AiPD: Autoinhibited Protein Database

Q7Z695

Gene name	ADCK2 (AARF)
Protein name	Uncharacterized aarF domain-containing protein kinase 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:90956
EC number
Protein Class

Descriptions

The function of ADCK2 is not yet clear. A similar protein, COQ8A, is autoinhibited by the intramolecular interaction between N-terminal region containing KxGQ motif and catalytic domain. The KxGQ motif in ADCK2 may also occlude the substrate binding site of the kinase domain.

Autoinhibitory domains (AIDs)

147-150 (Pseudo-Z-repeat) SS

Target domain	169-553 (ADCK-like domain)
Relief mechanism	PTM
Assay

AID

147-150 (Pseudo-Z-repeat)

Target domain

169-553 (ADCK-like domain)

Relief mechanism

PTM (Autophosphorylation)

Assay

Accessory elements

No accessory elements

References

Stefely JA et al. (2015) "Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis", Molecular cell, 57, 83-94

Autoinhibited structure

Activated structure

1 structures for Q7Z695

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Z695-F1	Predicted				AlphaFoldDB

531 variants for Q7Z695

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA369538045 rs1172419063	3	A>S		No	ClinGen gnomAD
rs962357791 CA168038253	4	P>T		No	ClinGen TOPMed
CA168038264 rs866036456	6	R>C		No	ClinGen Ensembl
CA4515800 rs764294162	6	R>H		No	ClinGen ExAC gnomAD
rs764294162 CA4515801	6	R>L		No	ClinGen ExAC gnomAD
CA369538121 rs1284508058	8	S>T		No	ClinGen TOPMed gnomAD
rs1171862123 CA369538127	8	S>Y		No	ClinGen TOPMed
rs1265564435 CA369538146	9	V>A		No	ClinGen gnomAD
CA4515803 rs767719347	9	V>F		No	ClinGen ExAC TOPMed gnomAD
rs767719347 CA369538134	9	V>I		No	ClinGen ExAC TOPMed gnomAD
rs994039173 CA168038287	10	R>G		No	ClinGen gnomAD
CA369538166 rs1207731170	10	R>M		No	ClinGen gnomAD
CA4515804 rs750682239	10	R>S		No	ClinGen ExAC
CA4515805 rs756163990	12	C>Y		No	ClinGen ExAC gnomAD
rs1440096341 CA369538208	13	L>P		No	ClinGen gnomAD
CA369538236 rs1180209015	14	S>*		No	ClinGen TOPMed gnomAD
CA369538238 rs1180209015	14	S>L		No	ClinGen TOPMed gnomAD
CA168038293 rs938234046	17	R>K		No	ClinGen TOPMed gnomAD
CA369538297 rs1378251358	17	R>W		No	ClinGen gnomAD
CA4515806 rs151015312	18	C>Y		No	ClinGen ESP ExAC gnomAD
rs1461070322 CA369538327	19	F>L		No	ClinGen gnomAD
rs1259428390 CA369538354	20	E>D		No	ClinGen TOPMed
CA168038298 rs1055398922	21	L>V		No	ClinGen TOPMed
rs539450262 CA168038299	22	R>G		No	ClinGen 1000Genomes
CA369538394 rs1325506321	23	Q>R		No	ClinGen gnomAD
rs1401218567 CA369538410	24	G>E		No	ClinGen gnomAD
CA4515808 rs752510115	25	L>R		No	ClinGen ExAC gnomAD
CA369538436 rs1376599687	26	S>N		No	ClinGen gnomAD
rs1037241483 CA168038342	30	P>L		No	ClinGen TOPMed gnomAD
rs1295876974 CA369538527	33	C>W		No	ClinGen gnomAD
rs1200128375 CA369538541	35	R>C		No	ClinGen gnomAD
rs368494131 CA4515815	37	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1405160459 CA369538578	38	R>G		No	ClinGen TOPMed gnomAD
CA4515816 rs775066819	38	R>S		No	ClinGen ExAC gnomAD
CA4515817 rs749696847	40	C>G		No	ClinGen ExAC gnomAD
CA4515818 rs140971515	42	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369538643 rs1424410579	44	L>R		No	ClinGen gnomAD
CA369538647 rs1329520927	45	G>D		No	ClinGen gnomAD
CA369538655 rs1449145266	46	T>S		No	ClinGen TOPMed gnomAD
rs1305122547 CA369538665	48	P>S		No	ClinGen gnomAD
rs1377539443 CA369538681	50	V>A		No	ClinGen gnomAD
CA369538683 rs1233208910	51	V>I		No	ClinGen gnomAD
rs978455804 CA168038391	54	C>R		No	ClinGen Ensembl
CA369538724 rs1317976691	57	V>A		No	ClinGen TOPMed gnomAD
rs762205061 CA4515821	57	V>M		No	ClinGen ExAC gnomAD
CA369538727 rs1220132793	58	G>R		No	ClinGen TOPMed gnomAD
CA369538728 rs1220132793	58	G>S		No	ClinGen TOPMed gnomAD
rs1460687407 CA369538732	59	E>K		No	ClinGen TOPMed
CA369538744 rs1306730304	60	G>A		No	ClinGen TOPMed gnomAD
CA369538743 rs1306730304	60	G>E		No	ClinGen TOPMed gnomAD
rs773373039 CA4515823	61	A>G		No	ClinGen ExAC gnomAD
rs772472209 CA4515822	61	A>P		No	ClinGen ExAC gnomAD
CA4515824 rs760917464	63	D>E		No	ClinGen ExAC TOPMed gnomAD
rs760917464 CA369538762	63	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1482268405 CA369538758	63	D>H		No	ClinGen gnomAD
rs1185769386 CA369538763	64	V>I		No	ClinGen TOPMed
CA4515825 rs766388161	65	L>P		No	ClinGen ExAC gnomAD
rs2968558 VAR_060990 CA4515826	66	S>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4515827 rs147151212	67	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369538786 rs1415411080	68	R>Q		No	ClinGen gnomAD
CA369538789 rs1197109387	69	R>G		No	ClinGen TOPMed
CA369538795 rs1337052295	69	R>S		No	ClinGen TOPMed
rs1257096612 CA369538801	70	V>A		No	ClinGen TOPMed
rs1257096612 CA369538800	70	V>G		No	ClinGen TOPMed
