Q86WV6
EV
Gene name |
STING1 |
Protein name |
Stimulator of interferon genes protein |
Names |
hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:340061 |
EC number |
|
Protein Class |
STIMULATOR OF INTERFERON GENES PROTEIN (PTHR34339) |
Descriptions
Stimulator of interferon genes (STING) plays a role as a sensor to directly bind cyclic diguanylate monophosphate (c-di-GMP), a bacterial second message, facilitates innate immune signaling, and promotes the production of type I interferon for the first line of defense immune. Autoinhibitory conformation of cytosolic c-di-GMP binding domain (CBD) is formed via the intramolecular interaction with the C-terminal tail (CTT), which hinders the binding of c-di-GMP on STING. The presumed CTT-binding site on CBD overlaps with the c-di-GMP-binding site. Upon c-di-GMP binding to CBD, the autoinhibition is relieved and the activated STING activates TBK1 and IRF3 for the induction of IFN response.
Autoinhibitory domains (AIDs)
Target domain |
153-340 (Cytosolic c-di-GMP binding domain (CBD)) |
Relief mechanism |
Ligand binding |
Assay |
Structural analysis |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
86 structures for Q86WV6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4EF4 | X-ray | 215 A | A/B | 139-379 | PDB |
| 4EF5 | X-ray | 245 A | A | 139-379 | PDB |
| 4EMT | X-ray | 150 A | A/B | 155-341 | PDB |
| 4EMU | X-ray | 190 A | A/B | 155-341 | PDB |
| 4F5D | X-ray | 300 A | A/B | 141-379 | PDB |
| 4F5E | X-ray | 260 A | A | 141-379 | PDB |
| 4F5W | X-ray | 220 A | A | 149-379 | PDB |
| 4F5Y | X-ray | 240 A | A/B | 149-379 | PDB |
| 4F9E | X-ray | 275 A | A | 139-379 | PDB |
| 4F9G | X-ray | 295 A | A/C | 139-379 | PDB |
| 4KSY | X-ray | 188 A | A | 138-379 | PDB |
| 4LOH | X-ray | 225 A | A/B | 155-341 | PDB |
| 4LOI | X-ray | 189 A | A/B | 155-341 | PDB |
| 4QXO | X-ray | 188 A | A | 155-341 | PDB |
| 4QXP | X-ray | 251 A | A/B | 155-341 | PDB |
| 4QXQ | X-ray | 242 A | A/B | 155-341 | PDB |
| 4QXR | X-ray | 237 A | A/B | 155-341 | PDB |
| 5BQX | X-ray | 200 A | A | 138-379 | PDB |
| 5JEJ | X-ray | 200 A | C/D/E | 342-377 | PDB |
| 6CFF | X-ray | 240 A | A | 139-379 | PDB |
| 6CY7 | X-ray | 220 A | A | 139-379 | PDB |
| 6DNK | X-ray | 195 A | A | 154-337 | PDB |
| 6DXG | X-ray | 191 A | A | 153-343 | PDB |
| 6DXL | X-ray | 245 A | A/B | 153-343 | PDB |
| 6MX0 | X-ray | 173 A | A/B | 155-341 | PDB |
| 6MX3 | X-ray | 136 A | A/B | 155-341 | PDB |
| 6MXE | X-ray | 247 A | A/B | 155-341 | PDB |
| 6NT5 | EM | 410 A | A/B | 1-379 | PDB |
| 6O8B | X-ray | 340 A | D/E | 155-379 | PDB |
| 6O8C | X-ray | 317 A | D/E | 342-379 | PDB |
| 6S26 | X-ray | 205 A | A/B | 140-343 | PDB |
| 6S27 | X-ray | 280 A | A | 140-343 | PDB |
| 6S86 | X-ray | 260 A | A/B | 140-343 | PDB |
| 6UKM | X-ray | 174 A | A | 155-341 | PDB |
| 6UKU | X-ray | 168 A | A | 155-341 | PDB |
| 6UKV | X-ray | 183 A | A/B | 155-341 | PDB |
| 6UKW | X-ray | 197 A | A/B | 155-341 | PDB |
| 6UKX | X-ray | 193 A | A/B | 155-341 | PDB |
| 6UKY | X-ray | 195 A | A | 155-341 | PDB |
| 6UKZ | X-ray | 152 A | A/B | 155-341 | PDB |
| 6UL0 | X-ray | 176 A | A | 155-341 | PDB |
| 6XF3 | X-ray | 238 A | A/B | 155-341 | PDB |
| 6XF4 | X-ray | 277 A | A/B | 155-341 | PDB |
| 6XNP | X-ray | 177 A | A/B | 155-341 | PDB |
| 6Y99 | X-ray | 298 A | A | 140-343 | PDB |
| 6YDB | X-ray | 280 A | A | 140-343 | PDB |
| 6YDZ | X-ray | 290 A | A | 140-343 | PDB |
| 6YEA | X-ray | 281 A | A | 140-343 | PDB |
| 6YWA | X-ray | 231 A | A/B | 140-343 | PDB |
| 6YWB | X-ray | 250 A | A | 140-343 | PDB |
| 6Z0Z | X-ray | 250 A | A | 140-343 | PDB |
| 6Z15 | X-ray | 250 A | A | 140-343 | PDB |
| 7A90 | X-ray | 319 A | A | 140-343 | PDB |
| 7KVX | X-ray | 248 A | A | 140-379 | PDB |
| 7KVZ | X-ray | 235 A | A | 140-379 | PDB |
| 7KW1 | X-ray | 180 A | A | 140-379 | PDB |
| 7MHC | X-ray | 232 A | A | 154-341 | PDB |
| 7OB3 | X-ray | 230 A | A | 140-343 | PDB |
