AiPD: Autoinhibited Protein Database

Q7Y180

Gene name	Os03g0668900 (LOC_Os03g46600, OsJ_12028, OSJNBa0039O18.14, OSJNBb0036M02.2)
Protein name	Acidic leucine-rich nuclear phosphoprotein 32-related protein 2
Names	ANP32/acidic nuclear phosphoprotein-like protein 2
Species	Oryza sativa subsp. japonica (Rice)
KEGG Pathway	osa:4333677
EC number
Protein Class

Descriptions

ANP32A(I1<sup>PP2A</sup>) regulates PP2A activity by functioning as a non-competitive inhibitor of this enzyme. PP2A is a major regulator of the phosphorylation of Tau. The activity of PP2A is compromised in Alzheimer's disease brain. ANP32A has an autoinhibitory domain that negatively affects the interaction of ANP32A with PP2Ac and its ability to modulate the PP2A activity, which lies within amino acid residues 121-163. The inhibitory role of the autoinhibitory region might be regulated through the phosphorylation of Ser-158 or both Ser-158 and Ser-204 by casein kinase II. The autoinhibition is disrupted by C-terminal region.

Autoinhibitory domains (AIDs)

137-179 (Autoinhibitory domain) SS

Target domain	12-179 (Leucine-rich region)
Relief mechanism	PTM, Others
Assay

AID

137-179 (Autoinhibitory domain)

Target domain

12-179 (Leucine-rich region)

Relief mechanism

PTM (Phosphorylation of Ser158 or both Ser158 and Ser204), Others (C-terminal acidic region-mediated neutralization)

Assay

Accessory elements

No accessory elements

References

Chen S et al. (2008) "I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A", The Journal of biological chemistry, 283, 10513-21

Autoinhibited structure

Activated structure

1 structures for Q7Y180

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7Y180-F1	Predicted				AlphaFoldDB

No variants for Q7Y180

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q7Y180

No associated diseases with Q7Y180

1 regional properties for Q7Y180

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	106 - 127	IPR001611

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

20 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P51122	ANP32A	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Bos taurus (Bovine)	SS
Q3SZC6	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Bos taurus (Bovine)	SS
Q5F4A3	ANP32E	Acidic leucine-rich nuclear phosphoprotein 32 family member E	Gallus gallus (Chicken)	SS
Q5ZMN0	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Gallus gallus (Chicken)	SS
Q8HY67	ANP32A	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Canis lupus familiaris (Dog) (Canis familiaris)	SS
Q9V895	Anp32a	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Drosophila melanogaster (Fruit fly)	SS
P39687	ANP32A	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Homo sapiens (Human)	EV
Q92688	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Homo sapiens (Human)	SS
Q9BTT0	ANP32E	Acidic leucine-rich nuclear phosphoprotein 32 family member E	Homo sapiens (Human)	SS
O43423	ANP32CP	Putative uncharacterized protein ANP32CP	Homo sapiens (Human)	SS
O35381	Anp32a	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Mus musculus (Mouse)	SS
Q9EST5	Anp32b	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Mus musculus (Mouse)	SS
P97822	Anp32e	Acidic leucine-rich nuclear phosphoprotein 32 family member E	Mus musculus (Mouse)	SS
Q5XIE0	Anp32e	Acidic leucine-rich nuclear phosphoprotein 32 family member E	Rattus norvegicus (Rat)	SS
Q9EST6	Anp32b	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Rattus norvegicus (Rat)	SS
P49911	Anp32a	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Rattus norvegicus (Rat)	SS
Q9SCQ7	At3g50690	Acidic leucine-rich nuclear phosphoprotein 32-related protein	Arabidopsis thaliana (Mouse-ear cress)	SS
Q6P1U7	anp32b	Acidic leucine-rich nuclear phosphoprotein 32 family member B	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	SS
Q6NUW5	anp32e	Acidic leucine-rich nuclear phosphoprotein 32 family member E	Danio rerio (Zebrafish) (Brachydanio rerio)	SS
Q7ZUP0	anp32a	Acidic leucine-rich nuclear phosphoprotein 32 family member A	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MADAAAPGED	DAAWERAIAA	AVKNAPFSAP	KTLTLDGAVK	STTGRLPSPS	LLGRYPSLEE
70	80	90	100	110	120
LSVAGARLSS	LAGLPRLPAL	RRLSLPDNRL	SGAASLAAVA	ESCGATLRHL	DLGNNRFADV
130	140	150	160	170	180
AELAPLAPHG	VESLDLYQCP	VTKAKGYRDK	VFALIPSLKF	LDGMDAEGND	CLDSDDEEDE
190	200	210	220	230	240
EEDEGEEGEG	EGDEEEEEEG	GEEGEGDEDD	EEEGDEEEDE	EEGEEEAEDE	EDEAGADEED
250	260	270
ESKVANGSKG	SSGSAQPNKR	KRDSEDDANG	DN