Q80YE7
SS
Gene name |
Dapk1 |
Protein name |
Death-associated protein kinase 1 |
Names |
DAP kinase 1 , EC 2.7.11.1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69635 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
DAPK2 (also named DRP-1), Death-associated protein kinase 2, is a Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that functions as a positive mediator of programmed cell death. DAPK2 has a DAP kinase homology region, which contains the catalytic domain (protein kinase domain) and the CaM-regulatory region, and the remaining C-terminal part, which displays no homology to any known protein and is required for self-dimerization. When binding to CaM, DAPK2 phosphorylates an exogenous substrate, the myosin light chain, in a Ca2+/CaM-dependent manner. The truncated protein, deletion of the CaM-regulatory domain, was converted into a constitutively active kinase. The death-promoting effects of DAPK2 depend on the functionality of the catalytic domain and on the presence of the C-terminal tail, yet further deletion of the CaM-regulatory domain abrogated the requirement for the C-terminal tail. Furthermore, the autophosphorylation of the Ser318 (Q9UIK4-1) within CaM-regulatory domain restrains the ability of DAPK2 to induce apoptosis and the homodimerization at basal state.
Autoinhibitory domains (AIDs)
Target domain |
13-275 (Protein kinase domain) |
Relief mechanism |
Partner binding, PTM |
Assay |
|
Accessory elements
160-182 (Activation loop from InterPro)
Target domain |
13-275 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Patel AK et al. (2011) "Structure of the dimeric autoinhibited conformation of DAPK2, a pro-apoptotic protein kinase", Journal of molecular biology, 409, 369-83
- Shohat G et al. (2002) "The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases", Biochimica et biophysica acta, 1600, 45-50
- Shani G et al. (2001) "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding", The EMBO journal, 20, 1099-113
- Inbal B et al. (2000) "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis", Molecular and cellular biology, 20, 1044-54
- Simon B et al. (2016) "Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites", Structure (London, England : 1993), 24, 851-61
- Horvath M et al. (2021) "14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites", Communications biology, 4, 986
- Cohen O et al. (1997) "DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity", The EMBO journal, 16, 998-1008
- Shohat G et al. (2001) "The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism", The Journal of biological chemistry, 276, 47460-7
- Temmerman K et al. (2014) "A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity", Chemistry & biology, 21, 264-73
Autoinhibited structure
Activated structure
1 structures for Q80YE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80YE7-F1 | Predicted | AlphaFoldDB |
62 variants for Q80YE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389255158 | 44 | I>V | No | EVA | |
| rs3389262680 | 61 | I>N | No | EVA | |
| rs3389303354 | 111 | L>P | No | EVA | |
| rs3389285997 | 134 | Q>* | No | EVA | |
| rs3404160835 | 220 | D>V | No | EVA | |
| rs3389300430 | 256 | L>Q | No | EVA | |
| rs3389245806 | 269 | S>I | No | EVA | |
| rs3389291725 | 282 | Q>K | No | EVA | |
| rs3389288503 | 300 | A>G | No | EVA | |
| rs3389215376 | 312 | I>K | No | EVA | |
| rs3389215376 | 312 | I>T | No | EVA | |
| rs3389245802 | 313 | S>T | No | EVA | |
| rs3389290517 | 430 | F>L | No | EVA | |
| rs47326827 | 437 | P>L | No | EVA | |
| rs3389290118 | 505 | N>H | No | EVA | |
| rs3389303333 | 511 | G>V | No | EVA | |
| rs3389215357 | 514 | P>A | No | EVA | |
| rs3389295319 | 582 | H>D | No | EVA | |
| rs3389290488 | 587 | D>N | No | EVA | |
| rs3389300395 | 595 | A>T | No | EVA | |
| rs3389288496 | 597 | C>R | No | EVA | |
| rs3389284791 | 617 | A>E | No | EVA | |
| rs3389303384 | 647 | E>K | No | EVA | |
| rs3413022606 | 653 | E>Q | No | EVA | |
| rs3389295348 | 690 | L>I | No | EVA | |
| rs3389288466 | 690 | L>P | No | EVA | |
| rs3389262689 | 710 | G>R | No | EVA | |
| rs3389300407 | 781 | S>F | No | EVA | |
| rs3389285944 | 796 | I>F | No | EVA | |
