AiPD: Autoinhibited Protein Database

Q86UV6

Gene name	TRIM74 (TRIM50C)
Protein name	Tripartite motif-containing protein 74
Names	Tripartite motif-containing protein 50C
Species	Homo sapiens (Human)
KEGG Pathway	hsa:378108
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-250 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

92-250 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q86UV6

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q86UV6-F1	Predicted				AlphaFoldDB

196 variants for Q86UV6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1462787185 CA367738831	3	W>C		No	ClinGen TOPMed
rs369836495 CA4284709	8	L>P		No	ClinGen ExAC gnomAD
rs1586221337 CA367738605	10	L>V		No	ClinGen Ensembl
CA4284706 rs547391636	13	W>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4284707 VAR_039576 CA367738522 rs121966	13	W>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD UniProt dbSNP
rs1407253488 CA367738363	16	C>Y		No	ClinGen TOPMed
CA367738335 rs1303244961	17	P>L		No	ClinGen TOPMed
CA367738292 rs138207083	19	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4284705 rs138207083	19	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA367738286 rs1554507168	19	C>Y		No	ClinGen gnomAD
rs782178527 CA4284701	23	F>S		No	ClinGen ExAC gnomAD
rs782491167 CA4284702	23	F>V		No	ClinGen ExAC gnomAD
rs531965602 CA4284699	24	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781854567 CA4284698	25	E>V		No	ClinGen ExAC gnomAD
CA367738019 rs1554507147	27	L>Q		No	ClinGen gnomAD
CA367737995 rs1307911702	28	M>I		No	ClinGen TOPMed
CA367738006 rs1554507143	28	M>K		No	ClinGen gnomAD
CA367738005 rs1554507143	28	M>T		No	ClinGen gnomAD
CA367737945 rs1554507141	30	Q>R		No	ClinGen gnomAD
CA4284695 rs782695078	31	C>*		No	ClinGen ExAC TOPMed gnomAD
CA4284692 rs782008343	32	G>C		No	ClinGen ExAC TOPMed gnomAD
CA367737871 rs1554507137	32	G>D		No	ClinGen gnomAD
CA4284693 rs782008343	32	G>S		No	ClinGen ExAC TOPMed gnomAD
rs782117895 CA4284690	38	G>C		No	ClinGen ExAC gnomAD
CA367737581 rs1361514506	39	C>F		No	ClinGen TOPMed gnomAD
CA367737590 rs1361514506	39	C>Y		No	ClinGen TOPMed gnomAD
CA4284689 rs782007875	45	Y>C		No	ClinGen ExAC gnomAD
CA367737409 rs1554507123	45	Y>D		No	ClinGen gnomAD
CA367737413 rs1554507123	45	Y>H		No	ClinGen gnomAD
rs1292663797 CA367737261	49	T>A		No	ClinGen TOPMed gnomAD
CA367737265 rs1292663797	49	T>P		No	ClinGen TOPMed gnomAD
rs782349287 CA4284688	52	R>C	Variant assessed as Somatic; 5.999e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782349287 CA367737188	52	R>G		No	ClinGen ExAC TOPMed gnomAD
rs782235312 CA4284687	52	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782235312 CA367737174	52	R>L		No	ClinGen ExAC TOPMed gnomAD
CA367737116 rs1554507109	54	P>L		No	ClinGen gnomAD
CA367737091 rs1554507107	55	M>I		No	ClinGen gnomAD
rs782324204 CA4284685	55	M>V		No	ClinGen ExAC TOPMed gnomAD
CA367737062 rs1192958723	57	W>R		No	ClinGen TOPMed
rs1554507103 CA367737016	58	Q>*		No	ClinGen gnomAD
rs1371632492 CA367736927	59	V>A		No	ClinGen TOPMed
CA367736884 rs1554507094	60	V>A		No	ClinGen gnomAD