rs1357775334 CA369538805	71	R>H		No	ClinGen TOPMed gnomAD
CA168038462 rs917101846	72	C>R		No	ClinGen gnomAD
rs757071763 CA4515830	72	C>Y		No	ClinGen ExAC gnomAD
rs574217210 CA4515832	73	S>G		No	ClinGen 1000Genomes ExAC gnomAD
CA4515831 rs574217210	73	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1291951905 CA369538816	73	S>T		No	ClinGen TOPMed
rs1360919022 CA369538823	74	G>E		No	ClinGen gnomAD
rs1268061856 CA369538821	74	G>R		No	ClinGen TOPMed gnomAD
rs1268061856 CA369538822	74	G>W		No	ClinGen TOPMed gnomAD
rs553849506 CA168038477	76	A>T		No	ClinGen Ensembl
CA168038479 rs375366072	77	G>C		No	ClinGen ESP gnomAD
CA369538849 rs1210110828	79	G>R		No	ClinGen gnomAD
rs1489318388 CA369538858	80	P>L		No	ClinGen gnomAD
CA369538862 rs1241594478	81	A>P		No	ClinGen gnomAD
CA369538860 rs1241594478	81	A>T		No	ClinGen gnomAD
rs779627139 CA4515834	81	A>V		No	ClinGen ExAC TOPMed gnomAD
CA369538865 rs1423564698	82	E>K		No	ClinGen gnomAD
CA369538876 rs1159810072	83	S>N		No	ClinGen gnomAD
rs1362943623 CA369538883	84	L>F		No	ClinGen gnomAD
rs140313292 CA4515835	84	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4515838 rs748675495	85	P>A		No	ClinGen ExAC gnomAD
CA4515839 rs772386520	85	P>L		No	ClinGen ExAC gnomAD
CA369538887 rs748675495	85	P>S		No	ClinGen ExAC gnomAD
COSM1244439 rs367917022 CA4515844	86	R>*	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs367917022 CA4515842	86	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs765258600 CA4515845	86	R>Q		No	ClinGen ExAC gnomAD
CA369538894 rs1420145582	87	A>E		No	ClinGen gnomAD
rs376611609 CA168038574	87	A>T		No	ClinGen ESP TOPMed
rs1355854417 CA369538912	89	P>L		No	ClinGen gnomAD
CA4515850 rs756036859	92	G>S		No	ClinGen ExAC gnomAD
CA369538968 rs1454118567	93	V>D		No	ClinGen gnomAD
CA369538962 rs1237157599	93	V>I		No	ClinGen TOPMed
rs867853634 CA168038588	94	F>S		No	ClinGen Ensembl
CA369539016 rs1382540757	96	H>Q		No	ClinGen gnomAD
CA369539014 rs1382540757	96	H>Q		No	ClinGen gnomAD
rs753480742 CA4515852	96	H>R		No	ClinGen ExAC TOPMed gnomAD
CA4515853 rs754460419	97	L>F		No	ClinGen ExAC gnomAD
rs754460419 CA4515854	97	L>V		No	ClinGen ExAC gnomAD
CA4515855 rs145231926	98	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145231926 CA168038623	98	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1383657229 CA369539079	101	L>F		No	ClinGen TOPMed gnomAD
rs1383657229 CA369539073	101	L>I		No	ClinGen TOPMed gnomAD
rs1302127344 CA369539092	102	R>H		No	ClinGen gnomAD
rs201013665 CA4515856	103	A>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201013665 CA168038672	103	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368706879 CA4515857	104	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA369539111 rs368706879	104	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs368706879 CA168038678	104	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1326804613 CA369539153	107	L>S		No	ClinGen TOPMed
rs372972431 CA4515858	108	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs771251360 CA4515859	110	F>C		No	ClinGen ExAC gnomAD
rs1386016608 CA369539216	111	F>V		No	ClinGen Ensembl
CA369539236 rs1357171303	112	P>S		No	ClinGen gnomAD
CA369539246 rs1271515338	113	L>F		No	ClinGen gnomAD
rs1468260496 CA369539251	113	L>R		No	ClinGen gnomAD
rs1404607207 CA369539255	114	L>V		No	ClinGen TOPMed
rs137941874 CA4515862	117	Y>C		No	ClinGen ESP ExAC TOPMed
CA369539291 rs137941874	117	Y>S		No	ClinGen ESP ExAC TOPMed
rs546451203 CA369539319	118	P>A		No	ClinGen ExAC TOPMed gnomAD
CA4515865 rs546451203	118	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1472841690 CA369539336	119	L>F		No	ClinGen TOPMed gnomAD
CA369539331 rs1472841690	119	L>I		No	ClinGen TOPMed gnomAD
CA369539351 rs1585839884	120	T>P		No	ClinGen Ensembl
CA369539372 rs1360219632	121	Y>N		No	ClinGen gnomAD
CA369539396 rs1221778633	122	L>V		No	ClinGen TOPMed gnomAD
rs1460644514 CA369539436	124	P>R		No	ClinGen gnomAD
CA4515868 rs149634554	124	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369539464 rs1170912956	125	S>R		No	ClinGen TOPMed gnomAD
CA369539567 COSM1448575 rs1304255744	130	W>*	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1389412434 CA369539592	132	H>P		No	ClinGen gnomAD
rs1389412434 CA369539589	132	H>R		No	ClinGen gnomAD
CA369539614 rs1489354281	134	L>F		No	ClinGen gnomAD
rs1030889383 CA168038772	135	L>V		No	ClinGen Ensembl
rs61737092 CA4515869	137	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1450124257 CA369539731	140	T>N		No	ClinGen gnomAD
rs1585839962 CA369539758	142	G>C		No	ClinGen Ensembl
CA369539767 rs1291565651	143	P>S		No	ClinGen gnomAD
CA369539781 rs1321787063	144	T>A		No	ClinGen TOPMed
CA4515873 rs764997853	150	Q>R		No	ClinGen ExAC gnomAD
