Q80TE7
PR
Gene name |
Lrrc7 (Kiaa1365, Lap1) |
Protein name |
Leucine-rich repeat-containing protein 7 |
Names |
Densin-180, Densin, Protein LAP1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:242274 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80TE7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80TE7-F1 | Predicted | AlphaFoldDB |
No variants for Q80TE7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q80TE7 | |||||
No associated diseases with Q80TE7
16 regional properties for Q80TE7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PDZ domain | 1403 - 1488 | IPR001478 |
| repeat | Leucine-rich repeat | 46 - 102 | IPR001611-1 |
| repeat | Leucine-rich repeat | 162 - 219 | IPR001611-2 |
| repeat | Leucine-rich repeat | 254 - 275 | IPR001611-3 |
| repeat | Leucine-rich repeat | 346 - 402 | IPR001611-4 |
| repeat | Leucine-rich repeat, typical subtype | 48 - 68 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 91 - 113 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 137 - 159 | IPR003591-3 |
| repeat | Leucine-rich repeat, typical subtype | 160 - 182 | IPR003591-4 |
| repeat | Leucine-rich repeat, typical subtype | 183 - 205 | IPR003591-5 |
| repeat | Leucine-rich repeat, typical subtype | 206 - 228 | IPR003591-6 |
| repeat | Leucine-rich repeat, typical subtype | 229 - 252 | IPR003591-7 |
| repeat | Leucine-rich repeat, typical subtype | 253 - 274 | IPR003591-8 |
| repeat | Leucine-rich repeat, typical subtype | 275 - 298 | IPR003591-9 |
| repeat | Leucine-rich repeat, typical subtype | 321 - 344 | IPR003591-10 |
| repeat | Leucine-rich repeat, typical subtype | 367 - 389 | IPR003591-11 |
14 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| axon initial segment | Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| dendritic spine | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| integral component of postsynaptic density membrane | The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein C-terminus binding | Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| positive regulation of neuron projection development | Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| receptor clustering | The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. |
| receptor localization to synapse | Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. |
40 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHH9 | ECM2 | Extracellular matrix protein 2 | Bos taurus (Bovine) | PR |
| P58874 | OPTC | Opticin | Bos taurus (Bovine) | PR |
| Q24K06 | LRRC10 | Leucine-rich repeat-containing protein 10 | Bos taurus (Bovine) | PR |
| Q9V780 | Lap1 | Protein lap1 | Drosophila melanogaster (Fruit fly) | PR |
| Q8IWT6 | LRRC8A | Volume-regulated anion channel subunit LRRC8A | Homo sapiens (Human) | PR |
| Q9HCJ2 | LRRC4C | Leucine-rich repeat-containing protein 4C | Homo sapiens (Human) | PR |
| Q9UFC0 | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 | Homo sapiens (Human) | PR |
| Q96L50 | LRR1 | Leucine-rich repeat protein 1 | Homo sapiens (Human) | PR |
| Q86UN2 | RTN4RL1 | Reticulon-4 receptor-like 1 | Homo sapiens (Human) | PR |
| Q8IWK6 | ADGRA3 | Adhesion G protein-coupled receptor A3 | Homo sapiens (Human) | PR |
| Q7L1W4 | LRRC8D | Volume-regulated anion channel subunit LRRC8D | Homo sapiens (Human) | PR |
| Q96FE5 | LINGO1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Homo sapiens (Human) | PR |
| Q8TDW0 | LRRC8C | Volume-regulated anion channel subunit LRRC8C | Homo sapiens (Human) | PR |
| Q38SD2 | LRRK1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Homo sapiens (Human) | EV |
| Q96NW7 | LRRC7 | Leucine-rich repeat-containing protein 7 | Homo sapiens (Human) | PR |
| A6H694 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Mus musculus (Mouse) | PR |
| Q9D9Q0 | Lrrc69 | Leucine-rich repeat-containing protein 69 | Mus musculus (Mouse) | PR |
| Q8BGI7 | Lrrc39 | Leucine-rich repeat-containing protein 39 | Mus musculus (Mouse) | PR |
| Q7TT36 | Adgra3 | Adhesion G protein-coupled receptor A3 | Mus musculus (Mouse) | PR |
| P59383 | Lrrn4 | Leucine-rich repeat neuronal protein 4 | Mus musculus (Mouse) | PR |
| Q9D1T0 | Lingo1 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q8R502 | Lrrc8c | Volume-regulated anion channel subunit LRRC8C | Mus musculus (Mouse) | PR |
| Q80WG5 | Lrrc8a | Volume-regulated anion channel subunit LRRC8A | Mus musculus (Mouse) | PR |
| Q8K0S5 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Mus musculus (Mouse) | PR |
