Q80WJ6
PR
Gene name |
Abcc12 (Mrp9) |
Protein name |
ATP-binding cassette sub-family C member 12 |
Names |
Multidrug resistance-associated protein 9 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:244562 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80WJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80WJ6-F1 | Predicted | AlphaFoldDB |
62 variants for Q80WJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412891123 | 6 | P>S | No | EVA | |
| rs3388979430 | 32 | M>I | No | EVA | |
| rs3388999004 | 33 | I>T | No | EVA | |
| rs3388985235 | 87 | D>G | No | EVA | |
| rs236199584 | 102 | K>E | No | EVA | |
| rs3388993132 | 118 | F>I | No | EVA | |
| rs3399412581 | 150 | Q>* | No | EVA | |
| rs3388998501 | 212 | T>M | No | EVA | |
| rs3388985266 | 214 | T>S | No | EVA | |
| rs3388967432 | 221 | V>* | No | EVA | |
| rs37996660 | 298 | K>N | No | EVA | |
| rs3389002247 | 334 | K>N | No | EVA | |
| rs3388998497 | 339 | K>E | No | EVA | |
| rs3388967471 | 345 | S>G | No | EVA | |
| rs3388950636 | 386 | N>I | No | EVA | |
| rs3388995897 | 400 | K>R | No | EVA | |
| rs36613524 | 454 | P>S | No | EVA | |
| rs243641293 | 459 | I>N | No | EVA | |
| rs226928606 | 464 | V>F | No | EVA | |
| rs3388967526 | 507 | G>V | No | EVA | |
| rs3388967489 | 508 | K>SDG* | No | EVA | |
| rs3388996323 | 533 | L>* | No | EVA | |
| rs3388996351 | 534 | Q>E | No | EVA | |
| rs3388950644 | 534 | Q>L | No | EVA | |
| rs3388991466 | 538 | V>M | No | EVA | |
| rs3389003115 | 566 | E>K | No | EVA | |
| rs3388985227 | 575 | H>R | No | EVA | |
| rs3388996285 | 586 | L>S | No | EVA | |
| rs3388991479 | 593 | D>V | No | EVA | |
| rs3388999365 | 598 | G>* | No | EVA | |
| rs3388973823 | 605 | S>P | No | EVA | |
| rs3388991505 | 627 | L>M | No | EVA | |
| rs3388993062 | 641 | H>L | No | EVA | |
| rs3388985225 | 700 | I>T | No | EVA | |
| rs3388967442 | 740 | D>Y | No | EVA | |
| rs3388996181 | 750 | T>A | No | EVA | |
| rs3388990589 | 780 | H>N | No | EVA | |
| rs3388973958 | 785 | A>V | No | EVA | |
| rs3388950674 | 834 | C>W | No | EVA | |
| rs3388999385 | 850 | L>F | No | EVA | |
| rs3388995926 | 866 | K>N | No | EVA | |
| rs3388999026 | 905 | L>Q | No | EVA | |
| rs3388995955 | 916 | L>V | No | EVA | |
| rs226830813 | 935 | V>L | No | EVA | |
| rs226830813 | 935 | V>M | No | EVA | |
| rs3388950639 | 948 | V>I | No | EVA | |
| rs3388979423 | 954 | G>D | No | EVA | |
| rs3388995924 | 959 | F>L | No | EVA | |
| rs3388973893 | 972 | E>K | No | EVA | |
| rs3388994647 | 1056 | S>T | No | EVA | |
| rs253562067 | 1098 | R>K | No | EVA | |
| rs3388995936 | 1103 | T>S | No | EVA | |
| rs3388995889 | 1126 | E>K | No | EVA | |
| rs3388998240 | 1143 | V>D | No | EVA | |
| rs3388990590 | 1194 | T>I | No | EVA | |
| rs3388999037 | 1220 | Y>* | No | EVA | |
| rs3388967488 | 1238 | E>* | No | EVA | |
| rs3388990598 | 1243 | R>G | No | EVA | |
| rs3388999092 | 1253 | L>F | No | EVA | |
| rs3388999010 | 1285 | I>N | No | EVA | |
| rs3388985302 | 1321 | R>L | No | EVA | |
| rs3399361198 | 1343 | D>G | No | EVA |
No associated diseases with Q80WJ6
No regional properties for Q80WJ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q80WJ6 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ABC-type transporter activity | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATPase-coupled transmembrane transporter activity | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38735 | VMR1 | ABC transporter ATP-binding protein/permease VMR1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P0CE68 | NFT1 | ABC transporter NFT1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q8HXQ5 | ABCC1 | Multidrug resistance-associated protein 1 | Bos taurus (Bovine) | PR |
| Q2QLE5 | CFTR | Cystic fibrosis transmembrane conductance regulator | Pan troglodytes (Chimpanzee) | PR |
| P91660 | Rh5 | Probable multidrug resistance-associated protein lethal(2)03659 | Drosophila melanogaster (Fruit fly) | PR |
| P13569 | CFTR | Cystic fibrosis transmembrane conductance regulator | Homo sapiens (Human) | PR |
| O95255 | ABCC6 | ATP-binding cassette sub-family C member 6 | Homo sapiens (Human) | PR |
| O15438 | ABCC3 | ATP-binding cassette sub-family C member 3 | Homo sapiens (Human) | PR |
| Q92887 | ABCC2 | ATP-binding cassette sub-family C member 2 | Homo sapiens (Human) | SS |
| O15439 | ABCC4 | ATP-binding cassette sub-family C member 4 | Homo sapiens (Human) | PR |