| 7Q3B | X-ray | 256 A | A | 140-343 | PDB |
| 7Q85 | X-ray | 236 A | A | 140-343 | PDB |
| 7R4H | EM | 234 A | L | 359-367 | PDB |
| 7SHO | X-ray | 225 A | B | 155-341 | PDB |
| 7SHP | X-ray | 220 A | A/B/C/D | 155-341 | PDB |
| 7SII | EM | 345 A | A/B/C/D | 1-344 | PDB |
| 7SSM | X-ray | 196 A | A | 155-341 | PDB |
| 7T9U | X-ray | 246 A | A | 149-345 | PDB |
| 7T9V | X-ray | 268 A | A/B | 149-345 | PDB |
| 7X9P | X-ray | 270 A | A | 150-379 | PDB |
| 7X9Q | X-ray | 240 A | A | 150-379 | PDB |
| 8A2H | X-ray | 269 A | A/B | 140-379 | PDB |
| 8A2I | X-ray | 216 A | A/B | 140-379 | PDB |
| 8A2J | X-ray | 232 A | A/B | 140-379 | PDB |
| 8A2K | X-ray | 189 A | A/B | 140-379 | PDB |
| 8B2J | X-ray | 217 A | A/B | 138-379 | PDB |
| 8FLK | EM | 400 A | A/B/C/D | 1-344 | PDB |
| 8FLM | EM | 290 A | A/B/C/D | 1-344 | PDB |
| 8GJX | X-ray | 260 A | A/B | 154-341 | PDB |
| 8GSZ | EM | 365 A | A/B | 1-379 | PDB |
| 8GT6 | EM | 347 A | A/B | 1-379 | PDB |
| 8IK3 | EM | 330 A | A/B/C/D/E/F/G/H | 1-379 | PDB |
| 8P45 | X-ray | 323 A | A | 140-343 | PDB |
| 8STH | X-ray | 197 A | A | 153-339 | PDB |
| 8STI | X-ray | 172 A | A | 153-339 | PDB |
| 8T5K | X-ray | 195 A | B | 154-341 | PDB |
| 8T5L | X-ray | 201 A | B | 154-341 | PDB |
| AF-Q86WV6-F1 | Predicted | AlphaFoldDB |
274 variants for Q86WV6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
RCV000810786 rs759944012 CA3435509 |
17 | G>R | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs189211438 RCV000884264 CA3435439 |
114 | G>S | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs142609349 RCV000540617 CA3435433 |
126 | L>I | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA3435431 rs149528532 RCV000923242 |
127 | S>L | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA170518 RCV000133402 rs587777611 |
147 | V>L | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
rs587777609 RCV000133400 CA170516 |
154 | N>S | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
rs587777610 RCV000133401 CA170517 RCV000481634 |
155 | V>M | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar TOPMed dbSNP gnomAD |
|
CA361480348 RCV000555475 rs1240603758 |
178 | R>W | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar dbSNP gnomAD |
|
rs201277595 CA3435373 RCV000529082 |
183 | N>S | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs201096097 RCV000539383 CA3435365 |
192 | G>V | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar ExAC TOPMed dbSNP gnomAD |
|
rs114834699 CA3435364 RCV000554557 |
194 | V>L | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
RCV000652340 CA3435362 rs760564156 COSM1061545 |
197 | R>Q | endometrium STING-associated vasculopathy with onset in infancy [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD |
|
CA3435351 rs144010323 RCV000533005 |
220 | R>H | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs199795457 RCV000652339 CA3435332 |
253 | R>W | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA361479624 RCV000689142 rs1561482476 |
281 | R>Q | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar Ensembl dbSNP |
|
COSM1229585 CA3435289 rs144683867 RCV000652341 |
310 | R>H | large_intestine STING-associated vasculopathy with onset in infancy [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA3435288 RCV000543070 rs140837017 |
313 | A>T | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
COSM1061543 rs144606267 RCV000702994 CA3435229 |
375 | R>C | endometrium STING-associated vasculopathy with onset in infancy [Cosmic, ClinVar] | Yes |
ClinGen cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
CA128747799 rs370381358 RCV000685279 |
376 | T>R | STING-associated vasculopathy with onset in infancy [ClinVar] | Yes |
ClinGen ClinVar ESP TOPMed dbSNP gnomAD |
|
rs1223377482 CA361482059 |
2 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1581455281 CA361482052 |
3 | H>P | No |
ClinGen Ensembl |
|
|
CA361482049 rs1282451703 |
