Q80UW5
Gene name |
Cdc42bpg |
Protein name |
Serine/threonine-protein kinase MRCK gamma |
Names |
CDC42-binding protein kinase gamma, DMPK-like gamma, Myotonic dystrophy kinase-related CDC42-binding kinase gamma, MRCK gamma, Myotonic dystrophy protein kinase-like gamma, Myotonic dystrophy protein kinase-like alpha |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:240505 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
212-236 (Activation loop from InterPro)
Target domain |
71-337 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q80UW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80UW5-F1 | Predicted | AlphaFoldDB |
69 variants for Q80UW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389521968 | 9 | E>D | No | EVA | |
| rs3408821410 | 22 | L>I | No | EVA | |
| rs3389525275 | 39 | A>P | No | EVA | |
| rs3389517054 | 54 | A>T | No | EVA | |
| rs3389525310 | 62 | K>R | No | EVA | |
| rs3389521521 | 70 | D>E | No | EVA | |
| rs3389521954 | 138 | F>I | No | EVA | |
| rs3412967854 | 158 | T>A | No | EVA | |
| rs3389469241 | 173 | Q>H | No | EVA | |
| rs3389533523 | 189 | L>M | No | EVA | |
| rs3389521149 | 218 | L>M | No | EVA | |
| rs3389533524 | 219 | R>C | No | EVA | |
| rs3408859107 | 234 | T>A | No | EVA | |
| rs3409010429 | 240 | P>L | No | EVA | |
| rs3389531202 | 252 | H>Q | No | EVA | |
| rs3389536715 | 286 | G>C | No | EVA | |
| rs3389521168 | 293 | D>N | No | EVA | |
| rs3389513375 | 312 | I>F | No | EVA | |
| rs3389469287 | 339 | G>W | No | EVA | |
| rs3389521527 | 381 | S>P | No | EVA | |
| rs3407907516 | 400 | S>C | No | EVA | |
| rs3409010441 | 408 | S>T | No | EVA | |
| rs3389521178 | 412 | M>K | No | EVA | |
| rs3389525319 | 415 | P>L | No | EVA | |
| rs3409010420 | 418 | T>A | No | EVA | |
| rs3389533451 | 468 | K>E | No | EVA | |
| rs3409298438 | 519 | R>L | No | EVA | |
| rs3408821408 | 522 | E>* | No | EVA | |
| rs3408225934 | 522 | E>D | No | EVA | |
| rs3408859124 | 522 | E>V | No | EVA | |
| rs3408859056 | 527 | L>R | No | EVA | |
| rs3389514294 | 560 | G>D | No | EVA | |
| rs3389526715 | 561 | Q>K | No | EVA | |
| rs3408532981 | 563 | T>A | No | EVA | |
| rs3389514264 | 567 | Q>H | No | EVA | |
| rs3389488059 | 591 | E>D | No | EVA | |
| rs3389533450 | 596 | G>* | No | EVA | |
| rs3389526759 | 648 | Q>L | No | EVA | |
| rs3409298450 | 669 | R>Q | No | EVA | |
| rs3389526714 | 767 | E>K | No | EVA | |
| rs3389429698 | 816 | S>C | No | EVA | |
| rs3389522491 | 817 | F>L | No | EVA | |
| rs3408931845 | 842 | E>V | No | EVA | |
| rs3389488078 | 850 | S>N | No | EVA | |
| rs3389514252 | 856 | V>L | No | EVA | |
| rs3389488037 | 927 | P>L | No | EVA | |
| rs3389531164 | 934 | R>L | No | EVA | |
| rs3389478210 | 935 | T>I | No | EVA | |
| rs3389526752 | 948 | A>V | No | EVA | |
| rs3389513430 | 970 | A>T | No | EVA | |
| rs3389536780 | 981 | D>E | No | EVA | |
| rs3389522522 | 999 | D>N | No | EVA | |
| rs3389522472 | 1027 | F>Y | No | EVA | |
| rs3409100101 | 1065 | R>Q | No | EVA | |
| rs3389429667 | 1140 | A>V | No | EVA | |
| rs3389514919 | 1178 | C>G | No | EVA | |
| rs3389521244 | 1194 | L>F | No | EVA | |
