Q84JX1

SS
Gene name
PME19 (ARATH5, At1g11590, T23J18.25)
Protein name
Probable pectinesterase/pectinesterase inhibitor 19
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G11590
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

21-172 (PMEI region) SS

Target domain

215-509 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q84JX1

Entry ID Method Resolution Chain Position Source
AF-Q84JX1-F1 Predicted AlphaFoldDB

179 variants for Q84JX1

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH01036524 34 F>L No 1000Genomes
ENSVATH01036525 38 L>F No 1000Genomes
ENSVATH07509164 43 S>W No 1000Genomes
ENSVATH01036529 46 S>L No 1000Genomes
ENSVATH04558920 61 S>Y No 1000Genomes
ENSVATH10992089 67 M>I No 1000Genomes
ENSVATH01036532 68 V>A No 1000Genomes
ENSVATH10992090 83 E>D No 1000Genomes
tmp_1_3892904_G_A 91 E>K No 1000Genomes
ENSVATH01036535 94 K>N No 1000Genomes
tmp_1_3892920_T_A 96 F>Y No 1000Genomes
tmp_1_3892936_G_T 101 E>D No 1000Genomes
tmp_1_3892935_A_G 101 E>G No 1000Genomes
tmp_1_3892934_G_A 101 E>K No 1000Genomes
ENSVATH01036536 103 T>A No 1000Genomes
ENSVATH10992092 111 V>G No 1000Genomes
ENSVATH04558922 113 E>K No 1000Genomes
ENSVATH04558923 118 E>Q No 1000Genomes
tmp_1_3892991_C_T 120 P>S No 1000Genomes
ENSVATH01036538 122 R>L No 1000Genomes
tmp_1_3893000_G_A 123 G>R No 1000Genomes
ENSVATH13880674 125 Y>C No 1000Genomes
ENSVATH01036539 126 E>Q No 1000Genomes
ENSVATH13880695 128 V>A No 1000Genomes
tmp_1_3893026_G_A 131 W>* No 1000Genomes
ENSVATH07509169 133 S>N No 1000Genomes
ENSVATH07509169 133 S>T No 1000Genomes
tmp_1_3893039_C_T 136 L>F No 1000Genomes
ENSVATH07509170 137 T>I No 1000Genomes
tmp_1_3893078_G_A 149 G>S No 1000Genomes
ENSVATH10992094 149 G>V No 1000Genomes
tmp_1_3893090_C_T 153 R>C No 1000Genomes
ENSVATH04558927 157 P>L No 1000Genomes
ENSVATH04558928 160 E>K No 1000Genomes
ENSVATH13880697 161 D>H No 1000Genomes
ENSVATH13880697 161 D>N No 1000Genomes
tmp_1_3893117_C_T 162 L>F No 1000Genomes
ENSVATH04558930 168 I>V No 1000Genomes
tmp_1_3893139_CT_GT,AT,C 169 A>D No 1000Genomes
tmp_1_3893139_CT_GT,AT,C 169 A>G No 1000Genomes
ENSVATH01036543 171 A>T No 1000Genomes
ENSVATH13880698 177 S>L No 1000Genomes
tmp_1_3893169_G_A 179 R>K No 1000Genomes
ENSVATH01036545 187 V>A No 1000Genomes
ENSVATH01036544 187 V>M No 1000Genomes
ENSVATH04558934 189 P>S No 1000Genomes
ENSVATH10992284 191 S>G No 1000Genomes
tmp_1_3893205_G_T 191 S>I No 1000Genomes
ENSVATH10992435 192 P>S No 1000Genomes
tmp_1_3893211_C_T 193 S>F No 1000Genomes
tmp_1_3893215_G_A 194 W>* No 1000Genomes
ENSVATH10992436 195 L>S No 1000Genomes
ENSVATH10992437 197 H>P No 1000Genomes
tmp_1_3893228_G_C 199 D>H No 1000Genomes
tmp_1_3893237_G_A 202 D>N No 1000Genomes
ENSVATH07509175 207 A>T No 1000Genomes
ENSVATH04558936 208 E>K No 1000Genomes
ENSVATH07509194 209 A>T No 1000Genomes
ENSVATH13880702 209 A>V No 1000Genomes
ENSVATH01036554 214 A>D No 1000Genomes
ENSVATH04558952 214 A>P No 1000Genomes
ENSVATH01036554 214 A>V No 1000Genomes
tmp_1_3893584_G_T 216 V>F No 1000Genomes
ENSVATH01036555 222 G>E No 1000Genomes
ENSVATH01036558 236 A>T No 1000Genomes
ENSVATH01036560 243 R>K No 1000Genomes
ENSVATH04558957 257 V>I No 1000Genomes
tmp_1_3893729_C_T 264 P>L No 1000Genomes
ENSVATH10992601 264 P>S No 1000Genomes
tmp_1_3893740_C_A 268 L>I No 1000Genomes
tmp_1_3893746_G_C 270 G>R No 1000Genomes
tmp_1_3893753_G_A 272 G>D No 1000Genomes
ENSVATH10992602 275 L>S No 1000Genomes
ENSVATH01036561 280 S>G No 1000Genomes
ENSVATH04558958 284 A>S No 1000Genomes
ENSVATH01036562 285 S>T No 1000Genomes
tmp_1_3893794_A_C 286 N>H No 1000Genomes
tmp_1_3893813_A_G 292 N>S No 1000Genomes
tmp_1_3893816_C_T 293 T>I No 1000Genomes
tmp_1_3893819_C_T 294 A>V No 1000Genomes
ENSVATH10992604 295 T>I No 1000Genomes
ENSVATH04558959 296 V>I No 1000Genomes
ENSVATH13880717 305 G>V No 1000Genomes
ENSVATH10992660 314 A>V No 1000Genomes
