Q7ZYI3

SS
Gene name
mdm4 (mdmx)
Protein name
Protein Mdm4
Names
Double minute 4 protein, Mdm2-like p53-binding protein, Mdmx protein, p53-binding protein Mdm4
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398466
EC number
Protein Class

Descriptions

MDM4 is a homologous protein that binds to p53 and regulates its activity. Intrinsically disordered region constitute an inhibitory module. It competes with the p53TAD for binding to the NTD of MDM4, thus lowering the affinity of MDMX for p53. Efficient binding of MDM4 to p53 requires a mechanism to relieve the allosteric self-inhibition.

Autoinhibitory domains (AIDs)

182-202 (Tryptohpan-rich segment) SS

Target domain

26-109 (SWIB/MDM2 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZYI3

Entry ID Method Resolution Chain Position Source
AF-Q7ZYI3-F1 Predicted AlphaFoldDB

No variants for Q7ZYI3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZYI3

No associated diseases with Q7ZYI3

2 regional properties for Q7ZYI3

Type Name Position InterPro Accession
domain Zinc finger, RanBP2-type 296 - 325 IPR001876
domain SWIB/MDM2 domain 26 - 109 IPR003121

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTSTALHLM DEQDPAPTTI QNTEESLVRV QPALLKILQS AGAKGDMFTL KQVMHYLGQY
70 80 90 100 110 120
IMVKGLYDKQ HQHIVHCGSD ELGKLLGITT FSVKDPRPLY DMLKKNLLRI SCTDAGHSPS
130 140 150 160 170 180
RNKSQASDSL ELEKSFASKT EVTDVIKRND CVSSDMCTSF DNSHLKGNES SDYTKQSLDF
190 200 210 220 230 240
IFEEWDEAGL PWWFLGNLRT NYNLQSIGST DIPSNQDIDT ATVSDTTDDM WFLNDSRTDR
250 260 270 280 290 300
INMEVKMESS DSLEEEVGEC DSKKPAQMIE LTLYEDDDDL DDTQSLSEDT DTEVTSEECW
310 320 330 340 350 360
QCTKCHKFNS PVKRYCYRCW ALRKDWYLDF PRLIHSSSTP TLPGKVSSQM IVDGLDIPDC
370 380 390 400 410 420
RRTVSAPMVG VQVPECRSLV PFLEPLDLAA NSKAFSESTD TLLTFKAAEA SLLSSRPLLE
430 440 450 460 470
PCQLCQRRQR NGSVVHGRTA HLVTCFSCAC NLKKNQKGCP VCEKPIQMVV KIYVA