CA4284683 rs782625979	61	D>G		No	ClinGen ExAC gnomAD
CA4284681 rs565612557	62	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs565612557 CA4284680	62	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4284678 rs141504192	63	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA4284676 rs782789009	64	S>N		No	ClinGen ExAC gnomAD
CA4284677 rs781803695	64	S>R		No	ClinGen ExAC gnomAD
CA4284674 rs576258262	66	L>F		No	ClinGen 1000Genomes ExAC gnomAD
CA4284673 rs782776623	67	P>H		No	ClinGen ExAC gnomAD
CA367736538 rs139055638	68	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4284672 rs782087154	68	N>S		No	ClinGen ExAC TOPMed gnomAD
CA4284670 rs782704499	69	V>I		No	ClinGen ExAC gnomAD
CA4284669 rs782071269	70	S>F		No	ClinGen ExAC gnomAD
CA4284667 rs782434083	71	L>V		No	ClinGen ExAC gnomAD
CA4284664 rs782352207	72	A>S		No	ClinGen ExAC gnomAD
rs782181016 CA4284663	73	W>S		No	ClinGen ExAC TOPMed gnomAD
CA160038752 rs561131319	74	V>A		No	ClinGen 1000Genomes
rs782404310 CA4284661	75	I>M		No	ClinGen ExAC TOPMed gnomAD
CA4284660 rs782291447	76	E>*		No	ClinGen ExAC gnomAD
CA367736285 rs782291447	76	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4284659 rs782625299	77	A>V		No	ClinGen ExAC gnomAD
rs1554507065 CA367736192	79	R>W		No	ClinGen gnomAD
rs781828251 CA4284656	80	L>I		No	ClinGen ExAC gnomAD
rs1554507060 CA367736126	81	P>R		No	ClinGen gnomAD
CA367736130 rs1554507063	81	P>S		No	ClinGen gnomAD
CA367736058 rs1384704481	83	D>G		No	ClinGen TOPMed
rs146897149 CA4284653	84	P>L		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA4284654 rs146897149	84	P>R		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs1554507057 CA367735968	86	P>S		No	ClinGen gnomAD
CA367735947 rs782798612	87	K>M		No	ClinGen ExAC TOPMed gnomAD
CA4284652 rs782798612	87	K>R		No	ClinGen ExAC TOPMed gnomAD
CA367735931 rs782167928	88	V>I		No	ClinGen ExAC gnomAD
CA4284651 rs782167928	88	V>L		No	ClinGen ExAC gnomAD
rs1554507052 CA367735878	89	C>Y		No	ClinGen gnomAD
rs1554507048 CA367735838	90	V>A		No	ClinGen gnomAD
rs782720979 CA367735847	90	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4284649 rs782720979	90	V>M		No	ClinGen ExAC TOPMed gnomAD
rs781916250 CA367735808	91	H>Q		No	ClinGen ExAC gnomAD
CA4284648 rs372465980	91	H>Y		No	ClinGen ESP ExAC gnomAD
rs1554507041 CA367735785	92	H>P		No	ClinGen gnomAD
rs553931678 CA4284645	93	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4284646 rs782320760	93	R>W		No	ClinGen ExAC gnomAD
rs367888418 CA4284642	95	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4284640 rs782360211	96	L>I		No	ClinGen ExAC gnomAD
CA367735611 rs1554507023	98	L>F		No	ClinGen gnomAD
CA367735613 rs1554507023	98	L>V		No	ClinGen gnomAD
rs1554507013 CA367735521	100	C>F		No	ClinGen gnomAD
CA367735551 rs1554507016	100	C>R		No	ClinGen gnomAD
rs376925165 CA4284638	101	E>D		No	ClinGen ESP ExAC gnomAD
rs1554507012 CA367735506	101	E>K		No	ClinGen gnomAD
rs782538831 CA4284637	102	K>N		No	ClinGen ExAC gnomAD
CA367735385 rs1554507009	104	Q>R		No	ClinGen gnomAD
rs1554507008 CA367735366	105	E>K		No	ClinGen gnomAD
rs781908131 CA4284636	106	L>P		No	ClinGen ExAC