| rs3389478128 | 1207 | L>Q | No | EVA | |
| rs3389501194 | 1211 | P>S | No | EVA | |
| rs3389488020 | 1287 | S>G | No | EVA | |
| rs3389522482 | 1296 | A>V | No | EVA | |
| rs3389536722 | 1311 | E>A | No | EVA | |
| rs3389429704 | 1343 | R>* | No | EVA | |
| rs3389521188 | 1371 | K>E | No | EVA | |
| rs3389533509 | 1377 | L>I | No | EVA | |
| rs3389533512 | 1415 | D>G | No | EVA | |
| rs3408859037 | 1420 | Q>H | No | EVA | |
| rs3389521908 | 1477 | Q>L | No | EVA | |
| rs3389521924 | 1540 | S>T | No | EVA |
No associated diseases with Q80UW5
10 regional properties for Q80UW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CRIB domain | 1436 - 1472 | IPR000095 |
| domain | Protein kinase domain | 71 - 337 | IPR000719 |
| domain | AGC-kinase, C-terminal | 338 - 408 | IPR000961 |
| domain | Citron homology (CNH) domain | 1091 - 1371 | IPR001180 |
| domain | Pleckstrin homology domain | 946 - 1067 | IPR001849 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 877 - 926 | IPR002219 |
| active_site | Serine/threonine-protein kinase, active site | 191 - 203 | IPR008271 |
| domain | Myotonic dystrophy protein kinase, coiled coil | 743 - 797 | IPR014930 |
| binding_site | Protein kinase, ATP binding site | 77 - 100 | IPR017441 |
| domain | Protein kinase, C-terminal | 357 - 398 | IPR017892 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
| protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| localization | Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. |
| peptidyl-threonine phosphorylation | The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28021 | ROCK2 | Rho-associated protein kinase 2 | Bos taurus (Bovine) | SS |
| Q9W1B0 | gek | Serine/threonine-protein kinase Genghis Khan | Drosophila melanogaster (Fruit fly) | SS |
| O75116 | ROCK2 | Rho-associated protein kinase 2 | Homo sapiens (Human) | SS |
| Q13464 | ROCK1 | Rho-associated protein kinase 1 | Homo sapiens (Human) | SS |
| Q5VT25 | CDC42BPA | Serine/threonine-protein kinase MRCK alpha | Homo sapiens (Human) | EV |
| Q9Y5S2 | CDC42BPB | Serine/threonine-protein kinase MRCK beta | Homo sapiens (Human) | SS |
| Q7TT50 | Cdc42bpb | Serine/threonine-protein kinase MRCK beta | Mus musculus (Mouse) | SS |
| Q3UU96 | Cdc42bpa | Serine/threonine-protein kinase MRCK alpha | Mus musculus (Mouse) | SS |
| P70335 | Rock1 | Rho-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| P70336 | Rock2 | Rho-associated protein kinase 2 | Mus musculus (Mouse) | SS |
| M3TYT0 | ROCK2 | Rho-associated protein kinase 2 | Sus scrofa (Pig) | SS |
| O54874 | Cdc42bpa | Serine/threonine-protein kinase MRCK alpha | Rattus norvegicus (Rat) | SS |
| Q62868 | Rock2 | Rho-associated protein kinase 2 | Rattus norvegicus (Rat) | EV |
