Q811D0

SS
Gene name
Dlg1 (Dlgh1)
Protein name
Disks large homolog 1
Names
Embryo-dlg/synapse-associated protein 97 , E-dlg/SAP97 , Synapse-associated protein 97 , SAP-97 , SAP97
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:13383
EC number
Protein Class

Descriptions

Dlg1 is a member of the membrane-associated guanylate kinase (MAGUK) family of PDZ domain-containing proteins and regulates surface expression of NMDA receptors. PDZ domain adjacent to SH3 and SH3 domain interacts with GK domain for autoinhibition.

Autoinhibitory domains (AIDs)

441-531 (PDZ 3 domain) SS

Target domain

695-883 (GK domain)

Relief mechanism

Ligand binding

Assay

541-642 (SH3 domain) SS

Target domain

695-883 (GK domain)

Relief mechanism

Partner binding, Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q811D0

Entry ID Method Resolution Chain Position Source
4OAJ X-ray 230 A A 317-406 PDB
AF-Q811D0-F1 Predicted AlphaFoldDB

23 variants for Q811D0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs247764317 88 P>S No EVA
rs32534858 91 A>T No EVA
rs3552191442 168 P>S No EVA
rs3552306317 176 T>P No EVA
rs3389391610 179 L>Q No EVA
rs3389402227 181 V>L No EVA
rs3389379258 254 F>Y No EVA
rs1131978964 275 C>S No EVA
rs1134306410 283 D>Y No EVA
rs1134683789 286 D>Y No EVA
rs3389402172 343 P>S No EVA
rs3389410887 359 A>G No EVA
rs3389408795 380 E>G No EVA
rs3389402158 382 V>F No EVA
rs3389391624 415 A>V No EVA
rs3406475061 524 S>G No EVA
rs3389427518 624 W>C No EVA
rs3389391596 704 Y>F No EVA
rs3389403766 707 V>M No EVA
rs32538528 708 N>K No EVA
rs3389327303 815 A>G No EVA
rs3389427478 817 K>N No EVA
rs3389360152 854 T>I No EVA

No associated diseases with Q811D0

11 regional properties for Q811D0

Type Name Position InterPro Accession
domain SH3 domain 581 - 651 IPR001452
domain PDZ domain 224 - 311 IPR001478-1
domain PDZ domain 317 - 406 IPR001478-2
domain PDZ domain 464 - 547 IPR001478-3
domain L27 domain 4 - 67 IPR004172
domain Guanylate kinase-like domain 715 - 890 IPR008144
domain Guanylate kinase/L-type calcium channel beta subunit 714 - 893 IPR008145
domain L27-1 6 - 63 IPR015143
domain Disks large homolog 1-4, PDZ-associated domain 404 - 465 IPR019583
domain Disks large homologue 1, N-terminal PEST domain 106 - 223 IPR019590
conserved_site Guanylate kinase, conserved site 747 - 764 IPR020590

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein
  • Basolateral cell membrane
  • Endoplasmic reticulum membrane
  • Postsynaptic density
  • Synapse
  • Cell membrane, sarcolemma
  • Cell junction
  • Cytoplasm
  • Apical cell membrane
  • Colocalizes with EPB41 at regions of intercellular contacts
  • Basolateral in epithelial cells
  • May also associate with endoplasmic reticulum membranes
  • Mainly found in neurons soma, moderately found at postsynaptic densities
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

38 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell projection membrane The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
immunological synapse An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
lateral loop Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
MPP7-DLG1-LIN7 complex A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.
myelin sheath abaxonal region The region of the myelin sheath furthest from the axon.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
node of Ranvier An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
paranode region of axon An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.
T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

11 GO annotations of molecular function

Name Definition
ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
L27 domain binding Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.
phosphatase binding Binding to a phosphatase.
potassium channel regulator activity Binds to and modulates the activity of a potassium channel.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
structural constituent of postsynaptic density The action of a molecule that contributes to the structural integrity of a postsynaptic density.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