rs1554507005 CA367735218	109	G>V		No	ClinGen gnomAD
rs782469729 CA4284634	112	G>S		No	ClinGen ExAC gnomAD
rs1554506999 CA367734971	118	Q>H		No	ClinGen gnomAD
rs1554506996 CA367734935	119	H>L		No	ClinGen gnomAD
rs1554506996 CA367734945	119	H>P		No	ClinGen gnomAD
CA4284632 rs781841646	121	P>L		No	ClinGen ExAC gnomAD
CA367734895 rs781841646	121	P>R		No	ClinGen ExAC gnomAD
rs782704738 CA4284631	123	T>M		No	ClinGen ExAC gnomAD
rs782060265 CA4284630	125	V>I		No	ClinGen ExAC gnomAD
CA4284629 rs781883184	126	S>Y		No	ClinGen ExAC gnomAD
CA367734708 rs1554506974	128	V>A		No	ClinGen gnomAD
CA4284627 rs3852229	128	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1554506973 CA367734688	129	C>R		No	ClinGen gnomAD
CA367734678 rs1554506970	129	C>Y		No	ClinGen gnomAD
CA4284626 rs577946101	131	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782108162 CA4284625	131	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782108162 CA4284624	131	R>L		No	ClinGen ExAC TOPMed gnomAD
rs782108162 CA367734618	131	R>P		No	ClinGen ExAC TOPMed gnomAD
CA367734616 rs1554506952	132	M>V		No	ClinGen TOPMed gnomAD
rs3095183 CA160038561	159	K>N		No	ClinGen gnomAD
CA160038556 rs199887265	163	R>*		No	ClinGen 1000Genomes
CA367733302 rs1297783318	168	S>L		No	ClinGen TOPMed gnomAD
rs1212493570 CA367733287	169	D>Y		No	ClinGen TOPMed gnomAD
CA367733233 rs1291610316	170	V>A		No	ClinGen TOPMed
rs569899247 CA4284615	173	W>C		No	ClinGen 1000Genomes ExAC gnomAD
CA4284614 rs782192242	176	R>C		No	ClinGen ExAC TOPMed gnomAD
CA367733073 rs1220572110	176	R>H		No	ClinGen TOPMed gnomAD
CA367733067 rs1220572110	176	R>L		No	ClinGen TOPMed gnomAD
rs782652307 CA4284613	177	R>C		No	ClinGen ExAC gnomAD
rs1250891646 CA367733049	177	R>H		No	ClinGen TOPMed
rs548419851 CA4284612	178	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs781846697 CA4284611	182	L>V		No	ClinGen ExAC gnomAD
rs1554506415 CA367732845	183	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs199997885 CA4284610	183	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367732797 rs1248773029	184	H>Q		No	ClinGen TOPMed gnomAD
rs781847215 CA4284608	185	P>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	185	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1554506412 CA367732766 CA367732771	186	V>L		No	ClinGen gnomAD
rs1554506405 CA367732731	188	E>K		No	ClinGen gnomAD
CA367732722 rs1554506405	188	E>Q		No	ClinGen gnomAD
CA367732660 rs1554506403	190	K>R		No	ClinGen gnomAD
rs782021589 CA4284604	192	R>C		No	ClinGen ExAC TOPMed gnomAD
CA367732611 rs782021589	192	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4284603 rs782806506	192	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1554506400 CA367732576	193	C>F		No	ClinGen gnomAD
rs1554506399 CA367732488	197	I>T		No	ClinGen gnomAD
rs782000340 CA4284601	198	G>R		No	ClinGen ExAC TOPMed
TCGA novel	199	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4284599 rs782358808	200	H>Q		No	ClinGen ExAC gnomAD
rs1321783933 CA367732367	202	R>C		No	ClinGen TOPMed gnomAD
