Q80XA6

PR
Gene name
Reps2 (Pob1)
Protein name
RalBP1-associated Eps domain-containing protein 2
Names
Partner of RalBP1, RalBP1-interacting protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:194590
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80XA6

Entry ID Method Resolution Chain Position Source
AF-Q80XA6-F1 Predicted AlphaFoldDB

35 variants for Q80XA6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389582702 9 C>Y No EVA
rs3411257499 74 E>D No EVA
rs3411144418 79 I>N No EVA
rs3412351673 80 T>I No EVA
rs3411144404 81 E>K No EVA
rs3389575545 82 L>Q No EVA
rs3389540503 83 C>R No EVA
rs3412893572 87 R>* No EVA
rs3389578223 91 F>L No EVA
rs3389489259 106 A>E No EVA
rs3389540441 109 G>S No EVA
rs3389585916 133 G>R No EVA
rs244925554 175 T>A No EVA
rs229218000 175 T>R No EVA
rs211983755 198 Y>S No EVA
rs241139493 221 P>S No EVA
rs260008700 228 G>D No EVA
rs243225974 228 G>S No EVA
rs3389582672 367 A>G No EVA
rs260595227 397 A>T No EVA
rs1134124412 496 S>P No EVA
rs1131701370 497 G>E No EVA
rs31346967 524 S>P No EVA
rs31346964 541 M>K No EVA
rs3409837519 543 A>S No EVA
rs3412441928 547 Q>L No EVA
rs3412643697 576 A>T No EVA
rs214519010 577 V>A No EVA
rs3411141617 581 M>V No EVA
rs3412126807 593 S>* No EVA
rs3412528937 595 Q>P No EVA
rs3412439334 596 K>N No EVA
rs3409837562 599 I>L No EVA
rs3411252224 600 Q>R No EVA
rs257535486 606 N>H No EVA

No associated diseases with Q80XA6

4 regional properties for Q80XA6

Type Name Position InterPro Accession
domain EH domain 21 - 122 IPR000261-1
domain EH domain 261 - 356 IPR000261-2
domain EF-hand domain 301 - 336 IPR002048
binding_site EF-Hand 1, calcium-binding site 314 - 326 IPR018247

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

2 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NFH8 REPS2 RalBP1-associated Eps domain-containing protein 2 Homo sapiens (Human) PR
Q9Z0R4 Itsn1 Intersectin-1 Mus musculus (Mouse) EV
Q9Z0R6 Itsn2 Intersectin-2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MEVAAGGGCG AGPPLLLSDS EQQCYSELFA RCAGAASGGP GPGPPEATRV APGTATAAAG
70 80 90 100 110 120
PVADLFRASQ LPPETLHQIT ELCGAKRVGY FGPTQFYVAL KLIAAAQAGL PVRTESIKCE
130 140 150 160 170 180
LPLPRFVMSK NDGEIRFGNP AELHGPKVQI PYLTTEKNSF KRMDNEDKQE TQSPTMSPLA
190 200 210 220 230 240
SPPSSPPHYQ RVSLSHGYSK LRSGTEQMHP APYERQPIGQ PEGPSSEGPG AKPFRRQASL
250 260 270 280 290 300
IRSFSVEREP QENNSNYPDE PWRITEEQRE YYVNQFRSLQ PDPSSFISGS VAKNFFTKSK
310 320 330 340 350 360
LSIPELSYIW ELSDADCDGA LTLSEFCAAF HLIVARKNGY PLPEGLPPTL QPEYLQAAFP
370 380 390 400 410 420
KSKWECAIFD SYSESMPANQ QSCDLNRMEK TSVKDVADFP VPTQDVTTAD DKQALKSTVN
430 440 450 460 470 480
ESLPKDVSED TATSKDYNSL KARPRSRSYS STSIEEAMKR GEDPPTPPPR PQKTHSRASS
490 500 510 520 530 540
LDLNKVFLPS APAANSGLLP PPPALPPRPC PTQSEPVSEA DLHSQLNRAP SQAAESSPTK
550 560 570 580 590 600
MDAPHAQPPS KPIRRKFRPE NQTTESQEPA AAVGGAVSAA MVKPHPTVQK QSSKQKKAIQ
610 620 630 640
TAIRKNKEAN AVLARLNSEL QQQLKEVHQE RIALENQLEQ LRPVTVL