3 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA361482053 rs1490896074 |
3 | H>Y | No |
ClinGen gnomAD |
|
|
CA128748276 rs888652949 |
9 | S>F | No |
ClinGen TOPMed |
|
|
CA361482005 rs1324808750 |
10 | I>T | No |
ClinGen TOPMed |
|
|
CA3435515 rs146423746 |
11 | P>L | No |
ClinGen ESP ExAC TOPMed |
|
|
rs764938723 CA3435513 |
12 | C>* | No |
ClinGen ExAC gnomAD |
|
|
CA361481988 rs1459518838 |
13 | P>S | No |
ClinGen Ensembl |
|
|
CA3435508 rs774780171 |
17 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361481951 rs1160723576 |
19 | Q>* | No |
ClinGen gnomAD |
|
|
RCV000762166 CA3435506 rs140011636 |
21 | A>T | No |
ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1481478083 CA361481929 |
22 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA361481928 rs1481478083 |
22 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
CA361481921 rs1485740792 |
23 | L>F | No |
ClinGen TOPMed |
|
|
CA3435505 rs773444460 |
24 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs769981002 CA3435504 |
25 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748298483 CA3435503 |
27 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1210399029 CA361481903 |
27 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1423922283 CA361481898 |
28 | A>T | No |
ClinGen TOPMed |
|
|
CA128748274 rs368407039 |
29 | C>Y | No |
ClinGen ESP |
|
|
CA361481875 rs1321304491 |
31 | V>A | No |
ClinGen gnomAD |
|
|
rs781125980 CA3435502 |
32 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1581455016 CA361481874 |
32 | T>P | No |
ClinGen Ensembl |
|
|
rs1414994311 CA361481859 |
34 | W>* | No |
ClinGen TOPMed |
|
|
rs1369102847 CA361481843 |
37 | G>R | No |
ClinGen gnomAD |
|
|
rs190214239 CA3435500 |
38 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA361481798 rs780099523 |
43 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435499 rs780099523 |
43 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435497 rs762935025 |
45 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435498 rs770653748 |
45 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA128748273 rs1000975914 |
46 | Y>C | No |
ClinGen Ensembl |
|
|
rs890114995 CA128748272 |
47 | L>P | No |
ClinGen TOPMed |
|
|
CA128748271 rs902177158 |
48 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
CA361481763 rs1581454917 |
50 | H>P | No |
ClinGen Ensembl |
|
|
rs1167476128 CA361481742 |
53 | S>F | No |
ClinGen gnomAD |
|
|
CA361481738 rs1292788155 |
54 | L>P | No |
ClinGen TOPMed |
|
|
CA128748270 rs1013765842 |
55 | Q>K | No |
ClinGen Ensembl |
|
|
CA128748269 rs931914513 |
57 | G>A | No |
ClinGen TOPMed gnomAD |
|
|
rs931914513 CA361481720 |
57 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1244103187 CA361481715 |
58 | L>R | No |
ClinGen gnomAD |
|
|
CA3435489 rs766819764 |
62 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs773534567 CA3435487 |
63 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA361481688 rs763356779 |
63 | V>F | No |
ClinGen ExAC gnomAD |
|
|
rs763356779 CA3435488 |
63 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA361481682 rs1258312127 |
64 | C>Y | No |
ClinGen TOPMed |
|
|
rs768649460 CA3435483 |
71 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs11554776 CA3435482 |
71 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3435484 rs768649460 |
71 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM482025 rs745727679 CA3435479 |
74 | H>Y | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA361481589 rs1450741219 |
76 | R>S | No |
ClinGen gnomAD |
|
|
CA3435462 rs11554775 |
78 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3435463 rs775712223 |
78 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs778841468 CA3435460 |
79 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA3435461 rs745817582 |
79 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA3435459 rs770660580 |
82 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs749059030 CA128748261 |
83 | R>K | No |
