Q80UG2
SS
Gene name |
Plxna4 (Kiaa1550) |
Protein name |
Plexin-A4 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:243743 |
EC number |
|
Protein Class |
|
Descriptions
PlexA1 (NOV, PLXN1) plays a role in axon guidance, invasive growth and cell migration. Sema domain of PlexA1 restricts PlexA1 to a basal inactive state by binding to the remainder of the ectodomain. Deletion analysis of the PlexinA1 ectodomain demonstrates that the sema domain prevents PlexinA1 activation in the basal state. Sema-deleted PlexinA1 is constitutively active, producing cell contraction, growth cone collapse, and inhibition of neurite outgrowth. Plexin A1 is autoinhibited by its sema domain, and Sema3A/NP1 releases this inhibition. According to mouse Plexin-A3 (P70208), Plexin may possess a segment preceding C1 domain and an RDB domain as autoinhibitory elements.
Autoinhibitory domains (AIDs)
Target domain |
1310-1863 (Plexin, cytoplasmic RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
1310-1863 (Plexin, RasGAP domain) |
Relief mechanism |
|
Assay |
|
Target domain |
1310-1863 (Plexin, RasGAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Takahashi T et al. (2001) "Plexina1 autoinhibition by the plexin sema domain", Neuron, 29, 429-39
- He H et al. (2009) "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration", Proceedings of the National Academy of Sciences of the United States of America, 106, 15610-5
- Wang Y et al. (2012) "Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization", Science signaling, 5, ra6
Autoinhibited structure
Activated structure
95 variants for Q80UG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388815009 | 39 | F>S | No | EVA | |
| rs3388810722 | 47 | A>T | No | EVA | |
| rs3388820430 | 116 | M>T | No | EVA | |
| rs3388805761 | 124 | N>S | No | EVA | |
| rs3388820680 | 145 | L>I | No | EVA | |
| rs3388819187 | 182 | L>V | No | EVA | |
| rs3388821079 | 186 | T>I | No | EVA | |
| rs3388821151 | 205 | K>M | No | EVA | |
| rs3396537217 | 214 | A>S | No | EVA | |
| rs3388810644 | 239 | F>L | No | EVA | |
| rs3388824066 | 288 | A>S | No | EVA | |
| rs3396785348 | 299 | C>* | No | EVA | |
| rs3396628570 | 299 | C>S | No | EVA | |
| rs3396203340 | 300 | E>Q | No | EVA | |
| rs3388826691 | 306 | Y>H | No | EVA | |
| rs3388820944 | 310 | Q>L | No | EVA | |
| rs3388816470 | 320 | V>M | No | EVA | |
| rs3388820907 | 322 | G>D | No | EVA | |
| rs3388820966 | 336 | T>A | No | EVA | |
| rs3396452595 | 346 | M>R | No | EVA | |
| rs3388826619 | 372 | S>F | No | EVA | |
| rs3396537284 | 386 | K>R | No | EVA | |
| rs3388820469 | 428 | R>S | No | EVA | |
| rs3388815025 | 446 | F>L | No | EVA | |
| rs3388821113 | 451 | S>G | No | EVA | |
| rs3388820942 | 469 | Y>H | No | EVA | |
| rs3388814538 | 477 | S>L | No | EVA | |
| rs3388814548 | 477 | S>T | No | EVA | |
| rs3388814518 | 498 | E>K | No | EVA | |
| rs3388815015 | 506 | V>E | No | EVA | |
| rs3396450290 | 535 | C>Y | No | EVA | |
| rs3388821155 | 539 | E>K | No | EVA | |
| rs3388821167 | 637 | K>M | No | EVA | |
| rs3388815019 | 711 | V>L | No | EVA | |
| rs3388820657 | 717 | K>R | No | EVA | |
| rs3388805722 | 719 | I>V | No | EVA | |
| rs3388800788 | 728 | Q>H | No | EVA | |
| rs3396626531 | 837 | C>W | No | EVA | |
| rs3388810626 | 899 | E>* | No | EVA | |
| rs3388826641 | 1016 | M>K | No | EVA | |
| rs3388800761 | 1019 | T>DG* | No | EVA | |
| rs3388810643 | 1019 | T>S | No | EVA | |
| rs3388820917 | 1021 | Q>E | No | EVA | |
| rs3388808269 | 1022 | V>M | No | EVA | |
| rs3388820672 | 1023 | D>Y | No | EVA | |
| rs258886619 | 1036 | V>M | No | EVA | |
| rs3388787490 | 1044 | I>T | No | EVA | |
| rs3388800780 | 1048 | W>R | No | EVA | |