CA4284597 rs781932462	202	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782284044 CA4284595	206	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4284594 rs367889722	209	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782505431 CA4284593	210	M>L		No	ClinGen ExAC gnomAD
rs1554506378 CA367732133	210	M>T		No	ClinGen gnomAD
rs782505431 CA367732144	210	M>V		No	ClinGen ExAC gnomAD
rs1554506375 CA367732103	211	Q>*		No	ClinGen gnomAD
TCGA novel	213	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367732026 rs1586214387	213	E>K		No	ClinGen Ensembl
CA367731941 rs1554506373	215	A>T		No	ClinGen gnomAD
CA4284590 rs782623090	216	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA367731888 rs1586214328	216	Q>R		No	ClinGen Ensembl
rs781813852 CA367731870	217	G>*		No	ClinGen ExAC gnomAD
rs781813852 CA4284588	217	G>R		No	ClinGen ExAC gnomAD
rs1554506365 CA367731814	218	T>I		No	ClinGen gnomAD
CA4284587 rs782799609	218	T>P		No	ClinGen ExAC gnomAD
rs782566380 CA367731805	219	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1267458876 CA367731801	219	R>Q		No	ClinGen TOPMed gnomAD
rs782566380 CA4284586	219	R>W		No	ClinGen ExAC TOPMed gnomAD
CA367731747 rs1554506359	221	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1554506361 CA367731751	221	R>W		No	ClinGen TOPMed gnomAD
CA367731730 rs1213755849	222	L>P		No	ClinGen TOPMed gnomAD
rs1554506357 CA367731695	224	Q>E		No	ClinGen gnomAD
rs1554506355 CA367731666	225	A>S		No	ClinGen gnomAD
rs1554506354 CA367731652	225	A>V		No	ClinGen gnomAD
rs782793664 CA4284584	226	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367731611 rs1554506347	227	C>G		No	ClinGen Ensembl
CA4284582 rs1554506347	227	C>R		No	ClinGen Ensembl
rs1554506344 CA367731595	227	C>W		No	ClinGen gnomAD
CA4284580 rs564705925	229	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA367731504 rs781788969	230	E>*		No	ClinGen ExAC TOPMed gnomAD
rs781788969 CA367731520	230	E>K		No	ClinGen ExAC TOPMed gnomAD
rs781788969 CA4284579	230	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA4284578 rs142617953	231	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs371578958 CA4284575	233	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4284573 rs781944642	235	E>*		No	ClinGen ExAC gnomAD
rs781944642 CA4284574	235	E>K		No	ClinGen ExAC gnomAD
rs782370006 CA4284572	237	H>N		No	ClinGen ExAC gnomAD
CA367731195 rs151125689	237	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4284569 rs782412242	238	H>P		No	ClinGen ExAC TOPMed gnomAD
CA367731128 rs782301449	238	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA4284570 rs782412242	238	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4284567 rs782638411	239	E>D		No	ClinGen ExAC gnomAD
CA367731118 rs1228781472	239	E>K		No	ClinGen TOPMed gnomAD
rs1554506318 CA367730987	241	I>N		No	ClinGen gnomAD
rs1278675013 CA367731001	241	I>V		No	ClinGen TOPMed
rs782514178 CA4284566	242	W>R		No	ClinGen ExAC TOPMed gnomAD
CA367730788 rs1586213801	245	H>R		No	ClinGen Ensembl
rs531900697 CA4284552	246	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367730733 rs1410043723	247	M>R		No	ClinGen TOPMed
rs1554506276 CA367730743	247	M>V		No	ClinGen gnomAD