ClinGen ExAC gnomAD |
|
|
rs749059030 CA3435458 |
83 | R>T | No |
ClinGen ExAC gnomAD |
|
|
CA3435457 rs777336363 |
86 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs867650202 CA128748259 |
86 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA361481528 rs1306838010 |
87 | A>S | No |
ClinGen gnomAD |
|
|
rs1224811053 CA361481507 |
90 | G>C | No |
ClinGen gnomAD |
|
|
rs1428188237 CA361481492 |
92 | P>H | No |
ClinGen gnomAD |
|
|
rs1404440533 CA361481487 |
93 | L>F | No |
ClinGen gnomAD |
|
|
CA3435455 rs752269574 |
94 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435454 rs780666926 |
94 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435453 rs373903765 |
95 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA128748258 rs1033930953 |
95 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs373903765 CA3435452 |
95 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA361481443 rs887937980 |
97 | A>D | No |
ClinGen Ensembl |
|
|
rs181566154 CA361481455 |
97 | A>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3435450 rs181566154 RCV000762165 |
97 | A>T | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
CA128748257 rs887937980 |
97 | A>V | No |
ClinGen Ensembl |
|
|
CA361481436 rs1211691657 |
98 | L>V | No |
ClinGen Ensembl |
|
|
rs754202874 CA3435448 |
101 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA361481388 rs1192578610 |
102 | S>C | No |
ClinGen gnomAD |
|
|
rs370253881 CA361481375 |
103 | I>S | No |
ClinGen gnomAD |
|
|
CA128748255 rs370253881 |
103 | I>T | No |
ClinGen gnomAD |
|
|
rs764292169 CA3435447 |
103 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA3435446 rs760969680 |
104 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs1331780242 CA361481352 |
106 | Y>C | No |
ClinGen gnomAD |
|
|
rs1473769146 CA361481354 |
106 | Y>H | No |
ClinGen gnomAD |
|
|
CA361481335 rs1261853832 |
108 | S>F | No |
ClinGen gnomAD |
|
|
rs1324388679 CA361481322 |
110 | P>R | No |
ClinGen gnomAD |
|
|
rs201699999 CA3435443 |
112 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs770875890 CA3435441 |
113 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769494344 CA3435438 |
115 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361481274 rs1358836126 |
118 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA128748254 rs944687447 |
121 | L>I | No |
ClinGen Ensembl |
|
|
rs1177687924 CA361481246 |
122 | A>G | No |
ClinGen gnomAD |
|
|
rs1324345443 CA361481233 |
125 | G>S | No |
ClinGen TOPMed |
|
|
CA3435432 rs149528532 |
127 | S>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA361481188 rs1346414429 |
132 | I>N | No |
ClinGen gnomAD |
|
|
rs1346414429 CA361481186 |
132 | I>S | No |
ClinGen gnomAD |
|
|
CA3435428 rs756483516 |
133 | L>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs889105527 CA128748230 |
138 | G>A | No |
ClinGen Ensembl |
|
|
rs1370637313 CA361481132 |
140 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1050129224 CA128748229 |
143 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA361481104 rs1252618649 |
144 | I>T | No |
ClinGen gnomAD |
|
|
rs755245286 CA3435406 |
144 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361481087 rs1174849472 |
147 | V>A | No |
ClinGen TOPMed |
|
|
CA361481057 rs184755982 |
151 | G>E | No |
ClinGen 1000Genomes gnomAD |
|
|
CA361481060 rs1394953297 |
151 | G>R | No |
ClinGen TOPMed |
|
|
rs184755982 CA128748228 |
151 | G>V | No |
ClinGen 1000Genomes gnomAD |
|
|
rs1433372015 CA361481051 |
152 | N>S | No |
ClinGen TOPMed |
|
|
rs765137654 CA3435401 |
157 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435402 rs773224678 |
157 | H>R | No |
ClinGen ExAC gnomAD |
|
|
CA3435403 rs762872695 |
157 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
rs11554779 CA3435400 |
158 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs767904008 CA128748227 |
160 | A>V | No |
ClinGen Ensembl |
|
|
CA361480997 rs1253633216 |
161 | W>* | No |