| rs3388824033 | 1066 | L>I | No | EVA | |
| rs3388819213 | 1099 | A>S | No | EVA | |
| rs3388810631 | 1103 | G>C | No | EVA | |
| rs3388820908 | 1116 | E>K | No | EVA | |
| rs3388820594 | 1121 | L>Q | No | EVA | |
| rs3388820945 | 1129 | I>F | No | EVA | |
| rs3388826595 | 1158 | T>S | No | EVA | |
| rs3388815034 | 1211 | V>E | No | EVA | |
| rs3388826605 | 1211 | V>M | No | EVA | |
| rs3388819199 | 1242 | A>T | No | EVA | |
| rs3388808283 | 1243 | V>M | No | EVA | |
| rs3388820918 | 1251 | F>Y | No | EVA | |
| rs3388815073 | 1268 | L>F | No | EVA | |
| rs3388820667 | 1321 | M>L | No | EVA | |
| rs3388819167 | 1322 | R>Q | No | EVA | |
| rs3388810702 | 1328 | I>F | No | EVA | |
| rs3388810653 | 1337 | L>P | No | EVA | |
| rs3388808298 | 1344 | Q>* | No | EVA | |
| rs3388814592 | 1362 | V>M | No | EVA | |
| rs3388816435 | 1370 | T>S | No | EVA | |
| rs3388826678 | 1400 | A>V | No | EVA | |
| rs3388819206 | 1509 | V>A | No | EVA | |
| rs3388787515 | 1516 | V>L | No | EVA | |
| rs3388816466 | 1518 | I>L | No | EVA | |
| rs3388787475 | 1519 | L>H | No | EVA | |
| rs3388805737 | 1532 | L>I | No | EVA | |
| rs3388805797 | 1565 | Q>H | No | EVA | |
| rs3388805780 | 1578 | K>N | No | EVA | |
| rs3388821104 | 1582 | T>I | No | EVA | |
| rs3388820417 | 1590 | D>N | No | EVA | |
| rs3388815010 | 1595 | A>T | No | EVA | |
| rs3388808306 | 1618 | S>C | No | EVA | |
| rs3388821114 | 1641 | T>N | No | EVA | |
| rs3388815074 | 1667 | R>W | No | EVA | |
| rs3388820600 | 1669 | S>C | No | EVA | |
| rs3388826652 | 1683 | T>I | No | EVA | |
| rs3388820614 | 1685 | G>D | No | EVA | |
| rs3388824071 | 1717 | D>V | No | EVA | |
| rs3507809344 | 1724 | D>N | No | EVA | |
| rs3388815006 | 1741 | C>S | No | EVA | |
| rs3388787480 | 1764 | S>I | No | EVA | |
| rs3388819227 | 1799 | Y>N | No | EVA | |
| rs3388813147 | 1800 | A>T | No | EVA | |
| rs3388810683 | 1807 | K>* | No | EVA | |
| rs3396598557 | 1809 | W>L | No | EVA | |
| rs3388816448 | 1815 | S>L | No | EVA | |
| rs3388819224 | 1885 | V>I | No | EVA |
No associated diseases with Q80UG2
15 regional properties for Q80UG2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Sema domain | 23 - 506 | IPR001627 |
| repeat | Plexin repeat | 508 - 557 | IPR002165-1 |
| repeat | Plexin repeat | 654 - 695 | IPR002165-2 |
| repeat | Plexin repeat | 803 - 854 | IPR002165-3 |
| domain | IPT domain | 856 - 950 | IPR002909-1 |
| domain | IPT domain | 952 - 1036 | IPR002909-2 |
| domain | IPT domain | 1038 - 1138 | IPR002909-3 |
| domain | IPT domain | 1140 - 1229 | IPR002909-4 |
| domain | Plexin, cytoplasmic RasGAP domain | 1310 - 1863 | IPR013548 |
| domain | PSI domain | 508 - 558 | IPR016201-1 |
| domain | PSI domain | 654 - 701 | IPR016201-2 |
| domain | PSI domain | 802 - 855 | IPR016201-3 |
| domain | Plexin, TIG domain 1 | 563 - 653 | IPR041019 |
| domain | Plexin, TIG domain 2 | 708 - 801 | IPR041362 |
| domain | Plexin, cytoplasmic RhoGTPase-binding domain | 1484 - 1596 | IPR046800 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cerebellar climbing fiber to Purkinje cell synapse | A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| semaphorin receptor complex | A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| semaphorin receptor activity | Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
27 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior commissure morphogenesis | Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| branchiomotor neuron axon guidance | The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
| chemorepulsion of branchiomotor axon | The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
