Q7TT50
SS
Gene name |
Cdc42bpb (Kiaa1124) |
Protein name |
Serine/threonine-protein kinase MRCK beta |
Names |
EC 2.7.11.1 , CDC42-binding protein kinase beta , DMPK-like beta , Myotonic dystrophy kinase-related CDC42-binding kinase beta , MRCK beta , Myotonic dystrophy protein kinase-like beta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:217866 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
CDC42BPA(MRCK) is a Cdc42-binding serine/threonine kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. A region containing the two distal CC domains (CC2 and CC3; residues 658-930) interacts intramolecularly with the kinase domain and negatively regulates its activity.
Autoinhibitory domains (AIDs)
Target domain |
76-342 (Protein kinase domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
217-241 (Activation loop from InterPro)
Target domain |
3-411 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q7TT50
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TT50-F1 | Predicted | AlphaFoldDB |
77 variants for Q7TT50
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3403065453 | 45 | A>V | No | EVA | |
| rs3389228781 | 63 | T>I | No | EVA | |
| rs3389221817 | 69 | M>I | No | EVA | |
| rs3389221836 | 85 | G>E | No | EVA | |
| rs3389277262 | 109 | K>N | No | EVA | |
| rs3389263715 | 168 | F>I | No | EVA | |
| rs3389221894 | 170 | D>E | No | EVA | |
| rs3389263915 | 170 | D>N | No | EVA | |
| rs3412748218 | 175 | D>Y | No | EVA | |
| rs3389257967 | 178 | R>S | No | EVA | |
| rs3413157024 | 204 | D>V | No | EVA | |
| rs3389277263 | 258 | Y>N | No | EVA | |
| rs3389277289 | 259 | G>R | No | EVA | |
| rs3404050720 | 311 | E>G | No | EVA | |
| rs3403015290 | 312 | E>* | No | EVA | |
| rs3389257895 | 316 | L>R | No | EVA | |
| rs3389257968 | 339 | H>R | No | EVA | |
| rs3389259182 | 349 | N>D | No | EVA | |
| rs3403740404 | 350 | I>L | No | EVA | |
| rs3403803902 | 351 | R>P | No | EVA | |
| rs3389228844 | 376 | M>K | No | EVA | |
| rs3410930421 | 448 | R>P | No | EVA | |
| rs3389246156 | 461 | L>Q | No | EVA | |
| rs230873833 | 492 | E>D | No | EVA | |
| rs3389263713 | 505 | N>Y | No | EVA | |
| rs13481651 | 585 | S>A | No | EVA | |
| rs3403065423 | 665 | K>E | No | EVA | |
| rs3389277221 | 668 | Q>K | No | EVA | |
| rs3389193117 | 669 | G>V | No | EVA | |
| rs3389270117 | 673 | P>L | No | EVA | |
| rs214560430 | 676 | A>S | No | EVA | |
| rs3389263745 | 714 | N>I | No | EVA | |
| rs3389263759 | 748 | H>Q | No | EVA | |
| rs3389221820 | 781 | E>* | No | EVA | |
| rs3389261087 | 873 | M>K | No | EVA | |
| rs3389234566 | 882 | A>D | No | EVA | |
| rs38926352 | 893 | V>I | No | EVA | |
| rs3389261617 | 946 | D>N | No | EVA | |
| rs29149337 | 991 | T>P | No | EVA | |
| rs3389270145 | 995 | Q>* | No | EVA | |
| rs3549714903 | 1001 | R>P | No | EVA | |
| rs3403065404 | 1019 | M>L | No | EVA | |
| rs3389228811 | 1040 | C>R | No | EVA | |
| rs3389270136 | 1041 | S>G | No | EVA | |
| rs3389259204 | 1042 | H>R | No | EVA | |
| rs3389259194 | 1074 | Q>* | No | EVA | |
| rs3389263687 | 1120 | A>T | No | EVA | |
| rs29145242 | 1171 | R>Q | No | EVA | |
| rs3389259137 | 1203 | K>R | No | EVA | |
| rs3389220243 | 1243 | A>P | No | EVA | |
| rs3389246175 | 1252 | G>E | No | EVA | |
| rs3389257890 | 1309 | W>* | No | EVA | |
| rs3389228854 | 1309 | W>R | No | EVA | |
| rs3389263721 | 1320 | F>I | No | EVA | |
| rs3389246217 | 1342 | S>L | No | EVA | |
