AiPD: Autoinhibited Protein Database

Q7Z4S6

Gene name	KIF21A (KIAA1708, KIF2)
Protein name	Kinesin-like protein KIF21A
Names	Kinesin-like protein KIF2 , Renal carcinoma antigen NY-REN-62
Species	Homo sapiens (Human)
KEGG Pathway	hsa:55605
EC number
Protein Class	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED (PTHR47969)

Descriptions

Kinesin (KIF) motor proteins play a major role in the transport of intracellular cargo and in the regulation of microtubule (MT) organization and dynamics in an ATP-dependent fashion. A prototypic kinesin includes a conserved globular N-terminal motor domain, which binds to MTs, hydrolyses ATP and converts its chemical energy to mechanical work. The kinesin motor domain is typically followed by a stalk domain often consisting of α-helical coiled-coil regions that are important for dimerization and a tail domain containing the binding sites for cargo or kinesin-regulatory proteins.
Intramolecular antiparallel coiled coil in the stalk domain autoinhibits the kinesin motor domain, preventing its interaction with microtubules (MTs) and ATP hydrolysis, thus regulating intracellular transport and MT dynamics. Interaction of the KIF21A regulatory domain with the KIF21B motor domain and sequence similarities to KIF7 and KIF27 strongly suggest a conservation of this regulatory mechanism in other kinesin-4 family members.

Autoinhibitory domains (AIDs)

Target domain	7-379 (Kinesin motor domain)
Relief mechanism	Partner binding, Others
Assay	Structural analysis, Deletion assay, Split protein assay, Mutagenesis experiment

AID

938-1023 (Coiled coil region)

Target domain

7-379 (Kinesin motor domain)

Relief mechanism

Partner binding (Binding of proteins such as Map1b, BIG 1, KANK1, and NCKX to the regulatory region), Others (CFEOM1-associated mutations)

Assay

Structural analysis, Deletion assay, Split protein assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Bianchi S et al. (2016) "Structural basis for misregulation of kinesin KIF21A autoinhibition by CFEOM1 disease mutations", Scientific reports, 6, 30668

van der Vaart B et al. (2013) "CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor", Developmental cell, 27, 145-160

Autoinhibited structure

Activated structure

6 structures for Q7Z4S6

Entry ID	Method	Resolution	Chain	Position	Source
5D3A	X-ray	250 A	A/B	938-1017	PDB
5NFD	X-ray	218 A	A/B	938-1017	PDB
5YBU	X-ray	189 A	B	1146-1167	PDB
5YBV	X-ray	212 A	C/D	1146-1167	PDB
7KLJ	X-ray	152 A	A/B	1337-1653	PDB
AF-Q7Z4S6-F1	Predicted				AlphaFoldDB