| Q5DU41 | Lrrc8b | Volume-regulated anion channel subunit LRRC8B | Mus musculus (Mouse) | PR |
| Q5RKR3 | Islr2 | Immunoglobulin superfamily containing leucine-rich repeat protein 2 | Mus musculus (Mouse) | PR |
| Q8C031 | Lrrc4c | Leucine-rich repeat-containing protein 4C | Mus musculus (Mouse) | PR |
| P70175 | Dlg3 | Disks large homolog 3 | Mus musculus (Mouse) | SS |
| Q811D0 | Dlg1 | Disks large homolog 1 | Mus musculus (Mouse) | SS |
| Q62108 | Dlg4 | Disks large homolog 4 | Mus musculus (Mouse) | SS |
| Q91XM9 | Dlg2 | Disks large homolog 2 | Mus musculus (Mouse) | SS |
| Q4V8G0 | Lrrc63 | Leucine-rich repeat-containing protein 63 | Rattus norvegicus (Rat) | PR |
| Q80WD0 | Rtn4rl1 | Reticulon-4 receptor-like 1 | Rattus norvegicus (Rat) | PR |
| P70587 | Lrrc7 | Leucine-rich repeat-containing protein 7 | Rattus norvegicus (Rat) | PR |
| Q9TZM3 | lrk-1 | Leucine-rich repeat serine/threonine-protein kinase 1 | Caenorhabditis elegans | SS |
| Q9SHI4 | RLP3 | Receptor-like protein 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5G5E0 | PIRL5 | Plant intracellular Ras-group-related LRR protein 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B0JZ65 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q68F79 | lrrc8e | Volume-regulated anion channel subunit LRRC8E | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| B0R160 | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTTKRKLIGR | LVPCRCFRGE | EEIISVLDYS | HCSLQQVPKE | VFNFERTLEE | LYLDANQIEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPKQLFNCQA | LRKLSIPDND | LSSLPTSIAS | LVNLKELDIS | KNGVQEFPEN | IKCCKCLTII |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EASVNPISKL | PDGFTQLLNL | TQLYLNDAFL | EFLPANFGRL | VKLRILELRE | NHLKTLPKSM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HKLAQLERLD | LGNNEFSELP | EVLDQIQNLR | ELWMDNNALQ | VLPGSIGKLK | MLVYLDMSKN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIETVDMDIS | GCEALEDLLL | SSNMLQQLPD | SIGLLKKLTT | LKVDDNQLTM | LPNTIGNLSL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEEFDCSCNE | LESLPPTIGY | LHSLRTLAVD | ENFLPELPRE | IGSCKNVTVM | SLRSNKLEFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEEIGQMQRL | RVLNLSDNRL | KNLPFSFTKL | KELAALWLSD | NQSKALIPLQ | TEAHPETKQR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLTNYMFPQQ | PRGDEDFQSD | SDSFNPTLWE | EQRQQRMTVA | FEFEDKKEDD | ESAGKVKALS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CQAPWDRGQR | GITLQPARLS | GDCCTPWARC | DQQIQDMPVP | QSDPQLAWGC | ISGLQQERSM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CAPLPVAAQS | TTLPSLSGRQ | VEINLKRYPT | PYPEDLKNMV | KSVQNLVGKP | SHGVRVENSN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PTANTEQTVK | EKFEHKWPVA | PKEITVEDSF | VHPANEMRIG | ELHPSLAETP | LYPPKLVLLG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KDKKESTDES | EVDKTHCLNN | SVSSGTYSDY | SPSQASSASS | NTRMKVGSLQ | ATAKDAVHNS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LWGNRIAPPF | PQPLDAKPLL | SQREAVPPGN | IPQRPDRLPM | SDAFPDNWTD | GSHYDNTGFV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SEEAAGENAN | NNPLLSSKAR | SVPAHGRRPL | IRQERIVGVP | LELEQSTHRH | TPETEVPPSN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PWQNWTRTPS | PFEDRTAFPS | KLETTPTTSP | LPERKDHMKE | PTETPGPFSP | GVPWEYHDPT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PNRSLGNVFS | QIHCRPDSSK | GVIAISKSTE | RLSPLMKDIK | SNKFKKSQSI | DEIDVGTYKV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YNIPLENYAS | GSDHLGSHER | PDKFLGPEHG | MSSMSRSQSV | PMLDDEMLMY | GSSKGPPQQK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ASMTKKVYQF | DQSFNPQGAV | EVKAEKRIPP | PFAHNSEYVQ | QPSKNIAKDL | VSPRAYRGYP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PMEQMFSFSQ | PSVNEDAMVN | AQFASQGPRA | GFLRRADSLA | SSTEMAMFRR | VSEPHELPPG |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| DRYGRATYRG | GLEGQSSISM | TDPQFLKRNG | RYEDEHPSYQ | EVKAQAGSFP | AKNLTQRRPL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SARSYSTESY | GASQTRPVSA | RPTMAALLEK | IPSDYNLGNY | GDKTSDNSDI | KTRPTPVKGE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ESCGKMPADW | RQQLLRHIEA | RRLDRTPSQQ | SNILDNGQED | VSPSGQWNPY | PLGRRDVPPD |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| TITKKAGSHI | QTLMGSQSLQ | HRSREQQPYE | GNINKVTIQQ | FQSPLPIQIP | SSQATRGPQP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| GRCLIQTKGQ | RSMDGYPEQF | CVRIEKNPGL | GFSISGGISG | QGNPFKPSDK | GIFVTRVQPD |
| 1450 | 1460 | 1470 | 1480 | ||
| GPASNLLQPG | DKILQANGHS | FVHMEHEKAV | LLLKSFQNTV | DLVIQRELTV |