tmp_1_3893994_G_A 317 A>T No 1000Genomes
tmp_1_3894012_G_A 323 A>T No 1000Genomes
ENSVATH10992662 325 R>C No 1000Genomes
ENSVATH10992663 328 G>C No 1000Genomes
ENSVATH10992663 328 G>S No 1000Genomes
ENSVATH01036570 344 A>T No 1000Genomes
ENSVATH10992664 344 A>V No 1000Genomes
ENSVATH10992716 351 R>C No 1000Genomes
tmp_1_3894105_T_A 354 Y>N No 1000Genomes
ENSVATH04558964 362 T>I No 1000Genomes
ENSVATH10992717 366 I>L No 1000Genomes
tmp_1_3894148_G_C 368 G>A No 1000Genomes
tmp_1_3894157_T_C 371 V>A No 1000Genomes
ENSVATH04558965 372 A>T No 1000Genomes
ENSVATH10992718 372 A>V No 1000Genomes
tmp_1_3894174_T_A 377 C>S No 1000Genomes
tmp_1_3894175_GC_G,AC 377 C>Y No 1000Genomes
tmp_1_3894187_C_T 381 A>V No 1000Genomes
ENSVATH10992722 383 Q>* No 1000Genomes
ENSVATH04558967 384 P>A No 1000Genomes
tmp_1_3894205_G_A 387 G>E No 1000Genomes
ENSVATH01036572 388 Q>* No 1000Genomes
tmp_1_3894219_A_C 392 I>L No 1000Genomes
tmp_1_3894237_G_A 398 A>T No 1000Genomes
tmp_1_3894240_T_A 399 F>I No 1000Genomes
tmp_1_3894241_T_A 399 F>Y No 1000Genomes
tmp_1_3894250_T_A 402 I>N No 1000Genomes
tmp_1_3894249_A_G 402 I>V No 1000Genomes
tmp_1_3894252_T_A 403 Y>N No 1000Genomes
tmp_1_3894259_G_A 405 G>D No 1000Genomes
ENSVATH10992724 405 G>S No 1000Genomes
tmp_1_3894263_C_A 406 F>L No 1000Genomes
tmp_1_3894264_A_T 407 T>S No 1000Genomes
tmp_1_3894286_C_G 414 T>S No 1000Genomes
tmp_1_3894289_C_G 415 A>G No 1000Genomes
ENSVATH04558970 417 S>L No 1000Genomes
tmp_1_3894298_A_T 418 D>V No 1000Genomes
tmp_1_3894325_A_G 427 Y>C No 1000Genomes
tmp_1_3894328_T_G 428 L>R No 1000Genomes
tmp_1_3894331_GA_AA,G 429 G>E No 1000Genomes
tmp_1_3894337_C_T 431 P>L No 1000Genomes
ENSVATH04558975 432 W>* No 1000Genomes
ENSVATH04558976 433 R>K No 1000Genomes
tmp_1_3894352_C_T 436 S>L No 1000Genomes
ENSVATH10992796 438 V>I No 1000Genomes
ENSVATH01036573 440 V>I No 1000Genomes
tmp_1_3894368_G_A 441 M>I No 1000Genomes
ENSVATH04558977 443 S>C No 1000Genomes
ENSVATH04558977 443 S>F No 1000Genomes
ENSVATH04558978 446 G>D No 1000Genomes
tmp_1_3894384_G_A 447 D>N No 1000Genomes
tmp_1_3894393_G_A 450 D>N No 1000Genomes
tmp_1_3894397_C_T 451 P>L No 1000Genomes
ENSVATH10992797 451 P>S No 1000Genomes
ENSVATH04558979 452 A>P No 1000Genomes
ENSVATH04558980 452 A>V No 1000Genomes
ENSVATH10992799 453 G>S No 1000Genomes
tmp_1_3894406_G_T 454 W>L No 1000Genomes
ENSVATH01036575 455 T>I No 1000Genomes
ENSVATH01036575 455 T>S No 1000Genomes
ENSVATH04558982 456 P>L No 1000Genomes
ENSVATH13880721 456 P>S No 1000Genomes
tmp_1_3894416_G_A 457 W>* No 1000Genomes
tmp_1_3894415_G_A 457 W>* No 1000Genomes
tmp_1_3894417_G_A 458 E>K No 1000Genomes
tmp_1_3894420_G_A 459 G>R No 1000Genomes
tmp_1_3894423_G_A 460 E>K No 1000Genomes
tmp_1_3894429_G_T,A 462 G>C No 1000Genomes
tmp_1_3894430_G_A 462 G>D No 1000Genomes
tmp_1_3894429_G_T,A 462 G>S No 1000Genomes
ENSVATH04558983 464 S>L No 1000Genomes
ENSVATH13880722 466 L>F No 1000Genomes
ENSVATH04558984 467 H>Y No 1000Genomes
ENSVATH04558985 469 R>C No 1000Genomes
ENSVATH10992800 469 R>H No 1000Genomes
ENSVATH10992801 470 E>K No 1000Genomes
ENSVATH04558986 474 R>K No 1000Genomes
ENSVATH04558987 476 P>L No 1000Genomes
ENSVATH01036577 477 G>R No 1000Genomes
ENSVATH01036578 478 A>D No 1000Genomes
ENSVATH01036578 478 A>G No 1000Genomes
ENSVATH01036578 478 A>V No 1000Genomes
ENSVATH01036580 483 R>G No 1000Genomes
ENSVATH04558988 483 R>K No 1000Genomes
tmp_1_3894502_G_A 486 W>* No 1000Genomes
ENSVATH10992803 488 G>S No 1000Genomes
tmp_1_3894513_A_T 490 K>* No 1000Genomes
ENSVATH01036582 494 D>N No 1000Genomes
ENSVATH01036582 494 D>Y No 1000Genomes
ENSVATH04558991 500 E>K No 1000Genomes
ENSVATH04558991 500 E>Q No 1000Genomes
ENSVATH10992876 503 V>L No 1000Genomes
ENSVATH04558992 504 A>T No 1000Genomes
tmp_1_3894567_G_T 508 D>Y No 1000Genomes
ENSVATH04558993 509 G>E No 1000Genomes

