Q80Y61

PR
Gene name
Baiap2l2
Protein name
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Names
BAI1-associated protein 2-like protein 2, Planar intestinal- and kidney-specific BAR domain protein, Pinkbar
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:207495
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

193-355 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q80Y61

Entry ID Method Resolution Chain Position Source
3OK8 X-ray 225 A A/B 1-220 PDB
AF-Q80Y61-F1 Predicted AlphaFoldDB

11 variants for Q80Y61

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389293325 38 L>P No EVA
rs3389293343 56 Q>* No EVA
rs3389374698 142 R>H No EVA
rs3389363364 155 K>M No EVA
rs3389352867 191 H>Y No EVA
rs258471142 385 V>L No EVA
rs238684647 392 P>L No EVA
rs3389390038 459 S>I No EVA
rs249468620 482 V>I No EVA
rs3389324811 493 P>S No EVA
rs3389377347 520 L>F No EVA

No associated diseases with Q80Y61

5 regional properties for Q80Y61

Type Name Position InterPro Accession
domain Sec7 domain 643 - 834 IPR000904
domain Mon2/Sec7/BIG1-like, HDS 1174 - 1255 IPR015403
domain Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain 23 - 198 IPR032629
domain Mon2/Sec7/BIG1-like, HUS domain 378 - 536 IPR032691
domain Sec7/BIG1-like, C-terminal domain 1561 - 1766 IPR046455

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Cell junction
  • Cytoplasmic vesicle membrane
  • Localizes to RAB13-positive vesicles and to the plasma membrane at intercellular contacts
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell-cell contact zone Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
clathrin complex A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

6 GO annotations of biological process

Name Definition
actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
positive regulation of actin cytoskeleton reorganization Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UHR4 BAIAP2L1 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 Homo sapiens (Human) PR
Q9UQB8 BAIAP2 Brain-specific angiogenesis inhibitor 1-associated protein 2 Homo sapiens (Human) EV
Q6UXY1 BAIAP2L2 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 Homo sapiens (Human) PR
Q8BKX1 Baiap2 BAR/IMD domain-containing adapter protein 2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAPEMDQFYR STMAIYKSIM EQFNPALENL VYLGNNYLRA FHALSEAAEV YFSAIQKIGE
70 80 90 100 110 120
QALQSSTSQI LGEILVQMSD TQRHLNSDLE VVVQTFHGDL LQHMEKNTKL DMQFIKDSCQ
130 140 150 160 170 180
HYEIEYRHRA ANLEKCMSEL WRMERKRDKN AREMKESVNR LHAQMQAFVS ESKRAAELEE
190 200 210 220 230 240
KRRYRFLAEK HLLLSNTFLQ FLGRARGMLQ NRVLLWKEQS EASRSPSRAH SPGLLGPALG
250 260 270 280 290 300
PPYPSGRLTP TRLDMPPRPL GEYGSPRSRH GSGSYGPEPA EARSASQLEP DRRSLPRTPS
310 320 330 340 350 360
ASSLYASSTQ RSRSNSFGER LGGGGARRVR ALVSHSEGAN HTLLRFSAGD VVEVLVPEAQ
370 380 390 400 410 420
NGWLYGKLEG SSASGWFPEA YVKPVEEIPV NPMNPVAPMN SMAPMSPMNE LPSRSYPLRG
430 440 450 460 470 480
SHSLDDLLDR PGNPTASSEY WDSQSRSRTP SRVPSRAPSP APPPLPSSRR SSVGSMGAAT
490 500 510 520
DVKKLMSWEQ NPPELFPRGT NPFATVKLRP TVTNDRSAPL IR