CA369540218 rs1585839991	151	W>R		No	ClinGen Ensembl
CA369540251 rs1359274597	152	A>V		No	ClinGen TOPMed
rs1485538925 CA369540280	154	T>S		No	ClinGen TOPMed gnomAD
rs757945662 CA4515875	155	R>L		No	ClinGen ExAC gnomAD
CA4515876 rs376548364	156	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs968462082 CA168038852	157	D>N		No	ClinGen Ensembl
CA4515878 rs757604223	157	D>V		No	ClinGen ExAC gnomAD
rs1254830348 CA369540368	160	S>*		No	ClinGen gnomAD
rs781418950 CA4515880	163	F>L		No	ClinGen ExAC gnomAD
rs1422620873 CA369540441	164	C>Y		No	ClinGen TOPMed
rs1460284301 CA369540465	165	A>V		No	ClinGen gnomAD
rs369907540 CA168038864	168	S>P		No	ClinGen ESP TOPMed
rs1310949681 CA369540575	170	L>R		No	ClinGen gnomAD
rs1244221501 CA369540624	173	R>*		No	ClinGen TOPMed
rs749351739 CA4515883	173	R>Q		No	ClinGen ExAC gnomAD
CA369540666 rs1400624340	175	T>M		No	ClinGen gnomAD
CA369540694 rs1280341368	177	H>Y		No	ClinGen gnomAD
rs1214999246 CA369540725	178	P>L		No	ClinGen TOPMed
CA4515884 rs768909247	178	P>S		No	ClinGen ExAC gnomAD
rs773237876 CA4515886	179	W>*		No	ClinGen ExAC gnomAD
CA4515887 rs760563067	180	T>I		No	ClinGen ExAC gnomAD
CA369540795 rs1563205218	181	H>Q		No	ClinGen Ensembl
CA168038912 rs1035102862	181	H>Y		No	ClinGen TOPMed
rs776303315 CA4515889	182	T>I		No	ClinGen ExAC gnomAD
CA4515888 rs766131767	182	T>P		No	ClinGen ExAC TOPMed gnomAD
CA4515891 rs764838169	184	R>L		No	ClinGen ExAC gnomAD
rs1263219128 CA369540931	187	R>W		No	ClinGen gnomAD
rs757853696 CA4515893	191	G>R		No	ClinGen ExAC gnomAD
CA4515894 rs763623427	193	D>N		No	ClinGen ExAC
CA4515896 rs764807562	194	W>*		No	ClinGen ExAC TOPMed gnomAD
CA369541153 rs1162335135	194	W>R		No	ClinGen gnomAD
CA168038943 rs764807562	194	W>S		No	ClinGen ExAC TOPMed gnomAD
CA369541217 rs1585840206	196	S>G		No	ClinGen Ensembl
CA168038965 rs992745506	196	S>I		No	ClinGen TOPMed gnomAD
rs1344970138 CA369541397	200	F>L		No	ClinGen gnomAD
CA369541377 rs1171694949	200	F>S		No	ClinGen TOPMed gnomAD
CA369541465 rs746218817	202	N>K		No	ClinGen ExAC gnomAD
CA4515901 rs756545274	203	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA369541483 rs1300177364	203	R>W		No	ClinGen gnomAD
CA4515902 rs780403894	205	P>H		No	ClinGen ExAC gnomAD
rs909882158 CA168039011	205	P>S		No	ClinGen TOPMed
CA4515903 rs550086664	206	V>A		No	ClinGen 1000Genomes ExAC gnomAD
CA168039059 rs962924677	208	S>*		No	ClinGen TOPMed gnomAD
CA369541577 rs962924677	208	S>L		No	ClinGen TOPMed gnomAD
CA4515905 rs779140491	210	C>S		No	ClinGen ExAC TOPMed gnomAD
rs367804517 CA4515906	213	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1262030344 CA369541687	214	V>M		No	ClinGen gnomAD
rs770769081 CA4515907	215	Y>C		No	ClinGen ExAC gnomAD
rs35108588 CA4515908	217	A>P		No	ClinGen ExAC TOPMed gnomAD
CA369541774 rs1191586320	218	Y>C		No	ClinGen gnomAD
CA4515910 rs568257091	218	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
rs1585840341 CA369541784	219	A>T		No	ClinGen Ensembl
CA369541837 rs1362169511	221	T>I		No	ClinGen TOPMed gnomAD
rs139976453 CA4515913	221	T>P		No	ClinGen ESP ExAC gnomAD
CA369541918 rs1255519887	225	E>D		No	ClinGen TOPMed
CA369541972 rs1438982666	228	S>G		No	ClinGen gnomAD
rs1325724285 CA369541977	228	S>N		No	ClinGen gnomAD
rs1205404952 CA369541986	229	V>L		No	ClinGen TOPMed
rs750990879 CA4515917	231	R>G		No	ClinGen ExAC gnomAD
rs756501596 CA4515918	231	R>K		No	ClinGen ExAC gnomAD
CA369542041 rs1224534033	233	G>D		No	ClinGen TOPMed gnomAD
rs1256468782 CA369542047	234	R>G		No	ClinGen TOPMed
rs780598246 CA369542070	235	A>G		No	ClinGen ExAC gnomAD
CA369542064 rs1237618441	235	A>P		No	ClinGen gnomAD
CA369542062 COSM1086257 rs1237618441	235	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs780598246 CA4515919	235	A>V		No	ClinGen ExAC gnomAD
rs1469580784 CA369542082	236	S>F		No	ClinGen gnomAD
CA4515921 rs754048538	237	C>R		No	ClinGen ExAC gnomAD
rs911643645 CA168039153	237	C>S		No	ClinGen TOPMed
CA369542100 rs1317115461	239	P>R		No	ClinGen TOPMed
rs1458015740 CA369542108	240	P>L		No	ClinGen gnomAD
rs755265730 CA369542111	241	F>L		No	ClinGen ExAC gnomAD
CA4515922 rs755265730	241	F>V		No	ClinGen ExAC gnomAD
CA168039161 rs747678556	243	H>R		No	ClinGen Ensembl
rs779336756 CA4515923	244	T>A		No	ClinGen ExAC gnomAD
CA369542153 rs1165660098	246	A>V		No	ClinGen gnomAD
rs1420102605 CA369542164	247	V>I		No	ClinGen TOPMed gnomAD
rs150611402 CA4515925	248	G>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4515924 rs565847198	248	G>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1585840470 CA369542206	250	L>M		No	ClinGen Ensembl
rs1563205359 CA369542217	250	L>P		No	ClinGen Ensembl
CA4515927 rs780941675	251	R>K		No	ClinGen ExAC gnomAD
rs745847746 CA4515928	252	E>Q		No	ClinGen ExAC gnomAD