No associated diseases with Q86UV6

6 regional properties for Q86UV6

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	191 - 454	IPR000719
domain	AGC-kinase, C-terminal	455 - 531	IPR000961
domain	Pleckstrin homology domain	557 - 659	IPR001849
active_site	Serine/threonine-protein kinase, active site	314 - 326	IPR008271
domain	RGS domain	54 - 175	IPR016137
binding_site	Protein kinase, ATP binding site	197 - 220	IPR017441

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name	Definition
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding	Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name	Definition
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.

46 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9G4	TRIM10	Tripartite motif-containing protein 10	Bos taurus (Bovine)	PR
Q2T9Z0	TRIM17	E3 ubiquitin-protein ligase TRIM17	Bos taurus (Bovine)	PR
E1BJS7	TRIM71	E3 ubiquitin-protein ligase TRIM71	Bos taurus (Bovine)	PR
Q7YRV4	TRIM21	E3 ubiquitin-protein ligase TRIM21	Bos taurus (Bovine)	PR
Q1PRL4	TRIM71	E3 ubiquitin-protein ligase TRIM71	Gallus gallus (Chicken)	PR
Q7YR32	TRIM10	Tripartite motif-containing protein 10	Pan troglodytes (Chimpanzee)	PR
O15553	MEFV	Pyrin	Homo sapiens (Human)	SS
Q9BTV5	FSD1	Fibronectin type III and SPRY domain-containing protein 1	Homo sapiens (Human)	PR
Q9H2S5	RNF39	RING finger protein 39	Homo sapiens (Human)	PR
P19474	TRIM21	E3 ubiquitin-protein ligase TRIM21	Homo sapiens (Human)	PR
Q9UJV3	MID2	Probable E3 ubiquitin-protein ligase MID2	Homo sapiens (Human)	PR
P29590	PML	Protein PML	Homo sapiens (Human)	PR
Q9C029	TRIM7	E3 ubiquitin-protein ligase TRIM7	Homo sapiens (Human)	PR
Q9NQ86	TRIM36	E3 ubiquitin-protein ligase TRIM36	Homo sapiens (Human)	PR
Q9UPQ4	TRIM35	E3 ubiquitin-protein ligase TRIM35	Homo sapiens (Human)	PR
Q6ZMU5	TRIM72	Tripartite motif-containing protein 72	Homo sapiens (Human)	PR
Q86UV7	TRIM73	Tripartite motif-containing protein 73	Homo sapiens (Human)	PR
Q8N9V2	TRIML1	Probable E3 ubiquitin-protein ligase TRIML1	Homo sapiens (Human)	PR
Q86XT4	TRIM50	E3 ubiquitin-protein ligase TRIM50	Homo sapiens (Human)	PR
Q5EBN2	TRIM61	Putative tripartite motif-containing protein 61	Homo sapiens (Human)	PR
Q9BZY9	TRIM31	E3 ubiquitin-protein ligase TRIM31	Homo sapiens (Human)	PR
Q2Q1W2	TRIM71	E3 ubiquitin-protein ligase TRIM71	Homo sapiens (Human)	PR
Q9BXM9	FSD1L	FSD1-like protein	Homo sapiens (Human)	PR
Q9WUH5	Trim10	Tripartite motif-containing protein 10	Mus musculus (Mouse)	PR
Q8BZT2	Sh3rf2	E3 ubiquitin-protein ligase SH3RF2	Mus musculus (Mouse)	PR
Q7TPM3	Trim17	E3 ubiquitin-protein ligase TRIM17	Mus musculus (Mouse)	PR
Q1XH17	Trim72	Tripartite motif-containing protein 72	Mus musculus (Mouse)	PR
Q60953	Pml	Protein PML	Mus musculus (Mouse)	PR
Q9JJ26	Mefv	Pyrin	Mus musculus (Mouse)	SS
Q99PQ1	Trim12a	Tripartite motif-containing protein 12A	Mus musculus (Mouse)	PR
Q61510	Trim25	E3 ubiquitin/ISG15 ligase TRIM25	Mus musculus (Mouse)	PR
Q810I2	Trim50	E3 ubiquitin-protein ligase TRIM50	Mus musculus (Mouse)	PR
Q1PSW8	Trim71	E3 ubiquitin-protein ligase TRIM71	Mus musculus (Mouse)	PR
Q3TL54	Trim43a	Tripartite motif-containing protein 43A	Mus musculus (Mouse)	PR
P86449	Trim43c	Tripartite motif-containing protein 43C	Mus musculus (Mouse)	PR
O77666	TRIM26	Tripartite motif-containing protein 26	Sus scrofa (Pig)	PR
O19085	TRIM10	Tripartite motif-containing protein 10	Sus scrofa (Pig)	PR
Q865W2	TRIM50	E3 ubiquitin-protein ligase TRIM50	Sus scrofa (Pig)	PR
Q920M2	Rnf39	RING finger protein 39	Rattus norvegicus (Rat)	PR
Q9JJ25	Mefv	Pyrin	Rattus norvegicus (Rat)	SS
A0JPQ4	Trim72	Tripartite motif-containing protein 72	Rattus norvegicus (Rat)	PR
Q810I1	Trim50	E3 ubiquitin-protein ligase TRIM50	Rattus norvegicus (Rat)	PR
D3ZVM4	Trim71	E3 ubiquitin-protein ligase TRIM71	Rattus norvegicus (Rat)	PR
F6QEU4	trim71	E3 ubiquitin-protein ligase TRIM71	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q640S6	trim72	Tripartite motif-containing protein 72	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
E7FAM5	trim71	E3 ubiquitin-protein ligase TRIM71	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAWQVSLLEL	EDWLQCPICL	EVFKESLMLQ	CGHSYCKGCL	VSLSYHLDTK	VRCPMCWQVV
70	80	90	100	110	120
DGSSSLPNVS	LAWVIEALRL	PGDPEPKVCV	HHRNPLSLFC	EKDQELICGL	CGLLGSHQHH
130	140	150	160	170	180
PVTPVSTVCS	RMKEELAALF	SELKQEQKKV	DELIAKLVKN	RTRIVNESDV	FSWVIRREFQ
190	200	210	220	230	240
ELRHPVDEEK	ARCLEGIGGH	TRGLVASLDM	QLEQAQGTRE	RLAQAECVLE	QFGNEDHHEF

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