1628 variants for Q7Z4S6

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001110640 rs1227646139	66	I>T	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar dbSNP gnomAD
rs113878846 RCV002540804 RCV000910070	139	A>S	Inborn genetic diseases [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001110639 COSM3376233 rs141530856	190	V>I	Congenital fibrosis of extraocular muscles type 1 pancreas [ClinVar, Cosmic]	Yes	cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM2065225 CA6511235 rs770064077 RCV000287713 COSM1361328	193	R>H	Congenital fibrosis of extraocular muscles type 1 Variant assessed as Somatic; MODERATE impact. large_intestine [ClinVar, NCI-TCGA, Cosmic]	Yes	ClinGen NCI-TCGA Cosmic cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV000389659 CA6511215 rs149328427	203	Q>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV003311584 rs267603451	236	Q>*	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar dbSNP gnomAD
VAR_074031	352	D>E	CFEOM1; de novo mutation [UniProt]	Yes	UniProt
RCV002535307 rs768580958 RCV000732988	356	M>L	Inborn genetic diseases [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
rs121912588 CA339982 RCV000002543 VAR_019399	356	M>T	Congenital fibrosis of extraocular muscles type 1 CFEOM1 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV000319726 rs745692702 RCV000903904 CA6511100	387	N>S	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000894701 CA6511073 RCV000262273 rs78616703	414	G>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs375541289 RCV001113865	427	M>V	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs886049345 CA10637334 RCV000354754	441	A>T	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000302061 rs149219011 CA6510978 RCV000954280	543	K>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6510911 RCV000289132 RCV001701946 rs79089655	627	G>V	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA6510910 rs765856120 RCV000399984	629	S>I	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1555167299 RCV000497582 CA384401387 RCV003159607	664	L>P	KIF21A-related condition [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs869025264 RCV000207402 CA351603	763	V>M	Congenital aniridia [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs200645253 CA6510851 RCV000352193	769	T>A	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000386473 rs779688115 CA6510787	811	L>F	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
rs764601859 CA6510771 RCV000281670	831	T>M	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs764601859 RCV001110553 COSM548312	831	T>R	lung Congenital fibrosis of extraocular muscles type 1 [Cosmic, ClinVar]	Yes	cosmic curated ClinVar ExAC TOPMed dbSNP gnomAD
RCV001110552 COSM4575362 COSM4575363 rs1458182449	835	R>W	Congenital fibrosis of extraocular muscles type 1 Variant assessed as Somatic; MODERATE impact. [ClinVar, NCI-TCGA]	Yes	NCI-TCGA Cosmic ClinVar NCI-TCGA TOPMed dbSNP gnomAD
rs145318959 COSM1163002 RCV001109765	887	A>V	Congenital fibrosis of extraocular muscles type 1 pancreas [ClinVar, Cosmic]	Yes	cosmic curated ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001109764 RCV000894861 rs149718388	895	P>L	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs886049344 RCV000259437 CA10637329	915	I>T	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs749644826 CA6510695 RCV000361240 RCV003362752	928	R>C	Congenital fibrosis of extraocular muscles type 1 Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000323422 rs886049343 CA10642076	933	I>N	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_074032	944	E>Q	CFEOM1 [UniProt]	Yes	UniProt
RCV000002546 rs267607200 CA115556	947	M>I	Fibrosis of extraocular muscles, congenital, 3b [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000002545 VAR_019400 CA252285 rs121912590	947	M>R	Congenital fibrosis of extraocular muscles type 1 CFEOM1 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_027021	947	M>T	CFEOM1 [UniProt]	Yes	UniProt
RCV000002544 rs121912589 VAR_019401 CA252284	947	M>V	Congenital fibrosis of extraocular muscles type 1 CFEOM1 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_074033	954	R>L	CFEOM1 [UniProt]	Yes	UniProt
rs121912586 RCV002254900 RCV000002541 CA115555 VAR_019402 RCV000002540	954	R>Q	Congenital fibrosis of extraocular muscles type 1 Fibrosis of extraocular muscles, congenital, 3b CFEOM1 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV000267056 rs121912585 RCV000002539 CA115554 RCV000002538 VAR_019403 RCV003398420	954	R>W	Congenital fibrosis of extraocular muscles type 1 Variant assessed as Somatic; MODERATE impact. KIF21A-related condition Fibrosis of extraocular muscles, congenital, 3b CFEOM1 [ClinVar, NCI-TCGA, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl NCI-TCGA dbSNP
VAR_074034	1008	A>P	CFEOM1 [UniProt]	Yes	UniProt
VAR_019404 rs121912587 RCV000002542 CA252283	1010	I>T	Congenital fibrosis of extraocular muscles type 1 CFEOM1 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001109763 rs1946526630	1028	V>I	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV000310515 RCV000882518 CA6510607 rs142268373	1050	N>S	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs150294289 RCV000363848 CA6510558 RCV000904253	1111	V>A	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001113783 rs1316892081	1185	P>L	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV000406843 rs149075970 CA6510462	1214	P>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000351593 rs75223821 CA6510438	1237	E>D	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs747176706 RCV001113782	1281	R>H	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar ExAC TOPMed dbSNP gnomAD
RCV000313138 CA10641128 rs886049342	1291	T>N	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs1565724893 RCV000779102	1293	S>missing	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar dbSNP
rs1565724702 RCV000779101	1296	N>missing	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar dbSNP
rs142879430 CA6510329 RCV000401978	1320	R>K	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000281544 rs886049341 CA10642067	1422	I>V	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
COSM1676830 COSM1676831 rs749290916 RCV002556197 RCV001112436	1423	R>Q	Congenital fibrosis of extraocular muscles type 1 Variant assessed as Somatic; MODERATE impact. Inborn genetic diseases [ClinVar, NCI-TCGA]	Yes	NCI-TCGA Cosmic ClinVar NCI-TCGA dbSNP gnomAD
rs781214904 RCV000373719 CA6510226	1426	T>M	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs748150530 CA6510167 RCV000335321	1491	H>Y	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000893947 rs62000373 RCV001111982	1505	S>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10641118 RCV000287324 rs886049340	1510	I>L	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
CA6510141 rs142038295 RCV000272319	1521	M>R	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV001111981 rs1942967439	1605	G>E	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinVar Ensembl dbSNP
RCV000326200 CA10642059 rs886049339	1631	A>T	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
rs373406994 RCV000268861 CA6510048	1654	R>L	Congenital fibrosis of extraocular muscles type 1 [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1939873512	2	L>S		No	Ensembl
rs998747931	2	L>V		No	TOPMed gnomAD
rs1939873512	2	L>W		No	Ensembl
rs2140543663	4	A>S		No	Ensembl
rs2140543663	4	A>T		No	Ensembl
rs901772088	4	A>V		No	TOPMed gnomAD
rs1269706987	5	P>A		No	gnomAD
rs942928510	7	E>D		No	TOPMed gnomAD
rs1283389822	9	S>Y		No	gnomAD
rs1040577254	10	V>L		No	TOPMed gnomAD
rs1040577254	10	V>M		No	TOPMed gnomAD
rs1383184252	14	V>D		No	gnomAD
rs1422024452	14	V>I		No	TOPMed gnomAD
rs1422024452	14	V>L		No	TOPMed gnomAD
rs753835660	16	I>M		No	ExAC TOPMed gnomAD
rs1949861277	19	Q>*		No	TOPMed gnomAD
rs1728873657	19	Q>H		No	TOPMed
rs1272892313	19	Q>R		No	TOPMed gnomAD
rs1196836806	20	L>F		No	gnomAD
TCGA novel	20	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1344943070	21	A>V		No	gnomAD
rs1289975638	22	K>E		No	gnomAD
rs1036918539	23	E>K		No	TOPMed gnomAD
TCGA novel	25	I>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs766144623	27	G>E		No	ExAC gnomAD
rs864321718	28	C>W		No	gnomAD
rs146467179	29	H>R		No	ESP ExAC TOPMed gnomAD
rs530120375	30	I>L		No	1000Genomes TOPMed gnomAD
rs751744115	30	I>T		No	ExAC gnomAD
rs530120375	30	I>V		No	1000Genomes TOPMed gnomAD
rs376379819	31	C>S		No	ESP ExAC TOPMed gnomAD
rs775439890	34	V>A		No	ExAC TOPMed gnomAD
rs775439890	34	V>G		No	ExAC TOPMed gnomAD
rs200140335	36	P>S		No	ESP ExAC TOPMed gnomAD
rs200140335	36	P>T		No	ESP ExAC TOPMed gnomAD
rs964997318 COSM321238	38	E>K	lung [Cosmic]	No	cosmic curated TOPMed
rs752560589	39	P>L		No	ExAC TOPMed gnomAD
rs1338137842	40	Q>H		No	TOPMed
rs1161423002	41	V>L		No	gnomAD
rs777328454	42	F>C		No	ExAC gnomAD
rs747408878	44	G>A		No	ExAC TOPMed gnomAD
TCGA novel	46	D>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs201016471	47	K>N		No	1000Genomes ExAC TOPMed gnomAD
rs1181921264	48	A>P		No	gnomAD
rs1181921264	48	A>T		No	gnomAD
rs778279184	50	T>A		No	ExAC TOPMed gnomAD
rs1949855738	54	V>L		No	Ensembl
rs749197486	56	D>G		No	ExAC TOPMed gnomAD
rs780002236	57	I>V		No	ExAC TOPMed gnomAD
TCGA novel	58	D>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM938955 COSM1651251	59	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1949854726	60	Q>R		No	TOPMed
rs1280148553	62	E>G		No	gnomAD
rs1196914694	64	I>F		No	TOPMed gnomAD
rs1566011738	64	I>T		No	Ensembl
rs1227646139	66	I>S		No	gnomAD
rs1949853648	67	Q>R		No	TOPMed
rs1949853098	69	I>T		No	TOPMed
rs764312133	69	I>V		No	ExAC gnomAD
rs375950963	70	E>D		No	ESP ExAC TOPMed gnomAD
TCGA novel	74	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs753023239	74	E>K		No	ExAC gnomAD
rs1949851973	75	G>A		No	Ensembl
TCGA novel	76	C>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1949851622	78	E>G		No	TOPMed
rs1411594155	81	N>D		No	TOPMed gnomAD
rs1026082131	81	N>S		No	Ensembl
rs1949850968	83	T>A		No	Ensembl
rs1398535026	85	F>C		No	gnomAD
rs1949850637	85	F>L		No	TOPMed gnomAD
TCGA novel	87	Y>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1476695099	98	M>V		No	TOPMed
TCGA novel rs1949839293	99	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs757125466	100	T>I		No	ExAC TOPMed gnomAD
rs757125466	100	T>K		No	ExAC TOPMed gnomAD
rs752832786	101	G>E		No	ExAC gnomAD
rs1949838687	101	G>R		No	TOPMed
rs1949838112	104	V>I		No	Ensembl
rs755059417	106	I>M		No	ExAC gnomAD
rs1949836950	109	E>D		No	TOPMed
TCGA novel	110	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs766924557	112	G>C		No	ExAC gnomAD
rs1173428205	114	I>V		No	TOPMed
rs1949835705	116	R>*		No	TOPMed
COSM1734426 rs750992981	116	R>Q	pancreas [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1340413916	120	H>N		No	TOPMed gnomAD
rs1949835141	120	H>Q		No	TOPMed
rs767747370	121	L>F		No	ExAC TOPMed gnomAD
rs767747370	121	L>V		No	ExAC TOPMed gnomAD
rs762274417	122	F>Y		No	ExAC gnomAD
rs1649896543	123	K>E		No	TOPMed
TCGA novel	124	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772743219	124	S>R		No	TOPMed gnomAD
rs1949834077	126	E>G		No	TOPMed
rs773829948	126	E>K		No	ExAC gnomAD
rs768314730	127	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs774980465	127	E>G		No	ExAC TOPMed gnomAD
rs774980465	127	E>V		No	ExAC TOPMed gnomAD
rs574944321	128	K>E		No	1000Genomes ExAC TOPMed gnomAD
rs745772090	129	K>I		No	ExAC
rs781230981	129	K>N		No	ExAC TOPMed gnomAD
COSM1639119 COSM1361329	129	K>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs148456295	130	H>P		No	ESP ExAC TOPMed gnomAD
rs148456295 COSM1705389	130	H>R	skin [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
TCGA novel	130	H>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1428463661	131	I>L		No	TOPMed gnomAD
rs746843180	131	I>T		No	ExAC TOPMed gnomAD
rs1428463661	131	I>V		No	TOPMed gnomAD
TCGA novel	132	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
COSM938954 COSM1651252	133	I>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs779218500	133	I>V		No	ExAC TOPMed gnomAD
COSM4864123 COSM938953	134	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1442945887	135	N>H		No	TOPMed gnomAD
rs964671160	136	G>E		No	Ensembl
rs1209459274	138	P>R		No	Ensembl
rs113878846	139	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1249716902	140	P>L		No	gnomAD
COSM4811402 COSM1299338	140	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs756263422	141	D>A		No	ExAC gnomAD
rs750860679	142	F>I		No	ExAC gnomAD
rs1275019194	144	V>A		No	gnomAD
rs1189046583	144	V>M		No	TOPMed gnomAD
rs1380112604	146	A>T		No	gnomAD
rs1949828944	146	A>V		No	TOPMed gnomAD
rs928789507	151	L>F		No	Ensembl
rs1482050446	151	L>H		No	gnomAD
rs1949713428	152	Y>C		No	TOPMed
rs1949713249	154	E>*		No	TOPMed
rs2139132518	158	D>A		No	1000Genomes
COSM4869728 COSM938952	158	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
RCV000896847 rs181888536	160	F>L		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1158465554	161	D>V		No	gnomAD
rs1472980527	162	T>I		No	TOPMed gnomAD