rs769508886 CA4515929	254	F>S		No	ClinGen ExAC gnomAD
CA4515930 rs775273615	256	Y>C		No	ClinGen ExAC gnomAD
rs762791078 CA4515931	257	L>F		No	ClinGen ExAC gnomAD
CA369542316 rs762791078	257	L>I		No	ClinGen ExAC gnomAD
CA4515932 rs768288290	257	L>R		No	ClinGen ExAC gnomAD
CA4515933 rs774097144	258	G>A		No	ClinGen ExAC gnomAD
CA168039216 rs890744377	260	G>C		No	ClinGen Ensembl
rs767080374 CA4515935	261	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs199796975 CA4515934	261	R>W		No	ClinGen 1000Genomes ExAC gnomAD
rs1318353440 CA369542382	262	K>E		No	ClinGen gnomAD
rs1206274193 CA369542406	263	P>L		No	ClinGen gnomAD
CA4515937 rs139708297	264	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139708297 CA4515936	264	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA369542465 rs1419056835	268	A>S		No	ClinGen TOPMed
rs754242732 CA4515940	269	D>G		No	ClinGen ExAC gnomAD
CA369542469 rs1167680822	269	D>N		No	ClinGen TOPMed
rs755461783 CA369542476	270	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs770381485 CA168039289	270	Q>H		No	ClinGen Ensembl
CA4515941 rs755461783	270	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1187510329 CA369542478	270	Q>P		No	ClinGen gnomAD
CA369542487 rs1424513942	271	S>L		No	ClinGen gnomAD
CA4515944 rs752984644	280	K>E		No	ClinGen ExAC TOPMed gnomAD
rs201925626 CA4515945 COSM1548511	282	D>E	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA168039317 rs149775476	282	D>H		No	ClinGen ESP
rs1470997855 CA369542574	285	G>V		No	ClinGen gnomAD
CA369542583 rs1308667781	287	N>Y		No	ClinGen Ensembl
CA4515946 rs777911509	288	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4515948 rs145047060	289	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs745744733 CA4515947	289	G>R		No	ClinGen ExAC gnomAD
CA4515950 rs375652254	292	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs375652254 CA4515949	292	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1292300382 CA369542610	292	R>W		No	ClinGen TOPMed gnomAD
CA369542617 rs768492335	293	A>G		No	ClinGen ExAC TOPMed gnomAD
CA4515951 rs768492335	293	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1270686171 CA369542627	295	V>F		No	ClinGen gnomAD
rs1306675992 CA369542634	296	P>S		No	ClinGen TOPMed gnomAD
CA369542648 rs1328807301	298	H>R		No	ClinGen TOPMed
CA4515954 rs773829719	301	E>Q		No	ClinGen ExAC gnomAD
CA369542683 rs1282304334	303	T>S		No	ClinGen gnomAD
rs1585840720 CA369542681	303	T>S		No	ClinGen Ensembl
rs1484733084 CA369542691	304	N>S		No	ClinGen TOPMed gnomAD
CA168039401 rs200726170	305	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs771418834 CA4515956	305	L>H		No	ClinGen ExAC gnomAD
rs200726170 CA4515955	305	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs760319677 CA4515958	307	S>F		No	ClinGen ExAC gnomAD
rs1140034 VAR_029992 CA4515957	307	S>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766988293 CA4515959	308	V>M		No	ClinGen ExAC gnomAD
CA369542745 rs1176094890	309	A>T		No	ClinGen gnomAD
rs777326586 CA4515960	311	K>T		No	ClinGen ExAC gnomAD
rs201524841 CA4515982	312	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA369542966 rs536967545	315	P>L		No	ClinGen TOPMed gnomAD
CA168039694 rs536967545	315	P>R		No	ClinGen TOPMed gnomAD
CA168039680 rs1025654669	315	P>T		No	ClinGen TOPMed
rs1215764326 CA369542976	316	G>D		No	ClinGen gnomAD
rs1179845448 CA369543045	319	A>S		No	ClinGen TOPMed gnomAD
CA369543048 rs1179845448	319	A>T		No	ClinGen TOPMed gnomAD
rs1235034063 CA369543062	320	Q>E		No	ClinGen gnomAD
CA4515984 rs751831945	320	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1156357792 CA369543083	322	H>N		No	ClinGen gnomAD
rs761837033 CA4515985	323	M>T		No	ClinGen ExAC gnomAD
rs1585841194 CA369543132	324	D>A		No	ClinGen Ensembl
rs767618887 CA4515987	325	L>M		No	ClinGen ExAC TOPMed gnomAD
CA168039716 rs955576974	326	L>Q		No	ClinGen TOPMed
CA4515988 rs754957785	328	M>L		No	ClinGen ExAC gnomAD
rs551500242 CA4515989	330	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369543321 rs752532902	332	S>R		No	ClinGen ExAC gnomAD
CA168039731 rs919343786	333	R>*		No	ClinGen TOPMed gnomAD
rs758167936 CA4515991	333	R>P		No	ClinGen ExAC TOPMed gnomAD
rs758167936 CA369543334	333	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1563205704 CA369543357	334	V>A		No	ClinGen Ensembl
CA369543354 rs1563205704	334	V>G		No	ClinGen Ensembl
rs1356140109 CA369543385	336	G>R		No	ClinGen gnomAD
rs1235408794 CA369543394	336	G>V		No	ClinGen gnomAD
CA369543402 rs770496284	337	V>F		No	ClinGen ExAC gnomAD
rs1585841284 CA369543406	337	V>G		No	ClinGen Ensembl
rs770496284 CA4515994	337	V>I		No	ClinGen ExAC gnomAD
CA4515995 rs780861662	338	L>F		No	ClinGen ExAC TOPMed gnomAD
CA369543484 rs1196809101	342	K>E		No	ClinGen TOPMed gnomAD
