Q7XEK4

EV
Gene name
ACA7
Protein name
Calcium-transporting ATPase 7, plasma membrane-type
Names
OsACA7, Ca(2+)-ATPase isoform 7
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4348639
EC number
7.2.2.10: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class
CATION TRANSPORTING ATPASE (PTHR24093)

Descriptions

Calcium-transporting ATPase 7 (ACA7) catalyzes the hydrolysis of ATP coupled with the translocation of calcium in a Ca2+-dependent manner. ACA enzymes contain an N-terminal autoinhibitory region, which serves a binding site of a calmodulin. Removal of the N-terminal region restored the calcium pump activity of ACA7. Calmodulin-binding to the autoinhibitory region releases the autoinhibition

Autoinhibitory domains (AIDs)

2-68 (N-terminal autoinhibitory region) EV

Target domain

439-812 (ATPase domain)

Relief mechanism

Partner binding

Assay

Deletion assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7XEK4

Entry ID Method Resolution Chain Position Source
AF-Q7XEK4-F1 Predicted AlphaFoldDB

No variants for Q7XEK4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7XEK4

No associated diseases with Q7XEK4

2 regional properties for Q7XEK4

Type Name Position InterPro Accession
domain Calponin homology domain 14 - 118 IPR001715
domain EB1, C-terminal 194 - 264 IPR004953

Functions

Description
EC Number 7.2.2.10 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Golgi apparatus membrane ; Multi-pass membrane protein
PANTHER Family PTHR24093 CATION TRANSPORTING ATPASE
PANTHER Subfamily PTHR24093:SF455 CALCIUM-TRANSPORTING ATPASE 12, PLASMA MEMBRANE-TYPE
PANTHER Protein Class primary active transporter
transporter
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
metal ion binding Binding to a metal ion.
P-type calcium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