rs1472980527	162	T>N		No	TOPMed gnomAD
rs745978127 COSM4863659 COSM938951	164	R>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs781488871	164	R>H		No	ExAC TOPMed gnomAD
rs781488871	164	R>L		No	ExAC TOPMed gnomAD
rs757781644	166	I>N		No	ExAC TOPMed gnomAD
rs757781644	166	I>T		No	ExAC TOPMed gnomAD
rs1949711468	168	A>T		No	Ensembl
rs752122331	169	K>R		No	ExAC TOPMed gnomAD
rs764421420	170	S>T		No	ExAC gnomAD
rs761738616	171	K>E		No	Ensembl
rs1949710590	172	K>I		No	Ensembl
rs1949710247	172	K>N		No	Ensembl
rs369178971 COSM1676845	173	S>*	large_intestine [Cosmic]	No	cosmic curated ESP gnomAD
COSM4498370 COSM4498371	173	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1949710074	173	S>P		No	TOPMed
rs758804095	174	N>I		No	ExAC TOPMed
rs758804095	174	N>S		No	ExAC TOPMed
rs1565998337	178	H>L		No	Ensembl
rs758912579	180	D>H		No	ExAC gnomAD
rs758912579	180	D>N		No	ExAC gnomAD
COSM4810790 COSM938950	180	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM1741361 rs1949708537	182	T>A	urinary_tract [Cosmic]	No	cosmic curated Ensembl
rs776209935	182	T>I		No	ExAC gnomAD
COSM3968182 rs776209935 COSM3968181	182	T>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC gnomAD
COSM6072388 COSM6072389	184	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs765869720	184	G>R		No	ExAC
rs1018223613	185	I>V		No	TOPMed gnomAD
rs1949707447	187	T>I		No	TOPMed
rs760646186	188	V>G		No	ExAC TOPMed gnomAD
rs773328520	189	G>D		No	ExAC gnomAD
rs1949706418	191	T>A		No	gnomAD
rs945939403	191	T>I		No	TOPMed gnomAD
rs1949706052	192	T>P		No	Ensembl
rs775802404	193	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1439385947	198	E>*		No	TOPMed
rs1371062772	201	M>L		No	gnomAD
rs768395970	202	M>L		No	ExAC TOPMed gnomAD
rs149328427	203	Q>P		No	ESP ExAC TOPMed gnomAD
rs746150457	204	C>F		No	TOPMed gnomAD
rs746150457	204	C>Y		No	TOPMed gnomAD
rs148027037	207	L>S		No	1000Genomes ESP ExAC gnomAD
rs771004518	209	A>D		No	ExAC gnomAD
rs1949655132	211	S>C		No	Ensembl
rs1949655309	211	S>T		No	Ensembl
rs778195029	212	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1274485860	213	T>K		No	TOPMed gnomAD
rs1949654807	213	T>P		No	Ensembl
rs1592366272	214	T>P		No	Ensembl
rs891941469	216	S>G		No	TOPMed gnomAD
rs1949653684	218	Q>H		No	Ensembl
rs1949653327	221	V>G		No	Ensembl
rs1949653165	222	Q>K		No	Ensembl
COSM1645567 COSM459526 rs567275114	225	R>C	cervix Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1949652600 COSM84147	225	R>H	pancreas [Cosmic]	No	cosmic curated gnomAD
rs753495640	227	H>Q		No	ExAC TOPMed gnomAD
rs1471828683	227	H>Y		No	TOPMed
TCGA novel	228	A>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM938949 rs779602428 COSM4867480	229	I>V	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	231	T>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1002148747	233	H>N		No	TOPMed
rs755633407	233	H>R		No	ExAC gnomAD
rs1336253126	234	V>L		No	gnomAD
rs1949650648	235	C>Y		No	TOPMed
rs968752395	236	Q>H		No	TOPMed
rs767206825	238	R>T		No	ExAC gnomAD
rs1398697802	239	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1949649363	240	C>R		No	gnomAD
COSM1322539	242	Q>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1682477634	242	Q>P		No	TOPMed
rs935761437	243	I>M		No	gnomAD
rs1949648806	244	D>A		No	gnomAD
TCGA novel	245	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1468192418	246	D>E		No	gnomAD
rs1164491796	246	D>Y		No	gnomAD
rs772197323	247	N>S		No	ExAC gnomAD
rs377116944	248	A>E		No	ExAC TOPMed gnomAD
rs1396157941	249	T>A		No	TOPMed
TCGA novel	250	D>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs769022716	252	K>R		No	ExAC gnomAD
rs749632095 RCV001355730	253	I>T		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs1949613554	254	I>T		No	Ensembl
rs1949612887	255	S>A		No	gnomAD
rs1949612542	258	A>G		No	Ensembl
rs1292335779	261	N>S		No	TOPMed gnomAD
COSM4867251 COSM938948	262	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1949612006	264	E>K		No	TOPMed gnomAD
rs745576659	265	T>N		No	ExAC gnomAD
rs1949611433	267	T>A		No	Ensembl
rs1592362966	267	T>N		No	Ensembl
COSM3688180 COSM3688181	269	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1592362890	270	F>L		No	Ensembl
rs1330960891	271	H>R		No	gnomAD
COSM4858627 COSM693267	274	D>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1949609929	274	D>N		No	gnomAD
rs1272845957	276	A>T		No	gnomAD
rs138390624	278	S>T		No	ESP ExAC TOPMed gnomAD
rs937811368	283	R>C		No	1000Genomes TOPMed gnomAD
COSM1676843 rs758156089	283	R>H	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
TCGA novel	283	R>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1949608069	284	T>I		No	Ensembl
rs1949607102	289	E>G		No	Ensembl
rs1017951046 COSM938947 COSM4868510	289	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs370066971	290	R>K		No	ESP
rs1478587281	291	A>G		No	gnomAD
rs765082569 COSM1361327 COSM4786483	291	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM1177175	293	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1592362425	294	G>A		No	Ensembl
rs750158577	294	G>C		No	ExAC TOPMed gnomAD
rs1177512217	295	I>V		No	gnomAD
rs1949605140 COSM41532	296	S>C	lung [Cosmic]	No	cosmic curated TOPMed
rs1179670901	297	I>V		No	TOPMed
rs1949604804	298	N>T		No	Ensembl
rs773472902	299	C>Y		No	ExAC gnomAD
rs767553587	300	G>E		No	ExAC gnomAD
COSM5643210 COSM5643209	300	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs764295598	303	A>P		No	ExAC gnomAD
rs781240040	305	G>D		No	Ensembl
TCGA novel	309	S>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs972411719	309	S>R		No	TOPMed gnomAD
rs1436855388	309	S>R		No	gnomAD
TCGA novel	312	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1949361146	312	G>R		No	Ensembl
rs1949360938	313	D>V		No	Ensembl
COSM693268 COSM4859377	315	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1351297429	318	A>P		No	TOPMed gnomAD
rs1344951736	318	A>V		No	gnomAD
rs1361472826	320	H>R		No	gnomAD
rs1204385293	321	V>D		No	TOPMed
rs1429561167	322	P>A		No	gnomAD
rs770246874	322	P>L		No	ExAC gnomAD
rs1490765240	323	Y>C		No	TOPMed gnomAD
rs1490765240	323	Y>F		No	TOPMed gnomAD
rs776365804	326	S>T		No	ExAC gnomAD
rs1949357660	329	T>A		No	TOPMed gnomAD
rs1024080688	329	T>I		No	Ensembl
rs1949357272	330	R>G		No	gnomAD
rs1833162130	332	L>P		No	TOPMed gnomAD
TCGA novel	333	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1949356480	333	Q>R		No	TOPMed
TCGA novel	334	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs971322383	337	G>E		No	TOPMed gnomAD
rs1183333668	337	G>R		No	TOPMed gnomAD
rs1454729970	338	G>V		No	TOPMed
TCGA novel	338	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1275123439	339	N>S		No	gnomAD
rs1949355192	340	S>I		No	TOPMed
rs772956810	343	I>L		No	ExAC TOPMed gnomAD
rs771443337	343	I>T		No	ExAC TOPMed gnomAD
rs772956810	343	I>V		No	ExAC TOPMed gnomAD
rs1948954674	344	M>L		No	Ensembl
rs1244589483	345	I>M		No	TOPMed
rs1948954301	345	I>T		No	gnomAD
COSM187103 rs143166999	346	A>T	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1592319162	348	V>D		No	Ensembl
TCGA novel	353	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1948952455	356	M>I		No	TOPMed
rs768580958	356	M>V		No	ExAC TOPMed gnomAD
rs992012618 COSM938945 COSM2065198	358	T>M	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs1948952236	358	T>S		No	TOPMed
COSM6072390 COSM6072391	359	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs779694955	361	T>S		No	ExAC gnomAD
TCGA novel	363	K>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	363	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1948950282	365	A>S		No	TOPMed
rs1592318930	365	A>V		No	Ensembl
rs778081595	366	N>H		No	ExAC TOPMed gnomAD
rs758353486	366	N>S		No	ExAC TOPMed gnomAD
rs752828477	367	R>*		No	ExAC TOPMed gnomAD
rs765481237	367	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs760108872	368	A>T		No	ExAC gnomAD
rs766620026	369	R>G		No	ExAC gnomAD
rs1948948515	369	R>K		No	Ensembl
rs761132468	371	I>V		No	ExAC gnomAD
rs767209233	372	K>R		No	ExAC gnomAD
rs1948947899	373	N>S		No	TOPMed gnomAD
rs761242353	375	V>L		No	ExAC TOPMed gnomAD
rs761242353	375	V>M		No	ExAC TOPMed gnomAD
rs1948947313	376	M>I		No	Ensembl
rs1186045282	376	M>T		No	gnomAD
rs968830367	377	V>A		No	gnomAD
rs1948947149	377	V>L		No	Ensembl
rs1021616179	378	N>S		No	gnomAD
rs1948946798	378	N>Y		No	gnomAD
rs773844977	380	D>N		No	ExAC gnomAD
rs1302414390	381	R>K		No	gnomAD
rs1388678542	382	A>T		No	gnomAD
rs749195583	383	S>C		No	ExAC TOPMed gnomAD
rs749195583	383	S>G		No	ExAC TOPMed gnomAD
rs1948945443	383	S>I		No	Ensembl
rs1349887483	385	Q>E		No	TOPMed gnomAD
rs369194542	385	Q>H		No	ESP ExAC TOPMed gnomAD
rs769430367	386	I>M		No	ExAC gnomAD
TCGA novel	386	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1019794380	387	N>D		No	TOPMed
RCV001773300 rs2138873313	389	L>I		No	ClinVar Ensembl dbSNP
COSM1676841 rs777791795	390	R>C	central_nervous_system [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs758689865	390	R>H		No	ExAC TOPMed gnomAD
RCV002223435 rs777791795	390	R>S		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs748441314	391	S>R		No	ExAC gnomAD
rs1199323292	392	E>K		No	gnomAD
COSM3811927 COSM3811926	394	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1287405376	395	R>*		No	Ensembl
rs779115969	395	R>Q		No	ExAC TOPMed gnomAD
rs267603450	396	L>F		No	ExAC gnomAD
rs1442245860	396	L>R		No	gnomAD
rs267603450	396	L>V		No	ExAC gnomAD
rs754258302	397	Q>H		No	ExAC gnomAD
rs76957342	397	Q>P		No	Ensembl
rs1464916547	398	M>L		No	gnomAD
rs1308921763	398	M>R		No	TOPMed gnomAD
rs1565945825	399	E>K		No	gnomAD
rs1948941362	401	M>L		No	TOPMed gnomAD
rs376944751	401	M>T		No	ESP ExAC TOPMed gnomAD
rs1948941362	401	M>V		No	TOPMed gnomAD
rs1278629407	402	E>G		No	gnomAD
rs931089309	404	K>R		No	Ensembl
rs898209512	405	T>R		No	Ensembl
rs1229330768	406	G>S		No	gnomAD
rs1948857862	408	R>G		No	Ensembl
COSM4786877 COSM1322540	408	R>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs946615924	409	I>V		No	Ensembl
rs1948857484	410	I>V		No	Ensembl
rs1948857263	411	D>A		No	Ensembl
rs1244207399	412	E>G		No	gnomAD
rs750947190	412	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1948856710	413	E>D		No	TOPMed
rs78616703	414	G>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs757651743	414	G>D		No	ExAC gnomAD
rs1416576490	415	V>M		No	TOPMed gnomAD
rs1948855733	416	E>D		No	TOPMed gnomAD
rs771773477	416	E>G		No	TOPMed gnomAD
rs1948855552	417	S>G		No	TOPMed
rs2138843354	418	I>M		No	Ensembl
rs879099697	418	I>V		No	Ensembl
rs751166979	419	N>S		No	ExAC TOPMed gnomAD
rs1948854860	420	D>V		No	gnomAD
rs1421287570	421	M>I		No	gnomAD
RCV000910155 rs551748818	421	M>V		No	ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1160923543	422	F>L		No	gnomAD
rs1472208880	424	E>D		No	gnomAD
rs375541289	427	M>L		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel rs1592312677	430	T>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
TCGA novel	431	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	434	N>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1471900499 COSM938944 COSM4870467	436	R>C	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs200436491	436	R>H		No	ExAC TOPMed gnomAD
rs764712550	439	I>V		No	ExAC gnomAD
rs1948851642	441	A>V		No	Ensembl
rs1439743720	442	M>I		No	gnomAD
rs1948851469	442	M>T		No	TOPMed
rs368294102	443	Q>*		No	ESP TOPMed gnomAD
rs368294102	443	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP NCI-TCGA TOPMed gnomAD
rs144601000	444	E>A		No	ESP ExAC TOPMed gnomAD
rs144601000	444	E>G		No	ESP ExAC TOPMed gnomAD
rs2138841416	445	T>A		No	Ensembl
rs770807001	445	T>K		No	ExAC TOPMed gnomAD
rs770807001	445	T>M		No	ExAC TOPMed gnomAD
rs1948850057	447	D>G		No	Ensembl
rs769003611	448	A>V		No	ExAC gnomAD
rs375768830	450	R>S		No	ESP ExAC TOPMed gnomAD
rs771402953	454	T>A		No	Ensembl
rs769811096	454	T>I		No	ExAC gnomAD
rs746352730	455	Q>R		No	ExAC TOPMed gnomAD
rs781683151	458	S>I		No	ExAC gnomAD
rs781683151	458	S>N		No	ExAC gnomAD
rs757563686	459	D>E		No	ExAC TOPMed gnomAD
rs1166484313	459	D>G		No	gnomAD
rs1183320157	461	A>V		No	gnomAD
rs1471332590	463	H>N		No	TOPMed gnomAD
rs1471332590	463	H>Y		No	TOPMed gnomAD
rs751929960	464	V>F		No	ExAC TOPMed gnomAD
rs751929960	464	V>I		No	ExAC TOPMed gnomAD
rs1948846699	465	L>I		No	gnomAD
rs778178203	466	A>D		No	ExAC TOPMed gnomAD
rs1948846517	466	A>T		No	Ensembl
COSM1511943 COSM6136709 COSM6136708 rs778178203	466	A>V	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs758057629	467	R>G		No	ExAC TOPMed gnomAD
COSM5233394 COSM548310	467	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1333883973	469	G>D		No	TOPMed gnomAD
rs1333883973	469	G>V		No	TOPMed gnomAD
TCGA novel	471	G>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs778450822	471	G>E		No	ExAC gnomAD
rs754452058	473	E>*		No	ExAC gnomAD
rs1211798681	473	E>G		No	TOPMed gnomAD
rs1211798681	473	E>V		No	TOPMed gnomAD
TCGA novel rs1948814189	474	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1486805804	476	S>G		No	gnomAD
rs1948813413	477	N>S		No	gnomAD
rs766053082	479	I>T		No	ExAC gnomAD
rs750432034	480	H>D		No	ExAC TOPMed gnomAD
rs1948812656	481	S>G		No	TOPMed