| rs3389255185 | 835 | I>T | No | EVA | |
| rs3389285941 | 854 | I>N | No | EVA | |
| rs3389218037 | 879 | P>H | No | EVA | |
| rs3389262695 | 916 | N>D | No | EVA | |
| rs3550219333 | 945 | R>W | No | EVA | |
| rs50649880 | 960 | S>P | No | EVA | |
| rs3389300445 | 989 | Q>E | No | EVA | |
| rs3389288455 | 1020 | E>* | No | EVA | |
| rs3404313069 | 1026 | S>R | No | EVA | |
| rs3404232522 | 1027 | E>G | No | EVA | |
| rs3389245836 | 1040 | L>F | No | EVA | |
| rs3389262687 | 1075 | D>G | No | EVA | |
| rs3389245767 | 1116 | W>C | No | EVA | |
| rs3389303309 | 1121 | D>V | No | EVA | |
| rs3389284843 | 1140 | F>S | No | EVA | |
| rs3389217955 | 1147 | K>E | No | EVA | |
| rs3389295282 | 1151 | N>S | No | EVA | |
| rs3389217948 | 1165 | A>T | No | EVA | |
| rs3389218014 | 1179 | R>G | No | EVA | |
| rs3389290082 | 1223 | M>L | No | EVA | |
| rs3389218043 | 1266 | S>I | No | EVA | |
| rs3389290498 | 1281 | S>I | No | EVA | |
| rs3389272648 | 1283 | T>M | No | EVA | |
| rs3389303356 | 1293 | Q>R | No | EVA | |
| rs3389288537 | 1300 | I>F | No | EVA | |
| rs3389303385 | 1300 | I>T | No | EVA | |
| rs46307655 | 1310 | R>Q | No | EVA | |
| rs3389284834 | 1326 | D>E | No | EVA | |
| rs3389255108 | 1338 | D>E | No | EVA | |
| rs3389255178 | 1338 | D>V | No | EVA | |
| rs49161067 | 1354 | L>H | No | EVA | |
| rs3389284825 | 1387 | D>E | No | EVA | |
| rs3389272560 | 1390 | D>Y | No | EVA |
3 associated diseases with Q80YE7
[MIM: 211600]: Cholestasis, progressive familial intrahepatic, 1 (PFIC1)
A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC1 inheritance is autosomal recessive. {ECO:0000269|PubMed:11093741, ECO:0000269|PubMed:15239083, ECO:0000269|PubMed:19731236, ECO:0000269|PubMed:20038848, ECO:0000269|PubMed:23197899, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:9500542}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 243300]: Cholestasis, benign recurrent intrahepatic, 1 (BRIC1)
A disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically. {ECO:0000269|PubMed:15239083, ECO:0000269|PubMed:19731236, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:9500542, ECO:0000269|PubMed:9918928}. Note=The disease is caused by variants affecting the gene represented in this entry.
[MIM: 147480]: Cholestasis of pregnancy, intrahepatic 1 (ICP1)
A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP1 causes fetal distress, spontaneous premature delivery and intrauterine death. ICP1 patients have spontaneous and progressive disappearance of cholestasis after delivery. {ECO:0000269|PubMed:15657619, ECO:0000269|PubMed:15888793, ECO:0000269|PubMed:19731236}. Note=The disease may be caused by variants affecting the gene represented in this entry.
Without disease ID
- A disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease before adulthood. PFIC1 inheritance is autosomal recessive. {ECO:0000269|PubMed:11093741, ECO:0000269|PubMed:15239083, ECO:0000269|PubMed:19731236, ECO:0000269|PubMed:20038848, ECO:0000269|PubMed:23197899, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:9500542}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A disorder characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration. Patients are asymptomatic between episodes, both clinically and biochemically. {ECO:0000269|PubMed:15239083, ECO:0000269|PubMed:19731236, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:9500542, ECO:0000269|PubMed:9918928}. Note=The disease is caused by variants affecting the gene represented in this entry.
- A liver disorder of pregnancy. It presents during the second or, more commonly, the third trimester of pregnancy with intense pruritus which becomes more severe with advancing gestation and cholestasis. Cholestasis results from abnormal biliary transport from the liver into the small intestine. ICP1 causes fetal distress, spontaneous premature delivery and intrauterine death. ICP1 patients have spontaneous and progressive disappearance of cholestasis after delivery. {ECO:0000269|PubMed:15657619, ECO:0000269|PubMed:15888793, ECO:0000269|PubMed:19731236}. Note=The disease may be caused by variants affecting the gene represented in this entry.
