Q86TW2

SS
Gene name
ADCK1
Protein name
AarF domain-containing protein kinase 1
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:57143
EC number
Protein Class

Descriptions

ADCK1 belongs to UbiB protein kinase family and may be involved in mitochondrial function. A similar protein, COQ8A, is autoinhibited by the intramolecular interaction between N-terminal region containing KxGQ motif and catalytic domain. The KxGQ motif in ADCK1 may also occlude the substrate binding site of the kinase domain.

Autoinhibitory domains (AIDs)

102-105 (Pseudo-Z-repeat) SS

Target domain

124-376 (ADCK-like domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q86TW2

Entry ID Method Resolution Chain Position Source
AF-Q86TW2-F1 Predicted AlphaFoldDB

No variants for Q86TW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q86TW2

No associated diseases with Q86TW2

2 regional properties for Q86TW2

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 125 - 371 IPR004147
domain ADCK1-like domain 124 - 376 IPR045307

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
lipid homeostasis Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
negative regulation of mitochondrial fusion Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
positive regulation of cristae formation Any process that activates or increases the frequency, rate or extent of cristae formation.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06567 MCP2 ABC1 family protein MCP2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3MIX3 ADCK5 Uncharacterized aarF domain-containing protein kinase 5 Homo sapiens (Human) SS
Q9MA15 ABC1K3 Protein ACTIVITY OF BC1 COMPLEX KINASE 3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
O04212 At2g40090 Putative ABC1 protein At2g40090 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV
70 80 90 100 110 120
PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF IKVGQHLGAL DYLLPEEYTS
130 140 150 160 170 180
TLKVLHSQAP QSSMQEIRQV IREDLGKEIH DLFQSFDDTP LGTASLAQVH KAVLHDGRTV
190 200 210 220 230 240
AVKVQHPKVR AQSSKDILLM EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA
250 260 270 280 290 300
EKVSQMLRHF DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK
310 320 330 340 350 360
MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR LNYCHLWQSL
370 380 390 400 410 420
IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI SQAPVTATED LEIRNNAANY
430 440 450 460 470 480
LPQISHLLNH VPRQMLLILK TNDLLRGIEA ALGTRASASS FLNMSRCCIR ALAEHKKKNT
490 500 510 520
CSFFRRTQIS FSEAFNLWQI NLHELILRVK GLKLADRVLA LICWLFPAPL