rs1231960088 CA369543493	343	W>G		No	ClinGen gnomAD
rs745424795 CA4515996	344	L>F		No	ClinGen ExAC gnomAD
CA369543514 rs1468230677	346	L>V		No	ClinGen gnomAD
CA369543526 rs1436624517 COSM3778162	348	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA369543538 rs1563205750	349	I>T		No	ClinGen Ensembl
rs1250465905 CA369543558	352	E>*		No	ClinGen gnomAD
CA4515998 rs770327818	353	F>C		No	ClinGen ExAC gnomAD
rs770327818 CA369543567	353	F>Y		No	ClinGen ExAC gnomAD
CA369543599 rs1369635549	357	M>I		No	ClinGen TOPMed
rs1184767561 CA369543601	358	V>I		No	ClinGen TOPMed
rs1189641003 CA369543611	359	Q>R		No	ClinGen gnomAD
rs1474277677 CA369544587	361	I>T		No	ClinGen TOPMed gnomAD
CA4516012 rs777714947	362	D>H		No	ClinGen ExAC TOPMed gnomAD
rs368382557 CA4516013 COSM4153889	364	R>C	ovary [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA4516014 rs150963091	364	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745347858 CA4516016	366	E>K		No	ClinGen ExAC gnomAD
CA369544725 rs1383018682	367	A>V		No	ClinGen gnomAD
CA369544784 rs1325060889	370	L>V		No	ClinGen gnomAD
rs769233732 CA4516018	371	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4516019 rs780564533	372	H>N		No	ClinGen ExAC gnomAD
rs1328192121 CA369544824	372	H>P		No	ClinGen gnomAD
CA369544886 rs1267095486	374	Q>H		No	ClinGen TOPMed
rs1243022515 CA369544914	376	N>D		No	ClinGen Ensembl
rs774714848 CA4516022	378	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4516021 rs768944788	378	R>W		No	ClinGen ExAC TOPMed gnomAD
rs762224232 CA4516023	379	N>S		No	ClinGen ExAC gnomAD
rs1411182964 CA369545041	381	K>N		No	ClinGen TOPMed
rs1263335432 CA369545045	382	A>T		No	ClinGen gnomAD
rs773463144 CA4516025	383	V>I		No	ClinGen ExAC TOPMed gnomAD
CA168042988 rs745452569	387	T>I		No	ClinGen ExAC TOPMed gnomAD
CA4516028 rs745452569	387	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1377161063 CA369545217	389	L>P		No	ClinGen gnomAD
rs150090657 CA4516030 COSM385583	390	R>C	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA4516031 COSM1448576 rs74761630	390	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs200177899 CA4516032	391	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369545260 rs1381852038	391	P>S		No	ClinGen gnomAD
rs1373610949 CA369545271	392	F>V		No	ClinGen gnomAD
CA369545344 rs1439382379	395	R>G		No	ClinGen gnomAD
CA4516033 rs767251823	396	E>G		No	ClinGen ExAC gnomAD
rs1013680811 CA168042994	396	E>K		No	ClinGen TOPMed
CA4516034 rs750061930	397	V>L		No	ClinGen ExAC gnomAD
CA4516035 rs376247400 COSM205022	401	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA369545521 rs1269170560	402	Y>C		No	ClinGen TOPMed
rs1348156091 CA369545514	402	Y>H		No	ClinGen gnomAD
CA369545553 rs1207673668	403	E>D		No	ClinGen gnomAD
rs761648468 CA4516049	404	E>K		No	ClinGen ExAC
CA369546677 rs1272623770	408	V>A		No	ClinGen TOPMed
CA369546696 rs1460072692	410	S>G		No	ClinGen gnomAD
CA369546702 rs1164591631	410	S>T		No	ClinGen gnomAD
CA369546726 rs1375293580	411	Y>C		No	ClinGen gnomAD
CA369546722 rs1355443257	411	Y>D		No	ClinGen gnomAD
rs963194779 CA168044026	412	Q>L		No	ClinGen TOPMed
CA369546740 rs963194779	412	Q>R		No	ClinGen TOPMed
CA369546753 rs1296903663	413	Q>P		No	ClinGen gnomAD
rs750029948 CA4516053	414	A>G		No	ClinGen ExAC gnomAD
rs865803385 CA168044032	414	A>T		No	ClinGen Ensembl
CA4516055 rs138501789	417	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA369546817 rs1585846634	418	V>G		No	ClinGen Ensembl
CA168044054 rs3748092	418	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4516057 rs3748092 VAR_041418	418	V>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs3748092 CA4516058 VAR_029993	418	V>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1311794570 CA369546829	419	D>E		No	ClinGen gnomAD
CA369546842 rs752945851	420	L>F		No	ClinGen ExAC gnomAD
CA369546849 rs1585846655	421	K>Q		No	ClinGen Ensembl
rs758695329 CA4516060	423	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1346560614 CA369546902	424	I>M		No	ClinGen TOPMed
CA369546905 rs1482774166	425	A>T		No	ClinGen gnomAD
rs376435154 CA4516061	426	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs771052975 CA4516063	426	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs376435154 CA4516062	426	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA4516066 rs770012583	431	M>T		No	ClinGen ExAC gnomAD
rs1195969083 CA369547102	435	M>I		No	ClinGen TOPMed
rs1390172628 CA369547091	435	M>T		No	ClinGen gnomAD
CA4516088 rs749441775	436	I>L		No	ClinGen ExAC gnomAD
rs1436781513 CA369548396	436	I>M		No	ClinGen TOPMed
CA4516087 rs749441775	436	I>V		No	ClinGen ExAC gnomAD
rs773243022 CA4516089	438	V>L		No	ClinGen ExAC gnomAD