TCGA novel	481	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs761541891	483	I>V		No	ExAC gnomAD
COSM938943 COSM2065175	485	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs143300316 COSM108456	485	E>K	skin [Cosmic]	No	cosmic curated Ensembl
rs1948811700	485	E>V		No	TOPMed
rs916797963	486	I>V		No	TOPMed gnomAD
COSM938942 rs1948811066 COSM4863679	487	E>K	Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
rs1948810735	488	D>A		No	TOPMed gnomAD
rs1948810904	488	D>Y		No	Ensembl
rs2138827295	489	L>V		No	Ensembl
rs1179718800	491	A>T		No	TOPMed gnomAD
TCGA novel	493	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs146440071	493	L>S		No	ESP ExAC TOPMed gnomAD
TCGA novel	493	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1453403699	495	E>K		No	TOPMed gnomAD
rs767618564	496	S>N		No	Ensembl
rs1948419475	497	E>A		No	Ensembl
rs773709604	498	A>T		No	ExAC gnomAD
rs1948418833	499	V>G		No	TOPMed gnomAD
rs772460803	500	N>Y		No	ExAC gnomAD
COSM4467858 rs774562432 COSM4467857	504	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
TCGA novel	506	N>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1481871548	507	L>M		No	gnomAD
rs1948417443	508	T>A		No	TOPMed gnomAD
rs1160277688	508	T>R		No	TOPMed
rs1948417225	510	A>G		No	Ensembl
rs1948416802	511	T>A		No	Ensembl
rs1452723005	512	A>G		No	TOPMed gnomAD
rs779882169	512	A>S		No	ExAC TOPMed gnomAD
rs779882169	512	A>T		No	ExAC TOPMed gnomAD
rs755633872	513	R>G		No	ExAC TOPMed gnomAD
rs1385293596	513	R>K		No	gnomAD
rs745377020	514	A>V		No	ExAC TOPMed gnomAD
rs144047911	515	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs993302961	519	G>E		No	Ensembl
rs569736835	519	G>R		No	1000Genomes ExAC TOPMed gnomAD
rs1948413540	521	S>P		No	TOPMed
rs1592284814	522	T>S		No	Ensembl
rs1364104176	524	S>F		No	gnomAD
TCGA novel	524	S>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1948412946	524	S>T		No	Ensembl
rs1349715518	525	P>L		No	gnomAD
rs758223938	525	P>S		No	ExAC TOPMed gnomAD
rs1431095676	527	I>M		No	TOPMed gnomAD
rs1948411879	527	I>V		No	Ensembl
rs960059923	529	S>P		No	Ensembl
rs1312032581	530	S>*		No	TOPMed
rs371442550	531	D>G		No	ESP ExAC TOPMed gnomAD
rs1948410647	532	K>T		No	TOPMed
rs867354889	533	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs139129865	534	T>I		No	ESP ExAC TOPMed gnomAD
TCGA novel	535	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs923122059	535	I>T		No	TOPMed
rs2138685600	536	E>K		No	Ensembl
rs1245668808	537	I>T		No	gnomAD
rs1204999624	538	I>K		No	gnomAD
TCGA novel	538	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs760678283	539	D>E		No	ExAC TOPMed gnomAD
rs1358721057	539	D>G		No	TOPMed gnomAD
rs1352108446 COSM275737	539	D>N	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1231578129	540	L>I		No	gnomAD
rs1347396430	540	L>P		No	gnomAD
rs1347396430	540	L>Q		No	gnomAD
rs1363043598	541	A>E		No	gnomAD
rs1236806542	541	A>P		No	gnomAD
rs1236806542	541	A>T		No	gnomAD
COSM2065161 COSM2065162	544	D>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1381571381	544	D>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs964475807	544	D>V		No	TOPMed gnomAD
COSM938941 COSM4863628	544	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs374696798	545	L>V		No	ESP ExAC gnomAD
rs1290382409	546	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
TCGA novel rs1134961	548	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Ensembl
COSM261662	550	R>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774962499	550	R>K		No	ExAC gnomAD
rs968902446	551	K>E		No	Ensembl
rs769101427	552	E>K		No	ExAC gnomAD
rs1173833175	553	K>N		No	TOPMed gnomAD
rs1165249973	554	R>K		No	gnomAD
TCGA novel	555	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1179328833	557	K>R		No	TOPMed gnomAD
COSM2065160 COSM1361325	558	R>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs774683597	558	R>M		No	Ensembl
rs774683597	558	R>T		No	Ensembl
rs1443639940	560	Q>H		No	TOPMed gnomAD
rs1947904409	561	K>Q		No	TOPMed
TCGA novel	562	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	563	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1947903943	564	E>K		No	TOPMed
rs1161243532	565	S>N		No	TOPMed
rs1024198839	567	R>*		No	TOPMed gnomAD
rs1258642320	567	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1482181587	568	E>G		No	gnomAD
rs191150586	569	E>A		No	1000Genomes TOPMed gnomAD
rs191150586	569	E>G		No	1000Genomes TOPMed gnomAD
rs988674826	570	R>G		No	TOPMed gnomAD
rs1254959041	571	S>N		No	gnomAD
rs1364807045	572	V>A		No	TOPMed gnomAD
rs775986011	573	A>G		No	ExAC gnomAD
rs770300950	576	E>G		No	ExAC TOPMed gnomAD
rs148688136	576	E>K		No	ESP ExAC TOPMed gnomAD
rs148688136	576	E>Q		No	ESP ExAC TOPMed gnomAD
rs746545050	577	D>G		No	ExAC TOPMed gnomAD
COSM4870400 COSM938940	577	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1947492141	578	N>S		No	Ensembl
rs1325359832	578	N>Y		No	TOPMed
rs777619166	582	D>E		No	ExAC TOPMed gnomAD
rs748137887	584	E>D		No	ExAC gnomAD
rs771990557	584	E>G		No	ExAC gnomAD
rs2138415603	585	K>E		No	Ensembl
rs778652648	585	K>N		No	ExAC gnomAD
rs1033430812	586	K>E		No	TOPMed
rs1399474327	589	K>N		No	TOPMed gnomAD
COSM325630 rs1407646031	590	G>C	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated TOPMed gnomAD
rs754807741	590	G>D		No	ExAC TOPMed gnomAD
rs1407646031	590	G>S		No	TOPMed gnomAD
rs1947489076	592	S>A		No	Ensembl
rs147231078	592	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
COSM938939 COSM4875650	593	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1468936451	595	E>K		No	gnomAD
rs906206403	597	N>D		No	TOPMed gnomAD
rs751656519	597	N>S		No	ExAC TOPMed gnomAD
rs1372629291	598	E>A		No	gnomAD
rs1592241041	599	L>I		No	Ensembl
TCGA novel	600	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1947486606	600	E>K		No	Ensembl
TCGA novel	601	V>=	Variant assessed as Somatic; LOW impact. [NCI-TCGA]	No	NCI-TCGA
rs373882115	601	V>A		No	ESP ExAC TOPMed gnomAD
rs758952493	601	V>L		No	ExAC TOPMed gnomAD
rs1173632775	604	S>R		No	gnomAD
rs1216438949	607	V>L		No	gnomAD
rs1448482009	608	S>N		No	gnomAD
rs1277934816	609	D>G		No	TOPMed gnomAD
rs1947450563	609	D>H		No	Ensembl
TCGA novel	610	H>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1463663866	610	H>R		No	TOPMed
rs1241747341	610	H>Y		No	TOPMed
rs139879235	612	D>N		No	ESP ExAC TOPMed gnomAD
rs1009678629	613	E>A		No	gnomAD
rs748099862	615	E>Q		No	Ensembl
TCGA novel	617	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs747284637	619	E>K		No	ExAC TOPMed gnomAD
rs747284637	619	E>Q		No	ExAC TOPMed gnomAD
rs1453778990 RCV001356104	621	E>missing		No	ClinVar dbSNP
RCV000968687 rs750450259	621	E>missing		No	ClinVar dbSNP
rs1373965379	623	D>E		No	TOPMed gnomAD
rs1947446887	623	D>G		No	gnomAD
rs777970404	624	I>T		No	ExAC gnomAD
rs758583396	625	D>G		No	ExAC gnomAD
rs1168393894	626	G>R		No	TOPMed gnomAD
rs1427945712	626	G>V		No	gnomAD
COSM1322541	628	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1440893509	630	S>P		No	TOPMed
TCGA novel	632	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1273575247	632	E>K		No	TOPMed gnomAD
rs2138399874	634	D>E		No	Ensembl
rs1353385135	634	D>G		No	TOPMed gnomAD
TCGA novel	636	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2138399705	636	E>D		No	Ensembl
rs755232716	638	D>G		No	ExAC gnomAD
rs1947442598	639	E>G		No	Ensembl
rs138836723	642	N>S		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1373202204	643	Y>F		No	TOPMed
TCGA novel	644	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1051668919	644	Q>E		No	Ensembl
rs1947399005	646	D>E		No	TOPMed
rs1337320262	646	D>G		No	gnomAD
rs2138386942	647	L>V		No	1000Genomes
rs778929196	654	I>M		No	ExAC TOPMed gnomAD
rs755495082	655	A>T		No	ExAC gnomAD
COSM5223882 COSM1476515	657	K>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	659	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs897649790	660	L>M		No	TOPMed
rs897649790	660	L>V		No	TOPMed
rs1947397615	661	I>V		No	Ensembl
rs2138386375	662	D>G		No	Ensembl
rs2138386300	663	E>Q		No	Ensembl
rs1374420922	666	N>K		No	gnomAD
rs75160352	666	N>T		No	Ensembl
COSM6136710 COSM6136711	668	Q>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel rs754348492	672	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC TOPMed gnomAD NCI-TCGA
rs1696445047	676	K>R		No	TOPMed
rs750028358	677	Q>H		No	ExAC gnomAD
rs756499040	677	Q>L		No	ExAC gnomAD
rs1369964741	678	Y>S		No	gnomAD
rs1156747011	679	E>V		No	gnomAD
COSM4863500 COSM938937	680	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs940074449	683	M>L		No	TOPMed gnomAD
rs2138384465	683	M>T		No	Ensembl
rs1180150511	684	M>I		No	TOPMed gnomAD
rs1408329611	684	M>K		No	gnomAD
rs1466720080	687	H>R		No	gnomAD
COSM1511945 COSM6136713 rs751062866 COSM6136712	690	R>L	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	cosmic curated NCI-TCGA Cosmic ExAC TOPMed gnomAD
rs751062866	690	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs761244403	690	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs201835314	691	D>N		No	Ensembl
rs1947391125	693	Q>*		No	Ensembl
rs1489790674	693	Q>H		No	gnomAD
rs1947390628	694	L>I		No	Ensembl
rs1394566563	697	D>A		No	TOPMed gnomAD
rs558091834	697	D>H		No	1000Genomes ExAC gnomAD
rs558091834	697	D>Y		No	1000Genomes ExAC gnomAD
rs762918844	698	Q>L		No	ExAC TOPMed gnomAD
rs762918844 RCV000915150	698	Q>R		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs192560751	699	V>M		No	1000Genomes ExAC TOPMed gnomAD
rs1309369202	700	L>F		No	gnomAD
rs1947389109	701	Q>R		No	TOPMed
rs1232370864	704	G>S		No	gnomAD
COSM4776543 rs753650390 COSM305993	705	S>L	Variant assessed as Somatic; MODERATE impact. endometrium haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1381584879	706	V>I		No	TOPMed gnomAD
rs1947339962	707	E>K		No	Ensembl
COSM3460395 COSM3460396	708	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs560037174	709	Y>H		No	1000Genomes ExAC gnomAD
TCGA novel	712	E>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1299873101	712	E>K		No	gnomAD
rs1947339333	713	K>E		No	gnomAD
rs1374518123	714	A>E		No	gnomAD
TCGA novel	714	A>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1432481022	714	A>T		No	gnomAD
rs1173694250	715	K>T		No	TOPMed gnomAD
rs756413250	716	K>N		No	ExAC TOPMed gnomAD
rs1467092894	716	K>Q		No	gnomAD
COSM1361324 rs1193021160 COSM4747037	717	V>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
TCGA novel	717	V>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs750788580	718	R>G		No	ExAC gnomAD
rs781602588	718	R>M		No	ExAC TOPMed gnomAD
TCGA novel	720	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1029964383	721	Y>C		No	TOPMed gnomAD
rs756882881	722	E>G		No	ExAC gnomAD
rs1592233191	722	E>K		No	Ensembl
rs751212958	724	K>N		No	ExAC gnomAD
rs1592233123	725	L>P		No	Ensembl
COSM5923968 COSM5923967	726	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs80326094	726	Q>K		No	Ensembl
rs1947335931	726	Q>R		No	Ensembl
rs1281244118	727	A>G		No	gnomAD
rs1281244118	727	A>V		No	gnomAD
rs1202432059	728	M>I		No	gnomAD
rs1592233019	728	M>R		No	TOPMed
rs1592233019	728	M>T		No	TOPMed
COSM1322542	734	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM71339	735	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763620963	735	L>I		No	ExAC gnomAD
rs1947333914	736	Q>H		No	TOPMed
rs1226589623	736	Q>K		No	gnomAD
TCGA novel	739	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1947333444	740	K>Q		No	Ensembl
TCGA novel	740	K>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs752626804	742	H>D		No	ExAC TOPMed gnomAD
COSM693273 COSM4862114	742	H>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752626804	742	H>Y		No	ExAC TOPMed gnomAD
rs1486943329	743	A>T		No	TOPMed gnomAD
rs961965933	743	A>V		No	Ensembl
rs759615987	744	R>K		No	ExAC TOPMed gnomAD
rs759615987	744	R>T		No	ExAC TOPMed gnomAD
rs770896441	747	K>Q		No	ExAC TOPMed gnomAD
COSM1361322 COSM5096817	748	N>I	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2138364197	748	N>S		No	1000Genomes
rs1393671045	749	Q>*		No	TOPMed gnomAD
rs1393671045	749	Q>K		No	TOPMed gnomAD
rs1014776876	751	Q>H		No	gnomAD
rs774463961	752	Y>*		No	ExAC gnomAD
rs528921927	752	Y>C		No	ExAC gnomAD
rs528921927	752	Y>F		No	ExAC gnomAD
rs112367509	754	K>R		No	Ensembl
rs370078871	755	Q>L		No	ESP TOPMed gnomAD
rs775997715	757	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1196503556 COSM4785921 COSM1361321	762	D>G	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA gnomAD
rs1362390539	762	D>Y		No	TOPMed
rs1354367889	763	V>G		No	gnomAD
rs1433614706	764	M>I		No	Ensembl
rs1318486272	765	E>K		No	gnomAD
rs1259861197	766	M>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1009420903	769	T>I		No	TOPMed gnomAD
TCGA novel	769	T>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM4449441 rs1219032396 COSM4449440	769	T>Q	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs1947054603	771	V>A		No	TOPMed
rs1440816430	771	V>I		No	gnomAD
COSM1676838 rs778271459 COSM938936	772	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs530439474	772	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs1947053701	773	L>R		No	Ensembl
