AiPD: Autoinhibited Protein Database

Q86XF7

Gene name	ZNF575
Protein name	Zinc finger protein 575
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:284346
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-81 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

7-81 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86XF7

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86XF7-F1	Predicted				AlphaFoldDB

269 variants for Q86XF7

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA406185251 rs1429813746	3	E>*		No	ClinGen gnomAD
CA406185257 rs1309793734	4	R>G		No	ClinGen gnomAD
rs745764744 CA9488015 COSM3823309	4	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs970170804 CA308760059	5	G>S		No	ClinGen gnomAD
rs527778849 CA406185268	6	A>E		No	ClinGen 1000Genomes ExAC gnomAD
CA9488018 rs760237290	6	A>T		No	ClinGen ExAC gnomAD
rs527778849 CA9488019	6	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA9488021 rs762142222	7	E>G		No	ClinGen ExAC TOPMed gnomAD
rs776405135 CA9488020	7	E>K		No	ClinGen ExAC gnomAD
CA406185273 rs762142222	7	E>V		No	ClinGen ExAC TOPMed gnomAD
CA9488022 rs765628762	8	S>A		No	ClinGen ExAC gnomAD
CA406185283 rs1277403241	9	A>S		No	ClinGen gnomAD
CA308760144 rs773518565	9	A>V		No	ClinGen Ensembl
CA308760188 rs922261028	11	G>W		No	ClinGen TOPMed
rs989888451 CA308760191	12	A>D		No	ClinGen TOPMed gnomAD
rs766918946 CA406185319	12	A>S		No	ClinGen ExAC gnomAD
rs766918946 COSM190332 CA9488025	12	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA406185322 rs989888451	12	A>V		No	ClinGen TOPMed gnomAD
rs1449550773 CA406185335	13	T>P		No	ClinGen gnomAD
CA406185354 rs1341947333	14	D>N		No	ClinGen TOPMed
rs1165360280 CA406185375	15	P>H		No	ClinGen gnomAD
CA406185369 rs1404746486	15	P>S		No	ClinGen gnomAD
rs781251207 CA9488029	16	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1318796388 CA406185406	17	P>S		No	ClinGen gnomAD
rs753011990 CA9488030	18	T>A		No	ClinGen ExAC TOPMed gnomAD
CA9488031 rs756440380	18	T>I		No	ClinGen ExAC gnomAD
rs941154325 COSM1481166 CA308760230	22	P>R	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1247066520 CA406185573	26	E>D		No	ClinGen gnomAD
CA406185566 rs1214010736	26	E>G		No	ClinGen gnomAD
rs771839769 CA9488035	26	E>K		No	ClinGen ExAC gnomAD
CA406185676 rs1468490016	28	P>A		No	ClinGen TOPMed gnomAD
rs1600031165 CA406185698	29	H>P		No	ClinGen Ensembl
rs1412488472 CA406185832	37	S>N		No	ClinGen gnomAD
rs985114697 CA308760728	37	S>R		No	ClinGen Ensembl
rs1366785329 CA406185872	39	S>L		No	ClinGen TOPMed gnomAD
rs1473447201 CA406185879	40	A>P		No	ClinGen gnomAD
rs541167010 CA9488046	42	G>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	42	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9488047 rs759506363	43	P>L		No	ClinGen ExAC gnomAD
rs1360948288 CA406185955	45	A>E		No	ClinGen gnomAD
rs1360948288 CA406185953	45	A>G		No	ClinGen gnomAD
CA406185947 rs1334860655	45	A>P		No	ClinGen TOPMed gnomAD
CA406185945 rs1334860655	45	A>T		No	ClinGen TOPMed gnomAD
rs1360948288 CA406185951	45	A>V		No	ClinGen gnomAD
rs1374777473 CA406185965	46	S>Y		No	ClinGen TOPMed
CA406185981 rs1446297510	47	A>G		No	ClinGen TOPMed
CA406185974 rs1300194091	47	A>T		No	ClinGen TOPMed
rs1446297510 CA406185983	47	A>V		No	ClinGen TOPMed
rs374781386 CA9488050	50	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA308760810 rs967013378	51	P>L		No	ClinGen TOPMed
rs756350661 CA9488051	51	P>T		No	ClinGen ExAC TOPMed
CA9488052 rs778145408	52	R>Q		No	ClinGen ExAC gnomAD
