AiPD: Autoinhibited Protein Database

Gene name	Orc1 (Orc1l)
Protein name	Origin recognition complex subunit 1
Names
Species	Rattus norvegicus (Rat)
KEGG Pathway	rno:313479
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

153-474 (Predicted disordered autoinhibitory region) PR

153-474 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q80Z32-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q80Z32

Type	Name	Position	InterPro Accession
domain	Toll/interleukin-1 receptor homology (TIR) domain	869 - 1016	IPR000157
repeat	Leucine-rich repeat	65 - 99	IPR001611-1
repeat	Leucine-rich repeat	271 - 318	IPR001611-2
repeat	Leucine-rich repeat	501 - 555	IPR001611-3
repeat	Leucine-rich repeat	576 - 597	IPR001611-4
repeat	Leucine-rich repeat	624 - 667	IPR001611-5
repeat	Leucine-rich repeat	704 - 725	IPR001611-6
repeat	Leucine-rich repeat	728 - 749	IPR001611-7
repeat	Leucine-rich repeat, typical subtype	66 - 85	IPR003591-1
repeat	Leucine-rich repeat, typical subtype	120 - 143	IPR003591-2
repeat	Leucine-rich repeat, typical subtype	195 - 218	IPR003591-3
repeat	Leucine-rich repeat, typical subtype	281 - 304	IPR003591-4
repeat	Leucine-rich repeat, typical subtype	305 - 329	IPR003591-5
repeat	Leucine-rich repeat, typical subtype	388 - 411	IPR003591-6
repeat	Leucine-rich repeat, typical subtype	412 - 435	IPR003591-7
repeat	Leucine-rich repeat, typical subtype	520 - 543	IPR003591-8
repeat	Leucine-rich repeat, typical subtype	574 - 597	IPR003591-9
repeat	Leucine-rich repeat, typical subtype	629 - 652	IPR003591-10
repeat	Leucine-rich repeat, typical subtype	678 - 701	IPR003591-11
repeat	Leucine-rich repeat, typical subtype	703 - 725	IPR003591-12
repeat	Leucine-rich repeat, typical subtype	727 - 749	IPR003591-13
repeat	BspA-type LRR region	355 - 423	IPR026906

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nuclear origin of replication recognition complex	A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
origin recognition complex	A multisubunit complex that is located at the replication origins of a chromosome.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA replication origin binding	Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
metal ion binding	Binding to a metal ion.

Name	Definition
DNA replication initiation	The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
mitotic DNA replication checkpoint signaling	A signal transduction process that contributes to a mitotic DNA replication checkpoint.
positive regulation of G0 to G1 transition	A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase.
positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P54784	ORC1	Origin recognition complex subunit 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q58DC8	ORC1	Origin recognition complex subunit 1	Bos taurus (Bovine)	PR
O16810	Orc1	Origin recognition complex subunit 1	Drosophila melanogaster (Fruit fly)	EV
Q13415	ORC1	Origin recognition complex subunit 1	Homo sapiens (Human)	PR
Q9Z1N2	Orc1	Origin recognition complex subunit 1	Mus musculus (Mouse)	PR
Q710E8	ORC1A	Origin of replication complex subunit 1A	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SU24	ORC1B	Origin of replication complex subunit 1B	Arabidopsis thaliana (Mouse-ear cress)	PR