COSM4812317 COSM1299337	777	M>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs747887370	778	K>R		No	ExAC gnomAD
COSM4845130 COSM4845129 rs778531745	780	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs754563722	781	Q>E		No	ExAC TOPMed gnomAD
rs754563722	781	Q>K		No	ExAC TOPMed gnomAD
rs1947052317	782	E>G		No	TOPMed
rs766429919	783	K>E		No	ExAC gnomAD
rs1247162394	784	A>D		No	TOPMed gnomAD
rs1247162394	784	A>G		No	TOPMed gnomAD
rs1453700596	784	A>S		No	gnomAD
rs1947050886	785	R>S		No	TOPMed
rs755870837	786	L>P		No	ExAC gnomAD
rs1947050210	787	T>A		No	gnomAD
rs899183697	788	E>A		No	gnomAD
rs1251317083	789	S>C		No	gnomAD
rs750179951	792	N>S		No	ExAC TOPMed gnomAD
rs1947049086	793	R>G		No	gnomAD
rs373936264	796	A>T		No	ESP ExAC
COSM1299336 COSM4810865	797	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1355495662	799	K>R		No	gnomAD
rs763062854	800	K>N		No	ExAC gnomAD
COSM468306 COSM4857394	800	K>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	800	K>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1232994660	801	D>N		No	gnomAD
rs202062095	801	D>V		No	ExAC gnomAD
rs371582303	803	R>C		No	ESP ExAC TOPMed gnomAD
rs1326193641	803	R>H		No	gnomAD
rs371582303	803	R>S		No	ESP ExAC TOPMed gnomAD
rs771426838	804	K>E		No	ExAC gnomAD
rs761306396	804	K>R		No	ExAC gnomAD
rs776751685	805	R>K		No	Ensembl
rs2138155038	807	H>D		No	Ensembl
rs778008456	807	H>R		No	ExAC TOPMed gnomAD
rs749005274	809	L>F		No	ExAC TOPMed gnomAD
rs1946661491	810	R>G		No	Ensembl
rs1946661254	810	R>K		No	TOPMed
rs1946660385	813	E>K		No	TOPMed
rs769384831	814	A>T		No	ExAC gnomAD
rs887820875	815	Q>P		No	TOPMed
COSM4931238 COSM4931237	817	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1416156635	819	Q>E		No	TOPMed gnomAD
rs1416156635	819	Q>K		No	TOPMed gnomAD
COSM1676836 COSM1676837	820	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs745745130	821	V>A		No	ExAC
rs1285146797	822	V>I		No	TOPMed gnomAD
TCGA novel	823	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781202644	824	R>C		No	ExAC TOPMed gnomAD
rs781202644	824	R>G		No	ExAC TOPMed gnomAD
COSM4041549 rs558002876 COSM4041550	824	R>H	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs751352937	825	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs751352937	825	R>G		No	ExAC TOPMed gnomAD
COSM1212403 rs777605261	825	R>H	large_intestine [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs777605261	825	R>L		No	ExAC TOPMed gnomAD
rs751352937	825	R>S		No	ExAC TOPMed gnomAD
COSM3671060 COSM3671061	826	K>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1272634893	829	E>V		No	TOPMed
rs1185704719	831	T>A		No	TOPMed
rs1946648663	832	A>T		No	TOPMed
rs1565819019	832	A>V		No	Ensembl
rs979633626	833	L>F		No	TOPMed gnomAD
COSM693274 COSM4860732 rs979633626	833	L>V	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated NCI-TCGA TOPMed gnomAD
rs762662150 COSM2065130 COSM2065129	834	R>C	Variant assessed as Somatic; MODERATE impact. urinary_tract [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM415877 rs775230732	834	R>H	urinary_tract [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs1351407142 COSM5840900 COSM5840899	835	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
TCGA novel	836	Q>K	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1946647257	837	V>I		No	TOPMed
rs866560111	838	R>G		No	gnomAD
RCV000994895 rs1592198426	839	P>L		No	ClinVar Ensembl dbSNP
rs377418348	840	M>T		No	ESP ExAC TOPMed gnomAD
rs1946646571	840	M>V		No	TOPMed
rs745390589	842	D>N		No	ExAC TOPMed gnomAD
rs377100439	844	V>G		No	Ensembl
rs770845892	845	A>G		No	ExAC TOPMed gnomAD
rs776073550	845	A>S		No	ExAC gnomAD
rs2138148644	846	G>W		No	Ensembl
rs78917178	847	K>E		No	ExAC gnomAD
rs756078781	848	V>G		No	ExAC
rs780333123	848	V>L		No	ExAC TOPMed gnomAD
rs1370378496	850	R>Q		No	TOPMed gnomAD
rs952754000	850	R>W		No	gnomAD
rs1300421030	852	L>V		No	gnomAD
rs750509204	853	S>N		No	ExAC TOPMed gnomAD
TCGA novel	855	S>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs767549345	855	S>F		No	ExAC gnomAD
rs757815392	856	D>Y		No	ExAC TOPMed gnomAD
rs764511984	857	A>E		No	ExAC gnomAD
TCGA novel	857	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774938793	858	P>L		No	ExAC TOPMed
rs369381971	858	P>S		No	ESP ExAC TOPMed gnomAD
rs369381971	858	P>T		No	ESP ExAC TOPMed gnomAD
rs1200130993	862	T>A		No	gnomAD
TCGA novel	864	S>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	864	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1260086082	866	A>V		No	TOPMed gnomAD
rs373609055	870	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
COSM4859702 rs746913383 COSM693275	873	A>S	lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	874	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1209001466	875	R>G		No	gnomAD
rs369621463	876	T>I		No	ESP ExAC TOPMed gnomAD
TCGA novel	877	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1313920515	878	A>V		No	gnomAD
rs747977668	879	Q>L		No	ExAC TOPMed gnomAD
rs747977668	879	Q>R		No	ExAC TOPMed gnomAD
rs1946636515	882	M>I		No	Ensembl
rs146428467	882	M>V		No	ESP ExAC gnomAD
rs1299585064	883	R>G		No	gnomAD
rs1401809989	883	R>I		No	TOPMed gnomAD
rs1401809989	883	R>T		No	TOPMed gnomAD
rs2138145260	884	I>M		No	Ensembl
rs781301465	888	R>K		No	ExAC gnomAD
rs781301465	888	R>T		No	ExAC gnomAD
rs757443106	889	V>I		No	ExAC TOPMed gnomAD
COSM3986888 COSM3986889	890	Q>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs201913108	892	L>F		No	ESP ExAC TOPMed gnomAD
rs1443528519	892	L>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1946634018	894	T>A		No	gnomAD
rs145533806 RCV000970245	894	T>M		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs149718388	895	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD
rs377107935	896	A>S		No	ESP ExAC gnomAD
rs1946632527	897	T>K		No	Ensembl
rs1223175612	898	N>D		No	TOPMed gnomAD
rs1592197166	898	N>T		No	Ensembl
rs1946631660	900	N>D		No	TOPMed gnomAD
rs753468576	900	N>K		No	ExAC gnomAD
COSM3460393 COSM3460394	901	R>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs755324647	902	K>Q		No	ExAC TOPMed gnomAD
TCGA novel	903	K>N	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1246547717	904	Y>*		No	TOPMed gnomAD
rs753476990	904	Y>C		No	ExAC TOPMed gnomAD
rs1355412839	904	Y>H		No	gnomAD
rs982903798	907	K>E		No	TOPMed gnomAD
rs1307979882	908	G>E		No	TOPMed gnomAD
rs1307979882	908	G>V		No	TOPMed gnomAD
rs2138138634	910	T>N		No	Ensembl
rs749918204 COSM1676834	912	R>*	haematopoietic_and_lymphoid_tissue [Cosmic]	No	cosmic curated ExAC TOPMed gnomAD
rs145303928	912	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs774185664	913	V>E		No	ExAC gnomAD
rs761776528	913	V>M		No	ExAC TOPMed gnomAD
rs1006504172	915	I>M		No	TOPMed
rs768448384	916	S>A		No	ExAC TOPMed gnomAD
rs1179385674	916	S>C		No	gnomAD
COSM3460392 COSM3460391	916	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs768448384	916	S>T		No	ExAC TOPMed gnomAD
rs1196712876	919	A>V		No	gnomAD
rs201804365	920	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs747284586 COSM4041547 COSM4041548	920	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs747284586	920	R>L		No	ExAC TOPMed gnomAD
rs747284586	920	R>P		No	ExAC TOPMed gnomAD
rs1351141435	922	K>N		No	gnomAD
rs1211233492	922	K>T		No	TOPMed gnomAD
rs777972416	924	Q>H		No	ExAC gnomAD
rs1284671239	924	Q>R		No	gnomAD
COSM4041546 COSM4041545	925	L>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs772077335	925	L>V		No	ExAC TOPMed gnomAD
rs779305683	926	L>F		No	ExAC TOPMed
rs779305683	926	L>I		No	ExAC TOPMed
rs755299026	927	E>*		No	ExAC
rs755738527	928	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs755738527	928	R>L		No	ExAC TOPMed gnomAD
rs750114694	929	R>T		No	ExAC gnomAD
rs1592195686	930	V>G		No	Ensembl
rs767011275	931	T>A		No	ExAC TOPMed gnomAD
rs1946610581	932	D>N		No	Ensembl
rs751455734	934	I>V		No	ExAC gnomAD
rs763933896	935	M>V		No	ExAC TOPMed gnomAD
rs1421552176	937	K>N		No	gnomAD
rs1946608931	942	N>S		No	TOPMed gnomAD
rs1409522933	943	M>T		No	TOPMed gnomAD
rs372545573	943	M>V		No	ESP TOPMed gnomAD
rs1056598799	945	A>S		No	TOPMed gnomAD
TCGA novel	945	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	951	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs376149427	952	K>E		No	ESP ExAC TOPMed gnomAD
rs745424578	952	K>M		No	gnomAD
rs773506249	953	Q>K		No	ExAC gnomAD
rs762149881	955	E>D		No	ExAC TOPMed gnomAD
rs905295295	955	E>G		No	TOPMed
rs1279279983	956	E>*		No	gnomAD
rs1220693174	958	T>I		No	TOPMed gnomAD
rs1220693174	958	T>K		No	TOPMed gnomAD
rs774269490	960	R>G		No	ExAC TOPMed gnomAD
COSM3398689 COSM3398690 rs2138124848	960	R>I	Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated Ensembl
COSM3416808 rs142292357 COSM170145	961	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs142292357	961	R>G		No	ESP ExAC TOPMed gnomAD
rs199795220	961	R>Q		No	1000Genomes ExAC TOPMed gnomAD
COSM3416807 COSM3416806	962	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs370441394	963	K>R		No	ESP ExAC TOPMed gnomAD
COSM938935 COSM4868648	964	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs770085648	964	L>V		No	ExAC gnomAD
rs1946577890	966	K>E		No	TOPMed
rs61733370	967	R>I		No	1000Genomes ESP ExAC TOPMed gnomAD
RCV000968252 rs61733370	967	R>K		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs61733370	967	R>T		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1397034944	969	E>A		No	TOPMed gnomAD
rs1439133785	969	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs144311378	971	I>L		No	ESP ExAC TOPMed gnomAD
rs746716611	971	I>T		No	ExAC gnomAD
rs144311378	971	I>V		No	ESP ExAC TOPMed gnomAD
rs1180924393	972	V>I		No	gnomAD
rs777109447	973	K>R		No	ExAC TOPMed gnomAD
rs1946575414	974	E>A		No	TOPMed
rs1244501187	974	E>D		No	gnomAD
rs2138122956	975	N>S		No	Ensembl
rs1308444424	976	G>E		No	TOPMed gnomAD
rs1001479403	976	G>R		No	TOPMed gnomAD
COSM257236	978	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs752627686	984	N>D		No	ExAC gnomAD
TCGA novel	985	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs149602555	985	I>V		No	ESP ExAC TOPMed gnomAD
rs968203446	986	N>S		No	TOPMed gnomAD
rs1946573186	988	E>A		No	TOPMed
TCGA novel	989	M>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1312231703	989	M>T		No	gnomAD
COSM6136714 COSM6136715	990	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	990	E>G	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1381400352	993	T>S		No	gnomAD
rs1946571907	994	A>P		No	Ensembl
rs377047702	996	I>T		No	ESP ExAC gnomAD
rs1331968401	997	D>G		No	gnomAD
rs61733764	997	D>H		No	gnomAD
rs61733764	997	D>N		No	gnomAD
rs761907530	999	I>V		No	ExAC TOPMed gnomAD
rs369034538	1002	S>G		No	ESP TOPMed gnomAD
TCGA novel	1006	C>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1946569843	1008	A>D		No	gnomAD
rs751774889	1009	N>S		No	Ensembl
rs751836346	1010	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed
rs764110171	1013	M>T		No	ExAC gnomAD
rs371835130	1014	E>D		No	Ensembl
rs1946568163	1015	E>K		No	TOPMed gnomAD
rs1245940570	1016	A>T		No	TOPMed
rs1305521189	1019	E>G		No	gnomAD
rs1192194635	1019	E>K		No	gnomAD
TCGA novel	1020	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1490945887	1020	G>D		No	TOPMed gnomAD
rs145207490	1021	E>K		No	1000Genomes
rs755957986	1022	T>A		No	ExAC TOPMed gnomAD
rs146384175	1023	L>S		No	ESP TOPMed
rs113796726	1024	D>E		No	gnomAD
rs1946527284	1025	V>A		No	TOPMed
rs751673366	1028	V>D		No	ExAC gnomAD
rs1241096457	1029	I>L		No	TOPMed gnomAD
rs1241096457	1029	I>V		No	TOPMed gnomAD
rs1946525951	1031	A>V		No	TOPMed
rs1946525677	1032	C>R		No	TOPMed
rs763228459	1033	T>I		No	ExAC TOPMed gnomAD
TCGA novel	1034	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1946525030	1034	L>V		No	Ensembl
rs1946524402	1035	T>K		No	Ensembl
rs892495726	1035	T>P		No	TOPMed
rs1295910635	1037	A>S		No	gnomAD
rs1360570327	1038	R>*		No	TOPMed gnomAD
rs1946523260	1038	R>Q		No	TOPMed gnomAD
rs1946523030	1039	Y>H		No	Ensembl
rs771841179	1043	H>Y		No	ExAC gnomAD
rs1193181698	1047	M>L		No	TOPMed gnomAD
rs1946520573	1048	G>D		No	gnomAD
rs1488780871	1048	G>R		No	gnomAD
rs1263931298	1049	I>V		No	gnomAD
rs1311773456	1052	G>D		No	TOPMed gnomAD
rs761139342	1054	Q>H		No	ExAC TOPMed gnomAD
rs773694301	1055	A>D		No	ExAC gnomAD
rs773694301	1055	A>G		No	ExAC gnomAD
rs773694301	1055	A>V		No	ExAC gnomAD
rs1230534151 COSM312336	1056	A>S	lung [Cosmic]	No	cosmic curated TOPMed gnomAD
rs2138080683	1057	Q>L		No	Ensembl
rs761520066	1059	E>D		No	ExAC TOPMed gnomAD
rs1197714585	1059	E>K		No	gnomAD
rs1027109820	1061	Q>*		No	Ensembl
rs1339343134	1064	V>G		No	gnomAD
rs767995169	1065	L>Q		No	ExAC
COSM1705381 rs915555359	1066	E>K	skin [Cosmic]	No	cosmic curated TOPMed gnomAD
rs1239402355	1067	G>V		No	TOPMed gnomAD
rs748836406	1068	R>*		No	ExAC gnomAD
rs1375258659	1068	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA gnomAD
rs1946446441	1070	K>R		No	TOPMed
TCGA novel	1071	Q>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs774930561	1072	T>A		No	ExAC gnomAD
TCGA novel	1073	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs769757650	1073	E>K		No	ExAC gnomAD
rs745833102	1075	T>I		No	ExAC TOPMed gnomAD
rs1946445134	1078	T>N		No	TOPMed