| rs3389263717 | 1353 | L>V | No | EVA | |
| rs3389277214 | 1355 | L>H | No | EVA | |
| rs3389220224 | 1364 | P>H | No | EVA | |
| rs3389270066 | 1373 | V>M | No | EVA | |
| rs3389257958 | 1381 | M>I | No | EVA | |
| rs3389277280 | 1423 | Q>R | No | EVA | |
| rs3389259168 | 1426 | F>Y | No | EVA | |
| rs3389228816 | 1437 | E>* | No | EVA | |
| rs3389246186 | 1445 | H>L | No | EVA | |
| rs3389260041 | 1456 | R>G | No | EVA | |
| rs3389270104 | 1461 | E>D | No | EVA | |
| rs3411600490 | 1469 | V>I | No | EVA | |
| rs3389220200 | 1491 | V>M | No | EVA | |
| rs3549837711 | 1523 | R>H | No | EVA | |
| rs242035398 | 1535 | I>V | No | EVA | |
| rs3389220193 | 1548 | Q>R | No | EVA | |
| rs3389246160 | 1574 | M>I | No | EVA | |
| rs3389257950 | 1594 | V>L | No | EVA | |
| rs3412914295 | 1595 | A>T | No | EVA | |
| rs3403803921 | 1597 | M>STCMPSPGPM* | No | EVA | |
| rs3389257910 | 1600 | G>W | No | EVA | |
| rs3389220232 | 1601 | D>N | No | EVA |
No associated diseases with Q7TT50
8 regional properties for Q7TT50
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 251 - 504 | IPR000719 |
| domain | SH2 domain | 130 - 229 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 252 - 500 | IPR001245 |
| domain | SH3 domain | 65 - 126 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 366 - 378 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 257 - 279 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 251 - 500 | IPR020635 |
| domain | Tyrosine-protein kinase Fgr, SH2 domain | 128 - 228 | IPR035693 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| actomyosin | Any complex of actin, myosin, and accessory proteins. |
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| protein-containing complex binding | Binding to a macromolecular complex. |
| small GTPase binding | Binding to a small monomeric GTPase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q28021 | ROCK2 | Rho-associated protein kinase 2 | Bos taurus (Bovine) | SS |
| Q9W1B0 | gek | Serine/threonine-protein kinase Genghis Khan | Drosophila melanogaster (Fruit fly) | SS |
| Q5VT25 | CDC42BPA | Serine/threonine-protein kinase MRCK alpha | Homo sapiens (Human) | EV |
| O75116 | ROCK2 | Rho-associated protein kinase 2 | Homo sapiens (Human) | SS |
| Q13464 | ROCK1 | Rho-associated protein kinase 1 | Homo sapiens (Human) | SS |
| Q9Y5S2 | CDC42BPB | Serine/threonine-protein kinase MRCK beta | Homo sapiens (Human) | SS |
| Q80UW5 | Cdc42bpg | Serine/threonine-protein kinase MRCK gamma | Mus musculus (Mouse) | PR |
| Q3UU96 | Cdc42bpa | Serine/threonine-protein kinase MRCK alpha | Mus musculus (Mouse) | SS |
| P70335 | Rock1 | Rho-associated protein kinase 1 | Mus musculus (Mouse) | SS |
| P70336 | Rock2 | Rho-associated protein kinase 2 | Mus musculus (Mouse) | SS |
| M3TYT0 | ROCK2 | Rho-associated protein kinase 2 | Sus scrofa (Pig) | SS |
| O54874 | Cdc42bpa | Serine/threonine-protein kinase MRCK alpha | Rattus norvegicus (Rat) | SS |
| Q62868 | Rock2 | Rho-associated protein kinase 2 | Rattus norvegicus (Rat) | EV |