rs1343795656 CA406186021	53	P>S		No	ClinGen gnomAD
CA406186030 rs1200552042	54	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1280188145 CA406186033	55	R>G		No	ClinGen TOPMed gnomAD
rs1280188145 CA406186034	55	R>W		No	ClinGen TOPMed gnomAD
CA9488053 rs750239924	56	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1252431713 CA406186043	57	P>A		No	ClinGen TOPMed gnomAD
rs1252431713 CA406186044	57	P>S		No	ClinGen TOPMed gnomAD
CA406186042 rs1252431713	57	P>T		No	ClinGen TOPMed gnomAD
CA9488056 rs369065915	58	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs199846217 CA9488055 COSM4131986	58	P>S	thyroid [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1555767033 CA406186066	59	P>S		No	ClinGen Ensembl
CA406186092 rs768507012	61	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9488057 rs768507012	61	R>S		No	ClinGen ExAC TOPMed gnomAD
CA9488058 rs372606320	62	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406186106 rs372606320	62	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406186108 rs372606320	62	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1456152481 CA406186124	63	H>Q		No	ClinGen gnomAD
rs1307978957 CA406186115	63	H>Y		No	ClinGen gnomAD
rs747667451 CA9488059	64	R>H		No	ClinGen ExAC TOPMed gnomAD
rs910855145 CA406186160	66	P>H		No	ClinGen Ensembl
rs910855145 CA308760852	66	P>L		No	ClinGen Ensembl
CA9488060 rs769365877	66	P>T		No	ClinGen ExAC TOPMed gnomAD
CA9488063 rs375927172	67	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA308760868 rs370571946	68	C>R		No	ClinGen ESP TOPMed gnomAD
rs1276245003 CA406186212	70	K>Q		No	ClinGen gnomAD
rs774613560 CA9488066	71	A>D		No	ClinGen ExAC TOPMed gnomAD
CA9488065 rs774613560	71	A>V		No	ClinGen ExAC TOPMed gnomAD
rs775644996 CA9488068	72	F>S		No	ClinGen ExAC gnomAD
CA9488067 rs767927673	72	F>V		No	ClinGen ExAC gnomAD
CA9488069 rs760905964	75	P>S		No	ClinGen ExAC gnomAD
CA308760896 rs866347256	80	T>A		No	ClinGen Ensembl
CA9488071 rs754164879	80	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406186432 rs758096029	81	H>N		No	ClinGen ExAC gnomAD
CA9488072 rs758096029	81	H>Y		No	ClinGen ExAC gnomAD
rs1167991571 CA406186461	82	R>C		No	ClinGen gnomAD
rs1391346213 CA406186462	82	R>H		No	ClinGen gnomAD
rs1162634451 CA406186481	83	L>*		No	ClinGen TOPMed
rs1161945001 CA406186485	83	L>F		No	ClinGen TOPMed gnomAD
rs1390547291 CA406186510	85	H>D		No	ClinGen gnomAD
rs907911175 CA308760932	85	H>Q		No	ClinGen TOPMed gnomAD
rs751333442 CA9488074	86	G>E		No	ClinGen ExAC TOPMed gnomAD
rs766156324 CA9488073	86	G>R		No	ClinGen ExAC TOPMed gnomAD
rs754887004 CA9488075	88	A>T		No	ClinGen ExAC gnomAD
CA406186570 rs1568507257	88	A>V		No	ClinGen Ensembl
CA406186578 rs1259931244	89	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA308760953 rs1040486624	90	P>S		No	ClinGen TOPMed
CA308760963 rs867493067	91	H>Y		No	ClinGen Ensembl
rs1343640612 CA406186641	92	P>L		No	ClinGen TOPMed gnomAD
CA406186684 rs1219973766	94	P>L		No	ClinGen TOPMed
rs1262603813 CA406186675	94	P>S		No	ClinGen TOPMed
CA9488077 rs747649150	95	D>E		No	ClinGen ExAC gnomAD
rs141800849 CA9488076	95	D>H		No	ClinGen 1000Genomes ExAC gnomAD
rs141800849 CA308760971	95	D>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs1356806015 CA406186712	96	C>R		No	ClinGen gnomAD
CA9488079 rs777378918	97	P>S		No	ClinGen ExAC gnomAD
CA308760984 rs866525238	99	A>S		No	ClinGen TOPMed
CA406186764 rs866525238	99	A>T		No	ClinGen TOPMed
CA406186775 rs1316169546	99	A>V		No	ClinGen TOPMed