rs780924477	1079	Q>P		No	ExAC gnomAD
rs780924477	1079	Q>R		No	ExAC gnomAD
rs1457631420	1080	N>K		No	gnomAD
rs1369122644	1081	Q>L		No	gnomAD
rs1437917259	1082	L>I		No	gnomAD
rs748309541	1083	L>S		No	ExAC gnomAD
rs992474024	1084	F>L		No	TOPMed
rs779110274	1084	F>L		No	ExAC gnomAD
rs1252460684	1084	F>S		No	gnomAD
rs1592185504	1085	H>R		No	Ensembl
rs1946442450	1085	H>Y		No	TOPMed
rs1946442071	1086	M>L		No	TOPMed gnomAD
rs960013288	1086	M>T		No	Ensembl
rs1946441676	1089	E>D		No	TOPMed
rs1946441471	1090	K>E		No	Ensembl
rs1946441247	1091	A>T		No	Ensembl
rs1946441045	1091	A>V		No	TOPMed
rs1451807193	1094	N>S		No	TOPMed
TCGA novel	1095	P>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755218415	1097	L>P		No	ExAC TOPMed gnomAD
rs753936272	1099	A>T		No	ExAC gnomAD
rs377193734	1101	L>I		No	ESP ExAC TOPMed gnomAD
rs1408837029	1101	L>P		No	TOPMed
rs1408837029	1101	L>Q		No	TOPMed
rs377193734	1101	L>V		No	ESP ExAC TOPMed gnomAD
COSM938934 COSM1651254	1102	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1946438829	1102	G>D		No	gnomAD
rs1423846263	1102	G>S		No	TOPMed gnomAD
rs1360492822	1104	A>D		No	TOPMed gnomAD
COSM3416804 COSM3416803	1105	L>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1946438233	1106	Q>R		No	TOPMed
rs367901380	1109	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1294831190	1109	D>G		No	TOPMed gnomAD
rs1946396957	1109	D>N		No	TOPMed
rs1946396232	1110	S>N		No	TOPMed
TCGA novel rs139033996	1110	S>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ESP ExAC TOPMed gnomAD
rs563027265	1111	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs1167441024	1112	P>L		No	TOPMed gnomAD
rs1167441024	1112	P>Q		No	TOPMed gnomAD
rs781481134	1116	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs778149010	1117	E>D		No	ExAC TOPMed gnomAD
rs140140022 RCV000912546	1117	E>Q		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs758701315	1119	S>N		No	ExAC gnomAD
rs2137914302	1121	D>H		No	Ensembl
rs201693220	1122	E>K		No	1000Genomes ExAC TOPMed gnomAD
rs764790302	1123	D>N		No	ExAC gnomAD
rs1945902688	1123	D>V		No	TOPMed
rs796231505	1124	A>T		No	TOPMed
rs187723045	1125	P>S		No	1000Genomes TOPMed gnomAD
rs187723045	1125	P>T		No	1000Genomes TOPMed gnomAD
rs887878200	1127	N>S		No	TOPMed gnomAD
rs1945900859	1129	P>L		No	Ensembl
rs1945900594	1132	E>D		No	gnomAD
TCGA novel	1133	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs965774800	1135	T>M		No	TOPMed gnomAD
rs753516869	1139	D>H		No	ExAC gnomAD
rs765831109	1140	L>I		No	ExAC TOPMed gnomAD
rs1945847349	1141	M>L		No	TOPMed
rs952973809	1147	V>A		No	Ensembl
rs750311917	1147	V>M		No	ExAC TOPMed gnomAD
rs761870399	1149	P>R		No	ExAC TOPMed gnomAD
rs1592156733	1150	K>T		No	TOPMed
rs372579199	1151	N>K		No	ESP ExAC TOPMed gnomAD
COSM3688179 COSM3688178	1152	K>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1179262275	1152	K>R		No	gnomAD
rs757111473	1153	A>V		No	ExAC gnomAD
rs1486236477	1154	R>*		No	TOPMed gnomAD
rs986963607 COSM175284	1154	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	cosmic curated NCI-TCGA TOPMed gnomAD
rs1945431009	1155	R>G		No	gnomAD
TCGA novel	1156	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs74778449	1156	R>K		No	Ensembl
rs1592139967	1157	T>P		No	Ensembl
rs763923109	1159	T>S		No	ExAC TOPMed gnomAD
rs762845087	1161	M>V		No	ExAC gnomAD
rs1346942612	1165	Y>C		No	TOPMed gnomAD
rs761003662	1165	Y>H		No	ExAC TOPMed
rs1346942612	1165	Y>S		No	TOPMed gnomAD
rs1275921808	1167	D>G		No	gnomAD
rs1381122416	1169	S>I		No	gnomAD
rs1945427121	1169	S>R		No	TOPMed
rs1227919873	1171	L>P		No	TOPMed
rs1945426888	1171	L>V		No	TOPMed
rs772220692	1172	A>P		No	ExAC TOPMed gnomAD
rs772220692	1172	A>T		No	ExAC TOPMed gnomAD
rs762173645	1177	T>A		No	ExAC gnomAD
rs774856036	1177	T>I		No	ExAC TOPMed gnomAD
rs554469530	1179	D>E		No	1000Genomes ExAC TOPMed gnomAD
rs760073207	1179	D>N		No	ExAC TOPMed gnomAD
rs575286430	1180	A>G		No	1000Genomes ExAC gnomAD
rs202078745	1180	A>T		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	1180	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs143083005	1181	S>C		No	ESP TOPMed gnomAD
rs143083005	1181	S>F		No	ESP TOPMed gnomAD
TCGA novel	1181	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs962843455	1182	L>F		No	TOPMed gnomAD
rs1188204192	1183	P>L		No	gnomAD
COSM4041543 COSM4041544	1184	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1238651079	1186	L>F		No	TOPMed gnomAD
COSM6072398 COSM6072399	1187	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1945420673	1188	P>L		No	TOPMed
rs954946455	1188	P>S		No	TOPMed
rs954946455	1188	P>T		No	TOPMed
rs1262449822	1189	V>I		No	TOPMed gnomAD
rs1262449822	1189	V>L		No	TOPMed gnomAD
rs1945419876	1190	A>G		No	Ensembl
rs1203990826	1190	A>T		No	gnomAD
rs1945419614	1192	G>R		No	Ensembl
rs1945419112	1193	Q>*		No	TOPMed gnomAD
COSM4833152 COSM4833151	1194	E>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1390414058	1194	E>V		No	TOPMed
COSM4832278 COSM4832279	1195	I>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1945418877	1195	I>V		No	TOPMed
rs1945418640	1199	T>P		No	TOPMed
rs1451001972	1200	E>G		No	TOPMed
rs1945417891	1201	T>A		No	Ensembl
rs1249207861	1202	S>I		No	TOPMed gnomAD
rs1026567466	1203	G>D		No	Ensembl
TCGA novel	1203	G>V	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1203	G>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1015969607	1204	T>I		No	TOPMed gnomAD
rs756814252	1204	T>P		No	ExAC TOPMed gnomAD
rs756814252	1204	T>S		No	ExAC TOPMed gnomAD
rs1394783161	1205	S>T		No	TOPMed gnomAD
rs1945415757	1208	E>G		No	Ensembl
rs557018562	1209	K>E		No	1000Genomes TOPMed gnomAD
TCGA novel	1209	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs758466226	1210	E>K		No	ExAC TOPMed gnomAD
rs1945414686	1211	L>F		No	TOPMed
rs1945414445	1212	S>F		No	TOPMed
rs866768006	1213	P>L		No	TOPMed
rs1945413905	1213	P>S		No	TOPMed
rs149075970	1214	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149075970	1214	P>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1945412683	1216	G>D		No	TOPMed gnomAD
rs571247823	1218	P>T		No	1000Genomes ExAC TOPMed gnomAD
TCGA novel	1219	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs147620197 COSM3398687	1220	K>E	central_nervous_system [Cosmic]	No	cosmic curated ESP TOPMed gnomAD
rs552970913	1220	K>R		No	1000Genomes TOPMed gnomAD
COSM1476513 COSM4813862	1221	I>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
TCGA novel	1222	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1592138934	1222	G>S		No	Ensembl
rs1945411222	1222	G>V		No	Ensembl
rs1945411013	1223	S>R		No	Ensembl
rs2137771966	1224	I>S		No	Ensembl
rs1945030197	1225	S>C		No	Ensembl
rs1945029662	1227	Q>K		No	Ensembl
rs1438184694	1227	Q>R		No	gnomAD
rs2137660591	1230	L>P		No	Ensembl
rs780767170	1230	L>V		No	Ensembl
rs1252175888	1231	S>L		No	gnomAD
rs1219822918	1233	K>E		No	gnomAD
rs750548981	1234	K>E		No	ExAC TOPMed gnomAD
rs750548981	1234	K>Q		No	ExAC TOPMed gnomAD
rs1291959900	1234	K>T		No	gnomAD
COSM1361319 COSM5091775 rs761074592	1235	I>F	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA
rs767779686	1235	I>M		No	ExAC gnomAD
rs145259176	1236	P>A		No	ESP ExAC TOPMed gnomAD
rs746483961	1237	E>Q		No	Ensembl
rs1334390547	1239	S>A		No	TOPMed
rs927536292	1239	S>F		No	TOPMed gnomAD
TCGA novel	1239	S>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs147861618	1240	P>L		No	ESP gnomAD
rs763411761	1240	P>S		No	ExAC TOPMed gnomAD
rs980738403	1241	V>L		No	TOPMed
rs776087480	1242	T>A		No	ExAC TOPMed gnomAD
rs1399041505	1242	T>I		No	gnomAD
rs776087480	1242	T>P		No	ExAC TOPMed gnomAD
rs776087480	1242	T>S		No	ExAC TOPMed gnomAD
rs569992788	1245	K>Q		No	1000Genomes ExAC TOPMed gnomAD
rs759940671	1245	K>R		No	ExAC TOPMed gnomAD
rs375504040	1246	A>P		No	ESP TOPMed gnomAD
rs375504040	1246	A>T		No	ESP TOPMed gnomAD
rs1592122713	1246	A>V		No	Ensembl
rs202059694	1248	E>K		No	ExAC TOPMed gnomAD
rs202059694	1248	E>Q		No	ExAC TOPMed gnomAD
rs746695893	1249	K>I		No	ExAC TOPMed gnomAD
rs1479940083	1252	K>I		No	gnomAD
rs1269171184	1254	K>R		No	TOPMed gnomAD
rs772806269	1257	E>K		No	ExAC TOPMed gnomAD
rs1432997726	1261	S>A		No	gnomAD
rs1367190751	1262	D>G		No	gnomAD
rs2137588687	1262	D>N		No	Ensembl
rs1334651917	1263	S>P		No	TOPMed gnomAD
rs1944784548	1264	G>E		No	gnomAD
rs1944784548	1264	G>V		No	gnomAD
rs201205072	1265	T>A		No	TOPMed
rs1592111055	1266	S>L		No	Ensembl
rs1944782965	1268	A>G		No	Ensembl
rs1177753954	1268	A>S		No	TOPMed gnomAD
rs773795201	1269	S>N		No	ExAC gnomAD
rs1592110965	1271	S>L		No	Ensembl
rs768618302	1272	P>R		No	ExAC gnomAD
rs1944781508	1273	P>S		No	TOPMed
COSM116656	1274	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1183539058	1275	S>P		No	gnomAD
rs1756239087	1276	P>S		No	TOPMed
rs139695269 COSM1476512	1279	R>Q	breast [Cosmic]	No	cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1384710859	1280	P>H		No	gnomAD
rs1384710859	1280	P>R		No	gnomAD
COSM4948628 COSM1361318 rs769601725	1281	R>C	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs752800426	1282	N>S		No	ExAC gnomAD
rs1245207332	1284	L>P		No	TOPMed gnomAD
rs1245207332	1284	L>R		No	TOPMed gnomAD
rs150630573 RCV000902855	1285	N>T		No	ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1944775541	1286	V>G		No	TOPMed gnomAD
TCGA novel	1287	F>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs755468804	1289	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs887165821 COSM4545797 COSM4545798	1289	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs755468804	1289	R>S		No	1000Genomes ExAC TOPMed gnomAD
rs1944774159	1290	L>F		No	Ensembl
rs1944773853	1290	L>P		No	TOPMed
TCGA novel	1291	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs886049342	1291	T>I		No	gnomAD
rs766790592	1292	V>F		No	ExAC TOPMed gnomAD
rs371178638	1294	Q>P		No	ESP ExAC TOPMed gnomAD
rs371178638	1294	Q>R		No	ESP ExAC TOPMed gnomAD
rs1565724787	1295	G>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	Ensembl NCI-TCGA
rs767268089	1297	T>A		No	ExAC gnomAD
COSM3811921 COSM415878	1298	S>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1944769629	1299	V>I		No	TOPMed gnomAD
rs768249226	1300	Q>H		No	ExAC gnomAD
rs1944768695	1301	Q>K		No	TOPMed gnomAD
rs1944768441	1303	K>E		No	TOPMed
rs1276329048	1303	K>M		No	TOPMed
rs11171717	1304	S>C		No	ExAC gnomAD
rs11171717	1304	S>Y		No	ExAC gnomAD
rs763602499	1305	D>V		No	ExAC TOPMed gnomAD
rs1012793782	1306	E>G		No	Ensembl
rs2137515461	1307	S>N		No	Ensembl
rs201618273	1310	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA
rs2137515299	1310	S>P		No	Ensembl
rs1944493117	1311	L>V		No	Ensembl
rs769695817	1312	S>L		No	ExAC TOPMed gnomAD
rs531164985	1313	E>D		No	ExAC TOPMed gnomAD
COSM3986886 COSM3986887	1315	H>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM2065060 rs781410152	1317	S>F	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1485764024 COSM3460390	1318	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1459792944	1318	S>P		No	TOPMed gnomAD
rs1459792944	1318	S>T		No	TOPMed gnomAD
rs142879430	1320	R>T		No	ESP ExAC TOPMed gnomAD
rs1460980013	1321	G>V		No	TOPMed
rs1944033331	1323	I>M		No	Ensembl
RCV003237995 rs2137384157	1323	I>T		No	ClinVar Ensembl dbSNP
rs1944033582	1323	I>V		No	TOPMed gnomAD
rs1444013812	1324	N>S		No	gnomAD
rs1410743282	1325	P>A		No	gnomAD
rs1944032519	1325	P>L		No	TOPMed
rs1944032279	1326	F>Y		No	TOPMed
rs1375008050	1328	A>T		No	TOPMed gnomAD
rs778528102	1329	S>P		No	ExAC TOPMed gnomAD
rs762576003	1330	K>E		No	TOPMed gnomAD
rs1424107928	1332	I>M		No	gnomAD
rs1944030545	1333	R>K		No	TOPMed
rs753262148	1333	R>S		No	ExAC TOPMed gnomAD
rs1565688929	1334	A>V		No	Ensembl
rs931031780	1337	L>F		No	gnomAD
rs931031780 RCV001758147	1337	L>I		No	ClinVar dbSNP gnomAD
rs1180639291	1338	Q>H		No	gnomAD
rs1472747319	1339	C>G		No	gnomAD
rs1426376893	1339	C>W		No	Ensembl
rs755967049	1340	I>M		No	ExAC TOPMed gnomAD
rs1471226955	1340	I>V		No	Ensembl
rs767162841	1342	I>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs761705954	1343	A>V		No	ExAC gnomAD
rs1256275079	1344	E>K		No	TOPMed gnomAD
rs751467047	1346	H>L		No	ExAC gnomAD
rs1348979571	1347	T>A		No	TOPMed gnomAD
rs930559700	1348	K>R		No	TOPMed gnomAD
COSM938931 COSM4874936	1349	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776530688	1350	V>A		No	ExAC
rs1352492048	1350	V>M		No	gnomAD
rs1036294156	1352	C>S		No	TOPMed gnomAD
rs1036294156	1352	C>Y		No	TOPMed gnomAD
rs771063766	1353	V>L		No	ExAC gnomAD
rs1225263157	1354	D>N		No	TOPMed gnomAD
rs1225263157	1354	D>Y		No	TOPMed gnomAD
rs1261194298	1355	S>A		No	TOPMed gnomAD
rs1261194298	1355	S>P		No	TOPMed gnomAD
rs980462939	1356	T>I		No	TOPMed gnomAD
rs761028766	1357	D>E		No	ExAC TOPMed gnomAD
rs139664756	1358	D>G		No	1000Genomes ESP ExAC TOPMed gnomAD
COSM6072400 COSM6072401	1358	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs139664756	1358	D>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs748495397	1359	L>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA gnomAD
rs1445476814	1359	L>P		No	TOPMed gnomAD
rs773322171	1360	L>missing	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs980893693	1361	F>L		No	TOPMed gnomAD
rs1413652783	1362	T>S		No	TOPMed gnomAD