55 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament.
amyloid precursor protein metabolic process The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
bicellular tight junction assembly The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.
branching involved in ureteric bud morphogenesis The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
embryonic skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase.
endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
establishment of centrosome localization The directed movement of the centrosome to a specific location.
establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
hard palate development The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes.
immunological synapse formation The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
lens development in camera-type eye The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
membrane raft organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of ERK1 and ERK2 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
negative regulation of p38MAPK cascade Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
negative regulation of T cell proliferation Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density).
peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.
phosphatidylinositol 3-kinase/protein kinase B signal transduction A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of multicellular organism growth Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
positive regulation of potassium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
regulation of potassium ion export across plasma membrane Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.
regulation of potassium ion import Any process that modulates the frequency, rate or extent of potassium ion import.
regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
regulation of protein localization to synapse Any process that modulates the frequency, rate or extent of protein localization to synapse.
regulation of ventricular cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.
smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.
T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
T cell proliferation The expansion of a T cell population by cell division. Follows T cell activation.
tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized.
ureteric bud development The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31007 dlg1 Disks large 1 tumor suppressor protein Drosophila melanogaster (Fruit fly) EV
Q9BXL7 CARD11 Caspase recruitment domain-containing protein 11 Homo sapiens (Human) EV
P78352 DLG4 Disks large homolog 4 Homo sapiens (Human) SS
Q15700 DLG2 Disks large homolog 2 Homo sapiens (Human) SS
Q92796 DLG3 Disks large homolog 3 Homo sapiens (Human) SS
Q12959 DLG1 Disks large homolog 1 Homo sapiens (Human) SS
Q8CIS0 Card11 Caspase recruitment domain-containing protein 11 Mus musculus (Mouse) SS
Q99KF0 Card14 Caspase recruitment domain-containing protein 14 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
P70175 Dlg3 Disks large homolog 3 Mus musculus (Mouse) SS
Q62108 Dlg4 Disks large homolog 4 Mus musculus (Mouse) SS
Q91XM9 Dlg2 Disks large homolog 2 Mus musculus (Mouse) SS
Q63622 Dlg2 Disks large homolog 2 Rattus norvegicus (Rat) EV
P31016 Dlg4 Disks large homolog 4 Rattus norvegicus (Rat) SS
Q62936 Dlg3 Disks large homolog 3 Rattus norvegicus (Rat) SS
Q62696 Dlg1 Disks large homolog 1 Rattus norvegicus (Rat) SS
G5ECY0 dlg-1 Disks large homolog 1 Caenorhabditis elegans SS
Q28C55 dlg1 Disks large homolog 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6R005 dlg4 Disks large homolog 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH7 dlg2 Disks large homolog 2 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5PYH5 dlg1l Discs large homolog 1-like protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MPVRKQDTQR ALHLLEEYRS KLSQTEDRQL RSSIERVINI FQSNLFQALI DIQEFYEVTL
70 80 90 100 110 120
LDNPKCVDHS KQCEPVQPVT TWEIASLPST AVTSETLPGS LSPPVEKYRY QDEEVLPPEH
130 140 150 160 170 180
ISPQVTNEVL GPELVHVSEK NLSEIENVHG FVSHSHISPI KPTEAVPPSS PIVPVTPALP
190 200 210 220 230 240
VPAESTVVLP SAPQANPPPV LVNTDSLETP TYVNGTDADY EYEEITLERG NSGLGFSIAG
250 260 270 280 290 300
GTDNPHIGDD SSIFITKIIT GGAAAQDGRL RVNDCILRVN EADVRDVTHS KAVEALKEAG
310 320 330 340 350 360
SIVRLYVKRR KPASEKIMEI KLIKGPKGLG FSIAGGVGNQ HIPGDNSIYV TKIIEGGAAH
370 380 390 400 410 420
KDGKLQIGDK LLAVNSVCLE EVTHEEAVTA LKNTSDFVYL KVAKPTSMYI NDGYAPPDIT
430 440 450 460 470 480
NSSSQSVDNH VSPSSCLGQT PTSPARYSPI SKAVLGDDEI TREPRKVVLH RGSTGLGFNI
490 500 510 520 530 540
VGGEDGEGIF ISFILAGGPA DLSGELRKGD RIISVNSVDL RAASHEQAAA ALKNAGQAVT
550 560 570 580 590 600
IVAQYRPEEY SRFEAKIHDL REQMMNSSVS SGSGSLRTSQ KRSLYVRALF DYDKTKDSGL
610 620 630 640 650 660
PSQGLNFRFG DILHVINASD DEWWQARQVT PDGESDEVGV IPSKRRVEKK ERARLKTVKF
670 680 690 700 710 720
NSKTRGDKGE IPDDMGSKGL KHVTSNASDS ESSYRGQEEY VLSYEPVNQQ EVNYTRPVII
730 740 750 760 770 780
LGPMKDRVND DLISEFPDKF GSCVPHTTRP KRDYEVDGRD YHFVTSREQM EKDIQEHKFI
790 800 810 820 830 840
EAGQYNNHLY GTSVQSVRAV AEKGKHCILD VSGNAIKRLQ IAQLYPISIF IKPKSMENIM
850 860 870 880 890 900
EMNKRLTEEQ ARKTFERAMK LEQEFTEHFT AIVQGDTLED IYNQVKQIIE EQSGPYIWVP
AKEKL