| Q63644 | Rock1 | Rho-associated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q7TT49 | Cdc42bpb | Serine/threonine-protein kinase MRCK beta | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQRLRALEQ | LVRGEAGGSP | GLDGLLDLLL | GVHQELSSAP | LRRERNVAQF | LSWASPFVTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VKELRLQRDD | FEILKVIGRG | AFGEVAVVRQ | RGSGQIFAMK | MLHKWEMLKR | AETACFREER |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVLVKGDSRW | VTALHYAFQD | EEYLYLVMDY | YAGGDLLTLL | SRFEDRLPPE | LAQFYLAEMV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAIHSLHQLG | YVHRDVKPDN | ILLDMNGHIR | LADFGSCLRL | NNNGMVDSSV | AVGTPDYISP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EILQAMEEGK | GHYGPQCDWW | SLGVCAYELL | FGETPFYAES | LVETYGKIMN | HEDHLQFPAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VTDVPASAQD | LIRQLLCRQE | ERLGRGGLDD | FRKHPFFEGV | DWERLATSTA | PYIPELRGPM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DTSNFDVDDD | TLNRPETLPP | SSHGAFSGHH | LPFVGFTYTS | GSPFDVQSSE | LMAAPEGTPH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CVEQVKVELS | HKCQEPLHGP | LQPQELVRLQ | KEVQVLQEKL | AETLRDSKAS | LSQTDGLHAR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SPAPNIQLQQ | EKDRLQQELT | EAQAALRVQD | AELCQAQNRQ | EEFLQRLWEA | QEREAAAASQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IQALNSQLEE | AWVVRRELEG | QVTTLSQEVT | RLQGQCKQES | SQAKTVHAAP | ETNGIGSPEG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QSQEAQLRKE | VAALREQLEH | ACSQGISVGK | EEVLCRLQEE | NQRLSREQER | LAGELELELQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SKQRLEGERR | ETESNWEAQI | ADILSWVNDE | KVSRGYLQAL | ATKMAEELES | LRNVGTQTLP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TRPLDHQWKA | RRLQKMEASA | RLELQSALEA | EIRAKQSLQE | QLTQVQEAQR | QAERRLQEAE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KQSQALQQEV | AELREELQAR | GPGDARPSTS | LIPLLSFWNT | EKDSAKDPGN | SGEGPRSGAE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AELRPEGRRS | LRMGSVFPRV | PAATTTPAEG | PPAKPGSHTL | RPRSFPSPTK | CLRCTSLMLG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LGRQGLGCDT | CGYFCHSACA | SQAPPCPVPP | ELLRTALGVH | PETGTGTAYE | GFLSVPRPSG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VRRGWQRVYA | ALSDSRLLLF | DAPDPRGSLA | SGVLLQALDL | RDPQFSATPV | LAPDVIHAQS |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| KDLPRIFRVT | ASQLTVPPTT | CTVLLLAENE | GERERWLQVL | GELQRLLLDA | RPRPRPVYTL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KEAYDNGLPL | LPHALCAAVI | DQERLALGTE | EGLFVIHLHS | NDIFQVGDCR | RVQRLAVSSA |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| AGLLAVLCGR | GPSVRLFALD | ELESAEVAGA | KIPESRGCQA | LVAGRILQAR | TPVLCVAVKR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| QVLCYQLGPG | PGPWQRRIRE | LQAPAPVQSL | GLLGDRLCVG | AAGTFALYPL | LNEAAPLALG |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TGLVAEELPA | SRGGLGEALG | AVELSLSELL | LLFATAGVYV | DSAGRKSRSH | ELLWPAAPTG |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| WGYTAPYLTV | FSENALDVFD | VRRAEWVQTV | PLKKVRPLNP | EGSLFLYGTE | KVRLTYLRNP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| LAEKDEFDIP | DLTDNSRRQL | FRTKSKRRFF | FRVSDELRQQ | QRREMLKDPF | VRSKFISPPT |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| NFNHLVHVGP | TEGRPNTRDG | TRAQEQKSRG | ARSSGPQRPH | SFSEAFRRPV | STGSDGLPGE |
| 1510 | 1520 | 1530 | 1540 | 1550 | |
| TDPLVKRKPW | TSLSSESVSC | PQGSLSPAAS | LIQVSERPRS | LPPDPESESS | P |