TCGA novel	1364	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1479807856	1365	K>Q		No	gnomAD
COSM2065044 rs756337041 COSM2065043	1367	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs562228123	1367	R>H		No	1000Genomes ExAC TOPMed gnomAD
rs756337041	1367	R>S		No	ExAC TOPMed gnomAD
rs1300102262	1370	K>E		No	TOPMed
rs1943836099	1371	V>L		No	TOPMed
rs774856058	1372	W>*		No	ExAC gnomAD
rs762262699	1372	W>R		No	ExAC TOPMed gnomAD
COSM4874236 COSM938930	1375	V>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2137327940	1377	G>V		No	Ensembl
TCGA novel	1378	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1367079034	1378	Q>R		No	gnomAD
rs1565677895	1379	E>K		No	Ensembl
rs1943833125	1380	I>R		No	Ensembl
rs543953019	1381	M>I		No	1000Genomes TOPMed
rs916696180	1381	M>L		No	TOPMed gnomAD
rs1943832504	1381	M>T		No	TOPMed
rs916696180	1381	M>V		No	TOPMed gnomAD
rs764380324	1383	L>R		No	ExAC gnomAD
rs1416916210	1383	L>V		No	gnomAD
rs775777214	1384	G>R		No	ExAC TOPMed gnomAD
rs775777214	1384	G>W		No	ExAC TOPMed gnomAD
rs1407687334	1385	G>R		No	TOPMed gnomAD
rs1407687334	1385	G>S		No	TOPMed gnomAD
rs769466593	1385	G>V		No	ExAC TOPMed gnomAD
rs1487519274	1386	H>Y		No	TOPMed
rs1943828624	1387	P>L		No	Ensembl
rs2137326315	1388	N>H		No	Ensembl
rs2137326172	1389	N>H		No	Ensembl
rs745549119	1389	N>I		No	ExAC TOPMed gnomAD
rs2137326008	1389	N>K		No	Ensembl
rs745549119	1389	N>S		No	ExAC TOPMed gnomAD
rs1943827345	1391	V>G		No	Ensembl
rs139013210	1391	V>M		No	ESP ExAC TOPMed gnomAD
COSM75151 rs746875582 COSM4947701	1396	C>Y	ovary Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD
rs1202745618	1397	N>D		No	gnomAD
rs925281361	1398	Y>C		No	TOPMed gnomAD
rs925281361	1398	Y>F		No	TOPMed gnomAD
rs771051669	1399	T>I		No	Ensembl
TCGA novel	1399	T>Y	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs2137325012	1401	L>W		No	Ensembl
rs758321044	1403	F>L		No	ExAC gnomAD
rs1344148767	1404	T>S		No	gnomAD
rs2137324478	1405	V>G		No	Ensembl
rs747949177	1405	V>I		No	ExAC TOPMed gnomAD
COSM1299335 COSM4812061	1406	S>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs2137324413	1406	S>L		No	Ensembl
rs778610172	1407	T>A		No	ExAC TOPMed gnomAD
rs2137324202	1408	S>F		No	Ensembl
rs1379688467	1409	Y>S		No	TOPMed gnomAD
rs2137323943	1410	I>M		No	Ensembl
rs190902651	1410	I>V		No	1000Genomes ExAC gnomAD
rs750669566	1412	V>L		No	ExAC TOPMed gnomAD
rs2137323697	1413	W>*		No	Ensembl
rs1943821797	1413	W>G		No	TOPMed
rs2137323534	1418	S>L		No	Ensembl
rs201680308	1418	S>T		No	ESP ExAC TOPMed gnomAD
rs974476147	1419	A>T		No	gnomAD
rs757338165	1420	K>E		No	ExAC TOPMed gnomAD
rs757338165	1420	K>Q		No	ExAC TOPMed gnomAD
rs2137323180	1421	C>G		No	Ensembl
rs751709193	1421	C>S		No	ExAC TOPMed gnomAD
rs751709193	1421	C>Y		No	ExAC TOPMed gnomAD
rs1164718381 COSM1705378 COSM1705377	1423	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA gnomAD
rs764649339	1424	T>A		No	ExAC TOPMed gnomAD
rs1291824309	1425	L>V		No	TOPMed gnomAD
rs781392170	1428	S>L		No	ExAC gnomAD
rs1297147858	1429	G>A		No	TOPMed gnomAD
rs1297147858	1429	G>D		No	TOPMed gnomAD
rs777756778	1430	Q>E		No	ExAC gnomAD
rs758899586	1430	Q>H		No	ExAC gnomAD
rs1943610952	1433	L>F		No	TOPMed
TCGA novel	1434	G>W	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1943610184	1435	D>E		No	Ensembl
rs1305397666	1435	D>N		No	TOPMed gnomAD
rs1226311136	1435	D>V		No	TOPMed
rs144392523	1436	A>D		No	ESP ExAC TOPMed gnomAD
rs144392523	1436	A>V		No	ESP ExAC TOPMed gnomAD
rs200589960	1437	C>F		No	ESP ExAC TOPMed gnomAD
rs200589960	1437	C>S		No	ESP ExAC TOPMed gnomAD
rs200589960	1437	C>Y		No	ESP ExAC TOPMed gnomAD
rs1943608853	1439	A>P		No	TOPMed
rs1943608853	1439	A>T		No	TOPMed
rs766103846	1440	S>I		No	ExAC TOPMed gnomAD
TCGA novel	1440	S>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs185075080	1440	S>R		No	1000Genomes ExAC TOPMed gnomAD
rs766103846	1440	S>T		No	ExAC TOPMed gnomAD
rs772735255	1441	T>I		No	ExAC gnomAD
COSM4947791 rs771502610 COSM1361315	1443	R>*	Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761755690 COSM3416801 COSM3416802	1443	R>Q	Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1943606674	1444	T>I		No	gnomAD
rs1259827334	1445	V>A		No	TOPMed gnomAD
TCGA novel	1446	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1565665239	1447	I>T		No	Ensembl
rs774163102	1448	P>T		No	ExAC TOPMed gnomAD
rs2137272949	1450	G>E		No	Ensembl
rs369666213	1452	N>D		No	ESP ExAC gnomAD
rs369666213	1452	N>H		No	ESP ExAC gnomAD
TCGA novel	1454	I>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs749073888	1454	I>V		No	ExAC gnomAD
rs1427117718	1455	N>D		No	TOPMed gnomAD
rs771111885	1458	A>S		No	ExAC TOPMed gnomAD
rs747264491	1458	A>V		No	ExAC TOPMed gnomAD
rs548227296	1459	L>V		No	1000Genomes ExAC TOPMed gnomAD
rs1943602400	1460	N>H		No	Ensembl
rs530018336	1460	N>K		No	1000Genomes ExAC TOPMed gnomAD
rs1255084857	1461	P>S		No	gnomAD
RCV000894967 rs748963082	1463	G>D		No	ClinVar ExAC TOPMed dbSNP gnomAD
rs568874833	1464	T>I		No	1000Genomes ExAC gnomAD
rs1943600335	1465	F>V		No	TOPMed
rs1943599861	1466	L>F		No	TOPMed
rs1366357542	1466	L>P		No	gnomAD
rs1300196237	1467	Y>C		No	TOPMed gnomAD
rs1300196237	1467	Y>F		No	TOPMed gnomAD
rs1290102511	1467	Y>H		No	TOPMed gnomAD
rs1007813259	1470	S>F		No	Ensembl
rs1381233597	1471	G>E		No	TOPMed gnomAD
rs149234238	1474	V>I		No	ESP TOPMed gnomAD
rs149234238	1474	V>L		No	ESP TOPMed gnomAD
COSM6072403 COSM6072402	1475	R>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1467627382	1476	M>I		No	gnomAD
rs1372844076	1478	D>N		No	TOPMed
TCGA novel	1479	L>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs755587423	1479	L>V		No	ExAC TOPMed gnomAD
rs1187806057	1484	S>C		No	gnomAD
TCGA novel	1484	S>P	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1425121304	1485	T>A		No	gnomAD
COSM3460387 COSM3460386	1486	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1332172227	1490	G>E		No	TOPMed
TCGA novel	1493	G>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs755501569	1493	G>S		No	ExAC gnomAD
rs1364901418	1494	P>H		No	TOPMed
rs756554787	1494	P>S		No	ExAC gnomAD
rs1222473844	1496	M>I		No	TOPMed
rs750868436	1496	M>L		No	ExAC gnomAD
rs750868436	1496	M>V		No	ExAC gnomAD
rs767064636	1498	L>F		No	ExAC TOPMed gnomAD
TCGA novel	1499	T>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs751006090	1500	V>A		No	ExAC gnomAD
TCGA novel	1502	Q>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs559104078	1503	I>N		No	1000Genomes ExAC gnomAD
rs559104078	1503	I>S		No	1000Genomes ExAC gnomAD
rs931221280	1503	I>V		No	Ensembl
rs1352452589	1505	S>G		No	TOPMed gnomAD
rs2137197164	1505	S>N		No	Ensembl
rs775422512	1506	G>E		No	ExAC gnomAD
rs1943301002	1506	G>R		No	Ensembl
rs375548931	1508	D>N		No	ESP ExAC gnomAD
rs1565649083	1508	D>V		No	Ensembl
rs375548931	1508	D>Y		No	ESP ExAC gnomAD
rs1158024107	1515	K>E		No	gnomAD
rs1023072936	1516	D>G		No	TOPMed gnomAD
rs1023072936	1516	D>V		No	TOPMed gnomAD
rs1472614748	1517	H>R		No	gnomAD
TCGA novel	1518	Y>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	1518	Y>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1378693683 COSM368030	1521	M>I	lung [Cosmic]	No	cosmic curated gnomAD
rs756823322	1521	M>V		No	ExAC gnomAD
rs1023408067	1524	V>I		No	Ensembl
rs1324792116	1525	T>A		No	TOPMed
rs1943123168	1525	T>I		No	TOPMed
COSM4899635 COSM4899636	1526	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs777209231	1528	A>G		No	ExAC TOPMed gnomAD
rs777209231	1528	A>V		No	ExAC TOPMed gnomAD
rs1448038974	1529	L>P		No	gnomAD
rs1209759462	1530	G>A		No	gnomAD
rs1943120717	1533	S>R		No	Ensembl
rs1362336549	1536	H>Y		No	gnomAD
rs1262925987	1537	N>S		No	TOPMed gnomAD
rs759553232	1540	P>A		No	ExAC gnomAD
rs1943119388	1540	P>L		No	Ensembl
COSM3871521 COSM3871522	1541	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1592028243	1541	P>S		No	Ensembl
rs753536074	1543	Y>C		No	ExAC gnomAD
rs1943118349	1544	D>G		No	Ensembl
rs766218025	1546	I>V		No	ExAC gnomAD
rs780066416	1547	E>D		No	ExAC gnomAD
TCGA novel	1548	A>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1346548419	1548	A>V		No	gnomAD
rs774716605	1551	I>S		No	ExAC TOPMed gnomAD
rs1413375205	1551	I>V		No	TOPMed gnomAD
rs763113489	1553	G>V		No	ExAC gnomAD
rs769068732	1553	G>W		No	ExAC gnomAD
rs775761627	1554	D>H		No	ExAC TOPMed gnomAD
rs775761627	1554	D>N		No	ExAC TOPMed gnomAD
rs1429547646	1557	F>C		No	TOPMed
rs1235926181	1558	S>I		No	gnomAD
rs1943113825	1559	G>R		No	TOPMed
rs1478111510	1560	S>A		No	gnomAD
rs982138535	1560	S>F		No	TOPMed
rs2137153523	1563	N>T		No	1000Genomes
rs746422413	1565	I>V		No	ExAC TOPMed gnomAD
rs771343710	1569	D>G		No	ExAC gnomAD
rs746600657	1572	Q>K		No	ExAC TOPMed gnomAD
rs1381721611	1572	Q>P		No	TOPMed
rs191093660	1574	D>E		No	1000Genomes ExAC TOPMed gnomAD
rs1273856513	1574	D>G		No	gnomAD
TCGA novel	1574	D>T	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
COSM1734419 COSM1734420	1577	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1157266802	1578	Q>*		No	gnomAD
rs748814688	1579	V>I		No	ExAC TOPMed gnomAD
rs780029810	1580	P>S		No	ExAC gnomAD
rs756170780	1581	N>D		No	ExAC gnomAD
rs750213364	1582	A>S		No	ExAC gnomAD
rs1942972642	1583	H>Y		No	TOPMed gnomAD
rs1490739730	1584	K>R		No	TOPMed
rs1189183372	1585	D>G		No	TOPMed gnomAD
rs1189183372	1585	D>V		No	TOPMed gnomAD
rs767452046	1586	W>L		No	ExAC gnomAD
rs758649013	1587	V>I		No	ExAC TOPMed gnomAD
rs765166685	1591	G>V		No	ExAC TOPMed gnomAD
rs1942969389	1592	V>L		No	gnomAD
rs2137122371	1593	V>L		No	Ensembl
rs141385146	1596	H>Y		No	ESP ExAC gnomAD
rs537501726	1598	V>I		No	1000Genomes ExAC TOPMed gnomAD
rs537501726	1598	V>L		No	1000Genomes ExAC TOPMed gnomAD
rs1565631039	1600	L>P		No	gnomAD
rs945173948	1600	L>V		No	Ensembl
rs1439161364	1603	C>G		No	Ensembl
COSM4041535 COSM4041536	1606	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs766876071	1606	G>D		No	ExAC gnomAD
rs1437592707	1615	T>A		No	gnomAD
rs773513818	1615	T>I		No	ExAC gnomAD
rs773513818	1615	T>N		No	ExAC gnomAD
rs893540223	1616	F>S		No	TOPMed
rs1347330994	1617	M>T		No	gnomAD
rs1942965110	1621	E>D		No	TOPMed
rs772438071	1623	K>N		No	ExAC TOPMed gnomAD
rs747732382	1624	G>C		No	ExAC gnomAD
rs10243	1624	G>D		No	TOPMed
rs747732382	1624	G>S		No	ExAC gnomAD
rs1161324215	1625	H>N		No	TOPMed gnomAD
rs943051896	1625	H>R		No	Ensembl
rs768248912	1626	D>G		No	ExAC gnomAD
rs1942962671	1627	S>T		No	gnomAD
rs1454548070	1629	I>F		No	TOPMed gnomAD
rs1942961799	1629	I>N		No	TOPMed
rs1454548070	1629	I>V		No	TOPMed gnomAD
rs748809944	1630	N>S		No	ExAC TOPMed gnomAD
rs1307686317	1631	A>D		No	TOPMed gnomAD
rs148144546	1632	I>L		No	1000Genomes ExAC TOPMed gnomAD
rs756075691	1632	I>M		No	ExAC gnomAD
rs148144546	1632	I>V		No	1000Genomes ExAC TOPMed gnomAD
COSM4862248 COSM693277	1634	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs781080527	1636	S>F		No	ExAC TOPMed gnomAD
rs781080527	1636	S>Y		No	ExAC TOPMed gnomAD
rs1301181207	1638	H>D		No	TOPMed gnomAD
rs1942957889	1641	T>S		No	Ensembl
rs1373843147	1642	A>P		No	gnomAD
rs1373843147	1642	A>S		No	gnomAD
rs1942105749	1644	D>E		No	Ensembl
rs1048446665	1645	D>E		No	TOPMed
rs777458254	1646	R>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs777458254	1646	R>G		No	ExAC TOPMed gnomAD
COSM220207 rs755174363	1646	R>Q	NS Variant assessed as Somatic; MODERATE impact. haematopoietic_and_lymphoid_tissue [Cosmic, NCI-TCGA]	No	NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs559949605	1647	T>A		No	1000Genomes ExAC TOPMed gnomAD
rs559949605	1647	T>P		No	1000Genomes ExAC TOPMed gnomAD
rs1240016204	1648	V>E		No	TOPMed gnomAD
rs780041023	1648	V>M		No	ExAC gnomAD
rs993800051	1649	R>I		No	TOPMed gnomAD
rs1348946004	1651	W>S		No	TOPMed gnomAD
rs896750929	1652	K>R		No	TOPMed gnomAD
rs1942102415	1653	A>G		No	Ensembl
rs376346007	1654	R>C		No	ESP ExAC TOPMed gnomAD
rs373406994 COSM4152803	1654	R>H	kidney [Cosmic]	No	cosmic curated ESP ExAC TOPMed gnomAD
rs376346007	1654	R>S		No	ESP ExAC TOPMed gnomAD
rs370691140	1655	N>S		No	ESP ExAC TOPMed gnomAD
rs1942101240	1655	N>Y		No	Ensembl
rs199566972	1656	L>F		No	Ensembl
rs1340484297	1656	L>S		No	gnomAD
COSM370736 rs1253389910	1657	Q>P	lung [Cosmic]	No	cosmic curated gnomAD
TCGA novel	1658	D>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1243077166	1659	G>S		No	gnomAD
rs1266144841	1660	Q>H		No	Ensembl
rs181255946	1660	Q>L		No	1000Genomes
TCGA novel	1661	I>M	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1321308319	1661	I>T		No	TOPMed gnomAD
rs1235189460	1662	S>P		No	TOPMed gnomAD
rs893438891	1665	G>E		No	Ensembl
rs769657363	1666	D>H		No	ExAC TOPMed gnomAD
rs769657363	1666	D>N		No	ExAC TOPMed gnomAD
rs769657363	1666	D>Y		No	ExAC TOPMed gnomAD
rs775014213	1667	L>M		No	ExAC gnomAD
rs769639690	1668	G>E		No	ExAC gnomAD
rs769639690	1668	G>V		No	ExAC gnomAD
rs770949743	1671	I>N		No	ExAC TOPMed gnomAD
rs770949743	1671	I>S		No	ExAC TOPMed gnomAD
rs770949743	1671	I>T		No	ExAC TOPMed gnomAD
rs777563049	1672	A>V		No	ExAC gnomAD
rs771768221	1673	S>N		No	ExAC gnomAD
rs1409209542	1674	N>D		No	gnomAD
COSM4934137 COSM4934136	1674	N>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs780239746	1675	N>L		No	ExAC TOPMed gnomAD