CA406186790 rs1294438278	100	F>L		No	ClinGen TOPMed
CA9488081 rs150616280	100	F>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9488080 rs141825879	100	F>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1382259845 CA406186806	101	S>P		No	ClinGen TOPMed
CA406186830 rs1363415479	102	Y>C		No	ClinGen TOPMed
rs1248763221 CA406186843	103	P>S		No	ClinGen gnomAD
rs774723566 CA406186859	104	S>A		No	ClinGen ExAC gnomAD
CA9488084 rs746227238	104	S>F		No	ClinGen ExAC gnomAD
CA9488083 rs774723566	104	S>T		No	ClinGen ExAC gnomAD
rs1458737688 CA406186918	107	A>V		No	ClinGen gnomAD
CA406186931 rs1165316872	108	A>V		No	ClinGen gnomAD
rs201054447 CA9488085 COSM3692837	110	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs566145753 CA9488086	110	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9488087 rs528658004	111	L>V		No	ClinGen 1000Genomes ExAC gnomAD
CA406186995 rs1393735832	112	T>M		No	ClinGen TOPMed gnomAD
TCGA novel	113	H>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308761070 rs868491577	114	S>R		No	ClinGen Ensembl
rs776880800 CA9488089	115	G>D		No	ClinGen ExAC
rs1340947511 CA406187029	115	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs866041359 CA406187041	116	A>S		No	ClinGen gnomAD
rs866041359 CA308761105	116	A>T		No	ClinGen gnomAD
rs1192700415 CA406187047	116	A>V		No	ClinGen TOPMed
rs762044331 CA9488092	117	R>H		No	ClinGen ExAC TOPMed gnomAD
rs762044331 CA406187057	117	R>L		No	ClinGen ExAC TOPMed gnomAD
rs751302181 CA9488094	118	P>L		No	ClinGen ExAC gnomAD
CA9488095 rs751302181	118	P>R		No	ClinGen ExAC gnomAD
CA9488093 rs765391464	118	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1197447913 CA406187073	119	H>L		No	ClinGen TOPMed
CA406187078 rs767425208	119	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs866892041 CA308761118	119	H>Y		No	ClinGen Ensembl
CA406187089 rs1198734395	120	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1198734395 CA406187090	120	P>R		No	ClinGen TOPMed gnomAD
rs1424951791 CA406187101	121	C>Y		No	ClinGen TOPMed gnomAD
rs1243237039 CA406187112	122	P>S		No	ClinGen TOPMed gnomAD
TCGA novel	124	C>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308761168 rs373118540	124	C>Y		No	ClinGen ESP
rs139734998 CA9488101	127	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs756871332 CA9488102	129	G>D		No	ClinGen ExAC gnomAD
CA308761188 rs1041945678	129	G>S		No	ClinGen TOPMed gnomAD
rs149796259 CA9488103	131	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746230424 CA9488104	131	R>H		No	ClinGen ExAC TOPMed gnomAD
CA406187248 rs1228718588	132	S>A		No	ClinGen gnomAD
rs1289222156 CA406187271	134	L>V		No	ClinGen gnomAD
CA9488106 rs780677737	135	A>V		No	ClinGen ExAC TOPMed gnomAD
rs747476632 CA9488107	137	H>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	138	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1395471546 CA406187327	138	L>P		No	ClinGen TOPMed
CA406187378 rs1213720444	142	A>P		No	ClinGen gnomAD
rs865820549 CA406187401	144	T>A		No	ClinGen TOPMed gnomAD
rs865820549 CA308761240	144	T>P		No	ClinGen TOPMed gnomAD
rs1183300843 CA406187419	145	R>C		No	ClinGen TOPMed gnomAD
CA9488108 rs769307860	145	R>H		No	ClinGen ExAC TOPMed gnomAD
CA406187424 rs769307860	145	R>P		No	ClinGen ExAC TOPMed gnomAD
CA406187467 rs1436026275	147	Y>F		No	ClinGen gnomAD
CA406187456 rs1377761721	147	Y>H		No	ClinGen TOPMed gnomAD
rs1436026275 CA406187469	147	Y>S		No	ClinGen gnomAD
