Q7ZUN8

SS
Gene name
ykt6 (zgc:55536)
Protein name
Synaptobrevin homolog YKT6
Names
EC 2.3.1.-
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:394067
EC number
2.3.1.-: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

Most SNAREs are permanently anchored to membranes, but the dually lipidated SNARE Ykt6 is found both on intracellular membranes and in the cytoplasm. The SNARE core is autoinhibited by the N-terminal longin domain. <br>The dynamics of Ykt6 are believed to be governed by the reversible palmitoylation of the protein, which cycles Ykt6 between intracellular membranes and the cytoplasm. Palmitoylation of Ykt6 increases the partition coefficient of Ykt6 to membranes, thereby shifting some populations of the protein from the cytosol to cellular membranes. Palmitoylation-mediated membrane insertion will further shift the conformational equilibrium of Ykt6 to the open state. The specific membrane localization and the amount of membrane-associated Ykt6 are predicted to be affected by its reversible palmitoylation machinery in cells, as the majority of Ykt6 exists in the unpalmitoylated cytosolic form

Autoinhibitory domains (AIDs)

7-127 (Longin domain) SS

Target domain

138-198 (v-SNARE coiled-coil homology)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZUN8

Entry ID Method Resolution Chain Position Source
AF-Q7ZUN8-F1 Predicted AlphaFoldDB

No variants for Q7ZUN8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZUN8

No associated diseases with Q7ZUN8

3 regional properties for Q7ZUN8

Type Name Position InterPro Accession
domain Longin domain 4 - 131 IPR010908
domain v-SNARE, coiled-coil homology domain 136 - 198 IPR042855
domain YKT6, SNARE motif 136 - 195 IPR045848

Functions

Description
EC Number 2.3.1.- Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasmic vesicle membrane ; Lipid-anchor ; Cytoplasmic side
  • Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side
  • Probably cycles through vesicles between Golgi and endosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

2 GO annotations of molecular function

Name Definition
SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

2 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36015 YKT6 Synaptobrevin homolog YKT6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q3T000 YKT6 Synaptobrevin homolog YKT6 Bos taurus (Bovine) SS
O15498 YKT6 Synaptobrevin homolog YKT6 Homo sapiens (Human) SS
Q9CQW1 Ykt6 Synaptobrevin homolog YKT6 Mus musculus (Mouse) SS
Q5EGY4 Ykt6 Synaptobrevin homolog YKT6 Rattus norvegicus (Rat) EV
Q9LVM9 YKT62 VAMP-like protein YKT62 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZRD6 YKT61 VAMP-like protein YKT61 Arabidopsis thaliana (Mouse-ear cress) SS
Q6P816 ykt6 Synaptobrevin homolog YKT6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MKLYSLSVLH KGSTKANLLK ATYDLSSFSF FQRSSVQEFM TFTSALIVER SALGSRASVK
70 80 90 100 110 120
EQEYLCHVYV RNDNLGGVVI ADSEYPSRVC FTLLDKVLDE FSRQVNSIDW PSGSPATIQY
130 140 150 160 170 180
TALDSHLARY QNPREADAMT KVQAELDETK IILHNTMESL LERGEKLDDL VQKSEHLGNQ
190
SKAFYKTARK QNSCCEIM