1 associated diseases with Q7Z4S6

[MIM: 135700]: Fibrosis of extraocular muscles, congenital, 1 (CFEOM1)

A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. . Note=The disease is caused by variants affecting the gene represented in this entry.

10 regional properties for Q7Z4S6

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	762 - 784	IPR001611-1
repeat	Leucine-rich repeat	818 - 841	IPR001611-2
repeat	Leucine-rich repeat	876 - 898	IPR001611-3
repeat	Leucine-rich repeat	932 - 954	IPR001611-4
repeat	Leucine-rich repeat	990 - 1008	IPR001611-5
domain	DAPIN domain	1 - 95	IPR004020
domain	NACHT nucleoside triphosphatase	211 - 528	IPR007111
domain	NACHT-associated domain	128 - 201	IPR029495
domain	NOD1/2, winged helix domain	460 - 512	IPR041075
domain	NACHT, LRR and PYD domains-containing protein, helical domain HD2	514 - 621	IPR041267

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell projection, dendrite Cell projection, axon	In neurons, localized to axons and dendrites
PANTHER Family	PTHR47969	CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED
PANTHER Subfamily	PTHR47969:SF30	KINESIN MOTOR DOMAIN-CONTAINING PROTEIN
PANTHER Protein Class	cytoskeletal protein microtubule binding motor protein microtubule or microtubule-binding cytoskeletal protein
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
kinesin complex	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

5 GO annotations of molecular function

Name	Definition
ankyrin repeat binding	Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.

1 GO annotations of biological process

Name	Definition
microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O95239	KIF4A	Chromosome-associated kinesin KIF4A	Homo sapiens (Human)	SS
Q2VIQ3	KIF4B	Chromosome-associated kinesin KIF4B	Homo sapiens (Human)	SS
P33176	KIF5B	Kinesin-1 heavy chain	Homo sapiens (Human)	EV
O60282	KIF5C	Kinesin heavy chain isoform 5C	Homo sapiens (Human)	EV
Q12840	KIF5A	Kinesin heavy chain isoform 5A	Homo sapiens (Human)	EV
Q2M1P5	KIF7	Kinesin-like protein KIF7	Homo sapiens (Human)	EV
Q86VH2	KIF27	Kinesin-like protein KIF27	Homo sapiens (Human)	SS
O75037	KIF21B	Kinesin-like protein KIF21B	Homo sapiens (Human)	EV
Q9P2E2	KIF17	Kinesin-like protein KIF17	Homo sapiens (Human)	EV
O00139	KIF2A	Kinesin-like protein KIF2A	Homo sapiens (Human)	PR
Q9NQT8	KIF13B	Kinesin-like protein KIF13B	Homo sapiens (Human)	EV
Q9H1H9	KIF13A	Kinesin-like protein KIF13A	Homo sapiens (Human)	SS
O43896	KIF1C	Kinesin-like protein KIF1C	Homo sapiens (Human)	SS
Q7M6Z4	Kif27	Kinesin-like protein KIF27	Mus musculus (Mouse)	SS
Q9QXL1	Kif21b	Kinesin-like protein KIF21B	Mus musculus (Mouse)	SS
B7ZNG0	Kif7	Kinesin-like protein KIF7	Mus musculus (Mouse)	SS
Q9QXL2	Kif21a	Kinesin-like protein KIF21A	Mus musculus (Mouse)	EV SS
Q7M6Z5	Kif27	Kinesin-like protein KIF27	Rattus norvegicus (Rat)	SS
F1M5N7	Kif21b	Kinesin-like protein KIF21B	Rattus norvegicus (Rat)	SS
Q58G59	kif7	Kinesin-like protein kif7	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MLGAPDESSV	RVAVRIRPQL	AKEKIEGCHI	CTSVTPGEPQ	VFLGKDKAFT	FDYVFDIDSQ
70	80	90	100	110	120
QEQIYIQCIE	KLIEGCFEGY	NATVFAYGQT	GAGKTYTMGT	GFDVNIVEEE	LGIISRAVKH
130	140	150	160	170	180
LFKSIEEKKH	IAIKNGLPAP	DFKVNAQFLE	LYNEEVLDLF	DTTRDIDAKS	KKSNIRIHED
190	200	210	220	230	240
STGGIYTVGV	TTRTVNTESE	MMQCLKLGAL	SRTTASTQMN	VQSSRSHAIF	TIHVCQTRVC
250	260	270	280	290	300
PQIDADNATD	NKIISESAQM	NEFETLTAKF	HFVDLAGSER	LKRTGATGER	AKEGISINCG
310	320	330	340	350	360
LLALGNVISA	LGDKSKRATH	VPYRDSKLTR	LLQDSLGGNS	QTIMIACVSP	SDRDFMETLN
370	380	390	400	410	420
TLKYANRARN	IKNKVMVNQD	RASQQINALR	SEITRLQMEL	MEYKTGKRII	DEEGVESIND
430	440	450	460	470	480
MFHENAMLQT	ENNNLRVRIK	AMQETVDALR	SRITQLVSDQ	ANHVLARAGE	GNEEISNMIH
490	500	510	520	530	540
SYIKEIEDLR	AKLLESEAVN	ENLRKNLTRA	TARAPYFSGS	STFSPTILSS	DKETIEIIDL
550	560	570	580	590	600
AKKDLEKLKR	KEKRKKKRLQ	KLEESNREER	SVAGKEDNTD	TDQEKKEEKG	VSERENNELE
610	620	630	640	650	660
VEESQEVSDH	EDEEEEEEEE	EDDIDGGESS	DESDSESDEK	ANYQADLANI	TCEIAIKQKL
670	680	690	700	710	720
IDELENSQKR	LQTLKKQYEE	KLMMLQHKIR	DTQLERDQVL	QNLGSVESYS	EEKAKKVRSE
730	740	750	760	770	780
YEKKLQAMNK	ELQRLQAAQK	EHARLLKNQS	QYEKQLKKLQ	QDVMEMKKTK	VRLMKQMKEE
790	800	810	820	830	840
QEKARLTESR	RNREIAQLKK	DQRKRDHQLR	LLEAQKRNQE	VVLRRKTEEV	TALRRQVRPM
850	860	870	880	890	900
SDKVAGKVTR	KLSSSDAPAQ	DTGSSAAAVE	TDASRTGAQQ	KMRIPVARVQ	ALPTPATNGN
910	920	930	940	950	960
RKKYQRKGLT	GRVFISKTAR	MKWQLLERRV	TDIIMQKMTI	SNMEADMNRL	LKQREELTKR
970	980	990	1000	1010	1020
REKLSKRREK	IVKENGEGDK	NVANINEEME	SLTANIDYIN	DSISDCQANI	MQMEEAKEEG
1030	1040	1050	1060	1070	1080
ETLDVTAVIN	ACTLTEARYL	LDHFLSMGIN	KGLQAAQKEA	QIKVLEGRLK	QTEITSATQN
1090	1100	1110	1120	1130	1140
QLLFHMLKEK	AELNPELDAL	LGHALQDLDS	VPLENVEDST	DEDAPLNSPG	SEGSTLSSDL
1150	1160	1170	1180	1190	1200
MKLCGEVKPK	NKARRRTTTQ	MELLYADSSE	LASDTSTGDA	SLPGPLTPVA	EGQEIGMNTE
1210	1220	1230	1240	1250	1260
TSGTSAREKE	LSPPPGLPSK	IGSISRQSSL	SEKKIPEPSP	VTRRKAYEKA	EKSKAKEQKH
1270	1280	1290	1300	1310	1320
SDSGTSEASL	SPPSSPPSRP	RNELNVFNRL	TVSQGNTSVQ	QDKSDESDSS	LSEVHRSSRR
1330	1340	1350	1360	1370	1380
GIINPFPASK	GIRAFPLQCI	HIAEGHTKAV	LCVDSTDDLL	FTGSKDRTCK	VWNLVTGQEI
1390	1400	1410	1420	1430	1440
MSLGGHPNNV	VSVKYCNYTS	LVFTVSTSYI	KVWDIRDSAK	CIRTLTSSGQ	VTLGDACSAS
1450	1460	1470	1480	1490	1500
TSRTVAIPSG	ENQINQIALN	PTGTFLYAAS	GNAVRMWDLK	RFQSTGKLTG	HLGPVMCLTV
1510	1520	1530	1540	1550	1560
DQISSGQDLI	ITGSKDHYIK	MFDVTEGALG	TVSPTHNFEP	PHYDGIEALT	IQGDNLFSGS
1570	1580	1590	1600	1610	1620
RDNGIKKWDL	TQKDLLQQVP	NAHKDWVCAL	GVVPDHPVLL	SGCRGGILKV	WNMDTFMPVG
1630	1640	1650	1660	1670
EMKGHDSPIN	AICVNSTHIF	TAADDRTVRI	WKARNLQDGQ	ISDTGDLGED	IASN