Q80XI3

SS
Gene name
Eif4g3
Protein name
Eukaryotic translation initiation factor 4 gamma 3
Names
eIF-4-gamma 3 , eIF-4G 3 , eIF4G 3 , eIF-4-gamma II , eIF4GII
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:230861
EC number
Protein Class

Descriptions

EIF4G is a probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimulate eIF4A helicase activity. Binding of eIF4E counteracts this autoinhibition, enabling eIF4G to stimulate eIF4A helicase activity.

Autoinhibitory domains (AIDs)

614-625 (eIF4E-binding domain) SS

Target domain

688-1062 (eIF4A-binding domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80XI3

Entry ID Method Resolution Chain Position Source
AF-Q80XI3-F1 Predicted AlphaFoldDB

No variants for Q80XI3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q80XI3

No associated diseases with Q80XI3

3 regional properties for Q80XI3

Type Name Position InterPro Accession
domain W2 domain 1410 - 1579 IPR003307
domain MIF4G-like, type 3 750 - 978 IPR003890
domain Initiation factor eIF-4 gamma, MA3 1215 - 1337 IPR003891

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

7 GO annotations of biological process

Name Definition
positive regulation of meiosis I Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q41583 Eukaryotic translation initiation factor isoform 4G-2 Triticum aestivum (Wheat) PR
Q95L46 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 Bos taurus (Bovine) PR
Q9H074 PAIP1 Polyadenylate-binding protein-interacting protein 1 Homo sapiens (Human) PR
Q04637 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 Homo sapiens (Human) EV
P78344 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 Homo sapiens (Human) PR
O43432 EIF4G3 Eukaryotic translation initiation factor 4 gamma 3 Homo sapiens (Human) EV
Q8VE62 Paip1 Polyadenylate-binding protein-interacting protein 1 Mus musculus (Mouse) PR
Q62448 Eif4g2 Eukaryotic translation initiation factor 4 gamma 2 Mus musculus (Mouse) PR
Q6NZJ6 Eif4g1 Eukaryotic translation initiation factor 4 gamma 1 Mus musculus (Mouse) SS
10 20 30 40 50 60
MNSQPQARSP FFQRPQIQPP RAAIPNSSPS IRPGVQTPTA VYQANQHIMM VNHLPMPYPV
70 80 90 100 110 120
TQGHQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFANAYGT PFYPSQPVYQ
130 140 150 160 170 180
SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPASTPTP
190 200 210 220 230 240
PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVFQS PSTVLRLVLS
250 260 270 280 290 300
GEKKEQAGQM PETAAGEPTP EPPRTSSPTS LPPLARSSLP SPMSAALSSQ PLFTAEDKCE
310 320 330 340 350 360
LPSSKEEDAP PVPSPTSCTA ASGPSLTDNS DICKKPCSVA PHDSQLISST ILINEMNGVG
370 380 390 400 410 420
EKLSAKENTV GMLRQEVLPL TLELEILEHP QEELKVECTP TPIAPSMLPA FSPAPPTPPT
430 440 450 460 470 480
SPPCPPVVLS AAIARSPAVA TEVQRVADEG ESLRTCLSKD AKEMQDKAES ESDGQAEETA
490 500 510 520 530 540
DPQSLHSGRS PAPVQTATTA PKSWKKTKEQ TRTPDEVLEA EAEPKAEEEL AVDSVLEPEQ
550 560 570 580 590 600
EKMSQGFPSE RDPSALKRGK AEEGNGEEAE PVRNGAESAS EGEGGDGNSG SADSSADGLT
610 620 630 640 650 660
FPFKAESWKP ADTEGKKQYD REFLLDIQFM PACIQKPEGL PPISDVVLDK INQPRLSMRT
670 680 690 700 710 720
LDPRILPRGP DFTPAFADFP RQTPGGRGVP LLNVGPRRSQ PGQRREPRKI ITVSVKEDVH
730 740 750 760 770 780
LRKAENAWKP SQKRDSHADD PESIKTQELF RKVRSILNKL TPQMFNQLMK QVSALTVDTE
790 800 810 820 830 840
ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF
850 860 870 880 890 900
EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML
910 920 930 940 950 960
TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ MEKIVKERKT
970 980 990 1000 1010 1020
SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI EEQEEQRKVQ QLMTKEKRRP
1030 1040 1050 1060 1070 1080
GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA
1090 1100 1110 1120 1130 1140
SESDALRSSA SSLNRFSPLQ PPAPSGSPSA TPLEFDSRRA LTSRGSMGRE KSDKPIPAGT
1150 1160 1170 1180 1190 1200
ARPNTFLRGS SKDLLDNQSQ EEQRREMLET VKQLTGGLDA ERASTEADRS KTRELAKSEM
1210 1220 1230 1240 1250 1260
CAVPAPDKPA LSEEEVERKS KSIIDEFLHI NDFKEATQCI EELSAQGPLH VFVKVGVEFT
1270 1280 1290 1300 1310 1320
LERSQITRDH MGHLLYQLVQ SEKLSKQDFF KGFSETLELA DDMAIDIPHI WLYLAELVTP
1330 1340 1350 1360 1370 1380
MLKEGGISMR ELIVEFSKPL LPVGRAGVLL SEILHLLCRQ MSHKKVGALW READLSWKDF
1390 1400 1410 1420 1430 1440
LPEGEDVHHF LLEQKLDFTE SEGPCSSEAL SKKELSAEEL SQRLEKLIME EKADDERIFD
1450 1460 1470 1480 1490 1500
WVEANLDESQ MSSPTFLRAL MTAVCKAAII ADCSTFRVDT AVIKQRVPIL LKYLDSDTEK
1510 1520 1530 1540 1550 1560
ELQALYALQA SIVKLDQPAN LLRMFFDCLY DEEVISEDAF YKWESSKDPA EQAGKGVALK
1570
SVTAFFTWLR EAEEESEDN