Q863I2

PR
Gene name
OXSR1
Protein name
Serine/threonine-protein kinase OSR1
Names
Duffy antigen/chemokine receptor, Oxidative stress-responsive 1 protein
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397618
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

268-529 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

163-191 (Activation loop from InterPro)

Target domain

17-291 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q863I2

Entry ID Method Resolution Chain Position Source
AF-Q863I2-F1 Predicted AlphaFoldDB

No variants for Q863I2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q863I2

No associated diseases with Q863I2

3 regional properties for Q863I2

Type Name Position InterPro Accession
domain Protein kinase domain 17 - 291 IPR000719
binding_site Protein kinase, ATP binding site 23 - 46 IPR017441
domain Serine/threonine-protein kinase OSR1/WNK, CCT domain 436 - 493 IPR024678

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

6 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of potassium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of T cell chemotaxis Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0K7 STRADB STE20-related kinase adapter protein beta Homo sapiens (Human) PR
Q7RTN6 STRADA STE20-related kinase adapter protein alpha Homo sapiens (Human) PR
Q9UEW8 STK39 STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens (Human) PR
O95747 OXSR1 Serine/threonine-protein kinase OSR1 Homo sapiens (Human) PR
Q8K4T3 Stradb STE20-related kinase adapter protein beta Mus musculus (Mouse) PR
Q3UUJ4 Strada STE20-related kinase adapter protein alpha Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
Q6P9R2 Oxsr1 Serine/threonine-protein kinase OSR1 Mus musculus (Mouse) PR
Q7TNZ6 Strada STE20-related kinase adapter protein alpha Rattus norvegicus (Rat) PR
O88506 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Rattus norvegicus (Rat) PR
O23304 BLUS1 Serine/threonine-protein kinase BLUS1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSEDSSALPW SINKDDYELQ EVIGSGATAV VQAAYCTPKK EKVAIKRINL EKCQTSMDEL
70 80 90 100 110 120
LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE
130 140 150 160 170 180
ATIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN
190 200 210 220 230 240
KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL
250 260 270 280 290 300
QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEYL
310 320 330 340 350 360
QEKILQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP
370 380 390 400 410 420
RVKESLTNSE LFSTTHPVGT LLQVPEQISA HLPQSAGQMP AQLTPVSLPP AAELAPVQAA
430 440 450 460 470 480
QAQSSGAGSQ ETKIPISLVL RLRNSKKELN DIRFEFTPGR DTAEGVSQEL ISAGLVDGRD
490 500 510 520
LVIVAANLQK IVEEPQSNRS VTFKLASGVE GSDIPDDSKL IGFAQLSIS