| cranial nerve morphogenesis | The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. |
| embryonic heart tube development | The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. |
| facial nerve morphogenesis | The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. |
| facial nerve structural organization | The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. |
| glossopharyngeal nerve morphogenesis | The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. |
| maintenance of synapse structure | A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| negative regulation of cell adhesion | Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| positive regulation of axonogenesis | Any process that activates or increases the frequency, rate or extent of axonogenesis. |
| postganglionic parasympathetic fiber development | The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example |
| regulation of axon extension involved in axon guidance | Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of negative chemotaxis | Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. |
| semaphorin-plexin signaling pathway | The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| semaphorin-plexin signaling pathway involved in axon guidance | Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
| sympathetic nervous system development | The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. |
| sympathetic neuron axon guidance | The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| trigeminal nerve morphogenesis | The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. |
| trigeminal nerve structural organization | The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. |
| vagus nerve morphogenesis | The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q769I5 | MET | Hepatocyte growth factor receptor | Bos taurus (Bovine) | PR |
| A0M8S8 | MET | Hepatocyte growth factor receptor | Felis catus (Cat) (Felis silvestris catus) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| O43157 | PLXNB1 | Plexin-B1 | Homo sapiens (Human) | EV SS |
| O75051 | PLXNA2 | Plexin-A2 | Homo sapiens (Human) | SS |
| P51805 | PLXNA3 | Plexin-A3 | Homo sapiens (Human) | SS |
| Q9UIW2 | PLXNA1 | Plexin-A1 | Homo sapiens (Human) | EV SS |
| O15031 | PLXNB2 | Plexin-B2 | Homo sapiens (Human) | SS |
| Q9ULL4 | PLXNB3 | Plexin-B3 | Homo sapiens (Human) | SS |
| Q9HCM2 | PLXNA4 | Plexin-A4 | Homo sapiens (Human) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| B2RXS4 | Plxnb2 | Plexin-B2 | Mus musculus (Mouse) | SS |
| P70206 | Plxna1 | Plexin-A1 | Mus musculus (Mouse) | EV SS |
| P70207 | Plxna2 | Plexin-A2 | Mus musculus (Mouse) | SS |
| Q3UH93 | Plxnd1 | Plexin-D1 | Mus musculus (Mouse) | SS |
| Q8CJH3 | Plxnb1 | Plexin-B1 | Mus musculus (Mouse) | SS |
| Q9QY40 | Plxnb3 | Plexin-B3 | Mus musculus (Mouse) | SS |
| Q9QZC2 | Plxnc1 | Plexin-C1 | Mus musculus (Mouse) | SS |
| P70208 | Plxna3 | Plexin-A3 | Mus musculus (Mouse) | EV SS |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| D3ZPX4 | Plxna3 | Plexin-A3 | Rattus norvegicus (Rat) | SS |
| D3ZLH5 | Plxnb3 | Plexin-B3 | Rattus norvegicus (Rat) | SS |