ClinGen gnomAD |
|
|
CA3435399 rs776407846 |
161 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs1561483994 CA361480977 |
164 | Y>D | No |
ClinGen Ensembl |
|
|
rs768359336 CA361480971 |
165 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768359336 CA3435398 |
165 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1302149326 CA361480963 |
166 | G>* | No |
ClinGen TOPMed gnomAD |
|
|
CA361480965 rs1302149326 |
166 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA3435396 rs532530144 |
168 | L>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs771648197 CA3435395 |
169 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1043499198 CA128748226 |
169 | R>W | No |
ClinGen gnomAD |
|
|
CA3435394 rs745313338 |
170 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA361480936 rs1581453327 |
171 | I>T | No |
ClinGen Ensembl |
|
|
CA128748004 rs891942279 |
175 | L>P | No |
ClinGen Ensembl |
|
|
rs775226478 CA3435378 |
178 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1248505100 CA361480327 |
180 | R>* | No |
ClinGen gnomAD |
|
|
CA3435376 rs759123296 |
180 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA361480326 rs759123296 COSM1061546 |
180 | R>Q | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
rs773990834 CA3435375 |
183 | N>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201277595 CA3435372 |
183 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201277595 CA3435374 |
183 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435370 rs747314479 |
188 | N>D | No |
ClinGen ExAC gnomAD |
|
|
CA3435367 rs750561744 |
191 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435368 rs150384595 |
191 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201096097 CA3435366 |
192 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3435363 rs763892914 |
197 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA128748002 rs200341894 |
199 | Y>D | No |
ClinGen gnomAD |
|
|
rs1581450494 CA361480195 |
201 | L>P | No |
ClinGen Ensembl |
|
|
CA3435359 rs375700017 |
204 | L>S | No |
ClinGen ESP ExAC TOPMed |
|
|
COSM1741902 CA3435358 rs774086578 |
205 | D>N | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC |
|
rs1236854527 CA361480154 |
208 | V>M | No |
ClinGen gnomAD |
|
|
rs1270347607 CA361480137 |
210 | D>E | No |
ClinGen gnomAD |
|
|
rs770567786 CA3435356 |
210 | D>G | No |
ClinGen ExAC gnomAD |
|
|
CA361480123 rs1218304113 |
212 | L>R | No |
ClinGen TOPMed |
|
|
rs777299936 CA3435354 |
213 | S>I | No |
ClinGen ExAC gnomAD |
|
|
rs1342489613 CA361480121 |
213 | S>R | No |
ClinGen gnomAD |
|
|
CA361480112 rs1159689080 |
214 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs775385223 CA128747999 |
215 | A>V | No |
ClinGen Ensembl |
|
|
CA361480092 rs1379034075 |
217 | P>A | No |
ClinGen gnomAD |
|
|
CA361480087 rs1581450379 |
218 | N>H | No |
ClinGen Ensembl |
|
|
rs1450226566 CA361480082 |
218 | N>K | No |
ClinGen TOPMed gnomAD |
|
|
CA3435353 rs769013090 |
218 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA361480071 rs1352824531 |
220 | R>C | No |
ClinGen gnomAD |
|
|
CA3435352 rs144010323 |
220 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA361480062 rs772425191 |
221 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA361480063 rs772425191 |
221 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA3435349 rs746097569 |
223 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs779071530 CA3435348 |
225 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
rs757354596 CA3435347 |
226 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA128747997 rs983208285 |
229 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
rs78233829 CA3435344 |
230 | G>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs78233829 CA361479995 |
230 | G>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3435345 rs370230460 |
230 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1131769 RCV000455115 CA3435341 |