| Q63644 | Rock1 | Rho-associated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q7TT49 | Cdc42bpb | Serine/threonine-protein kinase MRCK beta | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSAKVRLKKL | EQLLLDGPWR | NDSALSVETL | LDVLVCLYTE | CSHSALRRDK | YVAEFLEWAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFTQLVKDMQ | LHREDFEIIK | VIGRGAFGEV | AVVKMKNTER | IYAMKILNKW | EMLKRAETAC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FREERDVLVN | GDCQWITALH | YAFQDENYLY | LVMDYYVGGD | LLTLLSKFED | KLPEDMARFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IGEMVLAIDS | IHQLHYVHRD | IKPDNVLLDV | NGHIRLADFG | SCLKMNDDGT | VQSSVAVGTP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DYISPEILQA | MEDGMGKYGP | ECDWWSLGVC | MYEMLYGETP | FYAESLVETY | GKIMNHEERF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QFPSHVTDVS | EEAKDLIQRL | ICSRERRLGQ | NGIEDFKKHA | FFEGLNWENI | RNLEAPYIPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSSPSDTSNF | DVDDDMLRNI | EILPPGSHTG | FSGLHLPFIG | FTFTTESCFS | DRGSLKSMTQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SNTLTKDEDV | QRDLENSLQI | EAYERRIRRL | EQEKLELSRK | LQESTQTVQS | LHGSTRALGN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SNRDKEIKRL | NEELERMKSK | MADSNRLERQ | LEDTVTLRQE | HEDSTHRLKG | LEKQYRLARQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKEELHKQLV | EASERLKSQT | KELKDAHQQR | KRALQEFSEL | NERMSELRSL | KQKVSRQLRD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KEEEMEVAMQ | KIDSMRQDLR | KSEKSRKELE | ARLEDAAAEA | SKERKLREHS | ESFCKQMERE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LEALKVKQGG | RGPGAASEHQ | QEISKIRSEL | EKKVLFYEEE | LVRREASHVL | EVKNVKKEVH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DSESHQLALQ | KEVLMLKDKL | EKSKRERHSE | MEEAIGTVKD | KYERERAMLF | DENKKLTAEN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EKLCSFVDKL | TAQNRQLEDE | LQDLASKKES | VAHWEAQIAE | IIQWVSDEKD | ARGYLQALAS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KMTEELETLR | SSSLGSRTLD | PLWKVRRSQK | LDMSARLELQ | SALEAEIRAK | QLVQEELRKV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KDSSLAFESK | LKESEAKNRE | LLEEMQSLRK | RMEEKFRADT | GLKLPDFQDS | IFEYFNTAPL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AHDLTFRTSS | ASDQETQASK | MDLSPSVSVA | TSTEQQEDMA | RPQQRPSPVP | LPSTQALAMA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GPKPKAHQFS | IKSFPSPTQC | SHCTSLMVGL | IRQGYACEVC | AFSCHVSCKD | SAPQVCPIPP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EQSKRPLGVD | VQRGIGTAYK | GYVKVPKPTG | VKKGWQRAYA | VVCDCKLFLY | DLPEGKSTQP |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GVVASQVLDL | RDEEFAVSSV | LASDVIHATR | RDIPCIFRVT | ASLLGSPSKT | SSLLILTENE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| NEKRKWVGIL | EGLQAILHKN | RLKSQVVHVA | QEAYDSSLPL | IKAVLAAAIV | DGDRIAVGLE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EGLYVIELTR | DVIVRAADCK | KVYQIELAPK | EKIAILLCGR | NHHVHLYPWS | SFDGAEASNF |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| DIKLPETKGC | QLIATGTLRK | SSSTCLFVAV | KRLILCYEIQ | RTKPFHRKFS | ELVAPGHVQW |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| MAVFKDRLCV | GYPSGFSLLS | IQGDGPPLDL | VNPTDPSLAF | LSQQSFDALC | AVELKSEEYL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LCFSHMGLYV | DPQGRRSRMQ | ELMWPAAPVA | CSCSPTHVTV | YSEYGVDVFD | VRTMEWVQTI |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GLRRIRPLNS | DGSLNLLGCE | PPRLIYFKNK | FSGTILNVPD | TSDNSKKQML | RTRSKRRFVF |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| KVPEEERLQQ | RREMLRDPEL | RSKMISNPTN | FNHVAHMGPG | DGMQVLMDLP | LSAAPTVQEE |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| KQGPTPAGLP | RQPPSRSKPY | VSWPSSGGSE | PGVPVPLRSM | SDPDQDFDKE | PDSDSTKHST |
| 1690 | 1700 | 1710 | |||
| PSNSSNPSGP | PSPNSPHRSQ | LPMEGLDQPS | CDA |