Q7YR76

SS
Gene name
MYOCD
Protein name
Myocardin
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396571
EC number
Protein Class

Descriptions

Myocardin (MYOCD) is a transcriptional co-activator that promotes cardiac or smooth muscle gene programs through its interaction with myocyte-enhancing factor (MEF2) or serum-response factor (SRF). Isoforms of MYOCD with a truncated amino terminus show increased activity when compared with those with the full-length amino terminus. The cardiac-specific amino terminus acted in an autoinhibitory fashion to bind MYOCD via specific negatively charged residues and thereby repressed SRF-dependent MYOCD activity. Deletion of N-terminal MDH domain or mutagenesis of the residues within the domain disrupts autoinhibition.

Autoinhibitory domains (AIDs)

1-149 (MHD domain and linker) SS

Target domain

695-933 (TAD domain)

Relief mechanism

Others

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YR76

Entry ID Method Resolution Chain Position Source
AF-Q7YR76-F1 Predicted AlphaFoldDB

No variants for Q7YR76

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7YR76

No associated diseases with Q7YR76

4 regional properties for Q7YR76

Type Name Position InterPro Accession
domain SAP domain 368 - 402 IPR003034
repeat RPEL repeat 18 - 43 IPR004018-1
repeat RPEL repeat 62 - 87 IPR004018-2
repeat RPEL repeat 106 - 131 IPR004018-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

4 GO annotations of biological process

Name Definition
cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
transcription initiation-coupled chromatin remodeling An epigenetic mechanism of regulation of gene expression that involves chromatin remodeling to capacitate gene expression by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IZQ8 MYOCD Myocardin Homo sapiens (Human) EV
Q8VIM5 Myocd Myocardin Mus musculus (Mouse) SS
Q8R5I7 Myocd Myocardin Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MTLLGSEHSL LIRSKFRSVL QLRLQQRRTQ EQLANEGIIP PLRSPPAFHE QRRRLESDKA
70 80 90 100 110 120
ADTLKHKVRN RSDRGNVVKM HILQASSAER PVPAAQMKLK RARLADDLNE KIALRPGPLE
130 140 150 160 170 180
LVEKNILPVD CAVKEAIKGN QVSLSKSADA FAFEEDSSSD GLSPDQTRSE DLPGSAGSPL
190 200 210 220 230 240
DTKAAETPLA GPRGTVQDLT LGSENERNDS APQSGNQSDL GKQGLGPLGS PLPVHAAVKS
250 260 270 280 290 300
KSLSDGKNRH KKPKDPKPKV KKLKYHQYIP PDQKAEKSPP PMDSAYARLL QQQQLFLQLQ
310 320 330 340 350 360
ILSQQQQHRF SYPGIHQAQL KEPNEQMARN PNSSSAPLSS TPLSPAKNSF SGQTGVSSLK
370 380 390 400 410 420
PGPLPSNLDD LKVSELRQQL RIRGLPVSGT KTALMDRLRP FQDCSGNPVP NFGDITTVTF
430 440 450 460 470 480
PVTPSNALPS YQSSPSTSAF YHFGSTSSSP PISPASSDLS VAGSLPDTFN DASPSFGLHP
490 500 510 520 530 540
SPVHACAEES LMSSLNGGSL PPELDGLDSE KDKMLVEKQK VINELTWKLQ QEQRQVEELR
550 560 570 580 590 600
MQLQKQKRGT CPEKKPLPFL AAPIKQEDAG SSCPFAPLPR AVKRQSNSSE EQPAAGDAAR
610 620 630 640 650 660
LRPLGNTHCA ESSGQTNVLS STFLSPQCSP QHSPFGAVKS PQHISLPPSP NNPYFLPASS
670 680 690 700 710 720
GAPGEEHRVS SPVSSQVCTA QMVGLHSSDK AGPKFSNPSP TFSKSASAVS EITQPPSYED
730 740 750 760 770 780
AVKQQMTRSQ QMDELLDVLI ESGEMPADAR EDHSCLQKVP KIPGSSRSPT AALPKPSATF
790 800 810 820 830 840
DQASSGGQLA FDHYSNDSDE HLEVLLNSQS PLGKVSEVAL LKIGSEEPAF DGMADGFSGK
850 860 870 880 890 900
AAEELFNAHE ILPGPLSPMH TQFSPSSVDS SGLPLGFTES PWESMEWLDL TPPSSTQGFS
910 920 930
SLSTGGPSIF NIDFLDVTDL NLNSPMDLHL QQW