Q80YW0
Gene name |
Cyth4 (Pscd4) |
Protein name |
Cytohesin-4 |
Names |
PH, SEC7 and coiled-coil domain-containing protein 4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72318 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
58-246 (Sec7 domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
58-246 (Sec7 domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Malaby AW et al. (2013) "Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors", Proceedings of the National Academy of Sciences of the United States of America, 110, 14213-8
- DiNitto JP et al. (2007) "Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors", Molecular cell, 28, 569-83
Autoinhibited structure
Activated structure
1 structures for Q80YW0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80YW0-F1 | Predicted | AlphaFoldDB |
23 variants for Q80YW0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389377955 | 2 | D>E | No | EVA | |
| rs3389374466 | 7 | D>N | No | EVA | |
| rs3389374545 | 14 | G>E | No | EVA | |
| rs3389291016 | 22 | I>F | No | EVA | |
| rs3389324863 | 27 | K>M | No | EVA | |
| rs3389366824 | 71 | K>N | No | EVA | |
| rs221125237 | 77 | N>D | No | EVA | |
| rs3389374544 | 83 | L>H | No | EVA | |
| rs3389388626 | 99 | F>L | No | EVA | |
| rs3389374581 | 113 | T>I | No | EVA | |
| rs3389324829 | 165 | E>G | No | EVA | |
| rs3389290961 | 177 | G>* | No | EVA | |
| rs231023708 | 215 | T>S | No | EVA | |
| rs3389351879 | 240 | S>N | No | EVA | |
| rs3389374410 | 287 | C>S | No | EVA | |
| rs3389380423 | 298 | E>K | No | EVA | |
| rs3389366466 | 299 | P>H | No | EVA | |
| rs3389388675 | 334 | I>L | No | EVA | |
| rs3389366465 | 345 | V>M | No | EVA | |
| rs3389361743 | 346 | V>I | No | EVA | |
| rs3389334838 | 377 | V>L | No | EVA | |
| rs3389370813 | 378 | P>T | No | EVA | |
| rs3389324806 | 381 | D>H | No | EVA |
No associated diseases with Q80YW0
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intercellular bridge | A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| lipid binding | Binding to a lipid. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of ARF protein signal transduction | Any process that modulates the frequency, rate or extent of ARF protein signal transduction. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KI41 | CYTH2 | Cytohesin-2 | Bos taurus (Bovine) | SS |
| O43739 | CYTH3 | Cytohesin-3 | Homo sapiens (Human) | EV |
| Q15438 | CYTH1 | Cytohesin-1 | Homo sapiens (Human) | SS |
| Q99418 | CYTH2 | Cytohesin-2 | Homo sapiens (Human) | SS |
| Q9UIA0 | CYTH4 | Cytohesin-4 | Homo sapiens (Human) | SS |
| O08967 | Cyth3 | Cytohesin-3 | Mus musculus (Mouse) | EV |
| Q3TES0 | Iqsec3 | IQ motif and SEC7 domain-containing protein 3 | Mus musculus (Mouse) | SS |
| G3X9K3 | Arfgef1 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 | Mus musculus (Mouse) | PR |
| A2A5R2 | Arfgef2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | Mus musculus (Mouse) | PR |
| Q8R0S2 | Iqsec1 | IQ motif and SEC7 domain-containing protein 1 | Mus musculus (Mouse) | SS |
| P63034 | Cyth2 | Cytohesin-2 | Mus musculus (Mouse) | SS |
| Q9QX11 | Cyth1 | Cytohesin-1 | Mus musculus (Mouse) | SS |
| Q5DU25 | Iqsec2 | IQ motif and SEC7 domain-containing protein 2 | Mus musculus (Mouse) | SS |
| P97696 | Cyth3 | Cytohesin-3 | Rattus norvegicus (Rat) | SS |
| P97694 | Cyth1 | Cytohesin-1 | Rattus norvegicus (Rat) | SS |
| P63035 | Cyth2 | Cytohesin-2 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDVCHTDPAE | LSSGEAKELQ | QIKWHRKQLL | EDIQKLKDEI | ADVFAQIDCF | ESTEESRMAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KEKEMCIGRK | KFNMDPNKGI | QYLIEHKLLT | SDVQDIAQFL | YKGDGLNKTA | IGTYLGEKDP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INLQVLQAFV | DCHEFANLNL | VQALRQFLWS | FRLPGEAQKI | DRMMEAFAAR | YCLCNPGVFR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STDTCYVLSF | SVIMLNTGLH | NPNVRDRPPF | ERFVTMNRGI | NSGSDLPEEQ | LRNLFDSIKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPFSIPEDDG | GDLTHTFFNP | DREGWLLKLG | GRVKTWKRRW | FILTDNCLYY | FEFTTDKEPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GIIPLENLSV | QKVEDPKKPF | CLELYNPSCR | GQKIKACKTD | GDGKVVEGKH | ESYRISAANA |
| 370 | 380 | 390 | |||
| EERDQWIEAI | RASITRVPFY | DLLSARKKKI | VGK |