232 | H>R | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs767228149 CA3435342 |
232 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201670175 CA3435340 |
233 | A>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA128747996 rs1003779733 |
235 | I>F | No |
ClinGen TOPMed gnomAD |
|
|
CA361479950 rs1003779733 |
235 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1167471683 CA361479930 |
237 | D>G | No |
ClinGen TOPMed |
|
|
rs1291110297 CA361479934 |
237 | D>Y | No |
ClinGen gnomAD |
|
|
CA361479924 rs1371859236 |
238 | R>Q | No |
ClinGen gnomAD |
|
|
rs1435186136 CA361479906 |
241 | S>R | No |
ClinGen TOPMed |
|
|
CA361479881 rs1310757855 |
244 | I>F | No |
ClinGen TOPMed gnomAD |
|
|
CA361479877 rs1277337215 |
244 | I>M | No |
ClinGen TOPMed |
|
|
rs1301528991 CA361479856 |
247 | L>P | No |
ClinGen gnomAD |
|
|
rs761102285 CA3435335 |
249 | E>D | No |
ClinGen ExAC gnomAD |
|
|
rs772357103 CA361479837 |
250 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776001543 CA3435334 |
250 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA361479840 rs1581450165 |
250 | N>Y | No |
ClinGen Ensembl |
|
|
CA361479835 rs1409697347 |
251 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA361479821 rs199795457 |
253 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA361479819 rs148833313 |
253 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3435331 COSM1433482 rs148833313 |
253 | R>Q | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs774690247 CA3435312 |
254 | A>V | No |
ClinGen ExAC TOPMed |
|
|
CA3435309 rs368419459 |
255 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1200319844 CA361479797 |
255 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
rs769794754 CA3435306 |
256 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs773415324 CA3435307 |
256 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs140038439 CA3435304 |
262 | A>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs141928874 CA3435303 |
264 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3435302 rs746859252 |
267 | T>N | No |
ClinGen ExAC gnomAD |
|
|
rs1379763592 CA361479702 |
270 | A>S | No |
ClinGen TOPMed |
|
|
CA361479692 rs1312454509 |
271 | M>I | No |
ClinGen gnomAD |
|
|
rs374460516 CA128747914 |
273 | Q>* | No |
ClinGen ESP gnomAD |
|
|
rs1273442704 CA361479669 |
274 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
rs758202052 CA3435300 |
275 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA3435299 rs750077345 |
281 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1483629542 CA361479617 |
282 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA361479621 rs1199879569 |
282 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA3435298 rs778582118 |
286 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA361479547 rs1203275708 |
292 | C>G | No |
ClinGen gnomAD |
|
|
rs7380824 CA3435296 |
293 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3435297 rs756770138 |
293 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs1367219835 CA361479513 |
297 | D>V | No |
ClinGen gnomAD |
|
|
rs760019959 CA3435294 |
303 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs752003355 CA3435293 |
303 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763335050 CA3435290 |
310 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361479392 rs1175527417 |
315 | Q>H | No |
ClinGen TOPMed |
|
|
rs1480329051 CA361479398 |
315 | Q>K | No |
ClinGen TOPMed |
|
|
CA128747808 rs1024519291 |
317 | P>L | No |
ClinGen gnomAD |
|
|
rs1561482019 CA361479364 |
318 | A>S | No |
ClinGen Ensembl |
|
|
rs772018436 CA3435260 |
324 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200018086 CA3435258 |
325 | L>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3435257 rs201015563 |
327 | Q>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs957732368 CA128747807 |
327 | Q>P | No |
ClinGen TOPMed |
|
|
rs748947114 CA3435256 |
329 | V>F | No |
