Q7WG65

PR
Gene name
fumC
Protein name
Fumarate hydratase class II
Names
Fumarase C, Aerobic fumarase, Iron-independent fumarase
Species
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
KEGG Pathway
bbr:BB4054
EC number
4.2.1.2: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-347 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7WG65

Entry ID Method Resolution Chain Position Source
AF-Q7WG65-F1 Predicted AlphaFoldDB

No variants for Q7WG65

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7WG65

No associated diseases with Q7WG65

3 regional properties for Q7WG65

Type Name Position InterPro Accession
domain Fumarase C, C-terminal 407 - 460 IPR018951
conserved_site Fumarate lyase, conserved site 316 - 325 IPR020557
domain Fumarate lyase, N-terminal 11 - 341 IPR022761

Functions

Description
EC Number 4.2.1.2 Hydro-lyases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle.

1 GO annotations of molecular function

Name Definition
fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O.

2 GO annotations of biological process

Name Definition
fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTRTEKDTF GPIEVPEQHL WGAQTQRSLH FFAISTEKMP VPLVAAMARL KRAAAKVNAE
70 80 90 100 110 120
LGELDPQVAD AIMRAADEVV AGKWPDEFPL SVWQTGSGTQ SNMNMNEVLA NRASELLGGE
130 140 150 160 170 180
RGEGRKVHPN DHVNRGQSSN DTFPTAMHVA AAVEVEHRVL PALKALRGTL AAKSAAFYDI
190 200 210 220 230 240
VKIGRTHLQD ATPLTLGQEI SGYVAQLDLA EQQIRATLAG LHQLAIGGTA VGTGLNAHPQ
250 260 270 280 290 300
FSAKVSAELA HDTGSAFVSA PNKFQALASH EALLFAHGAL KTLAAGLMKI ANDVRWLASG
310 320 330 340 350 360
PRSGLGEISI PENEPGSSIM PGKVNPTQCE AVTMLAAQVM GNDVAINVGG ASGNFELNVF
370 380 390 400 410 420
KPLVIHNFLQ SVRLLADGMV SFDKHCAAGI EPNRERITEL VERSLMLVTA LNPHIGYDKA
430 440 450 460
AQIAKKAHKE NLSLKEAALA LGHLTEAQFA EWVVPGDMTN ARR