Q84K11

PR
Gene name
PP5
Protein name
Serine/threonine-protein phosphatase 5
Names
LePP5
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
sly:543849
EC number
Protein Class

Descriptions

(Annotation based on sequence homology with Q9NES8)
Protein phosphatase 5 is involved in the regulation of kinases and transcription factors. Its dephosphorylation activity is modulated by the C-terminal MEEVD motif of molecular chaperone Hsp90, which binds to the tetratricopeptide repeat (TPR) domain of protein phosphatase 5. The TRP domain is involved in autoinhibition and the addition of a peptide containing the MEEVD motif counteracts the autoinhibition of the TPR domain.

Autoinhibitory domains (AIDs)

112-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q84K11

Entry ID Method Resolution Chain Position Source
AF-Q84K11-F1 Predicted AlphaFoldDB

No variants for Q84K11

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q84K11

No associated diseases with Q84K11

3 regional properties for Q84K11

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 260 IPR000719
active_site Serine/threonine-protein kinase, active site 119 - 131 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein
  • Nucleus membrane; Multi-pass membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53043 PPT1 Serine/threonine-protein phosphatase T Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
P53041 PPP5C Serine/threonine-protein phosphatase 5 Homo sapiens (Human) EV
Q60676 Ppp5c Serine/threonine-protein phosphatase 5 Mus musculus (Mouse) SS
P53042 Ppp5c Serine/threonine-protein phosphatase 5 Rattus norvegicus (Rat) EV
Q9NES8 pph-5 Serine/threonine-protein phosphatase 5 Caenorhabditis elegans EV
Q84XU2 PAPP5 Serine/threonine-protein phosphatase 5 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MPGMEAENSN ASRAEELKQL ANEAFKGHKY SQAIDLYTQA IELNGENAVY YANRAFAHTK
70 80 90 100 110 120
LEEYGSAIQD GTRAIEIDPR YSKGYYRRGA AYLAMGKFKD ALKDFQQVKK LCPNDPDATK
130 140 150 160 170 180
KLKECEKAVM KLKFEEAISV PESQRRSVAD SIDYRSVGSG PGSSYVPTKT TAVSAAAALM
190 200 210 220 230 240
GVLVVYMGTK AATMVAAAAS AALLVVLITF LWGRCSDGFF TKSRTLELEV EPQYAGARIE
250 260 270 280 290 300
GDVVTLDFVK KMLDDFKNQK NLHKRYAYQI VLQTREMLRA LPSLVDIVVP EGKHFTVCGD
310 320 330 340 350 360
VHGQFYDLLN IFELNGLPSE DNPYLFNGDF VDRGSFSLEV ILTLFAFKCM CPSAIHLARG
370 380 390 400 410 420
NHESKSMNKI YGFEGEVRSK LSEIFVELFA EVFCCLPLAH VINEKVFVVH GGLFSVDGVK
430 440 450 460 470 480
LSDIRAIDRF CEPPEEGLMC ELLWSDPQPQ PGRGPSKRGV GLSFGGDVTK RFLQENNLDL
490 500 510 520 530 540
VVRSHEVKDE GYEIEHDGKL ITVFSAPNYC DQMGNKGAFI RFEAPDMKPN IVTFSAVPHP
550
DVKPMAYANN FLRMFS