No associated diseases with Q84JX1

3 regional properties for Q84JX1

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 215 - 509 IPR000070
domain Pectinesterase inhibitor domain 16 - 172 IPR006501
active_site Pectinesterase, Tyr active site 240 - 259 IPR018040

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

46 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
P09607 PME2.1 Pectinesterase 2.1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
P14280 PME1.9 Pectinesterase 1 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
Q96576 PME3 Pectinesterase 3 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
Q96575 PME2.2 Pectinesterase 2.2 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) SS
10 20 30 40 50 60
MLVKVFSFFI LMITMVVIGV SKEYCDDKQS CQNFLLELKA GSSSLSEIRR RDLLIIVLKN
70 80 90 100 110 120
SVRRIDMVMI GVMDDTKQHE EMENDLLGVK EDTKLFEEMM ESTKDRMIRS VEELLGGEFP
130 140 150 160 170 180
NRGSYENVHT WLSSVLTSYI TCIDEIGEGA YKRRVEPKLE DLISRARIAL ALFISISPRD
190 200 210 220 230 240
NTELISVIPN SPSWLFHVDK KDLYLNAEAL KKIADVVVAK DGTGKYSTVN AAIAAAPQHS
250 260 270 280 290 300
QKRFVIYIKT GIYDEIVVIE NTKPNLTLIG DGQDLTIITS NLSASNVRRT FNTATVASNG
310 320 330 340 350 360
NGFIGVDMCF RNTAGPAKGP AVALRVSGDM SVIYRCRVEG YQDALYPHSD RQFYRECFIT
370 380 390 400 410 420
GTVDFICGNA VAVFQFCQIV ARQPKMGQSN VITAQSRAFK DIYSGFTIQK CNITASSDLD
430 440 450 460 470 480
TTTVKTYLGR PWRIFSTVAV MQSFIGDLVD PAGWTPWEGE TGLSTLHYRE YQNRGPGAVT
490 500 510 520
SRRVKWSGFK VMKDPKQATE FTVAKLLDGE TWLKETRIPY ESGL