNK1E	Casein kinase I isoform epsilon	Gallus gallus (Chicken)	SS
P48730	CSNK1D	Casein kinase I isoform delta	Homo sapiens (Human)	SS
P49674	CSNK1E	Casein kinase I isoform epsilon	Homo sapiens (Human)	EV
O00311	CDC7	Cell division cycle 7-related protein kinase	Homo sapiens (Human)	PR
Q9DC28	Csnk1d	Casein kinase I isoform delta	Mus musculus (Mouse)	PR
Q9JMK2	Csnk1e	Casein kinase I isoform epsilon	Mus musculus (Mouse)	SS
Q8BN21	Vrk2	Serine/threonine-protein kinase VRK2	Mus musculus (Mouse)	PR
Q06486	Csnk1d	Casein kinase I isoform delta	Rattus norvegicus (Rat)	PR
P42169	C03C10.2	Putative casein kinase I C03C10.2	Caenorhabditis elegans	PR
P34516	K06H7.8	Putative serine/threonine-protein kinase K06H7.1	Caenorhabditis elegans	PR
Q6P647	csnk1d	Casein kinase I isoform delta	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q7T2E3	csnk1da	Casein kinase I isoform delta-A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q6P3K7	csnk1db	Casein kinase I isoform delta-B	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q7ZUS1	vrk1	Serine/threonine-protein kinase VRK1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MPPKRNEKYK	LPIPFPEGKV	LDDMEGNQWV	LGKKIGSGGF	GLIYLAFPTN	KPEKDARHVV
70	80	90	100	110	120
KVEYQENGPL	FSELKFYQRV	AKKDCIKKWI	ERKQLDYLGI	PLFYGSGLTE	FKGRSYRFMV
130	140	150	160	170	180
MERLGIDLQK	ISGQNGTFKK	STVLQLGIRM	LDVLEYIHEN	EYVHGDIKAA	NLLLGYKNPD
190	200	210	220	230	240
QVYLADYGLS	YRYCPNGNHK	QYQENPRKGH	NGTIEFTSLD	AHKGVALSRR	SDVEILGYCM
250	260	270	280	290	300
LRWLCGKLPW	EQNLKDPVAV	QTAKTNLLDE	LPQSVLKWAP	SGSSCCEIAQ	FLVCAHSLAY
310	320	330	340	350	360
DEKPNYQALK	KILNPHGIPL	GPLDFSTKGQ	SINVHTPNSQ	KVDSQKAATK	QVNKAHNRLI
370	380	390	400	410	420
EKKVHSERSA	ESCATWKVQK	EEKLIGLMNN	EAAQESTRRR	QKYQESQEPL	NEVNSFPQKI
430	440	450	460	470	480
SYTQFPNSFY	EPHQDFTSPD	IFKKSRSPSW	YKYTSTVSTG	ITDLESSTGL	WPTISQFTLS
490	500
EETNADVYYY	RIIIPVLLML	VFLALFFL