12 regional properties for Q80YE7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 160 - 280 | IPR000008 |
| domain | Protein kinase domain | 348 - 609 | IPR000719 |
| domain | AGC-kinase, C-terminal | 610 - 681 | IPR000961 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 38 - 89 | IPR002219-1 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 103 - 155 | IPR002219-2 |
| active_site | Serine/threonine-protein kinase, active site | 468 - 480 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 354 - 377 | IPR017441 |
| domain | Protein kinase, C-terminal | 631 - 671 | IPR017892 |
| domain | Diacylglycerol/phorbol-ester binding | 36 - 50 | IPR020454-1 |
| domain | Diacylglycerol/phorbol-ester binding | 52 - 61 | IPR020454-2 |
| domain | Diacylglycerol/phorbol-ester binding | 65 - 76 | IPR020454-3 |
| domain | Diacylglycerol/phorbol-ester binding | 142 - 154 | IPR020454-4 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| DAPK1-calmodulin complex | A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| syntaxin-1 binding | Binding to a syntaxin-1 SNAP receptor. |
15 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| apoptotic signaling pathway | The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. |
| cellular response to hydroperoxide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. |
| cellular response to type II interferon | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. |
| defense response to tumor cell | Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. |
| extrinsic apoptotic signaling pathway via death domain receptors | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| negative regulation of translation | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of autophagic cell death | Any process that activates or increases the frequency, rate or extent of autophagic cell death. |
| positive regulation of autophagy | Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of NMDA receptor activity | Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. |
| regulation of response to tumor cell | Any process that modulates the frequency, rate, or extent of a response to tumor cell. |
99 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A4IFM7 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Bos taurus (Bovine) | SS |
| Q0V7M1 | PSKH1 | Serine/threonine-protein kinase H1 | Bos taurus (Bovine) | SS |
| Q0VD22 | STK33 | Serine/threonine-protein kinase 33 | Bos taurus (Bovine) | PR |
| Q96NX5 | CAMK1G | Calcium/calmodulin-dependent protein kinase type 1G | Homo sapiens (Human) | SS |
| O15075 | DCLK1 | Serine/threonine-protein kinase DCLK1 | Homo sapiens (Human) | EV |
| Q14012 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | Homo sapiens (Human) | EV |
| Q9UIK4 | DAPK2 | Death-associated protein kinase 2 | Homo sapiens (Human) | EV |
| O94768 | STK17B | Serine/threonine-protein kinase 17B | Homo sapiens (Human) | PR |
| Q86YV6 | MYLK4 | Myosin light chain kinase family member 4 | Homo sapiens (Human) | SS |
| Q16566 | CAMK4 | Calcium/calmodulin-dependent protein kinase type IV | Homo sapiens (Human) | SS |
| P11801 | PSKH1 | Serine/threonine-protein kinase H1 | Homo sapiens (Human) | SS |
| Q8N568 | DCLK2 | Serine/threonine-protein kinase DCLK2 | Homo sapiens (Human) | PR |
| Q9UEE5 | STK17A | Serine/threonine-protein kinase 17A | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| Q9H1R3 | MYLK2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Homo sapiens (Human) | EV |
| Q32MK0 | MYLK3 | Myosin light chain kinase 3 | Homo sapiens (Human) | SS |
| Q8WWF8 | CAPSL | Calcyphosin-like protein | Homo sapiens (Human) | PR |
| Q6P2M8 | PNCK | Calcium/calmodulin-dependent protein kinase type 1B | Homo sapiens (Human) | SS |
| Q9BYT3 | STK33 | Serine/threonine-protein kinase 33 | Homo sapiens (Human) | PR |
| Q8NCB2 | CAMKV | CaM kinase-like vesicle-associated protein | Homo sapiens (Human) | SS |
| O43293 | DAPK3 | Death-associated protein kinase 3 | Homo sapiens (Human) | PR |
| Q8IU85 | CAMK1D | Calcium/calmodulin-dependent protein kinase type 1D | Homo sapiens (Human) | SS |
| P53355 | DAPK1 | Death-associated protein kinase 1 | Homo sapiens (Human) | EV |
| Q9QYK9 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Mus musculus (Mouse) | PR |
| Q91VB2 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Mus musculus (Mouse) | SS |
| Q8VCR8 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Mus musculus (Mouse) | SS |
| Q6PGN3 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Mus musculus (Mouse) | PR |