CA4516090 rs148326960	439	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1021224510 CA168047863	440	N>K		No	ClinGen TOPMed
rs1470501650 CA369548433	442	V>L		No	ClinGen TOPMed
rs1441569901 CA369548438	443	H>D		No	ClinGen gnomAD
rs966828430 CA168047866	443	H>L		No	ClinGen TOPMed gnomAD
rs966828430 CA369548443	443	H>R		No	ClinGen TOPMed gnomAD
CA369548446 rs1247469314	444	A>T		No	ClinGen gnomAD
CA4516091 rs770783927	446	L>H		No	ClinGen ExAC gnomAD
rs1585851534 CA369548469	447	H>P		No	ClinGen Ensembl
CA4516092 rs369891942	447	H>Q		No	ClinGen ESP ExAC gnomAD
CA168047910 rs970754211	450	N>K		No	ClinGen Ensembl
CA369548500 rs1247832752	452	L>Q		No	ClinGen gnomAD
CA369548503 rs1469148913	453	V>I		No	ClinGen gnomAD
rs1196071618 CA369548514	454	Q>R		No	ClinGen gnomAD
CA369548520 COSM2861401 rs1477987414	455	G>D	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
CA369548518 rs1251608254	455	G>R		No	ClinGen gnomAD
rs372957490 CA369548537	458	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4516096 rs372957490	458	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA369548545 rs1402130012	459	L>P		No	ClinGen gnomAD
rs200197811 CA4516097	461	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1448149743 CA369548570	463	Q>R		No	ClinGen gnomAD
CA168047940 rs926862140	464	E>K		No	ClinGen TOPMed gnomAD
rs369426384 CA4516099	465	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1435644663 CA369548586	466	Q>K		No	ClinGen gnomAD
CA168047959 rs941702313	467	L>P		No	ClinGen TOPMed gnomAD
rs1585851623 CA369548595	467	L>V		No	ClinGen Ensembl
CA4516101 rs781621360	469	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs1037544323 CA168047965	470	A>V		No	ClinGen TOPMed gnomAD
rs1585851632 CA369548622	471	D>G		No	ClinGen Ensembl
rs1335919307 CA369548629	472	I>T		No	ClinGen gnomAD
rs150836435 CA4516103	472	I>V		No	ClinGen ESP ExAC TOPMed
rs372965751 CA4516104	476	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1585851662 CA369548662	477	V>G		No	ClinGen Ensembl
CA4516106 rs544359320	477	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs200625798 CA4516108	478	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4516107 rs777523650	478	V>M		No	ClinGen ExAC gnomAD
CA4516110 rs200474792	480	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs199833545 CA4516111	481	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs911553458 CA168048003	482	S>P		No	ClinGen TOPMed gnomAD
CA4516112 rs143518658	483	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs763966821 CA4516114	484	L>F		No	ClinGen ExAC TOPMed gnomAD
rs763966821 CA4516113	484	L>I		No	ClinGen ExAC TOPMed gnomAD
CA168048036 rs1038893498	485	C>Y		No	ClinGen gnomAD
rs774650705 CA4516117	486	P>L		No	ClinGen ExAC TOPMed gnomAD
rs375726537 CA4516119	488	R>*		No	ClinGen ESP ExAC gnomAD
CA369548716 rs750816667	488	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4516120 rs750816667	488	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1003699102 CA168048081	490	V>M		No	ClinGen TOPMed
rs1275638187 CA369548730	491	L>P		No	ClinGen gnomAD
rs754974969 CA4516124	493	D>H		No	ClinGen ExAC
CA369548752 rs1485816714	495	G>D		No	ClinGen gnomAD
CA4516126 rs748232543	495	G>S		No	ClinGen ExAC gnomAD
rs1366522303 CA369548764	497	V>L		No	ClinGen gnomAD
rs1472310242 CA369548768	498	A>T		No	ClinGen gnomAD
rs146236319 CA4516128	498	A>V		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA369548773 rs1427730252	499	E>*		No	ClinGen gnomAD
CA369548774 rs1427730252	499	E>K		No	ClinGen gnomAD
rs1307553029 CA369548799	502	A>V		No	ClinGen gnomAD
CA4516131 rs527563445	507	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA369548831 rs1228691411	507	N>K		No	ClinGen TOPMed gnomAD
rs1272287641 CA369548845	509	R>L		No	ClinGen TOPMed gnomAD
CA369548843 rs1272287641	509	R>Q		No	ClinGen TOPMed gnomAD
CA369548842 rs1244487319 COSM231716	509	R>W	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
CA369548847 rs1340717461	510	A>S		No	ClinGen gnomAD
rs1273315811 CA369548862	512	F>S		No	ClinGen gnomAD
CA369548868 rs1262909690	513	M>L		No	ClinGen gnomAD
rs1408539619 CA369548878	514	A>D		No	ClinGen TOPMed
CA369548884 rs1585851871	515	V>G		No	ClinGen Ensembl
rs767990993 CA4516133	516	V>L		No	ClinGen ExAC gnomAD
CA369548897 rs1193714155	517	M>R		No	ClinGen gnomAD
rs1303860189 CA369548904	518	G>E		No	ClinGen TOPMed
CA369548901 rs1249629273	518	G>R		No	ClinGen TOPMed gnomAD
CA369548903 rs1249629273	518	G>R		No	ClinGen TOPMed gnomAD
CA4516148 rs199613316	520	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1488294 CA4516149 rs781057568	521	Q>H	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA369549952 rs1329952121	522	R>G		No	ClinGen gnomAD
rs1274897815 CA369549969	523	V>L		No	ClinGen TOPMed
CA4516150 rs745832779	525	E>G		No	ClinGen ExAC gnomAD