| B0S5N4 | plxna3 | Plexin A3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6BEA0 | plxna4 | Plexin-A4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAMPWNWTC | LLSHLLVVGM | GSSTLLPRQP | PQLSQKPSFV | TFRGEPAEGF | NHLVVDERTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HIYLGAVNRI | YKLSSDLKVL | VTHQTGPDED | NPKCYPPRIV | QTCNEPLAST | NNVNKMLLID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YKENRLIACG | SLYQGICKLL | RLEDLFKLGE | PFHKKEHYLS | GVNESGSVFG | VIVSYSNFDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLFIATAVDG | KPEYFPTISS | RKLTKNSEAD | GMFAYVFHDE | FVASMIKIPS | DTFTVIPDFD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IYYVYGFSSG | NFVYFLTLQP | EMVSPPGSTT | KEQVYTSKLV | RLCKEDTAFN | SYVEVPIGCE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RNGVEYRLLQ | AAYLSKAGAV | LGRTLGVRPD | DDLLFTVFSK | GQKRKMKSLD | ESALCIFILK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QINDRIKDRL | QSCYRGEGTL | DLAWLKVKDI | PCSSALLTID | DNFCGLDMNA | PLGVSEMVRG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IPVFTEDRDR | MTSVIAYVYK | NHSLAFVGTK | SGKLKKIRVD | GPKGNALQYE | TVQVVDSGPV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LRDMAFSKDH | EQLYIMSERQ | LTRVPVESCG | QYRSCGECLG | SGDPHCGWCV | LHNTCTRKER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CERSREPRRF | ASEMKQCVRL | TVHPNNISVS | QYNVLLVLET | YNVPELSAGV | NCTFEDLSEM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DGLVIGNQIQ | CYSPAAKEVP | RIITENGDHH | VVQLQLKSKE | TGMTFASTSF | VFYNCSVHNS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| CLSCVESPYR | CHWCKYRHVC | THDPNTCSFQ | EGRVKLPEDC | PQLLRVDKIL | VPVEVIKPIT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LKAKNLPQPQ | SGQRGYECIL | NIQGIEQRVP | ALRFNSSSVQ | CQNTSYSYEG | MEINNLPVEL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TVVWNGHFNI | DNPAQNKVYL | YKCGAMRESC | GLCLKADPDF | ECGWCQSPGQ | CTLRQHCPAH |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ESRWLELSGA | NSKCTNPRIT | EIIPVTGPRE | GGTKVTIRGE | NLGLEFRDIA | SHVKVAGVEC |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SPLVDGYIPA | EQIVCEMGEA | KPSQHAGFVE | ICVAVCRPEF | MARSSQLYYF | MTLTLADLKP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NRGPMSGGTQ | VTITGTNLNA | GSNVVVMFGS | QPCLFHRRSP | SYIICNTTSS | EEVLDMKVTV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| QVDRARIRQD | LVFQYVEDPT | IVRIEPEWSI | VSGNTPIAVW | GTHLDLIQNP | QIRAKHGGKE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| HINICEVLNA | TEMTCQAPAL | ALGPDHQSDL | TERPEEFGFI | LDNVQSLLIL | NKTNFTYYPN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PVFEAFSPSG | ILELKPGTPI | ILKGKNLIPP | VAGGNVKLNY | TVLVGEKPCT | VTVSDVQLLC |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| ESPNLIGRHK | VMARVGGMEY | SPGMVYIAPD | SPLSLPAIVS | IAVAGGLLII | FIVAVLIAYK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| RKSRESDLTL | KRLQMQMDNL | ESRVALECKE | AFAELQTDIH | ELTSDLDGAG | IPFLDYRTYT |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| MRVLFPGIED | HPVLRDLEVP | GYRQERVEKG | LKLFAQLINN | KVFLLSFIRT | LESQRSFSMR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| DRGNVASLIM | TVLQSKLEYA | TDVLKQLLAD | LIDKNLESKN | HPKLLLRRTE | SVAEKMLTNW |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| FTFLLYKFLK | ECAGEPLFSL | FCAIKQQMEK | GPIDAITGEA | RYSLSEDKLI | RQQIEYKTLV |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| LSCVSPDNVN | SPEVPVKILN | CDTITQVKEK | ILDAIFKNVP | CSHRPKAADM | DLEWRQGSGA |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| RMILQDEDIT | TKIENDWKRL | NTVAHYQVPD | GSVVALVSKQ | VTAYNAVNNS | TVSRTSASKY |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| ENMIRYTGSP | DSLRSRTPMI | TPDLESGVKL | WHLVKNHEHG | DQKEGDRGSK | MVSEIYLTRL |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LATKGTLQKF | VDDLFETIFS | TAHRGSALPL | AIKYMFDFLD | EQADKHGIHD | PHVRHTWKSN |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| CLPLRFWVNM | IKNPQFVFDI | HKNSITDACL | SVVAQTFMDS | CSTSEHRLGK | DSPSNKLLYA |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| KDIPSYKNWV | ERYYSDIGKM | PAISDQDMNA | YLAEQSRMHM | NEFNTMSALS | EIFSYVGKYS |
| 1870 | 1880 | 1890 | |||
| EEILGPLDHD | DQCGKQKLAY | KLEQVITLMS | LDS |