Q803U7

SS
Gene name
exo1 (zgc:55521)
Protein name
Exonuclease 1
Names
EC 3.1.-.- , Exonuclease I
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:406778
EC number
3.1.-.-: Acting on ester bonds
Protein Class

Descriptions

Human exonuclease 1 (Exo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity. It is a member of the 50 structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, XPG, and GEN1.<br>Upon mismatch recognition, first MutSα searches for Exo1 via bidirectional, one-dimensional diffusion along the DNA. Next, MutSα encounters Exo1 prebound at a nick and interacts with the C-terminal domain of Exo1, thereby alleviating the autoinhibition of the Exo1.

Autoinhibitory domains (AIDs)

285-348 (C-terminal autoinhibitory region) SS

Target domain

1-201 (Exonuclease 1-like domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q803U7

Entry ID Method Resolution Chain Position Source
AF-Q803U7-F1 Predicted AlphaFoldDB

No variants for Q803U7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q803U7

No associated diseases with Q803U7

8 regional properties for Q803U7

Type Name Position InterPro Accession
domain XPG, N-terminal 1 - 99 IPR006085
domain XPG-I domain 138 - 225 IPR006086
conserved_site Helix-hairpin-helix motif, class 2 212 - 245 IPR008918
repeat Tetratricopeptide repeat 96 - 129 IPR019734
conserved_site XPG conserved site 71 - 85 IPR019974-1
conserved_site XPG conserved site 141 - 155 IPR019974-2
domain Exonuclease-1, H3TH domain 213 - 289 IPR037315
domain Exonuclease 1-like, PIN-like domain 1 - 202 IPR044752

Functions

Description
EC Number 3.1.-.- Acting on ester bonds
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
5'-3' DNA exonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule.
5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis.
metal ion binding Binding to a metal ion.
single-stranded DNA 5'-3' DNA exonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule.

3 GO annotations of biological process

Name Definition
DNA double-strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12086 DIN7 DNA damage-inducible protein DIN7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9UQ84 EXO1 Exonuclease 1 Homo sapiens (Human) EV
Q9QZ11 Exo1 Exonuclease 1 Mus musculus (Mouse) SS
10 20 30 40 50 60
MGIQGLLQFI KDASEPMHVK KYRGQTVAVD TYCWLHKGAF SCAEKLAKGE PTDQYVSYCM
70 80 90 100 110 120
KFVDMLLSFG VKPILVFDGR NLPSKQEVEK SRRERRQANL QKGKQLLREG KITEARECFT
130 140 150 160 170 180
RSVNITPSMA HDVIRAARTR GVDCVVAPYE ADAQLAFLNK SDIAQAVITE DSDLLAFGCK
190 200 210 220 230 240
KVILKMDKQG NGLEIEQCHL GRCKSLGNIF TEEKFRYMCI LSGCDYLQSL YGIGLGKACK
250 260 270 280 290 300
LLRMANNPDI LKVIKKMGQY LKMDISVPEE YIEGFTKANN TFLYQLVFDP LRRKVVPLNP
310 320 330 340 350 360
YPDHINPAAL SYAGTNVGDE KGLQMALGNL DINTMQRIDD FNPDAPQTQP PKAPRSSSWN
370 380 390 400 410 420
DRCDKTATTQ ASIWSQNYEP GCTKSQSPTS PKRPPPTRGK ERIVSVQSLK LPQRESQVKR
430 440 450 460 470 480
PREDTSLSVD DLLEQYTAGV KRHCPETQPT TKPLTNDNKV SKENHCGSTS GPFRPRNRFA
490 500 510 520 530 540
TLLQWRNRSE EGTEEQGTCS RFFCHDESNI AETQEDSKQD SSQSVESQEK HVSQSGGDTS
550 560 570 580 590 600
SLCEEPEREQ DKDEPSSPPA SPSCSSRPAS VGLGVFSWSG TTKELNKSVS HPARDSTERQ
610 620 630 640 650 660
RSSSTPSGLS TLQQFHRNKA RISWAGPGLS LSSSPVEGSE DAGNSPGSPP SQDSAYFSQS
670 680 690 700 710 720
SSISASVENS LVTEDNSDKE KERDSVVSNS PSSSPLDRLK PAVNRTKVSG LSRKGACGQG
730 740 750 760 770 780
KGGKIETSAP ARASGLRRKP SGKKNVNNEN SPGLQATISG LWGAFSFKKD SPKLSATKKG
790 800
EPMSPVGENV VMETTQADKE IFIIAE