Q80XP9

SS
Gene name
Wnk3
Protein name
Serine/threonine-protein kinase WNK3
Names
Protein kinase lysine-deficient 3, Protein kinase with no lysine 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:279561
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

WNK family protein kinases are large enzymes that contain the catalytic lysine in a unique position compared with all other protein kinases. Rat WNK1 (Q9JIH7) contains an autoinhibitory region C-terminal to the catalytic kinase domain.

Autoinhibitory domains (AIDs)

439-462 (Autoinhibitory region) SS

Target domain

146-404 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

292-313 (Activation loop from InterPro)

Target domain

146-404 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q80XP9

Entry ID Method Resolution Chain Position Source
AF-Q80XP9-F1 Predicted AlphaFoldDB

15 variants for Q80XP9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs258144137 571 T>A No Ensembl
rs1132328273 590 S>* No Ensembl
rs1132798110 591 N>K No Ensembl
rs1135264779 592 Q>* No Ensembl
rs222609109 596 S>F No Ensembl
rs251405529 647 V>I No Ensembl
rs251135884 664 F>C No Ensembl
rs245099819 693 R>Q No Ensembl
rs224203078 778 G>S No Ensembl
rs29293581 795 G>V No Ensembl
rs29293576 922 Q>R No Ensembl
rs251196888 923 S>P No Ensembl
rs217031567 1331 N>K No Ensembl
rs261150929 1441 N>S No Ensembl
rs223419355 1701 A>P No Ensembl

No associated diseases with Q80XP9

2 regional properties for Q80XP9

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 78 - 208 IPR004821
domain CTP:phosphocholine cytidylyltransferase domain 75 - 224 IPR041723

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a chloride channel.
potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a potassium channel.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