ClinGen ExAC |
|
|
rs370524913 CA3435254 |
331 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs777366618 CA3435255 |
331 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA3435251 rs758939417 |
334 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1197819878 CA361479263 |
334 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA361479259 rs1254726825 |
335 | Q>K | No |
ClinGen gnomAD |
|
|
CA3435250 rs750836565 |
335 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs1224988149 CA361479249 |
336 | E>G | No |
ClinGen gnomAD |
|
|
CA361479253 rs1268179693 |
336 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA361479242 rs1581447941 |
337 | E>G | No |
ClinGen Ensembl |
|
|
CA361479225 rs1581447927 |
339 | E>G | No |
ClinGen Ensembl |
|
|
rs1581447923 CA361479208 |
341 | V>G | No |
ClinGen Ensembl |
|
|
rs1423748602 CA361479204 |
342 | T>N | No |
ClinGen TOPMed |
|
|
CA3435245 rs545936447 |
347 | K>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1581447861 CA361479116 |
350 | A>P | No |
ClinGen Ensembl |
|
|
CA3435244 rs143322684 |
350 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs977753165 CA128747806 |
352 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
CA361479073 rs1412839696 |
353 | S>I | No |
ClinGen gnomAD |
|
|
rs967033688 CA128747805 |
353 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1047355852 CA128747804 |
354 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
rs767416381 CA3435242 |
356 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA3435238 rs749035321 |
357 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA3435237 rs141830680 |
359 | Q>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs959223650 CA128747803 |
360 | E>D | No |
ClinGen TOPMed |
|
|
CA361478965 rs1272853302 |
361 | P>L | No |
ClinGen TOPMed |
|
|
rs749761756 CA128747802 |
362 | E>K | No |
ClinGen gnomAD |
|
|
CA361478944 rs1581447770 |
363 | L>F | No |
ClinGen Ensembl |
|
|
CA361478904 rs1200672371 |
366 | S>G | No |
ClinGen gnomAD |
|
|
CA3435233 rs747724298 |
367 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361478883 rs1215030543 |
368 | M>I | No |
ClinGen TOPMed |
|
|
rs148097726 CA3435232 |
368 | M>L | No |
ClinGen ESP ExAC gnomAD |
|
|
rs754379042 CA3435231 |
370 | K>R | No |
ClinGen ExAC gnomAD |
|
|
RCV000788123 CA361478865 rs1581447721 |
371 | P>T | No |
ClinGen ClinVar Ensembl dbSNP |
|
|
rs1456439839 CA361478849 |
373 | P>R | No |
ClinGen gnomAD |
|
|
CA3435228 rs117897081 |
375 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3435227 rs117897081 |
375 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA128747801 rs117897081 |
375 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA128747798 rs370381358 |
376 | T>K | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs370381358 CA128747800 |
376 | T>M | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA361478834 rs1368968919 |
377 | D>Y | No |
ClinGen gnomAD |
|
| VAR_081660 | 284 | R>S | probable disease-associated variant found in a 9-month-old patient who died following a fever and severe neck abscess without indication of any severe bacterial infection; may affect splicing; constitutively active mutant that promotes the production of type I interferon in absence of cyclic dinucleotide ligand; localizes to the perinuclear region in absence of cyclic dinucleotide ligand [UniProt] | No | UniProt |
1 associated diseases with Q86WV6
[MIM: 615934]: STING-associated vasculopathy, infantile-onset (SAVI)
An autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease. {ECO:0000269|PubMed:25029335, ECO:0000269|PubMed:25401470, ECO:0000269|PubMed:30842659}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- An autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease. {ECO:0000269|PubMed:25029335, ECO:0000269|PubMed:25401470, ECO:0000269|PubMed:30842659}. Note=The disease is caused by variants affecting the gene represented in this entry.