TCGA novel	149	C>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1410239313 CA406187518	149	C>W		No	ClinGen gnomAD
rs1320340881 CA406187522	150	P>T		No	ClinGen TOPMed gnomAD
CA406187544 rs1365189071	151	D>H		No	ClinGen TOPMed gnomAD
rs1365189071 CA406187542	151	D>N		No	ClinGen TOPMed gnomAD
CA9488110 rs761803419	152	C>R		No	ClinGen ExAC gnomAD
CA406187609 rs1250243649	154	K>Q		No	ClinGen TOPMed
CA308761280 rs200449716	155	S>A		No	ClinGen Ensembl
rs376747015 CA9488111	155	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA9488112 rs773361553	157	C>G		No	ClinGen ExAC TOPMed gnomAD
rs1600032157 CA406187701	157	C>S		No	ClinGen Ensembl
CA406187710 rs1260890769	158	Y>H		No	ClinGen TOPMed
CA406187724 rs1277332934	159	P>S		No	ClinGen gnomAD
CA406187746 rs1600032187	161	K>Q		No	ClinGen Ensembl
CA406187763 rs1226481292	162	L>M		No	ClinGen TOPMed
rs767338863 CA9488114	163	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA308761317 rs570329930	164	A>D		No	ClinGen gnomAD
CA406187792 rs570329930	164	A>V		No	ClinGen gnomAD
rs760551509 CA406187801	165	H>P		No	ClinGen ExAC gnomAD
rs760551509 CA9488116	165	H>R		No	ClinGen ExAC gnomAD
CA9488115 rs752513206	165	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA406187810 rs1267541458	166	R>C		No	ClinGen gnomAD
rs1555767137 CA9488117	168	T>R		No	ClinGen Ensembl
CA406187869 rs1600032286	170	H>P		No	ClinGen Ensembl
CA406187863 rs1166126521	170	H>Y		No	ClinGen gnomAD
COSM1394286 CA9488121 rs756776103	174	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA406187927 rs1430050737	175	R>C		No	ClinGen TOPMed
CA9488122 rs778606721	175	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406187948 rs1435423166	177	Y>H		No	ClinGen gnomAD
rs769218154 CA9488127	179	C>*		No	ClinGen ExAC TOPMed gnomAD
CA9488125 rs780516124	179	C>R		No	ClinGen ExAC gnomAD
CA406187991 rs769218154	179	C>W		No	ClinGen ExAC TOPMed gnomAD
CA9488126 rs747390626	179	C>Y		No	ClinGen ExAC gnomAD
CA9488131 rs773450105	181	H>L		No	ClinGen ExAC gnomAD
CA9488130 rs373389943	181	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed
rs145264344 CA9488132	185	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA406188145 rs1221209174	187	S>*		No	ClinGen gnomAD
CA406188192 rs1265695011	189	P>L		No	ClinGen TOPMed gnomAD
CA406188197 rs1198280196	190	S>P		No	ClinGen gnomAD
rs1054688211 CA308761451	191	K>N		No	ClinGen Ensembl
rs1186246337 CA406188215	191	K>Q		No	ClinGen gnomAD
rs1246952853 CA406188223	191	K>R		No	ClinGen gnomAD
rs764083929 CA9488136	193	A>P		No	ClinGen ExAC gnomAD
rs1411454776 CA406188271	194	A>T		No	ClinGen gnomAD
rs1165161580 CA406188335	197	L>P		No	ClinGen gnomAD
rs962086291 CA308761479	198	C>*		No	ClinGen TOPMed
CA9488138 rs376173848	198	C>R		No	ClinGen ESP ExAC gnomAD
CA9488139 rs764615050	198	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1568507694 CA406188399	200	D>G		No	ClinGen Ensembl
CA406188441 rs1272433112	202	P>L		No	ClinGen gnomAD
CA406188432 rs1431495755	202	P>T		No	ClinGen TOPMed gnomAD
CA406188454 rs751963732	203	T>I		No	ClinGen ExAC TOPMed gnomAD
CA9488145 rs751963732	203	T>N		No	ClinGen ExAC TOPMed gnomAD
CA9488144 rs779853529	203	T>S		No	ClinGen ExAC gnomAD
rs200619245 CA308761544	204	A>E		No	ClinGen 1000Genomes ExAC gnomAD
CA308761538 rs201779746	204	A>T		No	ClinGen 1000Genomes TOPMed gnomAD
rs200619245 CA9488147	204	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs748641238 CA9488149	205	P>S		No	ClinGen ExAC gnomAD
CA9488150 rs201519815	206	G>C		No	ClinGen ExAC TOPMed gnomAD