21 GO annotations of biological process

Name Definition
cell volume homeostasis Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
ion homeostasis Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
maintenance of blood-brain barrier Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of pancreatic juice secretion Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
negative regulation of sodium ion transport Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of calcium ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of ion transmembrane transporter activity Any process that activates or increases the activity of an ion transporter.
positive regulation of peptidyl-threonine phosphorylation Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of potassium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
positive regulation of sodium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
positive regulation of sodium ion transport Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of calcium ion import Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.
regulation of cation transmembrane transport Any process that modulates the frequency, rate or extent of cation transmembrane transport.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96J92 WNK4 Serine/threonine-protein kinase WNK4 Homo sapiens (Human) SS
Q9Y3S1 WNK2 Serine/threonine-protein kinase WNK2 Homo sapiens (Human) SS
Q9H4A3 WNK1 Serine/threonine-protein kinase WNK1 Homo sapiens (Human) SS
Q9BYP7 WNK3 Serine/threonine-protein kinase WNK3 Homo sapiens (Human) SS
Q99J45 Nrbp1 Nuclear receptor-binding protein Mus musculus (Mouse) PR
P83741 Wnk1 Serine/threonine-protein kinase WNK1 Mus musculus (Mouse) SS
Q80UE6 Wnk4 Serine/threonine-protein kinase WNK4 Mus musculus (Mouse) SS
Q3UH66 Wnk2 Serine/threonine-protein kinase WNK2 Mus musculus (Mouse) SS
Q6R2V0 WNK1 Serine/threonine-protein kinase WNK1 Sus scrofa (Pig) SS
Q9JIH7 Wnk1 Serine/threonine-protein kinase WNK1 Rattus norvegicus (Rat) EV
Q7TPK6 Wnk4 Serine/threonine-protein kinase WNK4 Rattus norvegicus (Rat) SS
X5M5N0 wnk-1 Serine/threonine-protein kinase WNK Caenorhabditis elegans SS
Q8RXE5 WNK10 Probable serine/threonine-protein kinase WNK10 Arabidopsis thaliana (Mouse-ear cress) PR
Q944Q0 WNK8 Serine/threonine-protein kinase WNK8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVL5 WNK4 Probable serine/threonine-protein kinase WNK4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STK6 WNK3 Probable serine/threonine-protein kinase WNK3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LST2 WNK7 Probable serine/threonine-protein kinase WNK7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MATDSGEPAS TEDSEKPDGV SFENRAARAV APLTVEARIK EKYSTFSASG ENIERKRFFR
70 80 90 100 110 120
KSVEMTEDDK VAESSRRDER KAATNISRVD KVPTNVLRGG QEVKYEQCSK ATSESSKDCF
130 140 150 160 170 180
KEKTEKEMEE EAEMKAVATS PSGRFLKFDI ELGRGAFKTV YKGLDTETWV EVAWCELQDR
190 200 210 220 230 240
KLTKAEQQRF KEEAEMLKGL QHPNIVRFYD SWESTLKGKK CIVLVTELMT SGTLKTYLKR
250 260 270 280 290 300
FKVMKPKVLR SWCRQILKGL QFLHTRTPPI IHRDLKCDNI FITGPTGSVK IGDLGLATLM
310 320 330 340 350 360
RTSFAKSVIG TPEFMAPEMY EEHYDESVDV YAFGMCMLEM ATSEYPYSEC QNAAQIYRKV
370 380 390 400 410 420
TSGIKPASFN KVTDPEVKEI IEGCIRQNKS ERLSIKDLLN HAFFAEDTGL RVELAEEDDC
430 440 450 460 470 480
SNSSLALRLW VEDPKKLKGK HKDNEAIEFS FNLEADTPEE VAYEMVKSGF FHESDSKAVA
490 500 510 520 530 540
KSIRDRVTLI KKIREKKPAG CLEERRDSQC KYVRNVLPQQ QTATLQPTPG PHTAAEYEET
550 560 570 580 590 600
EVDQHVRQQF LQGKPQQQSS SVRGDTSSEP TAGPVLHSDT SSHPTVAYSS NQTTSSQEQP
610 620 630 640 650 660
KLTQSPVLPV VQGQSSVMPI YAAGVGVVSQ SQISPLTIQK VSQIKPVSQP IGAEQQATLQ
670 680 690 700 710 720
NPDFVRSLNQ DVTSVKENTN NPDTPSGNGK QDRNKQRRAS CPRPEKGTKF QLTVLQVSVS
730 740 750 760 770 780
GDNMVECQLE THNNKMVTFK FDVDGDAPED IADYMVEDNF VLENEKEKFV EELRAIVGQA
790 800 810 820 830 840
QEILHVHSAV EKSIGVDSVA LESNSNQTGS SEQVLINSAS TQTSNESAPQ SSPVGRWRFC
850 860 870 880 890 900
INQTIKNREA QSPPSLQPSM AMVPGLHPFP SSRNTSNQAI SQNTVFTIEN NPGHRELFTS
910 920 930 940 950 960
KLDHKDVVDG KIGEHASIET EQSSISYQVE DDRQIMTPAT DNSNYSAALV CPVPGECEAL
970 980 990 1000 1010 1020
TSQAGMFMPT YPNQQAAVLA DVHIAYPGES VPIGGNAALT SVLVSSDQKP QSLSVQQPTI
1030 1040 1050 1060 1070 1080
DAEFISKEGE TTVNTETSSP KAVIATQTPG FEPAVILPAT ILESDGERPP KMEFADNRIK
1090 1100 1110 1120 1130 1140
TLDEKLRNLL YQEHSISSIC PESQKDTQSI DSPFSSSAED ILSYSMPEVI AISHCGIQDS
1150 1160 1170 1180 1190 1200
PAQSPNFQQT GSKILSNVAA SQPAHISVFK KDLNVITSVP SELCLHEMSP DASLPGDPEA
1210 1220 1230 1240 1250 1260
YPAAVSSDGT IHLQTGGGYF GLSFTCPSLK NPISRKSWTR KLKSWAYRLR QSTSFFKRSK
1270 1280 1290 1300 1310 1320
VRQVETEDKR SAIASDPIPL TREFSSDTRA LSRCKAMSGS FQRGRFQVIT VPQQQPVKMM
1330 1340 1350 1360 1370 1380
SFGKDHRPPF NKTTVQSSEQ ALTFAEAAVS QLIEVEPAMP THKASVSSRK LRTLYETFKE
1390 1400 1410 1420 1430 1440
DKGDPEQGDI VSYSTACETS VSSVATEKNV TSTTEVSVQS GSEPLDKEKN ESTPGKQTCT
1450 1460 1470 1480 1490 1500
NEFSATLAGN RKSVTKTRPE GDQYLPLREE QAYAQTQNSL FYSPSSPMSS DNESEIEDED
1510 1520 1530 1540 1550 1560
LKVELQRLRE KHIQEVVSLQ TQQNKELQEL YERLRATKDN KAQSSEVPLS PASPRRPRSF
1570 1580 1590 1600 1610 1620
KSKLRSRPQS MTHSDNLVVK DALGVESNTV SCQQSPASKK GMFTDDLHKL VDDWTRETVG
1630 1640 1650 1660 1670 1680
HFPSKPSLNQ LKQSQQKSEA ENWNKSCEST PSTMGYTSNW ISSLSQIRGA APTSLPQGLP
1690 1700 1710 1720 1730 1740
LPSFHGPLAS YGMPHVCQYN AVGAAGYPVQ WVGISGPAQQ SVVLPTQSGG LFQPGMNLQS
1750
FPAPPVQNPA SIPPGPK