31 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38929 PMC1 Calcium-transporting ATPase 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
D3K0R6 ATP2B4 Plasma membrane calcium-transporting ATPase 4 Bos taurus (Bovine) SS
Q01814 ATP2B2 Plasma membrane calcium-transporting ATPase 2 Homo sapiens (Human) SS
P23634 ATP2B4 Plasma membrane calcium-transporting ATPase 4 Homo sapiens (Human) EV
P20020 ATP2B1 Plasma membrane calcium-transporting ATPase 1 Homo sapiens (Human) SS
Q16720 ATP2B3 Plasma membrane calcium-transporting ATPase 3 Homo sapiens (Human) EV
G5E829 Atp2b1 Plasma membrane calcium-transporting ATPase 1 Mus musculus (Mouse) SS
Q9R0K7 Atp2b2 Plasma membrane calcium-transporting ATPase 2 Mus musculus (Mouse) SS
Q6Q477 Atp2b4 Plasma membrane calcium-transporting ATPase 4 Mus musculus (Mouse) SS
P23220 ATP2B1 Plasma membrane calcium-transporting ATPase 1 Sus scrofa (Pig) SS
P11506 Atp2b2 Plasma membrane calcium-transporting ATPase 2 Rattus norvegicus (Rat) SS
Q64542 Atp2b4 Plasma membrane calcium-transporting ATPase 4 Rattus norvegicus (Rat) SS
P11505 Atp2b1 Plasma membrane calcium-transporting ATPase 1 Rattus norvegicus (Rat) SS
Q64568 Atp2b3 Plasma membrane calcium-transporting ATPase 3 Rattus norvegicus (Rat) SS
Q2QMX9 ACA10 Calcium-transporting ATPase 10, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q2QY12 ACA9 Probable calcium-transporting ATPase 9, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q6ATV4 ACA3 Calcium-transporting ATPase 3, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q7X8B5 ACA5 Calcium-transporting ATPase 5, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q8RUN1 ACA1 Calcium-transporting ATPase 1, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q65X71 ACA6 Probable calcium-transporting ATPase 6, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q2RAS0 ACA8 Probable calcium-transporting ATPase 8, plasma membrane-type Oryza sativa subsp japonica (Rice) SS
Q37145 ACA1 Calcium-transporting ATPase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O64806 ACA7 Putative calcium-transporting ATPase 7, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
O22218 ACA4 Calcium-transporting ATPase 4, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LU41 ACA9 Calcium-transporting ATPase 9, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9M2L4 ACA11 Putative calcium-transporting ATPase 11, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9SZR1 ACA10 Calcium-transporting ATPase 10, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
O81108 ACA2 Calcium-transporting ATPase 2, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
Q9LF79 ACA8 Calcium-transporting ATPase 8, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) EV
Q9LIK7 ACA13 Putative calcium-transporting ATPase 13, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
Q9LY77 ACA12 Calcium-transporting ATPase 12, plasma membrane-type Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MECADYFIGS GRRCSPSTST STSREAWRPE KQWRKATNVI RGCHRLLRLG VLSAAAGIMR
70 80 90 100 110 120
RNPSYVEIKV HDEGELDVSS GGDGEAPVAF TVAADDESFK GLVKNKREDC FRLLGGGAGV
130 140 150 160 170 180
AAVLASGAER GIRGDDADVA RRKKAFGSNT YPKPKPKGFF RHVWDALADV FLIVLLVCAA
190 200 210 220 230 240
VSLAFGIKEH GIKDGWYDGV SIFLAVFLVA AVSAVSNHSQ GKRFDKLARE SENIMVSVVR
250 260 270 280 290 300
AARRQEVSIF DVVVGDVVVL KIGDVVPADG VFLDGHALQV DESSMTGEPH PVEVDAVKSP
310 320 330 340 350 360
FLASGVKVVD GYGKMVVTAV GTDTAWGEMM RTITRENTDP TPLQERLEGL TSSIGKVGIA
370 380 390 400 410 420
VAVLVFAVLT ARHFTGSTRD EQGNALFDKR NVTFNAVFSG LVGIFQQAVT IIVVAIPEGL
430 440 450 460 470 480
PLAVTLTLAF SMKRMVRENA LVRRLSACET MGSVTAICTD KTGTLTLNQM KVTEFWVGAD
490 500 510 520 530 540
RPRSAAAVNG GVVRLLCQGA GLNTTGSVYK PDNVSPPEIT GSPTEKALLS WAVEELPMDA
550 560 570 580 590 600
DALKRKCKVV RVEAFNSDKK RSGVMLRDAA TGAVTAHWKG AAEMVLARCT VYVGADGAAR
610 620 630 640 650 660
ELGVEQRRKL EQVINDMAAA SLRCIAFAYK QVVDGGDSDN AKIDDEGLTL LGFVGLKDPC
670 680 690 700 710 720
RPEVKSAIEA CTKAGIAVKM VTGDNVLTAR AIAKECGIIS GNDDDAAGVV IEGHEFRAMS
730 740 750 760 770 780
EQEQLAIVDN IRVMARSLPL DKLVLVQRLK QKGHVVAVTG DGTNDAPALK EADVGLSMGV
790 800 810 820 830 840
QGTEVAKESS DIVILNDNFD TVVTATRWGR CVYNNIQKFI QFQLTVNVAA LVINFVSAVT
850 860 870 880 890 900
TGRMPLTTVQ LLWVNLIMDT MGALALATDT PTAGLMRRPP IGRAAPLISN AMWRNLAAQA
910 920 930 940 950 960
AYQVAVLLAL QYRGFGGAGA GERANGTMIF NAFVLCQVFN EFNAREIERR NVFAGVHRNR
970 980 990 1000 1010 1020
MFLGIVAVTV ALQVVMVELL TKFAGTERLG WGQWGACVGI AAVSWPIGWA VKCIPVPERP
1030
FHEIITARRR RRRST