1 regional properties for Q86WV6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Stimulator of interferon genes protein, C-terminal | 154 - 337 | IPR047191 |
Functions
| Description | ||
|---|---|---|
| EC Number | ||
| Subcellular Localization |
|
|
| PANTHER Family | PTHR34339 | STIMULATOR OF INTERFERON GENES PROTEIN |
| PANTHER Subfamily | PTHR34339:SF1 | STIMULATOR OF INTERFERON GENES PROTEIN |
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
16 GO annotations of cellular component
| Name | Definition |
|---|---|
| autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. |
| autophagosome membrane | The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane | The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| secretory granule membrane | The lipid bilayer surrounding a secretory granule. |
| STING complex | A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2',3'-cyclic GMP-AMP binding | Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages. |
| cyclic-di-GMP binding | Binding to cyclic-di-GMP, cyclic dimeric guanosine monophosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of innate immune response | Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. |
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| cellular response to exogenous dsRNA | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. |
| cellular response to interferon-beta | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. |
| cellular response to organic cyclic compound | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| positive regulation of defense response to virus by host | Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of interferon-beta production | Any process that activates or increases the frequency, rate, or extent of interferon-beta production. |
| positive regulation of macroautophagy | Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. |
| positive regulation of protein binding | Any process that activates or increases the frequency, rate or extent of protein binding. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of type I interferon production | Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
| positive regulation of type I interferon-mediated signaling pathway | Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. |
| protein complex oligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of inflammatory response | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. |
| reticulophagy | The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KI99 | STING1 | Stimulator of interferon genes protein | Bos taurus (Bovine) | SS |
| E1C7U0 | STING1 | Stimulator of interferon genes protein | Gallus gallus (Chicken) | SS |
| Q3TBT3 | Sting1 | Stimulator of interferon genes protein | Mus musculus (Mouse) | SS |
| B8XX90 | STING1 | Stimulator of interferon genes protein | Sus scrofa (Pig) | SS |
| F1M391 | Sting1 | Stimulator of interferon genes protein | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPHSSLHPSI | PCPRGHGAQK | AALVLLSACL | VTLWGLGEPP | EHTLRYLVLH | LASLQLGLLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGVCSLAEEL | RHIHSRYRGS | YWRTVRACLG | CPLRRGALLL | LSIYFYYSLP | NAVGPPFTWM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LALLGLSQAL | NILLGLKGLA | PAEISAVCEK | GNFNVAHGLA | WSYYIGYLRL | ILPELQARIR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TYNQHYNNLL | RGAVSQRLYI | LLPLDCGVPD | NLSMADPNIR | FLDKLPQQTG | DHAGIKDRVY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SNSIYELLEN | GQRAGTCVLE | YATPLQTLFA | MSQYSQAGFS | REDRLEQAKL | FCRTLEDILA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAPESQNNCR | LIAYQEPADD | SSFSLSQEVL | RHLRQEEKEE | VTVGSLKTSA | VPSTSTMSQE |
| 370 | |||||
| PELLISGMEK | PLPLRTDFS |