| Q96J66 | ABCC11 | ATP-binding cassette sub-family C member 11 | Homo sapiens (Human) | PR |
| P33527 | ABCC1 | Multidrug resistance-associated protein 1 | Homo sapiens (Human) | PR |
| B2RX12 | Abcc3 | ATP-binding cassette sub-family C member 3 | Mus musculus (Mouse) | PR |
| Q8VI47 | Abcc2 | ATP-binding cassette sub-family C member 2 | Mus musculus (Mouse) | SS |
| O35379 | Abcc1 | Multidrug resistance-associated protein 1 | Mus musculus (Mouse) | PR |
| P26361 | Cftr | Cystic fibrosis transmembrane conductance regulator | Mus musculus (Mouse) | PR |
| Q6PQZ2 | CFTR | Cystic fibrosis transmembrane conductance regulator | Sus scrofa (Pig) | PR |
| Q8CG09 | Abcc1 | Multidrug resistance-associated protein 1 | Rattus norvegicus (Rat) | PR |
| Q63120 | Abcc2 | ATP-binding cassette sub-family C member 2 | Rattus norvegicus (Rat) | EV |
| Q6Y306 | Abcc12 | ATP-binding cassette sub-family C member 12 | Rattus norvegicus (Rat) | PR |
| Q00553 | CFTR | Cystic fibrosis transmembrane conductance regulator | Macaca mulatta (Rhesus macaque) | PR |
| Q9SKX0 | ABCC13 | ABC transporter C family member 13 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8H0 | ABCC12 | ABC transporter C family member 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C8G9 | ABCC1 | ABC transporter C family member 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZZ4 | ABCC6 | ABC transporter C family member 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M1C7 | ABCC9 | ABC transporter C family member 9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGEGPYLIS | DLDRRGHRRS | FAERYDPSLK | TMIPVRPRAR | LAPNPVDDAG | LLSFATFSWL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TPVMIRSYKH | TLTVDTLPPL | SPYDSSDINA | KRFQILWEEE | IKRVGPEKAS | LGRVVWKFQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TRVLMDVVAN | ILCIVMAALG | PTVLIHQILQ | HITSISSGHI | GIGICLCLAL | FTTEFTKVLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WALAWAINYR | TAIRLKVALS | TLIFENLLSF | KTLTHISAGE | VLNILSSDSY | SLFEAALFCP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPATIPILMV | VCAVYAFFIL | GSTALVGISV | YLIFIPIQMF | MAKLNSTFRR | SAISVTDKRV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QTMNEFLTCI | KLIKMYAWEE | SFINTIHDIR | KREKKLLEKA | GYVQSGNSAL | APIVSTIAIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| STFTCHIFLK | RKLTAPVAFS | VIAMFNVMKF | SIAILPFSVK | AVAEASVSLR | RMKKILIAKS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPSYITQPED | PDTILLLANA | TLTWEQEINR | KSDPPKAQIQ | KRHVFKKQRP | ELYSEQSRSD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QGVASPEWQS | GSPKSVLHNI | SFVVRKGKVL | GICGNVGSGK | SSLISALLGQ | MQLQKGVVAV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NGPLAYVSQQ | AWIFHGNVRE | NILFGEKYNH | QRYQHTVHVC | GLQKDLNSLP | YGDLTEIGER |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GVNLSGGQRQ | RISLARAVYA | NRQLYLLDDP | LSAVDAHVGK | HVFEECIKKT | LKGKTVVLVT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HQLQFLESCD | EVILLEDGEI | CEKGTHKELM | EERGRYAKLI | HNLRGLQFKD | PEHIYNVAMV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ETLKESPAQR | DEDAVLASGD | EKDEGKEPET | EEFVDTNAPA | HQLIQTESPQ | EGIVTWKTYH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TYIKASGGYL | VSFLVLCLFF | LMMGSSAFST | WWLGIWLDRG | SQVVCASQNN | KTACNVDQTL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| QDTKHHMYQL | VYIASMVSVL | MFGIIKGFTF | TNTTLMASSS | LHNRVFNKIV | RSPMSFFDTT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PTGRLMNRFS | KDMDELDVRL | PFHAENFLQQ | FFMVVFILVI | MAAVFPVVLV | VLAGLAVIFL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| ILLRIFHRGV | QELKQVENIS | RSPWFSHITS | SIQGLGVIHA | YDKKDDCISK | FKTLNDENSS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| HLLYFNCALR | WFALRMDILM | NIVTFVVALL | VTLSFSSISA | SSKGLSLSYI | IQLSGLLQVC |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VRTGTETQAK | FTSAELLREY | ILTCVPEHTH | PFKVGTCPKD | WPSRGEITFK | DYRMRYRDNT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PLVLDGLNLN | IQSGQTVGIV | GRTGSGKSSL | GMALFRLVEP | ASGTIIIDEV | DICTVGLEDL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| RTKLTMIPQD | PVLFVGTVRY | NLDPLGSHTD | EMLWHVLERT | FMRDTIMKLP | EKLQAEVTEN |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GENFSVGERQ | LLCMARALLR | NSKIILLDEA | TASMDSKTDT | LVQSTIKEAF | KSCTVLTIAH |
| 1330 | 1340 | 1350 | 1360 | ||
| RLNTVLNCDL | VLVMENGKVI | EFDKPEVLAE | KPDSAFAMLL | AAEVGL |