rs201519815 CA9488151	206	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9488152 rs749376716	207	S>G		No	ClinGen ExAC gnomAD
rs1017971278 CA308761578	207	S>R		No	ClinGen gnomAD
rs142034742 CA9488153	209	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	209	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406188659 rs746788767	210	T>I		No	ClinGen ExAC TOPMed gnomAD
rs746788767 CA9488156	210	T>S		No	ClinGen ExAC TOPMed gnomAD
rs768379607 CA9488157	211	A>S		No	ClinGen ExAC TOPMed gnomAD
rs768379607 CA406188683	211	A>T		No	ClinGen ExAC TOPMed gnomAD
CA406188771 rs1357478976	214	R>*		No	ClinGen gnomAD
rs761609288 CA9488159	216	S>F		No	ClinGen ExAC gnomAD
rs374968700 CA9488158	216	S>T		No	ClinGen ESP ExAC gnomAD
CA9488160 rs765230902	219	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1600032582 CA406188964	220	Q>R		No	ClinGen Ensembl
rs1212979946 CA406188989	221	A>D		No	ClinGen TOPMed
CA406189014 rs1600032592	222	F>L		No	ClinGen Ensembl
rs1287362542 CA406189025	222	F>S		No	ClinGen gnomAD
CA406189083 rs1445952386	224	Q>R		No	ClinGen TOPMed
CA406189099 rs1600032611	225	R>G		No	ClinGen Ensembl
rs1225095150 CA406189136	226	R>H		No	ClinGen TOPMed gnomAD
rs1275945869 CA406189150	227	L>*		No	ClinGen gnomAD
CA9488165 rs762614966	229	L>P		No	ClinGen ExAC gnomAD
TCGA novel	232	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9488166 rs544058514	233	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9488167 rs751305496	233	R>H		No	ClinGen ExAC gnomAD
CA406189307 rs1181138553	234	S>N		No	ClinGen TOPMed gnomAD
CA9488168 rs181113567	235	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406189328 rs1401233943	235	H>Y		No	ClinGen TOPMed gnomAD
CA406189379 rs1411533290	236	H>Q		No	ClinGen gnomAD
CA406189374 rs1325907640	236	H>R		No	ClinGen TOPMed
rs865862071 CA308761660	237	Q>*		No	ClinGen gnomAD
rs865862071 CA406189401	237	Q>E		No	ClinGen gnomAD
rs763342413 CA308761679	238	V>E		No	ClinGen gnomAD
rs763342413 CA406189452	238	V>G		No	ClinGen gnomAD
rs1413923148 CA406189459	239	E>K		No	ClinGen gnomAD
CA9488170 rs767732853	241	K>R		No	ClinGen ExAC TOPMed
CA9488172 rs756513094 CA406190260	242	G>R		No	ClinGen ExAC TOPMed gnomAD
rs151144919 CA9488176	244	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406190295 rs1336698602 COSM418204	244	R>T	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9488178 rs779079849	245	D>G		No	ClinGen ExAC gnomAD
CA9488177 rs780763886	245	D>H		No	ClinGen ExAC TOPMed gnomAD
CA406190299 rs780763886	245	D>N		No	ClinGen ExAC TOPMed gnomAD
CA406190301 rs780763886	245	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA406190324 rs1282420777	246	D>W		No	ClinGen gnomAD

No associated diseases with Q86XF7

3 regional properties for Q86XF7

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	128 - 409	IPR000719
active_site	Serine/threonine-protein kinase, active site	271 - 283	IPR008271
binding_site	Protein kinase, ATP binding site	134 - 157	IPR017441

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name	Definition
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P57682	KLF3	Krueppel-like factor 3	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLERGAESAA	GATDPSPTGK	EPVTKEAPHQ	GPPQKPSQSA	PGPTASAGSP	PRPRRRPPPQ
70	80	90	100	110	120
RPHRCPDCDK	AFSYPSKLAT	HRLAHGGARP	HPCPDCPKAF	SYPSKLAAHR	LTHSGARPHP
130	140	150	160	170	180
CPHCPKSFGH	RSKLAAHLWT	HAPTRPYPCP	DCPKSFCYPS	KLAAHRHTHH	ATDARPYPCP
190	200	210	220	230	240
HCPKAFSFPS	KLAAHRLCHD	PPTAPGSQAT	AWHRCSSCGQ	AFGQRRLLLL	HQRSHHQVEH

KGERD