| Q91YS8 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Mus musculus (Mouse) | SS |
| Q3UIZ8 | Mylk3 | Myosin light chain kinase 3 | Mus musculus (Mouse) | SS |
| Q6P8Y1 | Capsl | Calcyphosin-like protein | Mus musculus (Mouse) | PR |
| Q8BW96 | Camk1d | Calcium/calmodulin-dependent protein kinase type 1D | Mus musculus (Mouse) | SS |
| Q3UHL1 | Camkv | CaM kinase-like vesicle-associated protein | Mus musculus (Mouse) | SS |
| P08414 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Mus musculus (Mouse) | SS |
| Q9JLM8 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Mus musculus (Mouse) | SS |
| Q91YA2 | Pskh1 | Serine/threonine-protein kinase H1 | Mus musculus (Mouse) | SS |
| Q62407 | Speg | Striated muscle-specific serine/threonine-protein kinase | Mus musculus (Mouse) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q924X7 | Stk33 | Serine/threonine-protein kinase 33 | Mus musculus (Mouse) | PR |
| O54784 | Dapk3 | Death-associated protein kinase 3 | Mus musculus (Mouse) | PR |
| Q8VDF3 | Dapk2 | Death-associated protein kinase 2 | Mus musculus (Mouse) | EV |
| Q8BG48 | Stk17b | Serine/threonine-protein kinase 17B | Mus musculus (Mouse) | PR |
| Q7TNJ7 | Camk1g | Calcium/calmodulin-dependent protein kinase type 1G | Rattus norvegicus (Rat) | SS |
| P20689 | Mylk2 | Myosin light chain kinase 2, skeletal/cardiac muscle | Rattus norvegicus (Rat) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q91XS8 | Stk17b | Serine/threonine-protein kinase 17B | Rattus norvegicus (Rat) | PR |
| O08875 | Dclk1 | Serine/threonine-protein kinase DCLK1 | Rattus norvegicus (Rat) | PR |
| E9PT87 | Mylk3 | Myosin light chain kinase 3 | Rattus norvegicus (Rat) | SS |
| O70150 | Pnck | Calcium/calmodulin-dependent protein kinase type 1B | Rattus norvegicus (Rat) | PR |
| Q63092 | Camkv | CaM kinase-like vesicle-associated protein | Rattus norvegicus (Rat) | SS |
| Q63638 | Speg | Striated muscle-specific serine/threonine-protein kinase | Rattus norvegicus (Rat) | SS |
| O88764 | Dapk3 | Death-associated protein kinase 3 | Rattus norvegicus (Rat) | PR |
| P13234 | Camk4 | Calcium/calmodulin-dependent protein kinase type IV | Rattus norvegicus (Rat) | SS |
| Q63450 | Camk1 | Calcium/calmodulin-dependent protein kinase type 1 | Rattus norvegicus (Rat) | EV |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q5MPA9 | Dclk2 | Serine/threonine-protein kinase DCLK2 | Rattus norvegicus (Rat) | PR |
| Q5VQQ5 | CPK2 | Calcium-dependent protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q8LPZ7 | CPK3 | Calcium-dependent protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6K968 | CPK6 | Calcium-dependent protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| P53684 | CPK7 | Calcium-dependent protein kinase 7 | Oryza sativa subsp japonica (Rice) | PR |
| Q75GE8 | CPK8 | Calcium-dependent protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6I5I8 | CPK16 | Calcium-dependent protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6AVM3 | CCAMK | Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase | Oryza sativa subsp japonica (Rice) | PR |
| Q84SL0 | CPK20 | Calcium-dependent protein kinase 20 | Oryza sativa subsp. japonica (Rice) | SS |
| P53682 | CPK23 | Calcium-dependent protein kinase 23 | Oryza sativa subsp japonica (Rice) | PR |
| Q9TXJ0 | cmk-1 | Calcium/calmodulin-dependent protein kinase type 1 | Caenorhabditis elegans | PR |
| Q95QC4 | zyg-8 | Serine/threonine-protein kinase zyg-8 | Caenorhabditis elegans | PR |
| O44997 | dapk-1 | Death-associated protein kinase dapk-1 | Caenorhabditis elegans | SS |
| P28583 | Calcium-dependent protein kinase SK5 | Glycine max (Soybean) (Glycine hispida) | PR | |
| Q9M9V8 | CPK10 | Calcium-dependent protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q39016 | CPK11 | Calcium-dependent protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FX86 | CRK8 | CDPK-related kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SSF8 | CPK30 | Calcium-dependent protein kinase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38872 | CPK6 | Calcium-dependent protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q7XJR9 | CPK16 | Calcium-dependent protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SIQ7 | CPK24 | Calcium-dependent protein kinase 24 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJ61 | CPK25 | Calcium-dependent protein kinase 25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZV15 | CPK20 | Calcium-dependent protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P93759 | GK-1 | Calcium-dependent protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38870 | CPK2 | Calcium-dependent protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LJL9 | CRK2 | CDPK-related kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SG12 | CRK6 | CDPK-related kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCS2 | CRK5 | CDPK-related kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4I7 | CPK13 | Calcium-dependent protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6NLQ6 | CPK32 | Calcium-dependent protein kinase 32 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZSA4 | CPK27 | Calcium-dependent protein kinase 27 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38869 | CPK4 | Calcium-dependent protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42479 | CPK3 | Calcium-dependent protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1PE17 | CPK18 | Calcium-dependent protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q06850 | CPK1 | Calcium-dependent protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FMP5 | CPK17 | Calcium-dependent protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q38873 | CPK7 | Calcium-dependent protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E9C0 | CPK34 | Calcium-dependent protein kinase 34 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42438 | CPK8 | Calcium-dependent protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q42396 | CPK12 | Calcium-dependent protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKW4 | CPK28 | Calcium-dependent protein kinase 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVFRQENVD | DYYDTGEELG | SGQFAVVKKC | REKSTGLQYA | AKFIKKRRTK | SSRRGVSRED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IEREVSILKE | IRHPNVITLH | EVYENKTDVI | LILELVAGGE | LFDFLAEKES | LTEEEATEFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQILSGVYYL | HSLQIAHFDL | KPENIMLLDR | NVPKPRIKII | DFGLAHKIDF | GNEFKNIFGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEFVAPEIVN | YEPLGLEADM | WSIGVITYIL | LSGASPFLGD | TKQETLANVS | AVNYDFEEEF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FRNTSTLAKD | FIRRLLVKDP | KKRMTIQDSL | QHPWIKPKDT | QQALSRKASA | VNMEKFKKFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ARKKWKQSVR | LISLCQRLSR | SFLSRSNMSV | ARSDDTLDEE | DSFVMKAIIH | AINDDNVPGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QHLLGSLSSY | DVNQPNKHGT | PPLLIAAGCG | NIQMLQLLIK | RGSRIDVQDK | GGSNAIYWAS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RHGHVDTLKF | LNENKCPLDV | KDKSGETALH | VAARYGHADV | VQLLCSFGSN | PDFQDKEEET |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLHCAAWHGY | YSVAKALCEV | GCNVNIKNRE | GETPLLTASA | RGYHDIVECL | AEHGADLNAS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DKDGHIALHL | AVRRCQMEVI | KTLLGHGSFV | DFQDRHGNTP | LHVACKDGSA | PIVVALCEAS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CNLDISNKYG | RTPLHLAANN | GILDVVRYLC | LMGANVEALT | SDGKTAEDLA | KAEQHEHVAG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LLARLRKDTH | RGLFIQQLRP | TQNLQPRIKL | KLFGHSGSGK | STLVESLKCG | LLRSFFRRRR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PRLSSTNSTR | FPPSPLAAKP | TVSVSINNLY | PGCENVSVRS | RSMMFEPGLT | KGMLEVFVAP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SHHLHCSTDD | QSTKAIDIQN | AYLNGVGDFS | VWEFSGNPVY | FCCYDYFAAN | DPTSIHIIVF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SLEEPYEIQL | NQVIFWLSFL | KSLVPVEEPI | AFGGKLKNPL | RVVLVATHAD | IMNIPRPAGG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EFGYDKDTSL | LKEIRNRFGN | DLHVSNKLFV | LDAGASGSKD | IKVLRNHLQE | IRSQIVSGCS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PMTHLCEKII | STLPSWRKLN | GPNQLMSLQQ | FVYDVQDQLN | PLASEDDLRR | IAQQLHSTGE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| INIMQSETVQ | DVLLLDPRWL | CTNVLGKLLS | VETPRALHHY | RGRYTMEDIQ | RLVPDSDVEE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLQILDAMDI | CARDLSSGTM | VDIPALIKTD | SLQRSWADEE | DEVMVYGGVR | IVPVEHLTPF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PCGIFHKVQV | NLCRWIHQQS | AEGDADIRLW | VSGCRIANRG | AELLVLLVNH | GQGIEVQVRG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LETEKIKCCL | LLDSVCSTIE | TVMATTLPGL | LTVKHYLSPQ | QLREHHEPVM | VYQPRDFFRA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| QTLKESSLTN | TMGGYKESFS | SITCFGCHDV | YSQASLGMDI | HASDLSLLTR | RKLSRLLDPP |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| DPMGKDWCLL | AMNLGLPDMV | AKHNVNNRAS | RDFLPSPVHA | LLQEWTSYPE | STVGILISKL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| RELGRRDAAD | FLLKASSVFK | INLDGNGQEA | YASSCNSGTS | YNSISSVVSR | RDSHAWTPLY |
| DL |