Q7Y201
SS
Gene name |
PME13 (ARATH13, At2g26450, T9J22.12) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 13 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G26450 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
301-598 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q7Y201
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7Y201-F1 | Predicted | AlphaFoldDB |
64 variants for Q7Y201
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05597061 | 38 | A>G | No | 1000Genomes | |
| ENSVATH05597060 | 38 | A>T | No | 1000Genomes | |
| ENSVATH05597063 | 41 | G>E | No | 1000Genomes | |
| ENSVATH00249169 | 42 | G>A | No | 1000Genomes | |
| ENSVATH01900134 | 45 | A>S | No | 1000Genomes | |
| ENSVATH13414137 | 45 | A>V | No | 1000Genomes | |
| ENSVATH01900139 | 66 | N>K | No | 1000Genomes | |
| ENSVATH01900140 | 85 | P>S | No | 1000Genomes | |
| tmp_2_11251602_T_G | 108 | I>M | No | 1000Genomes | |
| ENSVATH00249170 | 111 | T>I | No | 1000Genomes | |
| ENSVATH01900141 | 131 | D>N | No | 1000Genomes | |
| ENSVATH13414138 | 137 | D>Y | No | 1000Genomes | |
| ENSVATH00249171 | 142 | F>L | No | 1000Genomes | |
| ENSVATH00249172 | 149 | A>G | No | 1000Genomes | |
| ENSVATH13414139 | 151 | N>S | No | 1000Genomes | |
| ENSVATH13414140 | 163 | S>I | No | 1000Genomes | |
| tmp_2_11251779_A_T | 167 | E>D | No | 1000Genomes | |
| ENSVATH01900143 | 176 | E>A | No | 1000Genomes | |
| ENSVATH05597065 | 181 | L>H | No | 1000Genomes | |
| ENSVATH00249173 | 186 | K>M | No | 1000Genomes | |
| ENSVATH00249174 | 189 | T>A | No | 1000Genomes | |
| ENSVATH05597066 | 195 | K>N | No | 1000Genomes | |
| ENSVATH05597067 | 210 | D>G | No | 1000Genomes | |
| ENSVATH05597069 | 218 | V>A | No | 1000Genomes | |
| tmp_2_11251985_C_T | 236 | S>F | No | 1000Genomes | |
| ENSVATH13414141 | 245 | S>Y | No | 1000Genomes | |
| ENSVATH14555595 | 257 | K>E | No | 1000Genomes | |
| ENSVATH05597070 | 260 | T>S | No | 1000Genomes | |
| ENSVATH05597071 | 261 | E>* | No | 1000Genomes | |
| tmp_2_11252062_A_G | 262 | N>D | No | 1000Genomes | |
| tmp_2_11252135_A_G | 286 | D>G | No | 1000Genomes | |
| ENSVATH14555596 | 293 | V>I | No | 1000Genomes | |
| ENSVATH13414142 | 294 | D>E | No | 1000Genomes | |
| tmp_2_11252158_G_A | 294 | D>N | No | 1000Genomes | |
| ENSVATH05597072 | 309 | S>N | No | 1000Genomes | |
| ENSVATH13414143 | 321 | A>E | No | 1000Genomes | |
| ENSVATH01900149 | 338 | I>F | No | 1000Genomes | |
| ENSVATH05597077 | 341 | E>D | No | 1000Genomes | |
| ENSVATH00249181 | 342 | Y>S | No | 1000Genomes | |
| ENSVATH05597078 | 369 | S>C | No | 1000Genomes | |
| ENSVATH05597079 | 374 | I>F | No | 1000Genomes | |
| tmp_2_11252523_A_G | 379 | T>A | No | 1000Genomes | |
| ENSVATH14555597 | 383 | V>I | No | 1000Genomes | |
| ENSVATH01900152 | 385 | Q>L | No | 1000Genomes | |
| tmp_2_11252788_T_G | 396 | F>C | No | 1000Genomes | |
| tmp_2_11252827_C_T | 409 | A>V | No | 1000Genomes | |
| ENSVATH14555598 | 444 | V>A | No | 1000Genomes | |
| ENSVATH05597086 | 452 | I>L | No | 1000Genomes | |
| ENSVATH13414175 | 460 | F>L | No | 1000Genomes | |
| ENSVATH13414176 | 473 | G>A | No | 1000Genomes | |
| ENSVATH13414177 | 484 | V>A | No | 1000Genomes | |
| tmp_2_11253078_G_A | 493 | V>I | No | 1000Genomes | |
| ENSVATH05597087 | 499 | I>F | No | 1000Genomes | |
| ENSVATH05597089 | 510 | E>K | No | 1000Genomes | |
| tmp_2_11253244_C_T | 548 | T>M | No | 1000Genomes | |
| ENSVATH13414178 | 554 | T>M | No | 1000Genomes | |
| tmp_2_11253265_T_C | 555 | L>S | No | 1000Genomes | |
| tmp_2_11253273_G_A | 558 | A>T | No | 1000Genomes | |
| tmp_2_11253274_C_T | 558 | A>V | No | 1000Genomes | |
| ENSVATH05597091 | 584 | E>K | No | 1000Genomes | |
| tmp_2_11253382_T_G | 594 | F>C | No | 1000Genomes | |
| tmp_2_11253397_G_A | 599 | W>* | No | 1000Genomes | |
| ENSVATH05597092 | 600 | I>V | No | 1000Genomes | |
| ENSVATH04131812 | 615 | A>Y | No | 1000Genomes |
No associated diseases with Q7Y201
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFQDFDKIQ | ERVNANRKRK | FRKRIIVGTV | SLLVVVAAIV | GGAFAYVAYE | KRNEQQQQQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QAKNHNKSGS | GNNVVKDSDK | KSPSPPTPSQ | KAPVSAAQSV | KPGQGDKIIQ | TLCSSTLYMQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ICEKTLKNRT | DKGFALDNPT | TFLKSAIEAV | NEDLDLVLEK | VLSLKTENQD | DKDAIEQCKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVEDAKEETV | ASLNKINVTE | VNSFEKVVPD | LESWLSAVMS | YQETCLDGFE | EGNLKSEVKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVNSSQVLTS | NSLALIKTFT | ENLSPVMKVV | ERHLLDDIPS | WVSNDDRRML | RAVDVKALKP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NATVAKDGSG | DFTTINDALR | AMPEKYEGRY | IIYVKQGIYD | EYVTVDKKKA | NLTMVGDGSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KTIVTGNKSH | AKKIRTFLTA | TFVAQGEGFM | AQSMGFRNTA | GPEGHQAVAI | RVQSDRSIFL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NCRFEGYQDT | LYAYTHRQYY | RSCVIVGTID | FIFGDAAAIF | QNCNIFIRKG | LPGQKNTVTA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QGRVDKFQTT | GFVVHNCKIA | ANEDLKPVKE | EYKSYLGRPW | KNYSRTIIME | SKIENVIDPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GWLRWQETDF | AIDTLYYAEY | NNKGSSGDTT | SRVKWPGFKV | INKEEALNYT | VGPFLQGDWI |
| 610 | |||||
| SASGSPVKLG | LYDA |