Q84R10
SS
Gene name |
PME36 (ARATH36, At3g60730, T4C21.140) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 36 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G60730 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
205-505 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q84R10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q84R10-F1 | Predicted | AlphaFoldDB |
32 variants for Q84R10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00429834 | 15 | F>Y | No | 1000Genomes | |
| ENSVATH12855627 | 24 | T>A | No | 1000Genomes | |
| tmp_3_22445108_G_A | 52 | A>T | No | 1000Genomes | |
| ENSVATH14461727 | 86 | L>M | No | 1000Genomes | |
| ENSVATH14461728 | 101 | W>R | No | 1000Genomes | |
| ENSVATH00429835 | 120 | R>C | No | 1000Genomes | |
| ENSVATH02531573 | 134 | V>M | No | 1000Genomes | |
| ENSVATH06350582 | 143 | K>E | No | 1000Genomes | |
| ENSVATH14461729 | 150 | K>I | No | 1000Genomes | |
| ENSVATH06350587 | 166 | P>A | No | 1000Genomes | |
| tmp_3_22445621_A_T | 167 | K>N | No | 1000Genomes | |
| ENSVATH12855629 | 175 | H>P | No | 1000Genomes | |
| ENSVATH00429836 | 179 | R>T | No | 1000Genomes | |
| tmp_3_22445684_C_G | 188 | N>K | No | 1000Genomes | |
| ENSVATH02531574 | 188 | N>Y | No | 1000Genomes | |
| tmp_3_22445685_C_A | 189 | Q>K | No | 1000Genomes | |
| tmp_3_22445686_A_C | 189 | Q>P | No | 1000Genomes | |
| ENSVATH06350589 | 217 | R>W | No | 1000Genomes | |
| ENSVATH06350590 | 239 | I>V | No | 1000Genomes | |
| ENSVATH02531575 | 241 | I>V | No | 1000Genomes | |
| ENSVATH06350591 | 251 | E>D | No | 1000Genomes | |
| ENSVATH02531576 | 258 | N>S | No | 1000Genomes | |
| ENSVATH12855630 | 300 | D>G | No | 1000Genomes | |
| ENSVATH12855631 | 306 | T>S | No | 1000Genomes | |
| tmp_3_22446185_T_A | 327 | Y>* | No | 1000Genomes | |
| ENSVATH06350595 | 334 | Y>N | No | 1000Genomes | |
| ENSVATH12855632 | 365 | A>T | No | 1000Genomes | |
| tmp_3_22446444_G_T | 382 | G>C | No | 1000Genomes | |
| ENSVATH12855633 | 393 | P>L | No | 1000Genomes | |
| ENSVATH00429837 | 447 | R>K | No | 1000Genomes | |
| ENSVATH06350607 | 464 | G>A | No | 1000Genomes | |
| ENSVATH12855658 | 494 | S>F | No | 1000Genomes |
No associated diseases with Q84R10
14 regional properties for Q84R10
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 1071 - 1194 | IPR000008 |
| domain | Phosphatidylinositol-specific phospholipase C, X domain | 320 - 465 | IPR000909 |
| domain | SH2 domain | 548 - 657 | IPR000980-1 |
| domain | SH2 domain | 666 - 756 | IPR000980-2 |
| domain | SH3 domain | 791 - 851 | IPR001452 |
| domain | Phospholipase C, phosphatidylinositol-specific, Y domain | 953 - 1070 | IPR001711 |
| domain | Pleckstrin homology domain | 27 - 144 | IPR001849-1 |
| domain | Pleckstrin homology domain | 489 - 680 | IPR001849-2 |
| domain | Pleckstrin homology domain | 804 - 933 | IPR001849-3 |
| domain | EF-hand domain | 152 - 187 | IPR002048 |
| binding_site | EF-Hand 1, calcium-binding site | 165 - 177 | IPR018247 |
| domain | PLC-gamma, C-terminal SH2 domain | 663 - 765 | IPR035023 |
| domain | PLC-gamma, N-terminal SH2 domain | 545 - 649 | IPR035024 |
| domain | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain | 791 - 850 | IPR035724 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTFVKVTDL | ITIMFFLAIA | AVITASNTAE | LDVLEMARTA | VVEAKTSFGS | MAVTEATSEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGSYYKLGLS | ECEKLYDESE | ARLSKLVVDH | ENFTVEDVRT | WLSGVLANHH | TCLDGLIQQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGHKPLVHSN | VTFVLHEALA | FYKKSRGHMK | KRLHGPARQG | HGPTRPKHRP | TRPNHGPGRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HHGPSRPNQN | GGMLVSWNPT | SSRADFVVAR | DGSATHRTIN | QALAAVSRMG | KSRLNRVIIY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IKAGVYNEKI | EIDRHMKNIM | LVGDGMDRTI | VTNNRNVPDG | STTYGSATFG | VSGDGFWARD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ITFENTAGPH | KHQAVALRVS | SDLSLFYRCS | FKGYQDTLFT | HSLRQFYRDC | HIYGTIDFIF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GDAAAVFQNC | DIFVRRPMDH | QGNMITAQGR | DDPHTNSGIS | IQHSRIRAAP | EFEAVKGRFK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SYLGRPWKKY | SRTVFLKTDI | DELIDPRGWR | EWSGSYALST | LYYGEFMNTG | AGAGTGRRVN |
| 490 | 500 | 510 | |||
| WPGFHVLRGE | EEASPFTVSR | FIQGDSWIPI | TGVPFSAGV |