rs1364547240 CA369549989	525	E>K		No	ClinGen TOPMed gnomAD
CA4516151 rs547137988	526	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs749098062 CA4516153	528	L>P		No	ClinGen ExAC gnomAD
CA4516154 rs768352557	529	H>Y		No	ClinGen ExAC gnomAD
rs1489453017 CA369550052	530	H>R		No	ClinGen gnomAD
CA369550070 rs199869285	532	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202086095 CA369550072	532	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202086095 CA4516156	532	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4516155 rs199869285	532	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1184631038 CA369550076	533	A>D		No	ClinGen gnomAD
rs1419681846 CA369550075	533	A>T		No	ClinGen gnomAD
rs139275171 CA4516158	535	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4516161 rs761270477	538	D>H		No	ClinGen ExAC gnomAD
CA4516160 rs761270477	538	D>N		No	ClinGen ExAC gnomAD
CA4516163 rs371820955	539	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA4516165 rs752883985	540	E>D		No	ClinGen ExAC TOPMed gnomAD
CA168049958 rs1055593713	541	G>R		No	ClinGen Ensembl
rs1585854031 CA369550132	542	F>V		No	ClinGen Ensembl
rs764159638 CA4516168	545	E>*		No	ClinGen ExAC TOPMed gnomAD
CA4516167 rs764159638	545	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1293706165 CA369550180	548	M>I		No	ClinGen gnomAD
rs756029213 CA4516169	548	M>R		No	ClinGen ExAC gnomAD
rs1323246248 CA369550183	549	L>M		No	ClinGen gnomAD
CA168050009 rs995192758	550	V>M		No	ClinGen Ensembl
rs200911610 CA369550200	552	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200911610 CA4516170	552	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs144927279 CA4516173	556	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs780896232 CA4516174	557	T>I		No	ClinGen ExAC TOPMed gnomAD
rs369695176 CA168050045	559	T>I		No	ClinGen ESP TOPMed gnomAD
CA369550252 rs1188859331	560	L>V		No	ClinGen gnomAD
CA369550268 rs1416447074	562	K>M		No	ClinGen gnomAD
rs1266609641 CA369550265	562	K>Q		No	ClinGen gnomAD
rs1209624480 CA369550288	563	L>R		No	ClinGen gnomAD
COSM1755127 CA369550291 rs1181261291	564	H>Y	urinary_tract [Cosmic]	No	ClinGen cosmic curated gnomAD
CA4516206 COSM1548510 rs561363159	567	S>R	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
COSM1548510 CA4516207 rs192475820	567	S>R	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
COSM1548510 CA369550314 rs192475820	567	S>R	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs759406238 CA4516208	570	S>C		No	ClinGen ExAC gnomAD
rs1412420614 CA369550370	576	L>M		No	ClinGen gnomAD
rs932557927 CA168051110	576	L>P		No	ClinGen Ensembl
rs1174865986 CA578278840	577	M>T		No	ClinGen gnomAD
CA369550392 rs1458562939	579	H>L		No	ClinGen gnomAD
rs1288142337 CA369551737	581	V>L		No	ClinGen gnomAD
CA369551778 rs1161383696	583	L>I		No	ClinGen TOPMed
rs1471731500 CA369551820	585	S>T		No	ClinGen TOPMed
rs767264371 CA4516238	586	N>S		No	ClinGen ExAC gnomAD
rs199846947 CA168054493	587	F>S		No	ClinGen Ensembl
CA4516239 rs749867364	589	S>A		No	ClinGen ExAC TOPMed gnomAD
rs1224449199 CA369551918	590	I>T		No	ClinGen gnomAD
rs531392135 CA4516240	591	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs780493274 CA4516241	594	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1179525120 CA369552030	596	V>M		No	ClinGen gnomAD
CA168054565 rs373767559	598	E>K		No	ClinGen ESP
rs200625749 CA4516243	602	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4516245 rs149060142	602	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149060142 CA4516244	602	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs772181288 CA4516246	606	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1404666118 CA369552216	606	P>T		No	ClinGen gnomAD
rs76105862 CA4516249	609	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs76105862 CA4516248	609	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4516251 rs1554491383	612	E>G		No	ClinGen Ensembl
CA369552370 rs1203252353	613	A>V		No	ClinGen gnomAD
rs141845048 CA4516254	614	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4516256 rs761704942	615	R>K		No	ClinGen ExAC TOPMed gnomAD
rs761704942 CA369552403	615	R>M		No	ClinGen ExAC TOPMed gnomAD
CA369552427 rs1343596956	617	F>Y		No	ClinGen gnomAD
rs1411475502 CA369552491	620	T>M		No	ClinGen TOPMed
VAR_029994 rs1046515 CA4516259	622	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4516264 rs754286018	625	P>T		No	ClinGen ExAC TOPMed gnomAD
VAR_041419 CA4516265 rs55922126	626	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4516266 rs55922126	626	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4516268 rs758810980	627	P>G		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q7Z695

3 regional properties for Q7Z695

Type	Name	Position	InterPro Accession
domain	ABC1 atypical kinase-like domain	169 - 218	IPR004147-1
domain	ABC1 atypical kinase-like domain	293 - 526	IPR004147-2
domain	ADCK2-like dom	169 - 553	IPR044095

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02981	YPL109C	ABC1 family protein YPL109C, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS

10	20	30	40	50	60
MVAPWRVSVR	VCLSHLRCFE	LRQGLSLLRP	SECPRDARLC	WLLLGTLPKV	VSLCGDVGEG
70	80	90	100	110	120
APDVLSRRRV	RCSGAAGAGP	AESLPRAGPL	GGVFLHLRLW	LRAGALLVKF	FPLLLLYPLT
130	140	150	160	170	180
YLAPSVSTLW	LHLLLKATET	SGPTYIKLGQ	WASTRRDLFS	EAFCAQFSKL	HVRVTPHPWT
190	200	210	220	230	240
HTERFLRQAF	GDDWGSILSF	ENREPVGSGC	VAQVYKAYAN	TAFLETDSVQ	RLGRASCLPP
250	260	270	280	290	300
FSHTGAVGGL	RELFGYLGNG	RKPPENLADQ	SFLERLLLPK	ADLVGSNAGV	SRAQVPGHQP
310	320	330	340	350	360
EATNLISVAV	KVLHPGLLAQ	VHMDLLLMKI	GSRVLGVLPG	IKWLSLPEIV	EEFEKLMVQQ
370	380	390	400	410	420
IDLRYEAQNL	EHFQVNFRNV	KAVKFPTPLR	PFVTREVLVE	TYEESVPVSS	YQQAGIPVDL
430	440	450	460	470	480
KRKIARLGIN	MLLKMIFVDN	FVHADLHPGN	ILVQGANGLS	SSQEAQLQQA	DICDTLVVAV
490	500	510	520	530	540
PSSLCPLRLV	LLDAGIVAEL	QAPDLRNFRA	VFMAVVMGQG	QRVAELILHH	ARASECRDVE
550	560	570	580	590	600
GFKTEMAMLV	TQARKNTITL	EKLHVSSLLS	SVFKLLMTHK	VKLESNFASI	VFAIMVLEGL
610	620
GRSLDPKLDI	LEAARPFLLT	GPVCPP